Etiologie

A partir des données d'une étude en population réalisée en Caroline du Nord, cette étude évalue l'association entre divers régimes alimentaires et le risque de carcinome épidermoïde de la tête et du cou (1 176 cas et 1 317 témoins)

• Associations Between Dietary Patterns and Head and Neck Cancer
  • American Journal of Epidemiology, sous presse, 2012 (résumé)
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  A partir des données d'une étude en population réalisée en Caroline du Nord, cette étude évalue l'association entre divers régimes alimentaires et le risque de carcinome épidermoïde de la tête et du cou (1 176 cas et 1 317 témoins)

  “Associations Between Dietary Patterns and Head and Neck Cancer”

  • Bradshaw, Patrick T.;Siega-Riz, Anna Maria;Campbell, Marci;Weissler, Mark C.;Funkhouser, William K.;Olshan, Andrew F.

  Few studies have examined the associations between dietary patterns and head and neck squamous cell carcinoma (SCC) or whether they differ by race. This was evaluated using data from a population-based case-control study (2002–2006) including 1,176 cases of head and neck SCC and 1,317 age-, race-, and gender-matched controls from central and eastern North Carolina whose diets had been assessed by food frequency questionnaire. Factor analysis identified 2 patterns of intake: 1) high consumption of fruits, vegetables, and lean protein and 2) high consumption of fried foods, high-fat and processed meats, and sweets. Associations were estimated using logistic regression, adjusting for matching factors and confounders. Heterogeneity by tumor site (oral/pharyngeal vs. laryngeal) and effect-measure modification were also evaluated. Reduced odds of head and neck SCC were found for the fruit, vegetable, and lean protein pattern (for highest quartile vs. lowest, odds ratio = 0.53, 95% ...

  
  

Mots clés : Voies aérodigestives supérieures; Etiologie (Facteurs exogènes : Nutrition et activité physique)

Menée sur 48 patientes ayant une mutation du gène BRCA1 et sur 96 témoins, cette étude exploratoire polonaise évalue l'association entre des niveaux plasmatiques de 14 micronutriments et le risque de cancer du sein

• Plasma micronutrients, trace elements, and breast cancer in BRCA1 mutation carriers: an exploratory study
  • Cancer Causes and Control, sous presse, 2012 (résumé)
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  Menée sur 48 patientes ayant une mutation du gène BRCA1 et sur 96 témoins, cette étude exploratoire polonaise évalue l'association entre des niveaux plasmatiques de 14 micronutriments et le risque de cancer du sein

  “Plasma micronutrients, trace elements, and breast cancer in BRCA1 mutation carriers: an exploratory study”

  • Kotsopoulos, Joanne;Sukiennicki, Grzegorz;Muszyńska, Magdalena;Gackowski, Daniel;Kąklewski, Krzysztof;Durda, Katarzyna;Jaworska, Katarzyna;Huzarski, Tomasz;Gronwald, Jacek;Byrski, Tomasz;Ashuryk, Oleg;Dębniak, Tadeusz;Tołoczko-Grabarek, Aleksandra;Stawicka, Małgorzata;Godlewski, Dariusz;Oliński, Ryszard;Jakubowska, Anna;Narod, Steven;Lubinski, Jan

  Purpose Few studies have evaluated the role of micronutrients or trace elements in breast cancer development among BRCA1 mutation carriers. To investigate a possible role of dietary and environmental exposures on cancer risk, we undertook an exploratory study, using a matched case–control design ( n = 48 cases and 96 controls), to evaluate the relationships between plasma levels of 14 micronutrients and breast cancer risk among BRCA1 mutation carriers in Poland. Methods We estimated the univariate odds ratios (OR) and 95 % confidence intervals (CI) for breast cancer associated with plasma levels for each of 14 micronutrients. Results Of the 14 analytes quantified, significant differences between cases and controls were seen for two (iron and retinol; p = 0.009 and p = 0.03, respectively). Women in the highest tertile of plasma iron had a 57 % lower risk, compared with those in the lowest quartile (OR = 0.43; 95 % CI 0.18–1.04; p for trend = 0.06). Increasing antimony levels were ...

  
  

Mots clés : Sein; Etiologie (Facteurs exogènes : Nutrition et activité physique)

Menée sur 6 136 hommes et femmes ayant travaillé dans l'industrie textile entre 1940 et 1973 et ayant occupé pendant 30 jours ou plus un poste de production les exposant aux fibres d'amiante chrysotile, cette étude montre une forte association entre la longueur et le diamètre de ces fibres et le risque de cancer du poumon

• Increased lung cancer mortality among chrysotile asbestos textile workers is more strongly associated with exposure to long thin fibres
  • Occupational and Environmental Medicine, sous presse, 2012 (résumé)
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  Menée sur 6 136 hommes et femmes ayant travaillé dans l'industrie textile entre 1940 et 1973 et ayant occupé pendant 30 jours ou plus un poste de production les exposant aux fibres d'amiante chrysotile, cette étude montre une forte association entre la longueur et le diamètre de ces fibres et le risque de cancer du poumon

  “Increased lung cancer mortality among chrysotile asbestos textile workers is more strongly associated with exposure to long thin fibres”

  • Loomis, Dana;Dement, John M;Elliott, Leslie;Richardson, David;Kuempel, Eileen D;Stayner, Leslie

  Background Animal data and physical models suggest that the carcinogenicity of asbestos fibres is related to their size and shape.Objectives To investigate the influence of fibre length and diameter on lung cancer risk in workers at asbestos textile mills in North Carolina and South Carolina, USA.Methods Men and women (n=6136) who worked ≥30 days in production and were employed between 1940 and 1973 were enumerated and followed for vital status through 2003. A matrix of fibre size-specific exposure estimates was constructed using determinations of fibre numbers and dimensions through analysis of 160 historical dust samples by transmission electron microscopy. Associations of lung cancer mortality with metrics of fibre exposure were estimated by Poisson regression with adjustment for age, sex, race and calendar year.Results Exposure to fibres throughout the range of length and diameter was significantly associated with increased risk of lung cancer. Models for fibres >5 μm long ...

  
  

Mots clés : Poumon; Etiologie (Facteurs exogènes : Exposition professionnelle)

A partir de questionnaires auprès de 226 patientes atteintes d'un cancer du poumon et de 269 témoins, cette étude, menée dans le sud-est de la Chine sur la période 2006-2010, évalue l'association entre des facteurs environnementaux, comportementaux ou diététiques et le risque de développer la maladie

• Environmental and Dietary Factors and Lung Cancer Risk Among Chinese Women: A Case-Control Study in Southeast China
  • Nutrition and Cancer, Vol. 64 (4), pp. 508-514, 2012 (résumé)
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  A partir de questionnaires auprès de 226 patientes atteintes d'un cancer du poumon et de 269 témoins, cette étude, menée dans le sud-est de la Chine sur la période 2006-2010, évalue l'association entre des facteurs environnementaux, comportementaux ou diététiques et le risque de développer la maladie

  “Environmental and Dietary Factors and Lung Cancer Risk Among Chinese Women: A Case-Control Study in Southeast China”

  • Lin, Yong;Cai, Lin

  After decades of increase, lung cancer has become the leading cause of cancer death among women. The mortality rate from lung cancer is ascending at a relatively steady rate, which has greatly affected the health of the female population and become a serious issue. A case-control study of 226 female lung cancer cases and 269 controls was conducted from 2006 to 2010 in Fujian Province. A structured questionnaire was used to gather information on demographic characteristics as well as dietary and environmental factors. Odds ratios and 95% confidence intervals were estimated by using univariate logistic regression. Multivariate unconditional logistic regression analysis was applied to evaluate the potential interactions of variables or confounders. The consumption of fruit, eggs, and tea was inversely associated with the risk of lung cancer. As expected, cooking oil fumes and environmental tobacco exposure were positively associated with elevated risk. In addition, frequent physical ...

  
  

Mots clés : Poumon; Etiologie (Facteurs exogènes : Environnement)

Menée sur une cohorte de 919 712 femmes ayant eu leur premier enfant entre 1967 et 2008 et à l'aide de données de deux registres norvégiens, cette étude évalue l'association entre la survenue, durant une première grossesse, de maladies liées à l'hypertension et le risque de cancer du sein

• Hypertensive diseases in pregnancy and breast cancer risk
  • British Journal of Cancer, sous presse, 2012 (résumé)
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  Menée sur une cohorte de 919 712 femmes ayant eu leur premier enfant entre 1967 et 2008 et à l'aide de données de deux registres norvégiens, cette étude évalue l'association entre la survenue, durant une première grossesse, de maladies liées à l'hypertension et le risque de cancer du sein

  “Hypertensive diseases in pregnancy and breast cancer risk”

  • Opdahl, S.;Romundstad, P. R.;Alsaker, M. D. K.;Vatten, L. J.

  Background : Hypertensive diseases in pregnancy may be associated with a reduced risk of breast cancer. Most previous studies are small and have shown conflicting results. Methods : In a cohort of 919 712 women who gave their first birth between 1967 and 2008, with linkage of information from two national registries, we assessed whether women with pregnancy hypertensive diseases are at reduced breast cancer risk. We used Cox regression to estimate hazard ratios (HRs) with 95% confidence intervals (CI). Results : Compared with women with a normotensive first pregnancy, women with hypertension or preeclampsia in their first pregnancy had a reduced breast cancer risk (HR 0.83, 95% CI 0.77, 0.90). A reduced risk was consistently observed for hypertensive disease in any pregnancy, for recurrent hypertensive disease in pregnancy, and before and after 50 years of age at breast cancer diagnosis. The association was strongest for women with hypertension in pregnancy, who delivered at ...

  
  

Mots clés : Sein; Etiologie (Facteurs endogènes)

Menée sur trois groupes de patients atteints de cancer (3 620 au total) et 2 296 témoins, cette étude identifie des variants de gènes de réparation de l'ADN en association avec un risque accru de second cancer chez les patients atteints d'un cancer de la peau autre qu'un mélanome

• A population-based study of DNA repair gene variants in relation to nonmelanoma skin cancer as a marker of a cancer-prone phenotype
  • Carcinogenesis, sous presse, 2012 (résumé)
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  Menée sur trois groupes de patients atteints de cancer (3 620 au total) et 2 296 témoins, cette étude identifie des variants de gènes de réparation de l'ADN en association avec un risque accru de second cancer chez les patients atteints d'un cancer de la peau autre qu'un mélanome

  “A population-based study of DNA repair gene variants in relation to nonmelanoma skin cancer as a marker of a cancer-prone phenotype”

  • Ruczinski, Ingo;Jorgensen, Timothy;Yao Shugart, Yin;Berthier Schaad, Yvette;Kessing, Bailey;Hoffman-Bolton, Judity;Helzlsouer, Kathy;Kao, W.H. Linda;Wheless, Lee;Francis, Lesley;Alani, Rhoda;Strickland, Paul;Smith, Michael;Alberg, Anthony

  For unknown reasons, nonmelanoma skin cancer (NMSC) is associated with increased risk of other malignancies. Focusing solely on DNA repair or epair-related genes, this study tested the hypothesis that DNA repair gene variants contribute to the increased cancer risk associated with a personal history of NMSC. From the parent CLUE II cohort study, established in 1989 in Washington County MD, the study consisted of a cancer-free control group (n=2,296) compared to three mutually exclusive groups of cancer cases ascertained through 2007: 1) Other (non-NMSC) cancer only (n=2,349); 2) NMSC only (n=694); and 3) NMSC plus other cancer (n=577). The frequency of minor alleles in 759 DNA repair single nucleotide polymorphisms (SNPs) was compared in these four groups. Comparing those with both NMSC and other cancer versus those with no cancer, 10 SNPs had allelic trend p-values<0.01. The two top-ranked SNPs were both within the thymine DNA glycosylase gene (TDG). One was a nonsynonymous coding ...

  
  

Mots clés : Peau (hors mélanome); Etiologie (Facteurs endogènes)

A partir de données administratives américaines portant sur 108 518 patients ayant une maladie inflammatoire de l'intestin, cette étude rétrospective de cohorte évalue l'association entre diverses maladies inflammatoires et le risque de cancer de la peau (mélanome ou autre), puis analyse l'influence des traitements associés sur ce risque

• Risk of Melanoma and Non-Melanoma Skin Cancer among Patients with Inflammatory Bowel Disease
  • Gastroenterology, sous presse, 2012 (résumé)
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  A partir de données administratives américaines portant sur 108 518 patients ayant une maladie inflammatoire de l'intestin, cette étude rétrospective de cohorte évalue l'association entre diverses maladies inflammatoires et le risque de cancer de la peau (mélanome ou autre), puis analyse l'influence des traitements associés sur ce risque

  “Risk of Melanoma and Non-Melanoma Skin Cancer among Patients with Inflammatory Bowel Disease”

  • Long, Millie D.;Martin, Christopher;Pipkin, Clare A.;Herfarth, Hans H.;Sandler, Robert S.;Kappelman, Michael D.

  Patients with inflammatory bowel disease (IBD) are at risk for certain malignancies. We aimed to determine the risk of melanoma and non-melanoma skin cancer (NMSC) in patients with IBD and how medications affect these risks. We performed retrospective cohort and nested case-control studies using administrative data from LifeLink™ Health Plan Claims Database from 1997 to 2009. The cohort comprised108,518 patients with IBD, were each matched to 4 individuals without IBD. Melanoma and NMSC risks were evaluated by incidence rate ratio (IRR) and by adjusted Cox proportional hazard ratio (HR) modeling. In nested case-control studies, patients with melanoma or NMSC were matched to 4 patients with IBD without melanoma or NMSC. Conditional logistic regression was used to determine associations between medications and both skin cancers. In the cohort, IBD was associated with an increased incidence of melanoma (IRR, 1.29; 95% confidence interval [CI], 1.09–1.53). Risk was greatest among ...

  
  

Mots clés : Mélanome; Etiologie (Facteurs endogènes)

Cette étude évalue l'association entre 16 conditions médicales auto-rapportées et le risque de leucémie myéloïde chez les patients adultes (420 cas de leucémie myéloïde aiguë, 186 cas de leucémie myéloïde chronique et 701 témoins)

• Medical conditions and risk of adult myeloid leukemia
  • Cancer Causes and Control, sous presse, 2012 (résumé)
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  Cette étude évalue l'association entre 16 conditions médicales auto-rapportées et le risque de leucémie myéloïde chez les patients adultes (420 cas de leucémie myéloïde aiguë, 186 cas de leucémie myéloïde chronique et 701 témoins)

  “Medical conditions and risk of adult myeloid leukemia”

  • Johnson, Kimberly;Blair, Cindy;Fink, James;Cerhan, James;Roesler, Michelle;Hirsch, Betsy;Nguyen, Phuong;Ross, Julie

  Purpose Although a few previous studies have reported positive associations between adult myeloid leukemia and a history of certain medical conditions, the etiology of most cases remains largely unknown. Our purpose was to examine associations between certain medical conditions and adult myeloid leukemia. Methods Using logistic regression, we evaluated associations between 16 self-reported medical conditions and myeloid leukemia in a case–control study of 670 cases [including 420 acute myeloid leukemia (AML) and 186 chronic myelogenous leukemia (CML)] and 701 population-based controls. Results We observed significant positive associations between AML and ulcerative colitis (odds ratio (OR) = 3.8; 95 % confidence interval (CI), 1.1–13) and between CML and peptic ulcer (OR = 2.0; 95% CI, 1.1–3.8). A personal cancer history increased both AML (OR = 2.6; 95% CI, 1.7–3.9) and CML (OR = 3.5; 95% CI, 2.0–5.8) risk even after excluding individuals who reported prior radiation and/or ...

  
  

Mots clés : Leucémie; Etiologie (Facteurs endogènes)