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Accueil Nota Bene Cancer V2 Numéro 140 du 12 Juin 2012 Traitements Fiche de publication

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Nota Bene Cancer Fiche de publication

Hypofractionated High-Dose Radiation Therapy for Prostate Cancer: Long-Term Results of a Multi-Institutional Phase II Trial

Mené sur 113 patients atteints d'un cancer de la prostate de stade T1 à T3N0M0, cet essai multicentrique de phase II évalue la toxicité gastro-intestinale et génito-urinaire d'une radiothérapie hypofractionnée à haute dose puis analyse les résultats biochimiques et cliniques associés au traitement

  • International journal of radiation oncology, biology, physics, sous presse, 2012 (résumé)

Résumé en anglais :
To report late gastrointestinal (GI) and genitourinary (GU) toxicity, biochemical and clinical outcomes, and overall survival after hypofractionated radiation therapy for prostate cancer (PC). Three institutions included 113 patients with T1 to T3N0M0 PC in a phase II study. Patients were treated with 56 Gy in 16 fractions over 4 weeks. Late toxicity was scored using Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria extended with additional symptoms. Biochemical outcome was reported according to the Phoenix definition for biochemical failure. The incidence of late GI and GU toxicity was low. The 3-year actuarial risk of developing late GU and GI toxicity of grade ≥2 was 13% and 8% respectively. Five-year biochemical non-evidence of disease (bNED) was 94%. Risk group, T stage, and deviation from planned hormone treatment were significant predictive factors for bNED. Deviation from hormone treatment remained significant in multivariate analysis. Five-year clinical non evidence of disease and overall survival was 95% and 91% respectively. No patient died from PC. Hypofractionated high-dose radiation therapy is a valuable treatment option for patients with PC, with excellent biochemical and clinical outcome and low toxicity.

NBC n° 140 du 12 Juin 2012

Mots clés : Prostate; Traitements (Traitements localisés : applications cliniques)

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