Etiologie

A partir des données de trois études cas-témoins en population japonaise, hawaïienne ou californienne, cette étude montre qu'une consommation élevée d'alcool peut modifier l'association entre la densité mammographique et le risque de cancer du sein (1 207 cas et 1 663 témoins)

• Higher alcohol intake may modify the association between mammographic density and breast cancer: An analysis of three case–control studies
  • Cancer Epidemiology, sous presse, 2012 (résumé)
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  A partir des données de trois études cas-témoins en population japonaise, hawaïienne ou californienne, cette étude montre qu'une consommation élevée d'alcool peut modifier l'association entre la densité mammographique et le risque de cancer du sein (1 207 cas et 1 663 témoins)

  “Higher alcohol intake may modify the association between mammographic density and breast cancer: An analysis of three case–control studies”

  • Conroy, Shannon M.;Koga, Karin;Woolcott, Christy G.;Dahl, Timothy;Byrne, Celia;Nagata, Chisato;Ursin, Giske;Yaffe, Martin J.;Vachon, Celine M.;Maskarinec, Gertraud

  Alcohol consumption and mammographic density are established risk factors for breast cancer. This study examined whether the association of mammographic density with breast cancer varies by alcohol intake. Mammographic density was assessed in digitized images for 1207 cases and 1663 controls from three populations (Japan, Hawaii, California) using a computer-assisted method. Associations were estimated by logistic regression. When comparing ever to never drinking, mean density was similar and consumption was not associated with breast cancer risk. However, within the Hawaii/Japan subset, women consuming >1 drink/day had a non-significantly elevated relative risk compared to never drinkers. Also in the Hawaii/Japan population, alcohol intake only modified the association between mammographic density and breast cancer in women consuming >1 drink/day (pinteraction = 0.05) with significant risk estimates of 3.65 and 6.58 for the 2nd and 3rd density tertiles as compared to 1.57 and 1.61 ...

  
  

Mots clés : Sein; Etiologie (Facteurs exogènes : Alcool)

Menée sur 173 patients atteints d'un carcinome épidermoïde avancé de la cavité buccale et ayant reçu entre 2004 et 2006 un traitement combinant une résection radicale et une radiothérapie adjuvante, cette étude prospective montre qu'une infection par le papillomavirus humain de type 16 est associée à une augmentation du risque de métastases distantes et à un pronostic défavorable

• Human Papillomavirus-16 Infection in Advanced Oral Cavity Cancer Patients Is Related to an Increased Risk of Distant Metastases and Poor Survival
  • PLoS ONE, Vol. 7 (7), pp. e40767, 2012 (article en libre accès)
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  Menée sur 173 patients atteints d'un carcinome épidermoïde avancé de la cavité buccale et ayant reçu entre 2004 et 2006 un traitement combinant une résection radicale et une radiothérapie adjuvante, cette étude prospective montre qu'une infection par le papillomavirus humain de type 16 est associée à une augmentation du risque de métastases distantes et à un pronostic défavorable

  “Human Papillomavirus-16 Infection in Advanced Oral Cavity Cancer Patients Is Related to an Increased Risk of Distant Metastases and Poor Survival”

  • Lee, Li-Ang;Huang, Chung-Guei;Liao, Chun-Ta;Lee, Li-Yu;Hsueh, Chuen;Chen, Tse-Ching;Lin, Chien-Yu;Fan, Kang-Hsing;Wang, Hung-Ming;Huang, Shiang-Fu;Chen, I. How;Kang, Chung-Jan;Ng, Shu-Hang;Yang, Shu-Li;Tsao, Kuo-Chien;Chang, Yu-Liang;Yen, Tzu-Chen

  Background :Human papillomavirus (HPV) is an oncogenic virus causing oropharyngeal cancers and resulting in a favorable outcome after the treatment. The role of HPV in oral cavity squamous cell carcinoma (OSCC) remains ambiguous. Objective : This study aimed to examine the effect of HPV infection on disease control among patients with OSCC following radical surgery with radiation-based adjuvant therapy. Patients and Method : We prospectively followed 173 patients with advanced OSCC (96% were stage III/IV) who had undergone radical surgery and adjuvant therapy between 2004 and 2006. They were followed between surgery and death or up to 60 months. Surgical specimens were examined using a PCR-based HPV blot test. The primary endpoints were the risk of relapse and the time to relapse; the secondary endpoints were disease-free survival, disease-specific survival, and overall survival. Results :The prevalence of HPV-positive OSCC was 22%; HPV-16 (9%) and HPV-18 (7%) were the genotypes most ...

  
  

Mots clés : Voies aérodigestives supérieures; Etiologie (Facteurs exogènes : Agents infectieux)

A partir d'échantillons sériques prélevés sur 468 patients atteints d'un lymphome et sur 522 témoins, cette étude cas-témoins évalue l'association entre une séropositivité au polyomavirus des cellules de Merkel et le risque de divers types de lymphome

• Antibody response to Merkel cell polyomavirus associated with incident lymphoma in the Epilymph case-control study in Spain
  • Cancer Epidemiology Biomarkers & Prevention, sous presse, 2012 (résumé)
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  A partir d'échantillons sériques prélevés sur 468 patients atteints d'un lymphome et sur 522 témoins, cette étude cas-témoins évalue l'association entre une séropositivité au polyomavirus des cellules de Merkel et le risque de divers types de lymphome

  “Antibody response to Merkel cell polyomavirus associated with incident lymphoma in the Epilymph case-control study in Spain”

  • Robles, Claudia;Poloczek, Andre;Casabonne, Delphine;Gonzalez-Barca, Eva;Bosch, Ramon;Benavente, Yolanda;Viscidi, Raphael P.;DE SANJOSE, SILVIA

  Background: Merkel Cell polyomavirus (MCV) has been identified as the cause of Merkel cell carcinoma. The increased incidence of chronic lymphocytic leukemia in Merkel cell cancer cohorts and the lymphotropic properties of the virus suggest a possible viral association with lymphomagenesis. To investigate this potential role we explored seroreactivity against MCV VP1 capsids within the Epilymph case-control study in Spain. Methods: Serum samples from 468 incident lymphomas, categorised into up to 11 entities, and 522 controls frequency matched by age, sex and recruitment center, were tested for MCV antibodies by enzyme immunoassay using Virus-Like-Particles. Adjusted multinomial logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (CI) associated to MCV seroprevalence. Immunosuppressed subjects were excluded. Results: MCV seroprevalence was 82% in controls and 85% in lymphoma cases. Among eleven lymphoma categories, MCV seropositivity was ...

  
  

Mots clés : Lymphome; Etiologie (Facteurs exogènes : Agents infectieux)

A partir des données de 16 registres américains portant sur la période 1980 - 2007, cette étude montre, par rapport à la population générale, un risque élevé de cancers de l'estomac ou de l'œsophage chez les patients atteints d'un SIDA (596 955 patients)

• Increased Risk of Stomach and Esophageal Malignancies in People with AIDS
  • Gastroenterology, sous presse, 2012 (résumé)
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  A partir des données de 16 registres américains portant sur la période 1980 - 2007, cette étude montre, par rapport à la population générale, un risque élevé de cancers de l'estomac ou de l'œsophage chez les patients atteints d'un SIDA (596 955 patients)

  “Increased Risk of Stomach and Esophageal Malignancies in People with AIDS”

  • Persson, E. Christina;Shiels, Meredith S.;Dawsey, Sanford M.;Bhatia, Kishor;Anderson, Lesley A.;Engels, Eric A.

  People infected with human immunodeficiency virus (HIV) have an increased risk of some malignancies, but little is known about the effects of infection on risk for cancers of the upper gastrointestinal tract. We evaluated the risks of different histologic and anatomic subtypes of carcinomas and non-Hodgkin lymphomas (NHLs) of the stomach and esophagus in people with AIDS. We analyzed data from the HIV/AIDS Cancer Match Study, which links data collected from 1980 to 2007 for 16 US population-based HIV and AIDS and cancer registries. We compared risks of stomach and esophageal malignancies in people with AIDS (n=596,955) with those of the general population using standardized incidence ratios (SIRs). We assessed calendar trends using Poisson regression. People with AIDS had increased risks of carcinomas of the esophagus (SIR=1.69; 95% confidence interval [CI], 1.37–2.07; n=95) and stomach (SIR=1.44; 95% CI, 1.17–1.76; n=96). Risk was increased for esophageal adenocarcinoma ...

  
  

Mots clés : Estomac; Etiologie (Facteurs exogènes : Agents infectieux)

Menée au Royaume Uni auprès d'une cohorte de 1 290 625 participantes âgées de plus de 55 ans et sans antécédent de cancer du sein, cette étude évalue l'association entre l'utilisation à long terme de la spironolactone et le risque de développer la maladie

• Spironolactone and risk of incident breast cancer in women older than 55 years: retrospective, matched cohort study
  • British Medical Journal, Vol. 345, 2012 (article en libre accès)
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  Menée au Royaume Uni auprès d'une cohorte de 1 290 625 participantes âgées de plus de 55 ans et sans antécédent de cancer du sein, cette étude évalue l'association entre l'utilisation à long terme de la spironolactone et le risque de développer la maladie

  “Spironolactone and risk of incident breast cancer in women older than 55 years: retrospective, matched cohort study”

  • Isla S Mackenzie;Thomas M MacDonald;Alastair Thompson;Steve Morant;Li Wei

  Objective : To investigate whether exposure to spironolactone treatment affects the risk of incident breast cancer in women over 55 years of age. Design : Retrospective, matched cohort study. Setting : General Practice Research Database, a primary care anonymised database representative of the general population in the United Kingdom. Participants : 1 290 625 female patients, older than 55 years and with no history of breast cancer, from 557 general practices with a total follow-up time of 8.4 million patient years. We excluded patients with poor quality data and those with no contacts with their general practitioner after their current registration date. Intervention : Exposed cohort included women who received at least two prescriptions of spironolactone after age 55 years, who were followed up from the first prescription (index date). We randomly selected two unexposed female controls for every exposed patient, matched by practice, year of birth, and socioeconomic scores (if ...

  
  

Mots clés : Sein; Etiologie (Facteurs exogènes : Autres)

Cette étude analyse les caractéristiques de lignées cellulaires établies à partir d'échantillons prélevés sur des patientes ayant développé une forme de lymphome non hodgkinien associé à la rupture d'un implant mammaire

• Survival Signals and Targets for Therapy in Breast Implant-Associated ALK- Anaplastic Large Cell Lymphoma
  • Clinical Cancer Research, sous presse, 2012 (résumé)
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  Cette étude analyse les caractéristiques de lignées cellulaires établies à partir d'échantillons prélevés sur des patientes ayant développé une forme de lymphome non hodgkinien associé à la rupture d'un implant mammaire

  “Survival Signals and Targets for Therapy in Breast Implant-Associated ALK- Anaplastic Large Cell Lymphoma”

  • Lechner, Melissa G;Megiel, Carolina;Church, Connor H;Angell, Trevor E;Russell, Sarah M;Sevell, Rikki B;Jang, Julie K;Brody, Garry S;Epstein, Alan L.

  Purpose: Anaplastic lymphoma kinase (ALK)-negative, T-cell, anaplastic, non-Hodgkin's lymphoma (T-ALCL) in patients with textured saline and silicone breast implants is a recently recognized clinical entity for which etiology and optimal treatment remain unknown. Experimental design: Using three newly established model cell lines from patient biopsy specimens, designated T-cell BReast Lymphoma (TLBR) -1 to -3, we characterized the phenotype and function of these tumors to identify mechanisms of cell survival and potential therapeutic targets. Results: Cytogenetics revealed chromosomal atypia with partial or complete trisomy and absence of the NPM-ALK (2;5) translocation. Phenotypic characterization showed strong positivity for CD30, CD71, T-cell CD2/5/7, and antigen presentation (HLA-DR, CD80, CD86) markers, and interleukin (IL)-2 (CD25, CD122) and IL-6 receptors. Studies of these model cell lines demonstrated strong activation of STAT3 signaling, likely related to autocrine ...

  
  

Mots clés : Lymphome; Etiologie (Facteurs exogènes : Autres)

Menée en Grande Bretagne sur une cohorte de 795 238 femmes âgées de 50 à 64 ans (20 058 cas de cancer du sein et 31 856 autres cas de cancer ; durée moyenne de suivi : 7,4 ans), cette étude prospective montre, sur une courte période, une augmentation du risque de cancer associé à la sieste diurne, puis suggère que cette augmentation s'explique par la présence d'une maladie au stade pré-clinique

• A short-term increase in cancer risk associated with daytime napping is likely to reflect pre-clinical disease: prospective cohort study
  • British Journal of Cancer, sous presse, 2012 (résumé)
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  Menée en Grande Bretagne sur une cohorte de 795 238 femmes âgées de 50 à 64 ans (20 058 cas de cancer du sein et 31 856 autres cas de cancer ; durée moyenne de suivi : 7,4 ans), cette étude prospective montre, sur une courte période, une augmentation du risque de cancer associé à la sieste diurne, puis suggère que cette augmentation s'explique par la présence d'une maladie au stade pré-clinique

  “A short-term increase in cancer risk associated with daytime napping is likely to reflect pre-clinical disease: prospective cohort study”

  • Cairns, B. J.;Travis, R. C.;Wang, X. S.;Reeves, G. K.;Green, J.;Beral, V.

  Background : Sleep disturbance, a correlate of which is daytime napping, has been hypothesised to be associated with risk of breast and other cancers. Methods : We estimated relative risks (RR) of breast and other invasive cancers by the reported frequency of daytime napping in a large prospective cohort of middle-aged women in the UK. Results :During an average of 7.4 years of follow-up, 20 058 breast cancers and 31 856 other cancers were diagnosed. Over the first 4 years of follow-up, daytime napping (sometimes/usually vs rarely/never) was associated with slightly increased risks of breast cancer (RR=1.10, 95% CI 1.06–1.15) and of other cancers (RR=1.12, 1.08–1.15), but the RRs decreased significantly with increasing follow-up time (P=0.001 and P=0.01, respectively, for trend). Four or more years after baseline, there was no elevated risk of breast cancer (RR=1.00, 0.96–1.05), and only marginally greater risk of other cancers (RR=1.04, 1.01–1.07). Conclusion :The effect of ...

  
  

Mots clés : Cancer (général); Etiologie (Facteurs exogènes : Autres)

Menée en population chinoise Han, cette étude montre une association entre deux polymorphismes à simple nucléotide des gènes GSTP1 et TERT (respectivement rs1695 et rs2853676 ) et le risque de gliome (301 cas et 302 témoins)

• Selected polymorphisms of GSTP1 and TERT were associated with glioma risk in Han Chinese
  • Cancer Epidemiology, sous presse, 2012 (résumé)
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  Menée en population chinoise Han, cette étude montre une association entre deux polymorphismes à simple nucléotide des gènes GSTP1 et TERT (respectivement rs1695 et rs2853676 ) et le risque de gliome (301 cas et 302 témoins)

  “Selected polymorphisms of GSTP1 and TERT were associated with glioma risk in Han Chinese”

  • Li, Gang;Jin, Tian-Bo;Wei, Xiao-Bin;He, Shi-Ming;Liang, Hong-Juan;Yang, Hai-Xia;Cui, Yan;Chen, Chao;Cai, Lin-Bo;Gao, Guo-Dong

  Background: Current evidence suggests that a majority of the inherited risks play a major role in glioma susceptibility, and glioma is due to the co-inheritance of multiple low-risk variants. These variants can be identified through association studies including such as genome-wide association studies (GWAS), which has led the glioma epidemiology researchers to focus on identifying potential disease-causing factors. Methods: We evaluated and validated 10 tag single nucleotide polymorphisms (tSNPs) in seven genes associated with glioma susceptibility in a Han Chinese population, including 301 glioma cases and 302 controls, using a multiplexed single nucleotide polymorphism (SNP) MassEXTEND assay. We ascertained the genotypic frequencies for each tSNP in control subjects were within Hardy–Weinberg equilibrium (HWE) using an exact test, and then compared the genotype and allele frequencies of glioma patients and control subjects using the χ2 test. We then applied three genetic models ...

  
  

Mots clés : Système nerveux central; Etiologie (Facteurs endogènes)

Menée en population japonaise auprès de 6 029 patients atteints d'un adénocarcinome du poumon et de 13 535 témoins, cette étude d'association sur le génome entier identifie deux nouveaux loci de susceptibilité à la maladie sur les chromosomes 17q24.3 et 6p21.3

• A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population
  • Natures Genetics, sous presse, 2012 (résumé)
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  Menée en population japonaise auprès de 6 029 patients atteints d'un adénocarcinome du poumon et de 13 535 témoins, cette étude d'association sur le génome entier identifie deux nouveaux loci de susceptibilité à la maladie sur les chromosomes 17q24.3 et 6p21.3

  “A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population”

  • Shiraishi, Kouya;Kunitoh, Hideo;Daigo, Yataro;Takahashi, Atsushi;Goto, Koichi;Sakamoto, Hiromi;Ohnami, Sumiko;Shimada, Yoko;Ashikawa, Kyota;Saito, Akira;Watanabe, Shun-ichi;Tsuta, Koji;Kamatani, Naoyuki;Yoshida, Teruhiko;Nakamura, Yusuke;Yokota, Jun;Kubo, Michiaki;Kohno, Takashi

  Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, Pcombined = 2.8 × 10−40, odds ratio (OR) = 1.41) and 3q28 (rs10937405, Pcombined = 6.9 × 10−17, OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, Pcombined = 7.4 × 10−11, OR = 1.20) and 6p21.3 (rs3817963, Pcombined = 2.7 × 10−10, OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.

  
  

Mots clés : Poumon; Etiologie (Facteurs endogènes)

A partir de données nord-américaines, européennes et japonaises issues de 18 études cas-témoins incluant au total 4 263 patientes atteintes d'un lymphome non hodgkinien et 5 971 témoins, cette étude analyse l'association entre des facteurs menstruels et reproductifs, l'usage d'une contraception hormonale et le risque de lymphome diffus à grandes cellules B ou de lymphome folliculaire

• Menstrual and reproductive factors, and hormonal contraception use: associations with non-Hodgkin lymphoma in a pooled analysis of InterLymph case–control studies
  • Annals of Oncology, sous presse, 2012 (résumé)
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  A partir de données nord-américaines, européennes et japonaises issues de 18 études cas-témoins incluant au total 4 263 patientes atteintes d'un lymphome non hodgkinien et 5 971 témoins, cette étude analyse l'association entre des facteurs menstruels et reproductifs, l'usage d'une contraception hormonale et le risque de lymphome diffus à grandes cellules B ou de lymphome folliculaire

  “Menstrual and reproductive factors, and hormonal contraception use: associations with non-Hodgkin lymphoma in a pooled analysis of InterLymph case–control studies”

  • Kane, E. V.;Roman, E.;Becker, N.;Bernstein, L.;Boffetta, P.;Bracci, P. M.;Cerhan, J. R.;Chiu, B. C. -H.;Cocco, P.;Costas, L.;Foretova, L.;Holly, E. A.;La Vecchia, C.;Matsuo, K.;Maynadie, M.;Sanjose, S.;Spinelli, J. J.;Staines, A.;Talamini, R.;Wang, S. S.;Zhang, Y.;Zheng, T.;Kricker, A.;for the InterLymph Consortium

  Background The two most common forms of non-Hodgkin lymphoma (NHL) exhibit different sex ratios: diffuse large B-cell lymphoma (DLBCL) occurs more frequently in men and follicular lymphoma (FL) more frequently in women. Looking among women alone, this pooled analysis explores the relationship between reproductive histories and these cancers.Materials and methods Self-reported reproductive histories from 4263 women with NHL and 5971 women without NHL were pooled across 18 case–control studies (1983–2005) from North America, Europe and Japan. Study-specific odd ratios (ORs) and confidence intervals (CIs) were estimated using logistic regression and pooled using random-effects meta-analyses.Results Associations with reproductive factors were found for FL rather than NHL overall and DLBCL. In particular, the risk of FL decreased with increasing number of pregnancies (pooled ORtrend = 0.88, 95% CI 0.81–0.96). FL was associated with hormonal contraception (pooled OR = 1.30, 95% CI ...

  
  

Mots clés : Lymphome; Etiologie (Facteurs endogènes)

Menée en population chinoise Han sur 279 patients atteints d'un cancer gastrique et sur 296 témoins en bonne santé, cette étude montre une association entre des polymorphismes à simple nucléotide des gènes IL-10, NOC3L, PSCA et MTRR et le risque de développer la maladie

• Polymorphisms of tumor-related genes IL-10, PSCA, MTRR and NOC3L are associated with the risk of gastric cancer in the Chinese Han population
  • Cancer Epidemiology, sous presse, 2012 (résumé)
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  Menée en population chinoise Han sur 279 patients atteints d'un cancer gastrique et sur 296 témoins en bonne santé, cette étude montre une association entre des polymorphismes à simple nucléotide des gènes IL-10, NOC3L, PSCA et MTRR et le risque de développer la maladie

  “Polymorphisms of tumor-related genes IL-10, PSCA, MTRR and NOC3L are associated with the risk of gastric cancer in the Chinese Han population”

  • Yuan, Li Juan;Jin, Tian Bo;Yin, Ji Kai;Du, Xi Lin;Wang, Qing;Dong, Rui;Wang, Sheng Zhi;Cui, Yan;Chen, Chao;Lu, Jian Guo

  Background : Gastric cancer is the fourth most common cancer in the world. Environmental and genetic factors both play critical roles in the etiology of gastric cancer. Hundreds of SNPs have been identified to have association with the risk of gastric cancer in many races. In this study, 25 SNPs in genes for IL-10, IL-1B, MTRR, TNF- а, PSCA, PLCE1 and NOC3L were analyzed to further evaluate their associations with gastric cancer susceptibility in the Chinese Han population. Methods : Two hundred and seventy nine gastric cancer patients and 296 healthy controls were recruited in this study. SNP genotyping was conducted using Sequenom MassARRAY RS1000. Data management and statistical analyses were conducted by Sequenom Typer 4.0 Software and Pearson's χ2 test. Results : One protective allele and three risk alleles for gastric cancer patients were found in this study. The allele “G” of rs1801394 in MTRR showed an association with a decreased risk of gastric cancer: odds ratio ...

  
  

Mots clés : Estomac; Etiologie (Facteurs endogènes)

Menée en population chinoise auprès de 7 436 patients atteints d'un cancer du poumon et auprès de 7 483 témoins, cette étude d'association sur le génome entier analyse les interactions entre le tabagisme et 5 loci de susceptibilité au cancer du poumon

• Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population
  • Nature Genetics, sous presse, 2012 (résumé)
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  Menée en population chinoise auprès de 7 436 patients atteints d'un cancer du poumon et auprès de 7 483 témoins, cette étude d'association sur le génome entier analyse les interactions entre le tabagisme et 5 loci de susceptibilité au cancer du poumon

  “Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population”

  • Dong, Jing;Hu, Zhibin;Wu, Chen;Guo, Huan;Zhou, Baosen;Lv, Jiachun;Lu, Daru;Chen, Kexin;Shi, Yongyong;Chu, Minjie;Wang, Cheng;Zhang, Ruyang;Dai, Juncheng;Jiang, Yue;Cao, Songyu;Qin, Zhenzhen;Yu, Dianke;Ma, Hongxia;Jin, Guangfu;Gong, Jianhang;Sun, Chongqi;Zhao, Xueying;Yin, Zhihua;Yang, Lei;Li, Zhiqiang;Deng, Qifei;Wang, Jiucun;Wu, Wei;Zheng, Hong;Zhou, Guoquan;Chen, Hongyan;Guan, Peng;Peng, Zhihang;Chen, Yijiang;Shu, Yongqian;Xu, Lin;Liu, Xiangyang;Liu, Li;Xu, Pin;Han, Baohui;Bai, Chunxue;Zhao, Yuxia;Zhang, Haibo;Yan, Ying;Amos, Christopher I.;Chen, Feng;Tan, Wen;Jin, Li;Wu, Tangchun;Lin, Dongxin;Shen, Hongbing

  To find additional susceptibility loci for lung cancer, we tested promising associations from our previous genome-wide association study (GWAS)1 of lung cancer in the Chinese population in an extended validation sample size of 7,436 individuals with lung cancer (cases) and 7,483 controls. We found genome-wide significant (P < 5.0 × 10−8) evidence for three additional lung cancer susceptibility loci at 10p14 (rs1663689, close to GATA3, P = 2.84 × 10−10), 5q32 (rs2895680 in PPP2R2B-STK32A-DPYSL3, P = 6.60 × 10−9) and 20q13.2 (rs4809957 in CYP24A1, P = 1.20 × 10−8). We also found consistent associations for rs247008 at 5q31.1 (IL3-CSF2-P4HA2, P = 7.68 × 10−8) and rs9439519 at 1p36.32 (AJAP1-NPHP4, P = 3.65 × 10−6). Four of these loci showed evidence for interactions with smoking dose (P = 1.72 × 10−10, P = 5.07 × 10−3, P = 6.77 × 10−3 and P = 4.49 × 10−2 for rs2895680, rs4809957, rs247008 and rs9439519, respectively). These results advance our understanding ...

  
  

Mots clés : Poumon; Etiologie (Interactions gènes-environnement)