Lutte contre les cancers

Qualité de vie, soins de support

A partir d'une revue de la littérature publiée jusqu'en janvier 2012 (22 études non randomisées, 7 essais contrôlés randomisés), cette étude évalue, en fonction des techniques utilisées et du point de vue de la durée de l'hospitalisation, des événements indésirables, du temps de récupération physique et de la mortalité, la qualité de vie et les résultats péri-opératoires après une néphrectomie partielle ou une néphrectomie radicale pour un carcinome localisé à cellules rénales

Systematic Review of Perioperative and Quality-of-life Outcomes Following Surgical Management of Localised Renal Cancer
• European urology, sous presse, 2012 (résumé)

Détails

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A partir d'une revue de la littérature publiée jusqu'en janvier 2012 (22 études non randomisées, 7 essais contrôlés randomisés), cette étude évalue, en fonction des techniques utilisées et du point de vue de la durée de l'hospitalisation, des événements indésirables, du temps de récupération physique et de la mortalité, la qualité de vie et les résultats péri-opératoires après une néphrectomie partielle ou une néphrectomie radicale pour un carcinome localisé à cellules rénales

“Systematic Review of Perioperative and Quality-of-life Outcomes Following Surgical Management of Localised Renal Cancer”

• Steven, MacLennan;Mari, Imamura;Marie, C. Lapitan;Muhammad Imran, Omar;Thomas, B. L. Lam;Ana, M. Hilvano-Cabungcal;Pam, Royle;Fiona, Stewart;Graeme, MacLennan;Sara, J. MacLennan;Philipp, Dahm;Steven, E. Canfield;Sam, McClinton;T. R. Leyshon Griffiths;Börje, Ljungberg;James, N'Dow,;Ucan Systematic Review Reference Group

Context : For the treatment of localised renal cell carcinoma (RCC), uncertainties remain over the perioperative and quality-of-life (QoL) outcomes for the many different surgical techniques and approaches of nephrectomy. Controversy also remains on whether newer minimally invasive nephron-sparing interventions offer better QoL and perioperative outcomes, and whether adrenalectomy and lymphadenectomy should be performed simultaneously with nephrectomy. These nononcologic outcomes are important because they may have a considerable impact on localised RCC treatment decision making. Objective :To review systematically all the relevant published literature comparing perioperative and QoL outcomes of surgical management of localised RCC (T1–2N0M0). Evidence acquisition : Relevant databases including Medline, Embase, and the Cochrane Library were searched up to January 2012. Randomised controlled trials (RCTs) or quasi-randomised controlled trials, prospective observational studies with ...

Mots clés : Rein; Lutte contre les cancers (Qualité de vie, soins de support)

Observation

A partir des données du registre suédois du cancer portant sur 9 384 patients atteints d'une néoplasie myéloproliférative diagnostiquée entre 1973 et 2008, cette étude évalue le taux de survie relative à 10 ans en fonction des sous-types de la maladie (thrombocythémie essentielle, polycythémie vera)

Patterns of Survival Among Patients With Myeloproliferative Neoplasms Diagnosed in Sweden From 1973 to 2008: A Population-Based Study
• Journal of Clinical Oncology, sous presse, 2012 (résumé)

Détails

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A partir des données du registre suédois du cancer portant sur 9 384 patients atteints d'une néoplasie myéloproliférative diagnostiquée entre 1973 et 2008, cette étude évalue le taux de survie relative à 10 ans en fonction des sous-types de la maladie (thrombocythémie essentielle, polycythémie vera)

“Patterns of Survival Among Patients With Myeloproliferative Neoplasms Diagnosed in Sweden From 1973 to 2008: A Population-Based Study”

• Hultcrantz, Malin;Kristinsson, Sigurdur Yngvi;Andersson, Therese M.-L.;Landgren, Ola;Eloranta, Sandra;Derolf, Åsa Rangert;Dickman, Paul W.;Björkholm, Magnus

Purpose Reported survival in patients with myeloproliferative neoplasms (MPNs) shows great variation. Patients with primary myelofibrosis (PMF) have substantially reduced life expectancy, whereas patients with polycythemia vera (PV) and essential thrombocythemia (ET) have moderately reduced survival in most, but not all, studies. We conducted a large population-based study to establish patterns of survival in more than 9,000 patients with MPNs.Patients and Methods We identified 9,384 patients with MPNs (from the Swedish Cancer Register) diagnosed from 1973 to 2008 (divided into four calendar periods) with follow-up to 2009. Relative survival ratios (RSRs) and excess mortality rate ratios were computed as measures of survival.Results Patient survival was considerably lower in all MPN subtypes compared with expected survival in the general population, reflected in 10-year RSRs of 0.64 (95% CI, 0.62 to 0.67) in patients with PV, 0.68 (95% CI, 0.64 to 0.71) in those with ET, and 0.21 (95% ...

Mots clés : Myélome multiple et maladies immunoprolifératives; Lutte contre les cancers (Observation)

Menée sur 802 patients atteints d'une myélofibrose primitive, cette étude multicentrique internationale compare, en fonction de la période de diagnostic (1980-1995, 1996-2007), les caractéristiques clinico-pathologiques de la maladie et la survie des patients

Improving Survival Trends In Primary Myelofibrosis: An International Study
• Journal of Clinical Oncology, sous presse, 2012 (résumé)

Détails

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Menée sur 802 patients atteints d'une myélofibrose primitive, cette étude multicentrique internationale compare, en fonction de la période de diagnostic (1980-1995, 1996-2007), les caractéristiques clinico-pathologiques de la maladie et la survie des patients

“Improving Survival Trends In Primary Myelofibrosis: An International Study”

• Cervantes, Francisco;Dupriez, Brigitte;Passamonti, Francesco;Vannucchi, Alessandro M.;Morra, Enrica;Reilly, John T.;Demory, Jean-Loup;Rumi, Elisa;Guglielmelli, Paola;Roncoroni, Elisa;Tefferi, Ayalew;Pereira, Arturo

Purpose Despite the lack of major improvements in the treatment of primary myelofibrosis (PMF), there are recent indications that the survival of patients might have increased over the years. This study was aimed at ascertaining whether survival prolongation has actually occurred in PMF.Patients and Methods A total of 802 patients diagnosed with PMF in four European countries were compared for the presentation of features and survival according to the diagnostic periods 1980 to 1995 (n = 434) and 1996 to 2007 (n = 368); relative survival was estimated for the two groups.Results Patients diagnosed between 1996 and 2007 more often had constitutional symptoms (31% v 23%) but a lower incidence of marked anemia (31% v 39%), leukocytosis greater than 25 × 109/L (9% v 13%), and blood blasts (27% v 33%); risk distribution was comparable between the two groups. Median survival was 4.6 years (95% CI, 4.0 to 5.1) for patients from 1980 to 1995 and 6.5 years (95% CI, 5.5 to 7.4) for patients ...

Mots clés : Myélome multiple et maladies immunoprolifératives; Lutte contre les cancers (Observation)

Menée entre 1997 et 2004 dans le Nord-Est de l'Angleterre auprès de 29 563 patients atteints d'un cancer colorectal, cette étude en population évalue le taux de guérison en fonction de l'âge des patients et du stade de la maladie au diagnostic

Cure by age and stage at diagnosis for colorectal cancer patients in North West England, 1997–2004: A population-based study
• Cancer Epidemiology, sous presse, 2012 (résumé)

Détails

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Menée entre 1997 et 2004 dans le Nord-Est de l'Angleterre auprès de 29 563 patients atteints d'un cancer colorectal, cette étude en population évalue le taux de guérison en fonction de l'âge des patients et du stade de la maladie au diagnostic

“Cure by age and stage at diagnosis for colorectal cancer patients in North West England, 1997–2004: A population-based study”

• Shack, L. G.;Shah, A.;Lambert, P. C.;Rachet, B.

Background: Stage and age at diagnosis are important prognostic factors for patients with colorectal cancer. However, the proportion cured by stage and age is unknown in England. Materials and methods: This population-based study includes 29,563 adult patients who were diagnosed and registered with colorectal cancer during 1997–2004 and followed till 2007 in North West England. Multiple imputation was used to provide more reliable estimates of stage at diagnosis, when these data were missing. Cure mixture models were used to estimate the proportion ‘cured’ and the median survival of the uncured by age and stage. Results: For both colon and rectal cancer the proportion of patients cured and median survival time of the uncured decreased with advancing stage and increasing age. Patients aged under 65 years had the highest proportion cured and longest median survival of the uncured. Conclusion: Cure of colorectal cancer patients is dependent on stage and age at diagnosis with ...

Mots clés : Colon-rectum; Lutte contre les cancers (Observation)

A partir d'un modèle statistique, cette étude évalue, pour chaque région du monde, le taux de cancers attribuables à l'inactivité physique et estime, du point de vue de la mortalité et de l'espérance de vie, le bénéfice apporté par un changement de comportement

Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy
• The Lancet, sous presse, 2012 (résumé)

Détails

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A partir d'un modèle statistique, cette étude évalue, pour chaque région du monde, le taux de cancers attribuables à l'inactivité physique et estime, du point de vue de la mortalité et de l'espérance de vie, le bénéfice apporté par un changement de comportement

“Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy”

• Lee, I. Min;Shiroma, Eric J.;Lobelo, Felipe;Puska, Pekka;Blair, Steven N.;Katzmarzyk, Peter T.

Strong evidence shows that physical inactivity increases the risk of many adverse health conditions, including major non-communicable diseases such as coronary heart disease, type 2 diabetes, and breast and colon cancers, and shortens life expectancy. Because much of the world's population is inactive, this link presents a major public health issue. We aimed to quantify the effect of physical inactivity on these major non-communicable diseases by estimating how much disease could be averted if inactive people were to become active and to estimate gain in life expectancy at the population level. For our analysis of burden of disease, we calculated population attributable fractions (PAFs) associated with physical inactivity using conservative assumptions for each of the major non-communicable diseases, by country, to estimate how much disease could be averted if physical inactivity were eliminated. We used life-table analysis to estimate gains in life expectancy of the population. ...
Physical activity for people with disabilities
• The Lancet, sous presse, 2012 (commentaire)

Détails

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A partir d'un modèle statistique, cette étude évalue, pour chaque région du monde, le taux de cancers attribuables à l'inactivité physique et estime, du point de vue de la mortalité et de l'espérance de vie, le bénéfice apporté par un changement de comportement

“Physical activity for people with disabilities”

• Rimmer, James H. ; Marques, Alexandre C.
Policies to promote physical activity in Brazil
• The Lancet, sous presse, 2012 (commentaire)

Détails

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A partir d'un modèle statistique, cette étude évalue, pour chaque région du monde, le taux de cancers attribuables à l'inactivité physique et estime, du point de vue de la mortalité et de l'espérance de vie, le bénéfice apporté par un changement de comportement

“Policies to promote physical activity in Brazil”

• Malta, Deborah Carvalho ; da Silva, Jarbas Barbosa
Stressing harms of physical inactivity to promote exercise
• The Lancet, sous presse, 2012 (commentaire)

Détails

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A partir d'un modèle statistique, cette étude évalue, pour chaque région du monde, le taux de cancers attribuables à l'inactivité physique et estime, du point de vue de la mortalité et de l'espérance de vie, le bénéfice apporté par un changement de comportement

“Stressing harms of physical inactivity to promote exercise”

• Wen, Chi Pang ; Wu, Xifeng
Physical activity: more of the same is not enough
• The Lancet, sous presse, 2012 (commentaire)

Détails

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A partir d'un modèle statistique, cette étude évalue, pour chaque région du monde, le taux de cancers attribuables à l'inactivité physique et estime, du point de vue de la mortalité et de l'espérance de vie, le bénéfice apporté par un changement de comportement

“Physical activity: more of the same is not enough”

• Hallal, Pedro C. ; Bauman, Adrian E. ; Heath, Gregory W. ; Kohl, Harold W. ; Lee, I. Min ; Pratt, Michael
Rethinking our approach to physical activity
• The Lancet, sous presse, 2012 (commentaire)

Détails

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A partir d'un modèle statistique, cette étude évalue, pour chaque région du monde, le taux de cancers attribuables à l'inactivité physique et estime, du point de vue de la mortalité et de l'espérance de vie, le bénéfice apporté par un changement de comportement

“Rethinking our approach to physical activity”

• Das, Pamela ; Horton, Richard

Mots clés : Cancer (général); Lutte contre les cancers (Observation)

A partir de données en population britannique portant sur 25 853 enfants atteints d'un cancer pédiatrique diagnostiqué entre 1978 et 2005, cette étude analyse, en fonction du type de cancer, l'évolution de la survie selon les périodes d'inclusion de nouveaux patients dans les essais cliniques

Population survival from childhood cancer in Britain during 1978–2005 by eras of entry to clinical trials
• Annals of Oncology, sous presse, 2012 (résumé)

Détails

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A partir de données en population britannique portant sur 25 853 enfants atteints d'un cancer pédiatrique diagnostiqué entre 1978 et 2005, cette étude analyse, en fonction du type de cancer, l'évolution de la survie selon les périodes d'inclusion de nouveaux patients dans les essais cliniques

“Population survival from childhood cancer in Britain during 1978–2005 by eras of entry to clinical trials”

• Stiller, C. A.;Kroll, M. E.;Pritchard-Jones, K.

Background Inclusion in clinical trials is generally viewed as best practice for most newly diagnosed childhood cancers, but the impact on population-based survival has rarely been examined.Patients and methods The population-based data were analysed for 25 853 children (66% of all registered childhood cancers) diagnosed in Britain during 1978–2005 with acute lymphoblastic leukaemia (ALL), acute myeloid leukaemia (AML), Hodgkin lymphoma, non-Hodgkin lymphoma, medulloblastoma, neuroblastoma, Wilms tumour, hepatoblastoma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma and germ-cell tumours. The Kaplan–Meier survival curves were compared by log-rank tests. Time trends were analysed by Cox regression. Separate analyses were done for children with ALL, medulloblastoma and neuroblastoma according to clinically relevant age thresholds.Results Survival increased significantly during 1978–2005 for every diagnostic category; the annual reduction in risk of death ranged from 2.7% ...

Mots clés : Cancer (général); Lutte contre les cancers (Observation)

A partir des données de 23 registres italiens du cancer, cette étude analyse la variabilité géographique de la prévalence partielle à 5 ans de la maladie

Cancer prevalence in Italy: an analysis of geographic variability
• Cancer Causes and Control, sous presse, 2012 (résumé)

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A partir des données de 23 registres italiens du cancer, cette étude analyse la variabilité géographique de la prévalence partielle à 5 ans de la maladie

“Cancer prevalence in Italy: an analysis of geographic variability”

• Guzzinati, Stefano;Buzzoni, Carlotta;De Angelis, Roberta;Rosso, Stefano;Tagliabue, Giovanna;Vercelli, Marina;Pannozzo, Fabio;Mangone, Lucia;Piffer, Silvano;Fusco, Mario;Giacomin, Adriano;Traina, Adele;Capocaccia, Riccardo;Dal Maso, Luigino;Crocetti, Emanuele;Airtum working group

Purpose Statistics on cancer prevalence are scanty. The objectives of this study were to describe the cancer prevalence in Italy and to explore determinants of geographic heterogeneity. Methods The study included data from 23 population-based cancer registries, including one-third of the Italian population. Five-year cancer prevalence was observed, and complete prevalence (i.e., all patients living after a cancer diagnosis) was estimated through sex-, age-, cancer site-, and observation period length-specific completeness indices by means of regression models. Results In 2006, 3.8 % of men and 4.6 % of women in Italy were alive after a cancer diagnosis, with a 5-year prevalence of 1.9 % and 1.7 % in men and women, respectively. A relevant geographic variability emerged for all major cancer sites. When compared to national pooled estimates, crude cancer prevalence proportions were 10 % higher in the north and 30 % lower in the south of Italy. However, these variations were consistently ...

Mots clés : Cancer (général); Lutte contre les cancers (Observation)

Cet article passe en revue les études épidémiologiques concernant la relation entre un diabète de type 1, l'incidence de cancers et la mortalité spécifique

Epidemiological evidence of a relationship between type-1 diabetes mellitus and cancer: A review of the existing literature
• International Journal of Cancer, sous presse, 2012 (résumé)

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Cet article passe en revue les études épidémiologiques concernant la relation entre un diabète de type 1, l'incidence de cancers et la mortalité spécifique

“Epidemiological evidence of a relationship between type-1 diabetes mellitus and cancer: A review of the existing literature”

• Gordon-Dseagu, Vanessa L. Z.;Shelton, Nicola;Mindell, Jennifer S.

This review explores the epidemiological evidence relating to type-1 diabetes (T1DM) and cancer incidence and mortality. Mortality rates among those with T1DM are higher in every age group compared with the general population; the majority of this mortality is due to factors related to the consequences of diabetes, such as cardiovascular and renal disease. For over 100 years, researchers have explored the relationships between diabetes and cancer and although there is now a large body of work on the subject, consensus has not been reached. Such research has tended to focus upon type-2 diabetes, with the result that very little is known about T1DM and cancer. As incidence of T1DM increases, by around 3% annually among children, the need for further research into its impact upon cancer incidence and mortality increases. Within this review, findings varied by study method utilised, T1DM definition used and study region and outcome measure explored. None of the case–control studies ...

Mots clés : Cancer (général); Lutte contre les cancers (Observation)

Ressources et infrastructures (Lutte contre les cancers)

Menée sur 1 206 patients atteints d'un cancer du côlon ou du rectum, cette étude française évalue, par rapport aux recommandations de bonnes pratiques, la qualité des soins (du diagnostic au traitement chirurgical) et identifie les facteurs associés au non respect de ces recommandations

Quality indicators for colorectal cancer surgery and care according to patient-, tumor-, and hospitalrelated factors
• BMC Cancer, Vol. 12 (1), pp. 297, 2012 (article en libre accès)

Détails

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Menée sur 1 206 patients atteints d'un cancer du côlon ou du rectum, cette étude française évalue, par rapport aux recommandations de bonnes pratiques, la qualité des soins (du diagnostic au traitement chirurgical) et identifie les facteurs associés au non respect de ces recommandations

“Quality indicators for colorectal cancer surgery and care according to patient-, tumor-, and hospitalrelated factors”

• Mathoulin-Pelissier, Simone;Becouarn, Yves;Belleannee, Genevieve;Pinon, Elodie;Jaffre, Anne;Coureau, Gaelle;Auby, Dominique;Renaud-Salis, Jean-Louis;Rullier, Eric

Background and methods: Colorectal cancer (CRC) care has considerably improved considerably, particularly since the implementation of a quality of care program centered around national evidence-based guidelines. Formal quality assessmentevaluation of the quality of care is however still needed. The aim of this research was to identify factors associated with practice variation in CRC patient care. CRC patients identified from all cancer centers in South-West France were included. We investigated variations in practices (from diagnosis to surgery), and compliance with recommended guidelines for colon and rectal cancer. We identified factors associated with three colon cancer practice variations potentially linked to better survival: examination of [greater than or equal to]12 lymph nodes (LN), non-use and use of adjuvant chemotherapy for stage II and stage III patients, respectively.RESULTS:We included 1,206 patients, 825 (68%) with colon and 381 (32%) with rectal cancer, from 53 ...

Mots clés : Colon-rectum; Lutte contre les cancers (Ressources et infrastructures (Lutte contre les cancers))

A partir d'une comparaison entre les fonds collectés pour la recherche sur le cancer et les dépenses de santé, cette étude montre, par rapport à la charge sociale que représente chaque type de cancer, des disparités au niveau de la répartition de ces fonds

A comparison of cancer burden and research spending reveals discrepancies in the distribution of research funding
• BMC Public Health, Vol. 12 (1), pp. 526, 2012 (article en libre accès)

Détails

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A partir d'une comparaison entre les fonds collectés pour la recherche sur le cancer et les dépenses de santé, cette étude montre, par rapport à la charge sociale que représente chaque type de cancer, des disparités au niveau de la répartition de ces fonds

“A comparison of cancer burden and research spending reveals discrepancies in the distribution of research funding”

• Carter, Ashley;Nguyen, Cecine

BACKGROUND:Ideally, the distribution of research funding for different types of cancer should be equitable with respect to the societal burden each type of cancer imposes. These burdens can be estimated in a variety of ways; "Years of Life Lost" (YLL) measures the severity of death in regard to the age it occurs, "Disability-Adjusted Life-Years" (DALY) estimates the effects of non-lethal disabilities incurred by disease and economic metrics focus on the losses to tax revenue, productivity or direct medical expenses. We compared research funding from the National Cancer Institute (NCI) to a variety of burden metrics for the most common types of cancer to identify mismatches between spending and societal burden.METHODS:Research funding levels were obtained from the NCI website and information for societal health and economic burdens were collected from government databases and published reports. We calculated the funding levels per unit burden for a wide range of different cancers and ...

Mots clés : Cancer (général); Lutte contre les cancers (Ressources et infrastructures (Lutte contre les cancers))

Cet article passe en revue 5 systèmes électroniques utilisés en oncologie clinique pour recueillir les données rapportées par les patients sur leur état de santé (symptômes, état psychologique, physique et fonctionnel)

Electronic patient-reported outcome systems in oncology clinical practice
• CA: A Cancer Journal for Clinicians, sous presse, 2012 (résumé)

Détails

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Cet article passe en revue 5 systèmes électroniques utilisés en oncologie clinique pour recueillir les données rapportées par les patients sur leur état de santé (symptômes, état psychologique, physique et fonctionnel)

“Electronic patient-reported outcome systems in oncology clinical practice”

• Bennett, Antonia V.;Jensen, Roxanne E.;Basch, Ethan

Answer questions and earn CME/CNE Patient-reported outcome (PRO) questionnaires assess topics a patient can report about his or her own health. This includes symptoms (eg, nausea, fatigue, diarrhea, pain, or frequent urination), physical functioning (eg, difficulty climbing stairs or difficulty fastening buttons), and mental health (eg, anxiety, fear, or worry). Electronic PRO (ePRO) systems are used in oncology clinical care because of 1) their ability to enhance clinical care by flagging important symptoms and saving clinicians time; 2) the availability of standardized methods for creating and implementing PROs in clinics; and 3) the existence of user-friendly platforms for patient self-reporting like tablet computers and automated telephone surveys. Many ePRO systems can provide actionable links to clinical care such as summary reports in a patient's electronic medical record and real-time e-mail alerts to providers when patients report acute needs. This review presents 5 examples ...