Lutte contre les cancers

Mené auprès de 42 survivantes d'un cancer du sein, cet essai randomisé évalue l'association entre leur alimentation et leur fatigue persistante

• Diet components associated with perceived fatigue in breast cancer survivors
  • European Journal of Cancer Care, sous presse, 2012 (résumé)
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  Mené auprès de 42 survivantes d'un cancer du sein, cet essai randomisé évalue l'association entre leur alimentation et leur fatigue persistante

  “Diet components associated with perceived fatigue in breast cancer survivors”

  • Guest, D. D.;Evans, E. M.;Rogers, L. Q.

  Little is known about the contribution of diet components independent of body composition to persistent fatigue in breast cancer survivors. Therefore, our study aim was to determine the associations among dietary intake and fatigue in relation to and independent of adiposity and physical activity (PA) in breast cancer survivors. Baseline data from 42 breast cancer survivors enrolled in a randomised exercise trial were analysed: fatigue (Functional Assessment of Cancer Therapy for fatigue), diet components (3-day diet record), body mass index, per cent body fat (dual-energy X-ray absorptiometry) and PA (accelerometer). The mean age was 54 ± 9 years with an average body mass index of 30.5 ± 8.1 kg/m2. Fatigue was positively associated with % of kcal/day fat intake (r= 0.31, P < 0.05) and inversely related to fibre g/day (r= 0.38, P < 0.05) and carbohydrate g/day intake (r= 0.31, P < 0.05). Mean fatigue was greater for participants eating <25 g/day of fibre compared with >25 g/day ...

  
  

Mots clés : Sein; Lutte contre les cancers (Qualité de vie, soins de support)

A partir des données d'une cohorte prospective, cette étude (13 cas et 15 témoins) évalue l'association entre le niveau de cytokines et la fatigue des patientes atteintes d'un cancer du sein 12 mois après leur traitement

• Post-cancer fatigue is not associated with immune activation or altered cytokine production
  • Annals of Oncology, sous presse, 2012 (résumé)
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  A partir des données d'une cohorte prospective, cette étude (13 cas et 15 témoins) évalue l'association entre le niveau de cytokines et la fatigue des patientes atteintes d'un cancer du sein 12 mois après leur traitement

  “Post-cancer fatigue is not associated with immune activation or altered cytokine production”

  • Cameron, B. A.;Bennett, B.;Li, H.;Boyle, F.;deSouza, P.;Wilcken, N.;Friedlander, M.;Goldstein, D.;Lloyd, A. R.

  Background Prolonged fatigue after cancer treatment is common. The pathophysiology of such post-cancer fatigue (PCF) is unknown, although cross-sectional studies suggest increased pro-inflammatory cytokine production. This study investigated the association between cytokine levels and fatigue from the time of treatment to 12 months later.Patients and methods A representative nested case–control series was derived from a prospective cohort of women treated for early-stage breast cancer, including 13 PCF cases and 15 matched control subjects who recovered uneventfully. Serum levels and in vitro production of the cytokines interleukin (IL)-1α, IL-2, interferon (IFN)-γ, IL-4, IL-6, IL-10, IL-12, and tumour necrosis factor (TNF)-β were measured by multiplex immunoassay in longitudinally collected samples. In addition, serum levels of neopterin and the anti-inflammatory regulators, IL-1 receptor antagonist, sIL-6R, and sTNF-rII, were assayed by enzyme-linked immunosorbent assay. Flow ...

  
  

Mots clés : Sein; Lutte contre les cancers (Qualité de vie, soins de support)

Menée auprès de 759 survivantes d'un cancer du sein âgées de plus de 70 ans, cette étude américaine évalue l'impact de l'âge et d'une histoire de cancer sur leurs symptômes et leurs fonctions physiques

• The effect of aging and cancer on the symptom experience and physical function of elderly breast cancer survivors
  • Cancer, sous presse, 2012 (résumé)
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  Menée auprès de 759 survivantes d'un cancer du sein âgées de plus de 70 ans, cette étude américaine évalue l'impact de l'âge et d'une histoire de cancer sur leurs symptômes et leurs fonctions physiques

  “The effect of aging and cancer on the symptom experience and physical function of elderly breast cancer survivors”

  • Bellury, Lanell;Pett, Marjorie A.;Ellington, Lee;Beck, Susan L.;Clark, Jane C.;Stein, Kevin D.

  BACKGROUND: The majority of cancer survivors are aged ≥65 years, yet, historically, cancer research has focused infrequently on older patients. The objective of this study was to examine predictors of physical function within a framework that integrates the gerontologic and oncologic needs of older cancer survivors. METHODS: Path analysis tested 759 women who were breast cancer survivors aged ≥70 years from the American Cancer Society Study of Cancer Survivors II to examine the cancer, aging, and personal characteristics that had an impact on symptoms and physical functioning. RESULTS: High levels of symptom bother (β = −.42) and comorbidities (β = −.21) were strongly associated with lower physical function. Comorbidity and social support (β = .21) indirectly influenced symptom bother through emotional status (β = −.35). The model demonstrated good fit with the data (chi-square statistic, 50.6; adjusted chi-square statistic, 2.8; P < .001; goodness-of-fit index, .98; ...

  
  

Mots clés : Sein; Lutte contre les cancers (Qualité de vie, soins de support)

Menée auprès de 346 participantes de 14 pays à l'aide du questionnaire "EORTC Quality of life Questionnaire", cette étude analyse la qualité de vie des patientes atteintes d'un cancer du col de l'utérus et traitées en hôpital

• Quality of life characteristics inpatients with cervical cancer
  • European journal of cancer (Oxford, England : 1990), sous presse, 2012 (résumé)
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  Menée auprès de 346 participantes de 14 pays à l'aide du questionnaire "EORTC Quality of life Questionnaire", cette étude analyse la qualité de vie des patientes atteintes d'un cancer du col de l'utérus et traitées en hôpital

  “Quality of life characteristics inpatients with cervical cancer”

  • Bjelic-Radisic, Vesna;Jensen, Pernille T.;Vlasic, Karin Kuljanic;Waldenstrom, Ann-Charlotte;Singer, Susanne;Chie, Weichu;Nordin, Andy;Greimel, Elfriede

  Annually about 500,000 women worldwide are diagnosed with cervical cancer. For many patients, young age at the time of diagnosis and a good prognosis regarding the disease imply a long life with the side-effects and sequels of various treatment options. The present study investigated the extent to which different quality of life (QoL) domains in patients during and after treatment for cervical cancer are affected according to menopausal status, treatment status and treatment modality. QoL data from 346 cervical cancer patients from 14 countries who were included in a cervical cancer module validation study of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of life Group were analysed according to menopausal status, treatment status and treatment modality. QOL was assessed using the EORTC Quality of life Questionnaire (QLQ)-C30 and the QLQ-CX24 module. Statistical analyses were performed using descriptive statistics and analysis of covariance. Active ...

  
  

Mots clés : Col de l'utérus; Lutte contre les cancers (Qualité de vie, soins de support)

Menée auprès de 949 participants, cette étude longitudinale américaine analyse les disparités dans les caractéristiques et l'intensité de la douleur ressentie par des patients atteints de cancer de stade avancé et traités en ambulatoire

• A longitudinal study of pain variability and its correlates in ambulatory patients with advanced stage cancer
  • Cancer, sous presse, 2012 (résumé)
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  Menée auprès de 949 participants, cette étude longitudinale américaine analyse les disparités dans les caractéristiques et l'intensité de la douleur ressentie par des patients atteints de cancer de stade avancé et traités en ambulatoire

  “A longitudinal study of pain variability and its correlates in ambulatory patients with advanced stage cancer”

  • Zhu, Junya;Davis, Roger B.;Stuver, Sherri O.;Berry, Donna L.;Block, Susan;Weeks, Jane C.;Weingart, Saul N.

  BACKGROUND: Although pain is common among patients with advanced cancer, little is known about longitudinal variability in pain intensity. For this report, the authors examined variability in pain intensity over 24 months among ambulatory patients with advanced stage cancers, associations between patient characteristics and within-patient pain variability, and the relation of pain variability to overall survival. METHODS: The sample comprised 949 patients with solid tumors who received care and reported pain scores in at least 3 different months within 24 months of their initial stage IV diagnosis during the period from 2004 to 2006. Pain intensity was measured using a scale ranging from 0 (no pain) to 10 (worst pain). Pain variability was defined as the standard deviation of the maximum monthly pain scores and was dichotomized at the 50th percentile into high and low variability groups. RESULTS: Considerable between-patient differences in pain variability (range, 0-5.77) were ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

Menée auprès de 72 patients stomisés, cette étude turque analyse l'efficacité d'un programme éducatif et thérapeutique quotidien pour améliorer leur qualité de vie

• The role of group education on quality of life in patients with a stoma
  • European Journal of Cancer Care, sous presse, 2012 (résumé)
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  Menée auprès de 72 patients stomisés, cette étude turque analyse l'efficacité d'un programme éducatif et thérapeutique quotidien pour améliorer leur qualité de vie

  “The role of group education on quality of life in patients with a stoma”

  • Altuntas, Y. E.;Kement, M.;Gezen, C.;Eker, H. H.;Aydin, H.;Sahin, F.;Okkabaz, N.;Oncel, M.

  Stoma education has been traditionally given in a one-to-one setting. Since 2007, daily group education programmes were organised for stoma patients and their relatives by our stoma therapy unit. The programmes included lectures on stoma and stoma care, and social activities in which patients shared their experiences with each other. Patients were also encouraged to expand interaction with each other and organise future social events. A total of 72 patients [44 (61.1%) male with a mean (±SD) age of 56.8 ± 13.6 years] with an ileostomy (n= 51, 70.8%), a colostomy (n= 18, 25.0%) or a urostomy (n= 3, 4.2%) were included in the study. Patients were asked to answer a survey (SF-36) face-to-face before the initiation of the programme, which was repeated 3 months later via telephone call. The comparison of pre-education and post-education SF-36 scores revealed a statistically significant improvement in all 8-scale profiles, but not in vitality scale, and both psychometrically-based and ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

Cette étude en population américaine (1 114 cas et 264 témoins) analyse les disparités ethniques dans les pratiques liées à la consommation d'alcool et dans le tabagisme, ainsi que dans l'incidence des cancers de la tête et du cou associés à ces facteurs de risque

• Racial differences in the relationship between tobacco, alcohol, and squamous cell carcinoma of the head and neck
  • Cancer Causes and Control, sous presse, 2012 (résumé)
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  Cette étude en population américaine (1 114 cas et 264 témoins) analyse les disparités ethniques dans les pratiques liées à la consommation d'alcool et dans le tabagisme, ainsi que dans l'incidence des cancers de la tête et du cou associés à ces facteurs de risque

  “Racial differences in the relationship between tobacco, alcohol, and squamous cell carcinoma of the head and neck”

  • Stingone, Jeanette;Funkhouser, William;Weissler, Mark;Bell, Mary;Olshan, Andrew

  Purpose Tobacco and alcohol use are well-known risk factors for squamous cell carcinoma of the head and neck (SCCHN), but there has been little examination of disparities in SCCHN and racial patterns of tobacco and alcohol use, especially for African-Americans. The Carolina Head and Neck Cancer Study, a population-based case–control study, was utilized to determine whether relationships between tobacco and alcohol use and SCCHN differed by race. Methods Using a rapid case ascertainment system, cases were recruited from 46 contiguous counties in North Carolina from 2002 to 2006. Controls, selected from motor vehicle records, were frequency-matched to cases on age, sex, and race. This analysis was based on 989 white and 351 African-American cases and 1,114 white and 264 African-American controls. Analyses were performed using unconditional logistic regression, adjusting for age, sex, race, education, and fruit and vegetable consumption. Results The association between SCCHN and ever ...

  
  

Mots clés : Voies aérodigestives supérieures; Lutte contre les cancers (Observation)

A partir des données des registres néerlandais du cancer, cette étude analyse l'évolution du cancer des sinus et de la cavité nasale sur la période 1973-2009

• Trends in sinonasal cancer in The Netherlands: More squamous cell cancer, less adenocarcinoma: A population-based study 1973–2009
  • European journal of cancer (Oxford, England : 1990), sous presse, 2012 (résumé)
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  A partir des données des registres néerlandais du cancer, cette étude analyse l'évolution du cancer des sinus et de la cavité nasale sur la période 1973-2009

  “Trends in sinonasal cancer in The Netherlands: More squamous cell cancer, less adenocarcinoma: A population-based study 1973–2009”

  • Kuijpens, J. L. P.;Louwman, Marieke W. J.;Peters, Rob;Janssens, Geert O. R. J.;Burdorf, A.;Coebergh, Jan-Willem W.

  Cancer of the nasal cavity or the paranasal sinuses (sinonasal cancer) is rare. Sinonasal cancer has been associated with various occupational risk factors such as exposure to dust of hard wood and leather. Also, a relationship with smoking habits has been suggested. We studied the long term trends in incidence to evaluate a putative effect of past preventive measures or changes in risk factors. A retrospective population-based descriptive study. To interpret the long term trends in incidence of sinonasal cancer in The Netherlands. Data of all 3329 patients >15years registered during 1989–2009 by the Netherlands Cancer Registry (NCR) were analysed, by data of 447 patients registered by the Eindhoven Cancer Registry (ECR) during 1973–2009 were analysed separately. Information on patients and tumour characteristics was obtained from both registries. The incidence was calculated per 1,000,000 person years and standardised using the European Standard Population. Squamous cell ...

  
  

Mots clés : Voies aérodigestives supérieures; Lutte contre les cancers (Observation)

A partir des données du registre suédois du cancer, cette étude analyse la prévalence et l'incidence cumulée de différents cancers primitifs avant et après un diagnostic de cancer de la prostate

• Primary cancers before and after prostate cancer diagnosis
  • Cancer, sous presse, 2012 (résumé)
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  A partir des données du registre suédois du cancer, cette étude analyse la prévalence et l'incidence cumulée de différents cancers primitifs avant et après un diagnostic de cancer de la prostate

  “Primary cancers before and after prostate cancer diagnosis”

  • Van Hemelrijck, Mieke;Drevin, Linda;Holmberg, Lars;Garmo, Hans;Adolfsson, Jan;Stattin, Pär

  BACKGROUND: The occurrence of multiple cancers may indicate common etiology; and, although some studies have investigated the risk of second primary cancers after prostate cancer (PCa), there are no studies on cancers before PCa. METHODS: The PCBaSe Sweden database is based on the National Prostate Cancer Register (NPCR), which covers >96% of PCa cases. The authors estimated the prevalence and cumulative incidence of different cancers before and after PCa diagnosis in 72,613 men according to PCa treatment and disease stage in PCBaSe and their matched comparison cohort of men who were free of PCa. RESULTS: In total, 6829 men were diagnosed with another primary cancer before their PCa diagnosis, including 138 men at the time of PCa diagnosis and 5230 men were diagnosed after PCa diagnosis. Cancer of the bladder or colon and nonmelanoma of the skin were the 3 most frequently observed cancers before and after PCa diagnosis. At the time of PCa diagnosis, the prevalence of these 3 cancers ...

  
  

Mots clés : Prostate; Lutte contre les cancers (Observation)

A partir des données des registres du cancer de Singapour et de deux zones européennes (Suède et Genève), cette étude analyse et compare l'incidence du cancer de la prostate ainsi que la mortalité, sur la période 1973 à 2006

• A comparative population-based study of prostate cancer incidence and mortality rates in Singapore, Sweden and Geneva, Switzerland from 1968 to 2006
  • BMC Cancer, Vol. 12 (1), pp. 222, 2012 (article en libre accès)
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  A partir des données des registres du cancer de Singapour et de deux zones européennes (Suède et Genève), cette étude analyse et compare l'incidence du cancer de la prostate ainsi que la mortalité, sur la période 1973 à 2006

  “A comparative population-based study of prostate cancer incidence and mortality rates in Singapore, Sweden and Geneva, Switzerland from 1968 to 2006”

  • Chen, Cynthia;Naidoo, Nasheen;Yang, Qian;Hartman, Mikael;Verkooijen, Helena MariekeM;Loy, En Yun;Bouchardy, Christine;Chia, Kee Seng;Chia, Sin Eng

  BACKGROUND:Prostate cancer is the most commonly diagnosed malignancy in men in Sweden and Geneva, and the third most common in men in Singapore. This population-based study describes trends in the incidence and mortality rates of prostate cancer in Singapore, Sweden and Geneva (Switzerland) from 1973 to 2006 and explores possible explanations for these different trends.METHODS:Data from patients diagnosed with prostate cancer were extracted from national cancer registries in Singapore (n?=?5,172), Sweden (n?=?188,783) and Geneva (n?=?5,755) from 1973 to 2006. Trends of incidence and mortality were reported using the Poisson and negative binomial regression models. The age, period and birth-cohort were tested as predictors of incidence and mortality rates of prostate cancer.RESULTS:Incidence rates of prostate cancer increased over all time periods for all three populations. Based on the age-period-cohort analysis, older age and later period of diagnosis were associated with a higher ...

  
  

Mots clés : Prostate; Lutte contre les cancers (Observation)

Menée auprès de 1 422 patients atteints d'un lymphome cutané primitif à cellules T, cette étude italienne analyse les facteurs de risques et l'évolution à long terme de la maladie

• Time course, clinical pathways, and long-term hazards risk trends of disease progression in patients with classic mycosis fungoides
  • Cancer, sous presse, 2012 (résumé)
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  Menée auprès de 1 422 patients atteints d'un lymphome cutané primitif à cellules T, cette étude italienne analyse les facteurs de risques et l'évolution à long terme de la maladie

  “Time course, clinical pathways, and long-term hazards risk trends of disease progression in patients with classic mycosis fungoides”

  • Quaglino, Pietro;Pimpinelli, Nicola;Berti, Emilio;Calzavara-Pinton, Piergiacomo;Alfonso Lombardo, Giuseppe;Rupoli, Serena;Alaibac, Mauro;Bottoni, Ugo;Carbone, Angelo;Fava, Paolo;Fimiani, Michele;Mamusa, Angela Maria;Titli, Stefano;Zinzani, Pier Luigi;Bernengo, Maria Grazia;On behalf of the Gruppo Italiano Linfomi, Cutanei

  BACKGROUND: Mycosis fungoides (MF) is an indolent primary cutaneous T-cell lymphoma. To the authors' knowledge, no data currently are available regarding the evolution over time of the risk of developing specific pathways of disease progression. METHODS: This retrospective study analyzed 1422 patients with MF who were diagnosed and followed from 1975 through 2010 in 27 Italian Study Group for Cutaneous Lymphoma centers. The primary objectives were to ascertain the time course, pathways, and hazards risk trends of cutaneous/extracutaneous disease progression; to evaluate whether different tumor-lymph node-metastasis-blood (TNMB) stages have different pathways of disease progression; and to analyze differences between tumor-stage and erythrodermic MF with regard to clinical onset, disease evolution, and prognosis. The secondary objective was to provide a further validation for the revised International Society for Cutaneous Lymphomas and the Cutaneous Lymphoma Task Force of the European ...

  
  

Mots clés : Lymphome; Lutte contre les cancers (Observation)

Menée auprès de 351 patients jeunes atteints d'une leucémie myéloïde aiguë, cette étude américaine évalue leur survie selon les tranches d'âge pendant le traitement (0-9 ans, 10-15 ans, 16-21 ans)

• Treatment outcome in older patients with childhood acute myeloid leukemia
  • Cancer, sous presse, 2012 (résumé)
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  Menée auprès de 351 patients jeunes atteints d'une leucémie myéloïde aiguë, cette étude américaine évalue leur survie selon les tranches d'âge pendant le traitement (0-9 ans, 10-15 ans, 16-21 ans)

  “Treatment outcome in older patients with childhood acute myeloid leukemia”

  • Rubnitz, Jeffrey E.;Pounds, Stanley;Cao, Xueyuan;Jenkins, Laura;Dahl, Gary;Bowman, W. Paul;Taub, Jeffrey W.;Pui, Ching-Hon;Ribeiro, Raul C.;Campana, Dario;Inaba, Hiroto

  BACKGROUND. Older age has historically been an adverse prognostic factor in pediatric acute myeloid leukemia (AML). To the authors' knowledge, the impact of age relative to that of other prognostic factors on the outcome of patients treated in recent trials is unknown. METHODS. Clinical outcome and causes of treatment failure of 351 patients enrolled on 3 consecutive protocols for childhood AML between 1991 and 2008 were analyzed according to age and protocol. RESULTS. The more recent protocol (AML02) produced improved outcomes for patients aged 10 years to 21 years compared with 2 earlier studies (AML91 and AML97), with 3-year rates of event-free survival (EFS), overall survival (OS), and cumulative incidence of refractory leukemia or recurrence (CIR) for this group being similar to those of patients aged birth to 9 years: EFS: 58.3% ± 5.4% versus 66.6% ± 4.9% (P = .20); OS: 68.9% ± 5.1% versus 75.1% ± 4.5% (P = .36); and CIR: 21.9% ± 4.4% versus 25.3% ± 4.2% (P = .59). The EFS ...

  
  

Mots clés : Leucémie; Lutte contre les cancers (Observation)

A partir des données des registres américains du cancer portant sur la période 1996 à 2007, cette étude analyse les disparités socioéconomiques dans l'incidence du carcinome hépatocellulaire et la survie des patients

• Socioeconomic status and hepatocellular carcinoma in the United States
  • Cancer Epidemiology Biomarkers & Prevention, sous presse, 2012 (résumé)
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  A partir des données des registres américains du cancer portant sur la période 1996 à 2007, cette étude analyse les disparités socioéconomiques dans l'incidence du carcinome hépatocellulaire et la survie des patients

  “Socioeconomic status and hepatocellular carcinoma in the United States”

  • Shebl, Fatma M.;Capo-Ramos, David E.;Graubard, Barry I.;McGlynn, Katherine A.;Altekruse, Sean F.

  Background: Hepatocellular carcinoma (HCC) has a poor prognosis and, unlike most cancers, HCC incidence and mortality rates are increasing in the United States. While risk is known to vary among different racial and ethnic groups, less is known about the variability of risk within these groups by neighborhood socioeconomic status (SES). Methods: HCC cases diagnosed in the Surveillance, Epidemiology and End Results (SEER) 11 cancer registries between 1996 and 2007 and the population of the SEER 11 catchment areas were studied. Analyses were performed to compare census-tract area family poverty, educational attainment and unemployment by race and ethnicity. A multiple linear regression model, weighted by the number of cases and the number of individuals in each census-tract, with adjustment for registry, was used to calculate mean differences in area-level attributes between HCC cases and the population. Results: HCC cases in most racial/ethnic groups had lower mean neighborhood-level ...

  
  

Mots clés : Foie; Lutte contre les cancers (Observation)

A partir de données portant sur une cohorte de 13 048 patients traités entre 1960 et 2009, cette étude cas-témoins analyse les facteurs de risque et l'incidence d'un cancer colorectal après un cancer pédiatrique

• Secondary Colorectal Carcinoma After Childhood Cancer
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  A partir de données portant sur une cohorte de 13 048 patients traités entre 1960 et 2009, cette étude cas-témoins analyse les facteurs de risque et l'incidence d'un cancer colorectal après un cancer pédiatrique

  “Secondary Colorectal Carcinoma After Childhood Cancer”

  • Nottage, Kerri;McFarlane, Joshua;Krasin, Matthew J.;Li, Chenghong;Srivastava, Deokumar;Robison, Leslie L.;Hudson, Melissa M.

  Purpose Colorectal carcinoma (CRC) has been described as a subsequent malignant neoplasm (SMN), although little is known about associated risk factors. We aimed to quantify the long-term risk of secondary CRC and identify treatment-related risk factors.Patients and Methods In this nested case-control study, 19 cases of adenocarcinoma of the colon or rectum were identified from 13,048 oncology patients treated for childhood cancer at St Jude Children's Research Hospital. Group 1 controls (n = 148) were matched for age at primary malignancy and follow-up interval. Group 2 controls (n = 72) were matched on primary diagnosis in addition to group 1 criteria. Exact conditional logistic regression was performed to calculate odds ratios (ORs) for chemotherapy and radiation exposure.Results Forty-year cumulative incidence of secondary CRC was 1.4%. Standardized incidence ratio was 10.9 (95% CI, 6.6 to 17.0) compared with that in the general US population. Secondary CRC was more likely in an ...

  
  

Mots clés : Colon-rectum; Lutte contre les cancers (Observation)

Menée en Australie auprès de 98 patientes nouvellement diagnostiquées avec un cancer du sein, cette étude analyse les facteurs psychologiques associés à une adhésion aux recommandations relatives à la prévention du risque de lymphœdème

• Psychosocial predictors of adherence to lymphedema risk minimization guidelines among women with breast cancer
  • Psycho-Oncology, sous presse, 2012 (résumé)
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  Menée en Australie auprès de 98 patientes nouvellement diagnostiquées avec un cancer du sein, cette étude analyse les facteurs psychologiques associés à une adhésion aux recommandations relatives à la prévention du risque de lymphœdème

  “Psychosocial predictors of adherence to lymphedema risk minimization guidelines among women with breast cancer”

  • Sherman, Kerry A.;Koelmeyer, Louise

  Background The effective management of lymphedema risk following breast cancer surgery and treatment requires enactment of simple behavioural strategies, including regularly checking for early lymphedema symptoms. Adopting a broad self-regulatory perspective, our aim for this study was to identify psychological factors associated with adherence to these risk management strategies. Methods Women (N = 98) recently diagnosed with breast cancer and scheduled for breast and lymph node surgery completed questionnaires prior to surgery and at 3 months post-surgery. Variables assessed included demographics, cognitive belief variables in relation to lymphedema and its management (perceived negative consequences, perceived lymphedema controllability, self-efficacy, perceived personal risk, perceived self-regulatory ability to manage risk-related distress), lymphedema knowledge, trait anxiety and adherence to lymphedema risk management recommendations. Results Greater adherence was ...

  
  

Mots clés : Sein; Lutte contre les cancers (Approches psycho-sociales)

Menée par téléphone auprès de femmes américaines (396 d'origine européenne et 349 d'origine latino-américaine), cette étude transversale analyse leur qualité de vie et leur détresse psychologique après un diagnostic de carcinome canalaire in situ

• Quality of life of Latina and Euro-American women with ductal carcinoma in situ
  • Psycho-Oncology, sous presse, 2012 (résumé)
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  Menée par téléphone auprès de femmes américaines (396 d'origine européenne et 349 d'origine latino-américaine), cette étude transversale analyse leur qualité de vie et leur détresse psychologique après un diagnostic de carcinome canalaire in situ

  “Quality of life of Latina and Euro-American women with ductal carcinoma in situ”

  • Bloom, Joan R.;Stewart, Susan L.;Napoles, Anna M.;Hwang, E. Shelly;Livaudais, Jennifer C.;Karliner, Leah;Kaplan, Celia P.

  Background Risk factors for psychosocial distress following a breast cancer diagnosis include younger age, history of depression, inadequate social support, and serious comorbid conditions. Although these quality of life (QOL) concerns have been studied in women with ductal carcinoma in situ (DCIS), Latina women have been understudied. Methods Data were from a cross-sectional telephone survey of Latina and Euro-American women with DCIS recruited through a population-based cancer registry. The sample included 396 Euro-American women and 349 Latina women; 156 were interviewed in English and 193 in Spanish, with a median of 2 years after diagnosis. Regression models were created for measures in each of the following four QOL domains: physical, psychological, social, and spiritual. Results Younger age, no partner, and lower income were related to lower QOL in various domains. Physical comorbidities were associated with lower physical, psychological, and social QOL; lingering effects of ...

  
  

Mots clés : Sein; Lutte contre les cancers (Approches psycho-sociales)

Menée auprès de 268 participantes, cette étude espagnole analyse l'utilisation des services de santé par les patientes atteintes d'un cancer du sein pendant leur chimiothérapie

• Use of health-care services during chemotherapy for breast cancer
  • European journal of cancer (Oxford, England : 1990), sous presse, 2012 (résumé)
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  Menée auprès de 268 participantes, cette étude espagnole analyse l'utilisation des services de santé par les patientes atteintes d'un cancer du sein pendant leur chimiothérapie

  “Use of health-care services during chemotherapy for breast cancer”

  • Baena-Cañada, José M.;Estalella-Mendoza, Sara;Rosado-Varela, Petra;Expósito-Álvarez, Inmaculada;González-Guerrero, Macarena;Díaz-Blanco, María C.;Cortés-Carmona, Cristina;Ramírez-Daffós, Patricia;Arriola-Arellano, Esperanza;Rueda-Ramos, Antonio;Solana-Grimaldi, Lourdes;Benítez-Rodríguez, Encarnación

  The authors analyse the effect of chemotherapy on the use of additional health-care resources and report the clinical and demographic factors associated with such use. In women with breast cancer, eligible to receive first-line (neo)-adjuvant or palliative chemotherapy, consultations with health-care practitioners (general practitioners [GPs] and specialists) and admissions to emergency department and to hospital were prospectively recorded. Differences were studied according to these clinical and demographic variables: age, tumour stage, performance status, weight, height, body mass index, surgery type, chemotherapy type, number of courses, comorbidity, marital status, educational level, social status and occupational status. Among 268 patients, 124 (42.2%) required one or more non-protocol health-care encounters. 180 visits were generated (GP 23.3%, specialist 35.5%, emergency department admission 21.1%, hospital admission 8.3%, others 3.3% and more than one resource 8.3%). Of total ...

  
  

Mots clés : Sein; Lutte contre les cancers (Analyses économiques et systèmes de soins)

A partir des données de deux études rétrospectives, cette étude (186 cas et 186 témoins) analyse le coût associé à un épanchement pleural chez des patients atteints d'une leucémie myéloïde chronique et traités avec des inhibiteurs de tyrosine kinase

• The economic burden of pleural effusions in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors
  • Journal of Medical Economics, sous presse, 2012 (résumé)
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  A partir des données de deux études rétrospectives, cette étude (186 cas et 186 témoins) analyse le coût associé à un épanchement pleural chez des patients atteints d'une leucémie myéloïde chronique et traités avec des inhibiteurs de tyrosine kinase

  “The economic burden of pleural effusions in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors”

  • Guérin, Annie;Wu, Eric Q.;Bollu, Vamsi K.;Williams, Denise;Guo, Amy;de Leon, Diego Ponce;Quintas-Cardama, Alfonso

  Tyrosine kinase inhibitors (TKI), the standard of care for patients with chronic myeloid leukemia (CML) patients, may in some cases lead to the development of pleural effusion (PE). The purpose of this study is to compare healthcare resource utilization and costs associated with PE among CML patients treated with a TKI therapy. Methods: Two large retrospective claims databases (1999–2009) were combined to identify adult CML patients who received ≥1 TKI prescription before the index date, which was defined as 30 days before the first PE diagnosis for patients with PE and a randomly selected date for PE-free patients. Patients were followed for 6 months after the index date. PE and PE-free patients were matched on a 1:1 ratio. PE-related resource utilization and costs (measured in 2009 US dollars) were estimated for PE patients. All-cause and CML-related resource utilization and costs were compared between PE and PE-free patients. Multivariate regression models were used to control ...

  
  

Mots clés : Leucémie; Lutte contre les cancers (Analyses économiques et systèmes de soins)

Menée auprès de 379 patients, cette étude américaine évalue l'efficacité d'un programme de détection de la détresse psychologique des patients atteints de cancer par les soignants (infirmières en chimiothérapie, radiologues, etc.) lors de l'administration des traitements

• How feasible is implementation of distress screening by cancer clinicians in routine clinical care?
  • Cancer, sous presse, 2012 (résumé)
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  Menée auprès de 379 patients, cette étude américaine évalue l'efficacité d'un programme de détection de la détresse psychologique des patients atteints de cancer par les soignants (infirmières en chimiothérapie, radiologues, etc.) lors de l'administration des traitements

  “How feasible is implementation of distress screening by cancer clinicians in routine clinical care?”

  • Mitchell, Alex J.;Lord, Karen;Slattery, Jo;Grainger, Lorraine;Symonds, Paul

  BACKGROUND: There is considerable uncertainty regarding the acceptability of routine distress screening. METHODS: In an unfunded implementation study, the authors asked 50 clinicians (chemotherapy nurses and treatment radiographers/radiation technologists) to implement a screening program for distress as part of routine care and to record their feedback after each clinical encounter. In total, 379 patients were screened using a simple paper-and-pencil versions of distress thermometer and the emotion thermometer (ET). RESULTS: Across all screening applications, clinicians believed that screening was useful during 43% of assessments and was not useful during 35.9% of assessments, and they were unsure or neutral in 21.1% of assessments. The application of the screening program assisted staff in changing their clinical opinion after 41.9% of assessments, and clinicians believed that the screening program helped with communication in >50% of assessments. However, 37.5% believed that ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Analyses économiques et systèmes de soins)

Menée au Royaume-Uni auprès de 1 392 participantes, cette étude analyse les connaissances des femmes relatives aux symptômes et facteurs de risque du cancer du col de l'utérus

• What do British women know about cervical cancer symptoms and risk factors?
  • European journal of cancer (Oxford, England : 1990), sous presse, 2012 (résumé)
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  Menée au Royaume-Uni auprès de 1 392 participantes, cette étude analyse les connaissances des femmes relatives aux symptômes et facteurs de risque du cancer du col de l'utérus

  “What do British women know about cervical cancer symptoms and risk factors?”

  • Low, Emma L.;Simon, Alice E.;Lyons, Jane;Romney-Alexander, Debbie;Waller, Jo

  To identify levels of cervical cancer risk factor and symptom awareness, as well as predictors of higher awareness in a United Kingdom (UK) female population. Population based survey. Participants’ homes in the UK. UK representative sample of females aged 16years and over (n=1392). Respondents completed the Cervical Cancer Awareness Measure which included questions on awareness of cervical cancer symptoms and risk factors (both recalled and recognised). Linear regression analyses were used to identify predictors of higher symptom and risk factor recognition scores. Awareness of cervical cancer symptoms and risk factors. Sixty-five percent of respondents were unable to recall any risk factors and 75% were unable to recall any symptoms. Awareness was higher when women were prompted (95% recognised at least one risk factor and 93% at least one symptom). Independent predictors of risk factor recognition were older age and higher education. Symptom recognition was associated with older ...

  
  

Mots clés : Col de l'utérus; Lutte contre les cancers (Sensibilisation et communication)

Mené auprès de 135 parents d'enfants âgés de moins de 18 ans et atteints de cancer, cet essai randomisé évalue l'efficacité d'une intervention visant à les conseiller dans la réduction de l'exposition au tabagisme passif de leur enfant

• Intervention to reduce secondhand smoke exposure among children with cancer: a controlled trial
  • Psycho-Oncology, sous presse, 2012 (résumé)
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  Mené auprès de 135 parents d'enfants âgés de moins de 18 ans et atteints de cancer, cet essai randomisé évalue l'efficacité d'une intervention visant à les conseiller dans la réduction de l'exposition au tabagisme passif de leur enfant

  “Intervention to reduce secondhand smoke exposure among children with cancer: a controlled trial”

  • Tyc, Vida L.;Huang, Qinlei;Nicholson, Jody;Schultz, Bethany;Hovell, Melbourne F.;Lensing, Shelly;Vukadinovich, Chris;Hudson, Melissa M.;Zhang, Hui

  Objective This randomized controlled trial tested the efficacy of parent-based behavioral counseling for reducing secondhand smoke exposure (SHSe) among children with cancer. It also examined predictors of smoking and SHSe outcomes. Methods Participants were 135 parents or guardians of nonsmoking children with cancer, <18 years, at least 30 days postdiagnosis, and living with at least one adult smoker. Parents were randomized to either a standard care control group or an intervention consisting of six counseling sessions delivered over 3 months. Parent-reported smoking and child SHSe levels were obtained at baseline, 3, 6, 9, and 12 months. Children provided urine samples for cotinine analyses. Results Reductions in parent-reported smoking and exposure were observed in both the intervention and control conditions. There was a significantly greater reduction in parent-reported smoking and child SHSe at 3 months for the intervention group compared with the control group. Child ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Sensibilisation et communication)

Menée au Danemark auprès de 2 202 participants, cette étude transversale analyse les perceptions et les besoins des patients atteints de cancer en matière de communication avec l'équipe soignante et médicale

• Cancer patients’ evaluation of communication: a report from the population-based study ‘The Cancer Patient’s World’
  • Supportive Care in Cancer, sous presse, 2012 (résumé)
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  Menée au Danemark auprès de 2 202 participants, cette étude transversale analyse les perceptions et les besoins des patients atteints de cancer en matière de communication avec l'équipe soignante et médicale

  “Cancer patients’ evaluation of communication: a report from the population-based study ‘The Cancer Patient’s World’”

  • Ross, Lone;Petersen, Morten;Johnsen, Anna;Lundstrøm, Louise;Groenvold, Mogens

  Purpose The aims of this study were to assess how communication with health care staff is perceived by Danish cancer patients and to characterise those patients who report problems in communication. Methods In a cross-sectional survey, a nationally representative sample of 2,202 cancer patients who had been in contact with a hospital department during the past year was invited to respond to a questionnaire. Communication with doctors and nurses was assessed separately as were their abilities as listeners, doctors’ use of an understandable language, timing of the information, duration of consultations, and whether doctors criticised other doctors. Results A total of 1,490 cancer patients responded to the questionnaire. Of these, 24 % reported one or more problems with the areas of communication measured. The problem most frequently reported (by 12 %) was not having sufficient time for consultations. More patients reported problems with doctors’ communication and abilities as ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Sensibilisation et communication)

Menée en Italie auprès de 50 oncologues travaillant en oncogériatrie, cette étude analyse leurs comportements et leurs pratiques de communication lors de l'annonce de mauvaises nouvelles aux patients âgés

• Physicians' age and sex influence breaking bad news to elderly cancer patients. Beliefs and practices of 50 Italian oncologists: the G.I.O.Ger study
  • Psycho-Oncology, sous presse, 2012 (résumé)
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  Menée en Italie auprès de 50 oncologues travaillant en oncogériatrie, cette étude analyse leurs comportements et leurs pratiques de communication lors de l'annonce de mauvaises nouvelles aux patients âgés

  “Physicians' age and sex influence breaking bad news to elderly cancer patients. Beliefs and practices of 50 Italian oncologists: the G.I.O.Ger study”

  • Locatelli, C.;Piselli, P.;Cicerchia, M.;Repetto, L.

  Purpose We attempt to shed light on the truth-telling attitudes and practices of oncologists working with a geriatric population in Italy. Participants and method Physicians caring for cancer patients were asked to complete a specific survey centred on their beliefs, attitudes and practices towards truth telling to elderly cancer patients. Results Of 50 physicians surveyed, 68% were men. Physicians practising in the south of Italy were significantly older and more likely to be of male gender in comparison with physicians practising from the north and central areas. Eighty-four per cent of physicians consider the family to be an obstacle to a direct communication with the elderly. Forty-four per cent of male physicians who are faced with a family's request of nondisclosure talk with the patient, whereas 37.5% of female physicians talk with the family. For 60% of interviewed physicians, the reason underpinning the caregiver's choice of nondisclosure is to delay the emotional ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Sensibilisation et communication)

Menée en Turquie, cet essai randomisé (67 cas et 53 témoins) évalue l'efficacité d'une méthode dérivée de l'acupuncture (acupression) pour prévenir les nausées et vomissements liés à la chimiothérapie

• The efficiency of the acupressure in prevention of the chemotherapy-induced nausea and vomiting
  • Supportive Care in Cancer, sous presse, 2012 (résumé)
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  Menée en Turquie, cet essai randomisé (67 cas et 53 témoins) évalue l'efficacité d'une méthode dérivée de l'acupuncture (acupression) pour prévenir les nausées et vomissements liés à la chimiothérapie

  “The efficiency of the acupressure in prevention of the chemotherapy-induced nausea and vomiting”

  • Genç, Aslı;Can, Gulbeyaz;Aydiner, Adnan

  Purpose This experimental study was planned to assess the efficiency of the acupressure in prevention of the chemotherapy-induced nausea and vomiting (CINV). Methods This single-blinded randomized trial was performed at Istanbul University Institute of Oncology between October 2010 and January 2011. The patients, diagnosed with breast, gynecological, or lung cancer treated by doxorubicin-based- or cisplatin-based treatment were included in the study. Taking the consent of the patients, they were divided into experimental ( n = 67) and control groups ( n = 53) in line with the randomization list prepared before. The patient description form, Rhodes Index of Nausea, Vomiting, and Retching (INVR), and Functional Assessment of Cancer Therapy-General were used in data collection. Non-parametric tests were applied. Results The patients in the experimental and control groups were identical in terms of sociodemographic features and their conditions. Most of the patients were married (84 %), ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Médecines parallèles)