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Accueil Nota Bene Cancer V2 Numéro 137 du 22 Mai 2012 Lutte contre les cancers

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Nota Bene Cancer Numéro 137 du 22 Mai 2012 RSS

Lutte contre les cancers

Qualité de vie, soins de support

A partir de questionnaires auprès de 440 patientes atteintes d'un cancer du sein en rémission (âge médian : 52 ans), cette étude analyse la relation entre le profil psychosocial des patientes, leur niveau réel d'activité physique et leurs besoins en soins de support

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    A partir de questionnaires auprès de 440 patientes atteintes d'un cancer du sein en rémission (âge médian : 52 ans), cette étude analyse la relation entre le profil psychosocial des patientes, leur niveau réel d'activité physique et leurs besoins en soins de support

    “Physical activity levels and supportive care needs for physical activity among breast cancer survivors with different psychosocial profiles: a cluster-analytical approach”

    • Charlier, C.;Pauwels, E.;Lechner, L.;Spittaels, H.;Bourgois, J.;De Bourdeaudhuij, I.;Van Hoof, E.

    The transition from breast cancer patient to survivor is associated with many treatment-related and psychosocial factors, which can influence health behaviour and associated needs. First, this study aimed to identify clusters of treatment-related and psychosocial factors among breast cancer survivors. Second, clusters' physical activity levels and care needs for physical activity were evaluated. Breast cancer survivors (n= 440; 52 ± 8 years) (3 weeks to 6 months post treatment) completed self-reports on physical and psychological symptoms; illness representations; social support and coping; physical activity and care needs for physical activity. Analyses identified four clusters: (1) a low distress-active approach group; (2) a low distress-resigned approach group; (3) a high distress-active approach group; and (4) a high distress-emotional approach group. Physical activity levels were higher in the low distress groups than in the high distress-emotional approach group. However, women ...


Mots clés : Sein; Lutte contre les cancers (Qualité de vie, soins de support)

Menée en population européenne, cette étude analyse et compare, chez des survivants d'un cancer du colon ou du rectum et en population saine, la prévalence des dysfonctionnements sexuels

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    Menée en population européenne, cette étude analyse et compare, chez des survivants d'un cancer du colon ou du rectum et en population saine, la prévalence des dysfonctionnements sexuels

    “Higher prevalence of sexual dysfunction in colon and rectal cancer survivors compared with the normative population: A population-based study”

    • Den Oudsten, B. L.;Traa, M. J.;Thong, M. S. Y.;Martijn, H.;De Hingh, I. H. J. T.;Bosscha, K.;van de Poll-Franse, L. V.

    Background To compare colorectal cancer survivors with a normative population regarding erectile dysfunction, ejaculation problems, dyspareunia, dry vagina, sexual functioning (SF) and enjoyment (SE). In addition, the sociodemographic, clinical and psychological correlates of (dys)function in survivors are examined. Patients and methods The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-CR38 sexuality subscales were completed by survivors (n = 1371; response rate 82%), of which 1359 received surgical treatment and were included in the analysis. The normative population consisted of 400 participants (response rate 78%). Results Erectile problems were more often present in rectal cancer (54%) than colon cancer survivors (25%) and the normative population (27%; p < .0001). They also had more ejaculation problems (68%) than colon cancer survivors (47%; p < .001). Dry vagina was common in colon (28%) and rectal cancer survivors ...


Mots clés : Colon-rectum; Lutte contre les cancers (Qualité de vie, soins de support)

Menée auprès de 181 survivants d'un cancer ayant reçu une greffe de moelle osseuse, cette étude américaine analyse l'impact de facteurs économiques, de difficultés liées à l'emploi et à la couverture sociale sur leur stress et leur qualité de vie

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    Menée auprès de 181 survivants d'un cancer ayant reçu une greffe de moelle osseuse, cette étude américaine analyse l'impact de facteurs économiques, de difficultés liées à l'emploi et à la couverture sociale sur leur stress et leur qualité de vie

    “Economic survivorship stress is associated with poor health-related quality of life among distressed survivors of hematopoietic stem cell transplantation”

    • Hamilton, Jada G.;Wu, Lisa M.;Austin, Jane E.;Valdimarsdottir, Heiddis;Basmajian, Katie;Vu, AnnaMarie;Rowley, Scott D.;Isola, Luis;Redd, William H.;Rini, Christine

    Background Hematopoietic stem cell transplantation is a demanding cancer treatment associated with enduring physical and psychological complications. Survivors' well-being may be further compromised by exposure to chronic stressors common to this population, including difficulties arising from costly medical care, changes in employment status, and health insurance coverage. Thus, we hypothesized that financial, employment, and insurance stressors (collectively referred to as economic survivorship stressors) would be associated with poorer health-related quality of life (HRQOL) among hematopoietic stem cell transplantation survivors. Methods Survivors (n = 181; M = 640 days post-transplant) completed the measures of study variables through mailed questionnaires and telephone interviews. Hierarchical regression analyses were conducted to test the hypothesized associations between economic survivorship stressors and HRQOL, and to examine whether social and situational factors ...


Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

Mené sur 27 patients atteints d'un cancer localement avancé et/ou métastatique de la région pelvienne (11 hommes, 16 femmes ; âge : 47 à 86 ans ; durée médiane de suivi : 6 mois), cet essai de phase 1 évalue l'efficacité et la toxicité d'une radiothérapie accélérée de courte durée sur le contrôle des symptômes et la qualité de vie des patients

  • Short-Course Accelerated Radiotherapy in Palliative Treatment of Advanced Pelvic Malignancies: A Phase I Study
    International journal of radiation oncology, biology, physics, sous presse, 2012 (résumé)
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    Mené sur 27 patients atteints d'un cancer localement avancé et/ou métastatique de la région pelvienne (11 hommes, 16 femmes ; âge : 47 à 86 ans ; durée médiane de suivi : 6 mois), cet essai de phase 1 évalue l'efficacité et la toxicité d'une radiothérapie accélérée de courte durée sur le contrôle des symptômes et la qualité de vie des patients

    “Short-Course Accelerated Radiotherapy in Palliative Treatment of Advanced Pelvic Malignancies: A Phase I Study”

    • Caravatta, Luciana;Padula, Gilbert D. A.;Macchia, Gabriella;Ferrandina, Gabriella;Bonomo, Pierluigi;Deodato, Francesco;Massaccesi, Mariangela;Mignogna, Samantha;Tambaro, Rosa;Rossi, Marco;Flocco, Mariano;Scapati, Andrea;Scambia, Giovanni;Pacelli, Fabio;Valentini, Vincenzo;Cellini, Numa;Morganti, Alessio G.

    To define the maximum tolerated dose of a conformal short-course accelerated radiotherapy in patients with symptomatic advanced pelvic cancer. A phase I trial in 3 dose-escalation steps was designed: 14 Gy (3.5-Gy fractions), 16 Gy (4-Gy fractions), and 18 Gy (4.5-Gy fractions). The eligibility criteria included locally advanced and/or metastatic pelvic cancer and Eastern Cooperative Oncology Group performance status of ≤3. Treatment was delivered in 2 days with twice-daily fractionation and at least an 8-hour interval. Patients were treated in cohorts of 6-12 to define the maximum tolerated dose. The dose-limiting toxicity was defined as any acute toxicity of grade 3 or greater, using the Radiation Therapy Oncology Group scale. Pain was recorded using a visual analog scale. The effect on quality of life was evaluated according to Cancer Linear Analog Scale (CLAS). Of the 27 enrolled patients, 11 were male and 16 were female, with a median age of 72 years (range 47-86). The primary ...


Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

Observation

A partir des données des registres américains du cancer portant sur la période 1973-2007, cette étude évalue le risque, les caractéristiques et le pronostic d'un cancer du sein chez les survivantes d'un lymphome hodgkinien

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    A partir des données des registres américains du cancer portant sur la période 1973-2007, cette étude évalue le risque, les caractéristiques et le pronostic d'un cancer du sein chez les survivantes d'un lymphome hodgkinien

    “Risk, Characteristics, and Prognosis of Breast Cancer after Hodgkin's Lymphoma”

    • Veit-Rubin, Nikolaus;Rapiti, Elisabetta;Usel, Massimo;Benhamou, Simone;Vinh-Hung, Vincent;Vlastos, Georges;Bouchardy, Christine

    Abstract Purpose. To assess breast cancer (BC) risk after Hodgkin's lymphoma (HL) and compare characteristics, risk of second BC, and prognosis of patients with these BCs with patients with first primary BC.Patients and Methods. We considered all 9,620 women with HL recorded in the Surveillance, Epidemiology and End Results dataset in 1973–2007. We calculated age-period standardized incidence ratios of BC. We compared patient, tumor, and treatment characteristics, risk of second BC, and prognosis between patients with BC after HL (n = 316) and patients with other BCs occurring during the same period (n = 450,413) using logistic regression and Cox models adjusted for confounders.Results. HL patients had a 2.4-fold higher risk for developing BC (95% confidence interval [CI], 2.2–2.7) than the general population. Age at HL diagnosis and radiation therapy influenced this risk. Compared with first primary BCs, BCs after HL were diagnosed at a younger age, at an earlier stage, were less ...


Mots clés : Sein; Lutte contre les cancers (Observation)

Menée dans quatre comtés norvégiens, cette étude analyse l'évolution de la mortalité par cancer du sein dans le contexte du déploiement progressif d'un programme de dépistage de la maladie entre 1996 et 2004 (durée moyenne de suivi : 5,9 ans)

  • Breast cancer mortality in Norway after the introduction of mammography screening
    International Journal of Cancer, sous presse, 2012 (résumé)
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    Menée dans quatre comtés norvégiens, cette étude analyse l'évolution de la mortalité par cancer du sein dans le contexte du déploiement progressif d'un programme de dépistage de la maladie entre 1996 et 2004 (durée moyenne de suivi : 5,9 ans)

    “Breast cancer mortality in Norway after the introduction of mammography screening”

    • Olsen, Anne Helene;Lynge, Elsebeth;Njor, Sisse H.;Kumle, Merethe;Waaseth, Marit;Braaten, Tonje;Lund, Eiliv

    An organized mammography screening program was gradually implemented in Norway during the period 1996–2004. Norwegian authorities have initiated an evaluation of the program. Our study focused on breast cancer mortality. Using Poisson regression, we compared the change in breast cancer mortality from before to during screening in four counties starting the program early controlling for change in breast cancer mortality during the same time in counties starting the program late. A follow-up model included death in all breast cancers diagnosed during the follow-up period. An evaluation model included only breast cancers diagnosed in ages where screening was offered. The study group had been invited for screening one to three times and followed for on average of 5.9 years. In the follow-up model, 314 breast cancer deaths were observed in the study group, and 523, 404 and 638, respectively, in the four control groups. The ratio between the changes in breast cancer mortality between ...


Mots clés : Sein; Lutte contre les cancers (Observation)

A partir des données des registres néerlandais du cancer entre 1994 et 2008, cette étude analyse l'évolution des disparités socioéconomiques dans le recours à une biopsie du ganglion sentinelle et à une chirurgie conservatrice chez les patientes atteintes d'un cancer du sein

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    A partir des données des registres néerlandais du cancer entre 1994 et 2008, cette étude analyse l'évolution des disparités socioéconomiques dans le recours à une biopsie du ganglion sentinelle et à une chirurgie conservatrice chez les patientes atteintes d'un cancer du sein

    “Small but significant socioeconomic inequalities in axillary staging and treatment of breast cancer in the Netherlands”

    • Aarts, M. J.;Hamelinck, V. C.;Bastiaannet, E.;Coebergh, J. W. W.;Liefers, G. J.;Voogd, A. C.;van der Sangen, M.;Louwman, W. J.

    Background: The use of sentinel node biopsy (SNB), lymph node dissection, breast-conserving surgery, radiotherapy, chemotherapy and hormonal treatment for breast cancer was evaluated in relation to socioeconomic status (SES) in the Netherlands, where access to care was assumed to be equal. Methods: Female breast cancer patients diagnosed between 1994 and 2008 were selected from the nationwide population-based Netherlands Cancer Registry (N=176 505). Socioeconomic status was assessed based on income, employment and education at postal code level. Multivariable models included age, year of diagnosis and stage. Results: Sentinal node biopsy was less often applied in high-SES patients (multivariable analyses, 49 years: odds ratio (OR) 0.70 (95% CI: 0.56–0.89); 50–75 years: 0.85 (0.73–0.99)). Additionally, lymph node dissection was less common in low-SES patients aged 76 years (OR 1.34 (0.95–1.89)). Socioeconomic status-related differences in treatment were only significant in ...


Mots clés : Sein; Lutte contre les cancers (Observation)

A partir d'une revue de la littérature et des données d'une cohorte incluant 1 543 participants, cette méta-analyse évalue l'impact de l'obésité sur la survie des patients atteints d'un carcinome à cellules rénales

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    A partir d'une revue de la littérature et des données d'une cohorte incluant 1 543 participants, cette méta-analyse évalue l'impact de l'obésité sur la survie des patients atteints d'un carcinome à cellules rénales

    “Body mass index and survival in patients with renal cell carcinoma: a clinical-based cohort and meta-analysis”

    • Choi, Yuni;Park, Bumsoo;Jeong, Byong Chang;Seo, Seong Il;Jeon, Seong Soo;Choi, Han Yong;Adami, Hans-Olov;Lee, Jung Eun;Lee, Hyun Moo

    Growing evidence suggests that obesity, an established cause of renal cell cancer (RCC), may also be associated with a better prognosis. To evaluate the association between RCC survival and obesity, we analyzed a large cohort of patients with RCC and undertook a meta-analysis of the published evidence. We collected clinical and pathologic data from 1,543 patients who underwent nephrectomy for RCC between 1994 and 2008 with complete follow-up through 2008. Patients were grouped according to BMI (kg/m2): underweight, <18.5; normal weight, 18.5 to < 23; overweight, 23 to < 25; and obese, ≥ 25. We estimated survival using the Kaplan-Meier method and Cox proportional hazard models to examine the impact of BMI on overall survival (OS) and cancer-specific survival (CSS) with adjustment for covariates. We performed a meta-analysis of BMI and OS, CSS, and recurrence free survival (RFS) from all relevant studies using a random-effects model. The 5-year CSS increased from 76.1% in the lowest ...


Mots clés : Rein; Lutte contre les cancers (Observation)

Menée sur la période 1964-2008, cette étude de cohorte en population suédoise évalue le risque de cancer du moignon gastrique après une gastrectomie pour traiter un ulcère bénin de l'estomac

  • Gastric stump cancer after distal gastrectomy for benign gastric ulcer in a population-based study
    International Journal of Cancer, sous presse, 2012 (résumé)
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    Menée sur la période 1964-2008, cette étude de cohorte en population suédoise évalue le risque de cancer du moignon gastrique après une gastrectomie pour traiter un ulcère bénin de l'estomac

    “Gastric stump cancer after distal gastrectomy for benign gastric ulcer in a population-based study”

    • Lagergren, Jesper;Lindam, Anna;Mason, Robert M.

    The risk of cancer in the gastric remnant after distal gastrectomy for benign ulcer disease has been assessed mainly in studies of small sample size, selected series and limited follow-up time. This was a population-based cohort study of patients who had undergone distal gastrectomy for benign ulcer disease in 1964–2008 in Sweden. Data for follow-up for cancer and censoring for death were obtained from nationwide registries of Cancer and Population, respectively. The number of observed cancer cases in the gastrectomy cohort was divided by the expected number, calculated from the cancer incidence of the Swedish population of corresponding age, sex and calendar year. Relative risks were presented as standardized incidence ratios (SIRs) with 95% confidence intervals (CIs). The distal gastrectomy cohort included 18,912 patients and 323,676 person-years at risk. The observed total number of gastric stump cancers (n = 140) was not higher than expected (SIR 0.84, 95% CI 0.71–0.99). There ...


Mots clés : Estomac; Lutte contre les cancers (Observation)

A partir de données médicales de Caroline du Nord portant sur la période 1998-2010, cette étude analyse l'évolution de l'incidence des adénocarcinomes colorectaux et de la mortalité spécifique chez les patients atteints d'une maladie inflammatoire de l'intestin (82 cas)

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    A partir de données médicales de Caroline du Nord portant sur la période 1998-2010, cette étude analyse l'évolution de l'incidence des adénocarcinomes colorectaux et de la mortalité spécifique chez les patients atteints d'une maladie inflammatoire de l'intestin (82 cas)

    “Incidence and Mortality of Colorectal Adenocarcinoma in Persons with Inflammatory Bowel Disease from 1998 to 2010”

    • Herrinton, Lisa J.;Liu, Liyan;Levin, Theodore R.;Allison, James E.;Lewis, James D.;Velayos, Fernando

    The relationship between inflammatory bowel disease (IBD) and incidence and mortality of colorectal adenocarcinoma (CRC) has not been recently evaluated. We calculated the incidence and standardized incidence and mortality rate ratios (SMR) of CRC among adult individuals with intact colons using Kaiser Permanente of Northern California’s database of members with IBD and general membership data for the period of 1998–June 2010 (data through 2008 was used to calculate mortality). We also evaluated trends in medication use and rates of cancer detection over time. We identified 29 cancers among persons with Crohn’s disease (CD) and 53 among persons with ulcerative colitis (UC). Overall, the incidence rates of cancer among individuals with CD, UC, or in the general membership were 75.0, 76.0, and 47.1 per 100,000 person-years. In the general population, the incidence of CRC was 21% higher in 2007–2010 than in 1998–2001 (P for the trend, <.0001), coincident the growth of CRC ...


Mots clés : Colon-rectum; Lutte contre les cancers (Observation)

Menée au Vénézuéla à partir de 329 échantillons inclus en paraffine, cette étude transversale évalue la prévalence d'une infection par différents types de papillomavirus humain dans les néoplasies intraépithéliales cervicales de grade 2 et 3

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    Menée au Vénézuéla à partir de 329 échantillons inclus en paraffine, cette étude transversale évalue la prévalence d'une infection par différents types de papillomavirus humain dans les néoplasies intraépithéliales cervicales de grade 2 et 3

    “Human papillomavirus in invasive cervical cancer and cervical intraepithelial neoplasia 2 and 3 in Venezuela: A cross-sectional study”

    • Sánchez-Lander, Jorge;Cortiñas, Paula;Loureiro, Carmen Luisa;Pujol, Flor Helene;Medina, Francisco;Capote-Negrín, Luis;Bianchi, Gino;García-Barriola, Victoria;Ruiz-Benni, Angela;Avilán-Rovira, José;Acosta, Humberto

    Background This study investigated the distribution of human papillomavirus (HPV) types in invasive cervical cancer (ICC), cervical intraepithelial neoplasia 2 (CIN2) and cervical intraepithelial neoplasia 3 (CIN3) in Venezuela. Methods Paraffin-embedded samples from 329 women from 29 medical centers of the 24 states of Venezuela were analyzed to determine the distribution of HPV types for ICC, CIN2, and CIN3, the prevalence of single and multiple infection, and the association of HPV types with severity of lesion, comparing CIN2 versus CIN3+ (CIN3 and ICC). The samples were analyzed with the polymerase chain reaction (PCR) followed by reverse hybridization for the identification of HPV types. Results HPV was identified in 95/96 ICC specimens (98.9%), in 142/149 CIN3 (95.3%) and in 78/84 CIN2 samples (92.8%). The most common types for ICC and CIN3 were: HPV16, 18, 31, and 33, and for CIN2 were HPV16, 31, 51, 52, and 18. HPV single infection was found in 82.1% of ICC cases, in 79.4% of ...


Mots clés : Col de l'utérus; Lutte contre les cancers (Observation)

A partir de questionnaires auprès de 7 414 patients ayant survécu à un cancer pédiatrique (âge : 21,2 à 58,8 ans ; durée médiane de suivi : 22,7 ans) et de 2 374 témoins frères et soeurs (âge : 18,4 à 62,6 ans), cette étude évalue la prévalence de fractures dans cette population et identifie les facteurs de risques associés

  • Fractures among long-term survivors of childhood cancer
    Cancer, sous presse, 2012 (résumé)
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    A partir de questionnaires auprès de 7 414 patients ayant survécu à un cancer pédiatrique (âge : 21,2 à 58,8 ans ; durée médiane de suivi : 22,7 ans) et de 2 374 témoins frères et soeurs (âge : 18,4 à 62,6 ans), cette étude évalue la prévalence de fractures dans cette population et identifie les facteurs de risques associés

    “Fractures among long-term survivors of childhood cancer”

    • Wilson, Carmen L.;Dilley, Kimberley;Ness, Kirsten K.;Leisenring, Wendy L.;Sklar, Charles A.;Kaste, Sue C.;Stovall, Marilyn;Green, Daniel M.;Armstrong, Gregory T.;Robison, Leslie L.;Kadan-Lottick, Nina S.

    BACKGROUND: Although reductions in bone mineral density are well documented among children during treatment for cancer and among childhood cancer survivors, little is known about the long-term risk of fracture. The objective of this study was to ascertain the prevalence of and risk factors for fractures among individuals participating in the Childhood Cancer Survivor Study (CCSS). METHODS: Analyses included 7414 ≥5-year survivors of childhood cancer diagnosed between 1970 and 1986 who completed the 2007 CCSS follow-up questionnaire and a comparison group of 2374 siblings. Generalized linear models stratified by sex were used to compare the prevalence of reported fractures between survivors and siblings. RESULTS: The median ages at follow-up among survivors and siblings were 36.2 years (range, 21.2-58.8 years) and 38.1 years (range, 18.4-62.6 years), respectively, with a median 22.7 years of follow-up after cancer diagnosis for survivors. Approximately 35% of survivors and 39% of ...


Mots clés : Cancer (général); Lutte contre les cancers (Observation)

A partir des données du registre breton des cancers pédiatriques, cette étude évalue l'incidence des cancers de l'enfant sur la période 1991-2005 et analyse ses fluctuations temporelles et géographiques

  • Childhood cancer incidence in French Brittany, 1991–2005
    Revue d'Épidémiologie et de Santé Publique, sous presse, 2012 (résumé)
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    A partir des données du registre breton des cancers pédiatriques, cette étude évalue l'incidence des cancers de l'enfant sur la période 1991-2005 et analyse ses fluctuations temporelles et géographiques

    “Childhood cancer incidence in French Brittany, 1991–2005”

    • Gagnière, B.;Tron, I.;Guillois-Bécel, Y.;Gourvellec, G.;Le Gall, E.;Gandemer, V.

    Background : The aim of this study was to describe childhood cancer incidence in French Brittany from 1991 to 2005, as well as its temporal and geographical variations. Methods : Childhood cancer incidence was analyzed from the data from the Brittany child tumor registry. Crude rates, world age standardized rates and cumulative rates were estimated for all cancers and for each diagnosis group. Standardized rates were also estimated for each of the four Brittany districts. Poisson regressions were performed to estimate trends in annual rates and to compare incidence rates between 2000–2005 and 1991–1999 periods, and between districts. Results : Between 1991 and 2005, 1176 incident cancer cases were recorded in children younger than 15. Age standardized incidence was 169.5 cases per million of children per year. The most frequent cancers were leukemia (30%), central nervous system tumors (24%), lymphomas (12%) and neuroblastomas (8%). For the period 1991–2005 in Brittany, the risk ...


Mots clés : Cancer (général); Lutte contre les cancers (Observation)

Approches psycho-sociales

A partir des données des registres danois et de celles de 1 208 participantes, cet essai analyse les facteurs d'inclusion et de participation des patientes atteintes d'un cancer du sein à des essais randomisés portant sur des psychothérapies de gestion du stress

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    A partir des données des registres danois et de celles de 1 208 participantes, cet essai analyse les facteurs d'inclusion et de participation des patientes atteintes d'un cancer du sein à des essais randomisés portant sur des psychothérapies de gestion du stress

    “Who participates in a randomized trial of mindfulness-based stress reduction (MBSR) after breast cancer? A study of factors associated with enrollment among Danish breast cancer patients”

    • Würtzen, Hanne;Dalton, Susanne Oksbjerg;Andersen, Klaus Kaae;Elsass, Peter;Flyger, Henrik Lavlund;Sumbundu, Antonia;Johansen, Christoffer

    Background Discussion regarding the necessity to identify patients with both the need and motivation for psychosocial intervention is ongoing. Evidence for an effect of mindfulness-based interventions among cancer patients is based on few studies with no systematic enrollment. Methods We used Danish population-based registries and clinical databases to determine differences in demographics, breast cancer and co-morbidity among 1208 women eligible for a randomized controlled trial (www.clinicaltrials.gov identifier: NCT00990977) of mindfulness-based stress reduction MBSR. Results Participants (N = 336) were found to be younger (p < 0.001) and have a less recent diagnosis at invitation than decliners (N = 872; p < 0.001). After adjustment for age and time since diagnosis at invitation, a statistically significant difference was also found between the two groups in use of psychologist sessions (p < 0.05), whereas neither breast cancer variables nor co-morbidity was ...


Mots clés : Sein; Lutte contre les cancers (Approches psycho-sociales)

Cette étude américaine (57 cas et 30 témoins) analyse les capacités cognitives de survivantes d'un cancer du sein à 10 ans ou plus, en fonction de leur âge et du traitement reçu

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    Cette étude américaine (57 cas et 30 témoins) analyse les capacités cognitives de survivantes d'un cancer du sein à 10 ans ou plus, en fonction de leur âge et du traitement reçu

    “Cognitive features 10 or more years after successful breast cancer survival: comparisons across types of cancer interventions”

    • Nguyen, Christopher M.;Yamada, Torricia H.;Beglinger, Leigh J.;Cavanaugh, Joseph E.;Denburg, Natalie L.;Schultz, Susan K.

    Background The present study examined the long-term cognitive implications of cancer treatment among breast cancer survivors aged 65 years and older to better understand the long term implications of cancer treatment. Methods Fifty-seven women survivors were compared with 30 healthy older female adult comparisons, matched in terms of age and education, with no history of cancer. Cancer survivors were also compared on the basis of treatment intervention, involving chemotherapy (n = 27) versus local therapy through surgery and radiation (n = 30). Results As a group, the breast cancer survivors scored lower on measures of general cognitive function, working memory, psychomotor speed, and executive function when compared with the normal comparisons. Among the cancer survivors, those who received local therapy scored lower than the other survivors and normal comparisons on measures of verbal learning, visual perception and construction, as well as visual attention and short-term ...


Mots clés : Sein; Lutte contre les cancers (Approches psycho-sociales)

A partir d'une revue systématique de la littérature (15 études), cette étude analyse l'impact d'une stigmatisation de patients, atteints d'un cancer du poumon, sur leur qualité de vie

  • A Systematic Review of the Impact of Stigma and Nihilism on Lung Cancer Outcomes
    BMC Cancer, Vol. 12 (1), pp. 184, 2012 (article en libre accès)
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    A partir d'une revue systématique de la littérature (15 études), cette étude analyse l'impact d'une stigmatisation de patients, atteints d'un cancer du poumon, sur leur qualité de vie

    “A Systematic Review of the Impact of Stigma and Nihilism on Lung Cancer Outcomes”

    • Chambers, Suzanne;Dunn, Jeffrey;Occhipinti, Stefano;Hughes, Suzanne;Baade, Peter;Sinclair, Sue;Aitken, Joanne;Youl, Pip;O'Connell, Dianne

    BACKGROUND:This study systematically review the evidence on the influence of stigma and nihilism on lung cancer patterns of care; patients' psychosocial and quality of life (QOL) outcomes; and how this may link to public health programs.METHODS:Medline, EMBASE, ProQuest, CINAHL and PsycINFO databases were searched. The inclusion criteria were: included lung cancer patients and/or partners or caregivers and/or health professionals (either at least 80% of participants had lung cancer or were partners or caregivers of lung cancer patients, or there was a lung cancer specific sub-group focus or analysis), assessed stigma or nihilism with respect to lung cancer and published in English between 1st January 1999 and 31st January 2011. Trial quality and levels of evidence were assessed.RESULTS:Eighteen articles describing 15 studies met inclusion criteria. The seven qualitative studies were high quality with regard to data collection, analysis and reporting; however most lacked a clear ...


Mots clés : Poumon; Lutte contre les cancers (Approches psycho-sociales)

A partir d'entretiens semi-dirigés auprès de 16 femmes ayant apporté un soutien psychologique par téléphone à des patientes atteintes, comme elles, d'un cancer gynécologique, cette étude analyse leur intérêt et les problèmes rencontrés au cours de l'intervention

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    A partir d'entretiens semi-dirigés auprès de 16 femmes ayant apporté un soutien psychologique par téléphone à des patientes atteintes, comme elles, d'un cancer gynécologique, cette étude analyse leur intérêt et les problèmes rencontrés au cours de l'intervention

    “Telephone peer support for women with gynaecological cancer: benefits and challenges for supporters”

    • Pistrang, Nancy;Jay, Zara;Gessler, Sue;Barker, Chris

    Objective Despite the prevalence of one-to-one peer support programmes for people with cancer, little research has examined its impact on the supporters themselves. This qualitative study examined a telephone-delivered one-to-one peer support intervention for women with gynaecological cancer, focussing on supporters' subjective experiences of benefits or costs to themselves and challenges arising in the support process. Methods Semi-structured interviews (N = 24) were conducted with 16 women who provided peer support for 24 patients. Transcripts were analysed thematically using the Framework approach. Results Participants described significant personal benefits of providing support, including enhanced self-esteem and well-being, and gaining a new perspective and closure on their cancer experience. They experienced no adverse consequences, but several challenges arose, for example, finding a balance between emotional involvement and detachment, and supporting someone with a poor ...


Mots clés : Cancer (général); Lutte contre les cancers (Approches psycho-sociales)

Sensibilisation et communication

A partir d'une revue systématique de la littérature, cette étude analyse les caractéristiques et l'efficacité d'interventions ciblées permettant d'améliorer la participation et l'implication du patient lors des consultations en oncologie

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    A partir d'une revue systématique de la littérature, cette étude analyse les caractéristiques et l'efficacité d'interventions ciblées permettant d'améliorer la participation et l'implication du patient lors des consultations en oncologie

    “Enhancing patient participation in oncology consultations: a best evidence synthesis of patient-targeted interventions”

    • Henselmans, Inge;de Haes, Hanneke C. J. M.;Smets, Ellen M. A.

    Objective Because of the complexity of cancer consultations, the contribution of patients is often limited. This systematic review examined the characteristics and effectiveness of patient-targeted interventions that aim to enhance cancer patients' participation in the consultation. Methods Relevant studies were selected by a search of databases until mid-2010 (Pubmed, PsycINFO and CINAHL), citations in relevant reviews as well as backward/forward citations. A Best Evidence Synthesis was performed, taking into account the quality of studies. Results A total of 52 publications were included, describing 46 studies and 30 unique interventions. One-third was delivered through either written or multimedia material, two-thirds face to face. Most originated from English-speaking countries. Half targeted heterogeneous cancer populations, one-third targeted women with breast cancer. Half focussed on initial treatment-planning consultations. Overall, there was evidence for an effect on observed ...


Mots clés : Cancer (général); Lutte contre les cancers (Sensibilisation et communication)

Ressources et infrastructures (Lutte contre les cancers)

A partir d'une revue de la littérature, cette étude analyse les recommandations concernant l'intensité et la durée du suivi des patients après cystectomie radicale pour un cancer de la vessie

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    A partir d'une revue de la littérature, cette étude analyse les recommandations concernant l'intensité et la durée du suivi des patients après cystectomie radicale pour un cancer de la vessie

    “Follow-up After Surgical Treatment of Bladder Cancer: A Critical Analysis of the Literature”

    • Viktor, Soukup;Marko, Babjuk;Joaquim, Bellmunt;Guido, Dalbagni;Gianluca, Giannarini;Oliver, W. Hakenberg;Harry, Herr;Eric, Lechevallier;Maria, J. Ribal

    Context : Follow-up of patients treated for bladder cancer (BCa) is of great importance for both non–muscle-invasive BCa (NMIBC) and muscle-invasive BCa (MIBC) because of the high incidence of recurrence and progression. The schedule and methods of follow-up should reflect the individual clinical situation. Objective : To evaluate the existing evidence for intensity and duration of follow-up recommendations in patients after surgical treatment of BCa. Evidence acquisition : We searched the Medline, Embase, and Cochrane databases for published data on the follow-up of patients with NMIBC and MIBC after radical cystectomy (RC). Evidence synthesis : Follow-up in patients with NMIBC is necessary because of the high probability of tumour recurrence and the risk of progression. Cystoscopy plus cytology are the standard methods for follow-up. Cystoscopy should be done 3 mo after the transurethral resection in every patient, and the frequency after that depends on the individual ...


Mots clés : Vessie; Lutte contre les cancers (Ressources et infrastructures (Lutte contre les cancers))

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