Lutte contre les cancers

Qualité de vie, soins de support

Cet article résume le rapport d'un groupe d'experts de l'American Cancer Society concernant des recommandations en matière de nutrition et d'activité physique visant à améliorer la qualité de vie et la survie des patients atteints d'un cancer

Nutrition and physical activity guidelines for cancer survivors
• CA: A Cancer Journal for Clinicians, sous presse, 2012 (résumé)

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Cet article résume le rapport d'un groupe d'experts de l'American Cancer Society concernant des recommandations en matière de nutrition et d'activité physique visant à améliorer la qualité de vie et la survie des patients atteints d'un cancer

“Nutrition and physical activity guidelines for cancer survivors”

• Rock, Cheryl L.;Doyle, Colleen;Demark-Wahnefried, Wendy;Meyerhardt, Jeffrey;Courneya, Kerry S.;Schwartz, Anna L.;Bandera, Elisa V.;Hamilton, Kathryn K.;Grant, Barbara;McCullough, Marji;Byers, Tim;Gansler, Ted

Answer questions and earn CME/CNE Cancer survivors are often highly motivated to seek information about food choices, physical activity, and dietary supplements to improve their treatment outcomes, quality of life, and overall survival. To address these concerns, the American Cancer Society (ACS) convened a group of experts in nutrition, physical activity, and cancer survivorship to evaluate the scientific evidence and best clinical practices related to optimal nutrition and physical activity after the diagnosis of cancer. This report summarizes their findings and is intended to present health care providers with the best possible information with which to help cancer survivors and their families make informed choices related to nutrition and physical activity. The report discusses nutrition and physical activity guidelines during the continuum of cancer care, briefly highlighting important issues during cancer treatment and for patients with advanced cancer, but focusing largely on ...

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

Observation

Menée sur 13 722 patientes atteintes d'un cancer du sein invasif diagnostiqué entre 1990 et 2000, cette étude rétrospective de cohorte évalue l'intérêt de mettre en place une équipe de soins multidisciplinaires pour améliorer la survie des patientes

Effects of multidisciplinary team working on breast cancer survival: retrospective, comparative, interventional cohort study of 13 722 women
• British Medical Journal, Vol. 344, 2012 (article en libre accès)

Détails

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Menée sur 13 722 patientes atteintes d'un cancer du sein invasif diagnostiqué entre 1990 et 2000, cette étude rétrospective de cohorte évalue l'intérêt de mettre en place une équipe de soins multidisciplinaires pour améliorer la survie des patientes

“Effects of multidisciplinary team working on breast cancer survival: retrospective, comparative, interventional cohort study of 13 722 women”

• Eileen M Kesson;Gwen M Allardice;W David George;Harry J G Burns;David S Morrison

Objectives : To describe the effect of multidisciplinary care on survival in women treated for breast cancer. Design : Retrospective, comparative, non-randomised, interventional cohort study. Setting : NHS hospitals, health boards in the west of Scotland, UK. Participants : 14 358 patients diagnosed with symptomatic invasive breast cancer between 1990 and 2000, residing in health board areas in the west of Scotland. 13 722 (95.6%) patients were eligible (excluding 16 diagnoses of inflammatory cancers and 620 diagnoses of breast cancer at death). Intervention : In 1995, multidisciplinary team working was introduced in hospitals throughout one health board area (Greater Glasgow; intervention area), but not in other health board areas in the west of Scotland (non-intervention area). Main outcome measures : Breast cancer specific mortality and all cause mortality. Results : Before the introduction of multidisciplinary care (analysed time period January 1990 to September 1995), breast ...
Specialist multidisciplinary team working in the treatment of cancer
• British Medical Journal, Vol. 344, 2012 (éditorial)

Détails

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Menée sur 13 722 patientes atteintes d'un cancer du sein invasif diagnostiqué entre 1990 et 2000, cette étude rétrospective de cohorte évalue l'intérêt de mettre en place une équipe de soins multidisciplinaires pour améliorer la survie des patientes

“Specialist multidisciplinary team working in the treatment of cancer”

• Gina Brown

Mots clés : Sein; Lutte contre les cancers (Observation)

A partir des données de 4 essais européens de phase III évaluant des traitements adjuvants et incluant 2 672 patients atteints d'un mélanome cutané de stade I/II, cette étude montre que le pronostic est plus favorable chez les femmes que chez les hommes

Superior Outcome of Women With Stage I/II Cutaneous Melanoma: Pooled Analysis of Four European Organisation for Research and Treatment of Cancer Phase III Trials
• Journal of Clinical Oncology, sous presse, 2012 (résumé)

Détails

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A partir des données de 4 essais européens de phase III évaluant des traitements adjuvants et incluant 2 672 patients atteints d'un mélanome cutané de stade I/II, cette étude montre que le pronostic est plus favorable chez les femmes que chez les hommes

“Superior Outcome of Women With Stage I/II Cutaneous Melanoma: Pooled Analysis of Four European Organisation for Research and Treatment of Cancer Phase III Trials”

• Joosse, Arjen;Collette, Sandra;Suciu, Stefan;Nijsten, Tamar;Lejeune, Ferdy;Kleeberg, Ulrich R.;Coebergh, Jan Willem W.;Eggermont, Alexander M.M.;de Vries, Esther

Purpose Several studies observed a female advantage in the prognosis of cutaneous melanoma, for which behavioral factors or an underlying biologic mechanism might be responsible. Using complete and reliable follow-up data from four phase III trials of the European Organisation for Research and Treatment of Cancer (EORTC) Melanoma Group, we explored the female advantage across multiple end points and in relation to other important prognostic indicators.Patients and Methods Patients diagnosed with localized melanoma were included in EORTC adjuvant treatment trials 18832, 18871, 18952, and 18961 and randomly assigned during the period of 1984 to 2005. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% CIs for women compared with men, adjusted for age, Breslow thickness, body site, ulceration, performed lymph node dissection, and treatment.Results A total of 2,672 patients with stage I/II melanoma were included. Women had a highly consistent and independent ...

Mots clés : Mélanome; Lutte contre les cancers (Observation)

Menée en population dans la région nord-est de l'Angleterre, cette étude évalue, sur la période 2000-2009, l'évolution de l'incidence du cancer du col de l'utérus chez les jeunes femmes âgées de 20 à 29 ans, la compare à celle constatée chez les femmes plus âgées et identifie les facteurs associés à cette évolution

Cervical cancer incidence in young women: a historical and geographic controlled UK regional population study
• British Journal of Cancer, sous presse, 2012 (résumé)

Détails

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Menée en population dans la région nord-est de l'Angleterre, cette étude évalue, sur la période 2000-2009, l'évolution de l'incidence du cancer du col de l'utérus chez les jeunes femmes âgées de 20 à 29 ans, la compare à celle constatée chez les femmes plus âgées et identifie les facteurs associés à cette évolution

“Cervical cancer incidence in young women: a historical and geographic controlled UK regional population study”

• Patel, A.;Galaal, K.;Burnley, C.;Faulkner, K.;Martin-Hirsch, P.;Bland, M. J.;Leeson, S.;Beer, H.;Paranjothy, S.;Sasieni, P.;Naik, R.

Background : The commencing age of cervical screening in England was raised from 20 to 25 years in 2004. Cervical cancer incidence in young women of England is increasing. It is not clear if this is due to either greater exposure to population risk factors or reduced cervical screening. Methods : We measured if the relative risk of cervical cancer in younger women (20–29 years) of the north-east of England (NE) differed to that of women aged 30yrs and above since 2004. We also measured average annual percentage change (AAPC) in the 3 yr moving average incidence for all age-groups. Regional screening coverage rate and population risk factors were reviewed. Comparisons were made with Wales where screening continues to commence from the age of 20 yrs. Results : Cervical cancer incidence in women aged 20–29 increased annually by an average of 10.3% between 2000 and 2009. The rise in women aged 30–39 was less steep (3.5%/year) but no significant rise was observed in women aged ...

Mots clés : Col de l'utérus; Lutte contre les cancers (Observation)

A partir des données d'un registre britannique du cancer portant sur 50 656 hommes et 48 723 femmes, cette étude analyse, sur la période 1998-2007, l'évolution de l'incidence et de la survie associées au cancer du pancréas, de l'ampoule de Vater, des voies biliaires, du foie, de la vésicule biliaire et du duodénum

Incidence and survival for hepatic, pancreatic and biliary cancers in England between 1998 and 2007
• Cancer Epidemiology, sous presse, 2012 (résumé)

Détails

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A partir des données d'un registre britannique du cancer portant sur 50 656 hommes et 48 723 femmes, cette étude analyse, sur la période 1998-2007, l'évolution de l'incidence et de la survie associées au cancer du pancréas, de l'ampoule de Vater, des voies biliaires, du foie, de la vésicule biliaire et du duodénum

“Incidence and survival for hepatic, pancreatic and biliary cancers in England between 1998 and 2007”

• Coupland, Victoria H.;Kocher, Hemant M.;Berry, David P.;Allum, William;Linklater, Karen M.;Konfortion, Julie;Møller, Henrik;Davies, Elizabeth A.

Introduction: Hepatic, pancreatic and biliary (HPB) cancers are a group of diverse malignancies managed ideally in specialist centres. This study describes recent patterns in the incidence and survival of HPB cancers in England over a ten year period (1998–2007). Methods: Data on 99,379 English patients (50,656 males; 48,723 females) diagnosed with HPB cancers between 1998 and 2007 were extracted from the National Cancer Data Repository. Data were divided into six site-specific cancer groups; pancreas, ampulla of Vater, biliary tract, primary liver, gallbladder and duodenum. Age-standardised incidence rates (per 100,000 European standard population, (ASR(E))) were calculated for each of the six groups by year of diagnosis and by socioeconomic deprivation. Survival was estimated using the Kaplan–Meier method. Results: The largest group was pancreatic cancers (63%), followed by primary liver (14%) and biliary cancers (13%). ASR(E) were highest for pancreatic and primary liver ...

Mots clés : Cancer (général); Lutte contre les cancers (Observation)

Approches psycho-sociales

A partir d'entretiens et de questionnaires auprès de 60 patientes atteintes d'un cancer du sein nouvellement diagnostiqué, cette étude analyse leurs présupposés sur la maladie puis identifie les raisons pour lesquelles elles refusent des traitements conventionnels et choisissent des traitements alternatifs

Beliefs and Perceptions of Women with Newly Diagnosed Breast Cancer Who Refused Conventional Treatment in Favor of Alternative Therapies
• The Oncologist, sous presse, 2012 (résumé)

Détails

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A partir d'entretiens et de questionnaires auprès de 60 patientes atteintes d'un cancer du sein nouvellement diagnostiqué, cette étude analyse leurs présupposés sur la maladie puis identifie les raisons pour lesquelles elles refusent des traitements conventionnels et choisissent des traitements alternatifs

“Beliefs and Perceptions of Women with Newly Diagnosed Breast Cancer Who Refused Conventional Treatment in Favor of Alternative Therapies”

• Citrin, Dennis L.;Bloom, Diane L.;Grutsch, James F.;Mortensen, Sara J.;Lis, Christopher G.

Abstract Purpose. Although breast cancer is a highly treatable disease, some women reject conventional treatment opting for unproven “alternative therapy” that may contribute to poor health outcomes. This study sought to understand why some women make this decision and to identify messages that might lead to greater acceptance of evidence-based treatment.Patients and Methods. This study explored treatment decision making through in-depth interviews with 60 breast cancer patients identified by their treating oncologist. Thirty refused some or all conventional treatment, opting for alternative therapies, whereas 30 accepted both conventional and alternative treatments. All completed the Beck Anxiety Inventory and the Rotter Locus of Control scale.Results. Negative first experiences with “uncaring, insensitive, and unnecessarily harsh” oncologists, fear of side effects, and belief in the efficacy of alternative therapies were key factors in the decision to reject potentially ...

Mots clés : Sein; Lutte contre les cancers (Approches psycho-sociales)

Ressources et infrastructures (Lutte contre les cancers)

Cet article analyse la participation de représentants d'associations de patients au processus de soutien aux recherches sur le cancer au Royaume-Uni dans les années 1990

When Subjects Bite Back: The Bristol Cancer Help Centre Study and Increasing Consumer Involvement in UK Medical Research in the 1990s
• Social History of Medicine, Vol. 25 (2), pp. 500-519, 2012 (résumé)

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Cet article analyse la participation de représentants d'associations de patients au processus de soutien aux recherches sur le cancer au Royaume-Uni dans les années 1990

“When Subjects Bite Back: The Bristol Cancer Help Centre Study and Increasing Consumer Involvement in UK Medical Research in the 1990s”

• Dawes, Laura L.

This paper examines the controversy surrounding the 1990 ‘Bristol Study’ as an indicator of developments in health activism and medical research in the United Kingdom in the subsequent decade, and as a case study of the motivations prompting people to become activists. Researchers investigating complementary therapies at the Bristol Cancer Help Centre found the therapies were associated with poorer survival prospects. However, the study was later shown to be seriously flawed. Stung by researchers' insensitivity, participants formed the Bristol Study Support Group (BSSG) to lobby for new funding and journal review procedures, and for participants to be co-investigators. Their agenda was symptomatic of activists increasingly seeking to become integral to research processes. Groups like the BSSG were helped by the New Labour party's interest in increasing civic involvement. However, activist participation was limited to research planning and administration, not results ...