Etiologie

Facteurs exogènes : Tabac

A partir des données de 6 études indépendantes incluant au total 12 364 participants dont 2 932 fumeurs, cette étude évalue, par comparaison avec la consommation auto-rapportée de cigarettes, l'association entre deux polymorphismes à simple-nucléotide situés sur le chromosome 15q25, des mesures objectives d'exposition au tabac et le risque de cancer du poumon

Association Between Genetic Variants on Chromosome 15q25 Locus and Objective Measures of Tobacco Exposure
• Journal of the National Cancer Institute, sous presse, 2012 (résumé)

Détails

Fermer
A partir des données de 6 études indépendantes incluant au total 12 364 participants dont 2 932 fumeurs, cette étude évalue, par comparaison avec la consommation auto-rapportée de cigarettes, l'association entre deux polymorphismes à simple-nucléotide situés sur le chromosome 15q25, des mesures objectives d'exposition au tabac et le risque de cancer du poumon

“Association Between Genetic Variants on Chromosome 15q25 Locus and Objective Measures of Tobacco Exposure”

• Munafò, Marcus R.;Timofeeva, Maria N.;Morris, Richard W.;Prieto-Merino, David;Sattar, Naveed;Brennan, Paul;Johnstone, Elaine C.;Relton, Caroline;Johnson, Paul C. D.;Walther, Donna;Whincup, Peter H.;Casas, Juan P.;Uhl, George R.;Vineis, Paolo;Padmanabhan, Sandosh;Jefferis, Barbara J.;Amuzu, Antoinette;Riboli, Elio;Upton, Mark N.;Aveyard, Paul;Ebrahim, Shah;Hingorani, Aroon D.;Watt, Graham;Palmer, Tom M.;Timpson, Nicholas J.;EPIC Study Group;Davey Smith, George

Background Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking-related health outcomes. Previous studies have typically relied on self-reported smoking behavior, which may not fully capture interindividual variation in tobacco exposure.Methods We investigated the association of rs1051730 and rs16969968 genotype (referred to as rs1051730–rs16969968, because these are in perfect linkage disequilibrium and interchangeable) with both self-reported daily cigarette consumption and biochemically measured plasma or serum cotinine levels among cigarette smokers. Summary estimates and descriptive statistical data for 12 364 subjects were obtained from six independent studies, and 2932 smokers were included in the analyses. Linear regression was used to calculate the per-allele association of ...
Genetic Variants, Tobacco Exposure and Lung Cancer Risk
• Journal of the National Cancer Institute, sous presse, 2012 (communiqué de presse)

Détails

Fermer
A partir des données de 6 études indépendantes incluant au total 12 364 participants dont 2 932 fumeurs, cette étude évalue, par comparaison avec la consommation auto-rapportée de cigarettes, l'association entre deux polymorphismes à simple-nucléotide situés sur le chromosome 15q25, des mesures objectives d'exposition au tabac et le risque de cancer du poumon

“Genetic Variants, Tobacco Exposure and Lung Cancer Risk”

Mots clés : Poumon; Etiologie (Facteurs exogènes : Tabac)

Facteurs exogènes : Nutrition et activité physique

A partir d'une revue systématique de la littérature publiée jusqu'en septembre 2011 (10 études de cohorte), cette méta-analyse évalue l'association entre la consommation de glucides, la charge et l'indice glycémiques et le risque de cancer du pancréas

Dietary fructose, carbohydrates, glycemic indices and pancreatic cancer risk: a systematic review and meta-analysis of cohort studies
• Annals of Oncology, sous presse, 2012 (résumé)

Détails

Fermer
A partir d'une revue systématique de la littérature publiée jusqu'en septembre 2011 (10 études de cohorte), cette méta-analyse évalue l'association entre la consommation de glucides, la charge et l'indice glycémiques et le risque de cancer du pancréas

“Dietary fructose, carbohydrates, glycemic indices and pancreatic cancer risk: a systematic review and meta-analysis of cohort studies”

• Aune, D.;Chan, D. S. M.;Vieira, A. R.;Navarro Rosenblatt, D. A.;Vieira, R.;Greenwood, D. C.;Cade, J. E.;Burley, V. J.;Norat, T.

Background: Dietary carbohydrates, glycemic load and glycemic index have been hypothesized to influence pancreatic cancer risk, but epidemiological studies have been inconsistent. We conducted a systematic review and meta-analysis of prospective studies to clarify these results.Methods: PubMed and several other databases were searched for prospective studies of intake of carbohydrates, glycemic index and glycemic load and pancreatic cancer up to September 2011. Summary relative risks were estimated using a random effects model.Results: Ten cohort studies (13 publications) were included in the meta-analysis. The summary relative risk (RR) per 10 glycemic index units was 1.02 [95% confidence interval (CI): 0.93–1.12, I2 = 0%], per 50 glycemic load units was 1.03 (95% CI: 0.93–1.14, I2 = 10%), per 100 g/day of total carbohydrates was 0.97 (95% CI: 0.81–1.16, I2 = 35%), and per 25 g/day of sucrose intake was 1.05 (95% CI: 0.85–1.23, I2 = 53%). A positive association was observed ...

Mots clés : Pancréas; Etiologie (Facteurs exogènes : Nutrition et activité physique)

Menée sur une cohorte de 66 714 personnes (durée de suivi : 20 ans), cette étude évalue l'association entre divers régimes alimentaires, le niveau sérique à jeun du peptide C et le risque de cancer colorectal (985 cas de cancer colorectal, 758 cas de cancer du côlon)

A dietary pattern that is associated with C-peptide and risk of colorectal cancer in women
• Cancer Causes and Control, sous presse, 2012 (résumé)

Détails

Fermer
Menée sur une cohorte de 66 714 personnes (durée de suivi : 20 ans), cette étude évalue l'association entre divers régimes alimentaires, le niveau sérique à jeun du peptide C et le risque de cancer colorectal (985 cas de cancer colorectal, 758 cas de cancer du côlon)

“A dietary pattern that is associated with C-peptide and risk of colorectal cancer in women”

• Fung, Teresa;Hu, Frank;Schulze, Matthias;Pollak, Michael;Wu, Tianying;Fuchs, Charles;Giovannucci, Edward

Purpose Higher serum C-peptide concentrations have shown to be associated with an increased risk of colorectal cancer (CRC). Therefore, we used diet information to identify food groups that correlated with fasting serum concentrations of C-peptide and assess the association of this dietary pattern and CRC risk. Methods Major food contributors to fasting C-peptide concentrations were identified with stepwise linear regression in a subsample ( n = 833) of women from a large cohort. We then summed the consumption frequency of the major food contributors to form a C-peptide dietary pattern for the entire cohort ( n = 66,714). Risk for CRC was computed using Cox proportional hazard model with the C-peptide dietary pattern score as the predictor. Results In up to 20 years of follow-up, we ascertained 985 cases of CRC and 758 colon cancer. After adjusting for confounders, the C-peptide dietary pattern, characterized by higher meat, fish, and sweetened beverage intake, but lower coffee, high ...

Mots clés : Colon-rectum; Etiologie (Facteurs exogènes : Nutrition et activité physique)

Facteurs exogènes : Exposition professionnelle

Menée sur 640 infirmières âgées de 40 à 60 ans, cette étude transversale évalue l'association entre un travail posté par rotation et la densité mammaire

Rotating night shift work and mammographic density
• Cancer Epidemiology Biomarkers & Prevention, sous presse, 2012 (résumé)

Détails

Fermer
Menée sur 640 infirmières âgées de 40 à 60 ans, cette étude transversale évalue l'association entre un travail posté par rotation et la densité mammaire

“Rotating night shift work and mammographic density”

• Peplonska, Beata;Bukowska, Agnieszka;Sobala, Wojciech;Reszka, Edyta;Gromadzińska, Jolanta;Wasowicz, Wojciech;Lie, Jenny Anne;Kjuus, Helge;Ursin, Giske

Background: An increased risk of breast cancer has been observed in night shift workers. Exposure to artificial light at night, disruption of the endogenous circadian rhythm with suppression of the melatonin synthesis have been suggested mechanisms. We investigated the hypothesis that rotating night shift work is associated with mammographic density. Methods:We conducted a cross-sectional study on the association between rotating night shift work characteristics, 6-sulfatoxymelatonin(6MTs) creatinine adjusted in a spot morning urine sample and a computer-assisted measure of mammographic density in 640 nurses and midwives aged 40-60. The associations were evaluated using regression models adjusted for age, BMI, menopausal status, age at menopause, age at menarche, smoking, and the calendar season of the year when mammography was performed. Results:The adjusted means of percent mammographic density and absolute density were slightly higher among women working rotating night shifts, but ...

Mots clés : Sein; Etiologie (Facteurs exogènes : Exposition professionnelle)

Menée sur 465 employés de l'industrie manufacturière, cette étude américaine évalue l'association entre une exposition professionnelle aux fibres de l'amphibole contenues dans la vermiculite et le risque de développer un mésothéliome 31 ans plus tard

Mesothelioma Associated With Commercial Use of Vermiculite Containing Libby Amphibole
• Journal of Occupational and Environmental Medicine, sous presse, 2012 (résumé)

Détails

Fermer
Menée sur 465 employés de l'industrie manufacturière, cette étude américaine évalue l'association entre une exposition professionnelle aux fibres de l'amphibole contenues dans la vermiculite et le risque de développer un mésothéliome 31 ans plus tard

“Mesothelioma Associated With Commercial Use of Vermiculite Containing Libby Amphibole”

• Dunning, Kari K.;Adjei, Stephen;Levin, Linda;Rohs, Amy M.;Hilbert, Tim;Borton, Eric;Kapil, Vikas;Rice, Carol;LeMasters, Grace K.;Lockey, James E.

Objectives: To describe asbestos-related mortality among manufacturing workers who expanded and processed Libby vermiculite that contained amphibole fiber. Methods: Standardized mortality ratio was calculated for 465 white male workers 31 years after last Libby vermiculite exposure. Results: Two workers died from mesothelioma, resulting in a significantly increased standardized mortality ratio of 10.5 (95% confidence interval, 1.3 to 38.0). These workers were in the upper 10th percentile of cumulative fiber exposure, that is, 43.80 and 47.23 fiber-years/cm3, respectively. One additional worker with cumulative fiber exposure of 5.73 fiber-years/cm3 developed mesothelioma but is not deceased. There were no other significantly increased standardized mortality ratios. Conclusions: Workers expanding and processing Libby vermiculite in a manufacturing setting demonstrated an increased risk for the development of mesothelioma following exposure to the amphibole fiber contained within this ...

Mots clés : Mésothéliome; Etiologie (Facteurs exogènes : Exposition professionnelle)

Facteurs exogènes : Environnement

Menée en Espagne, cette étude cas-témoins (349 cas et 513 témoins) évalue l'association entre une exposition domestique au radon, le comportement tabagique, le type histologique et le risque de cancer du poumon

Residential radon exposure, histological types and lung cancer risk. A case-control study in Galicia, Spain
• Cancer Epidemiology Biomarkers & Prevention, sous presse, 2012 (résumé)

Détails

Fermer
Menée en Espagne, cette étude cas-témoins (349 cas et 513 témoins) évalue l'association entre une exposition domestique au radon, le comportement tabagique, le type histologique et le risque de cancer du poumon

“Residential radon exposure, histological types and lung cancer risk. A case-control study in Galicia, Spain”

• Barros-Dios, Juan;Ruano-Ravina, Alberto;Perez-Rios, Monica;Castro-Bernardez, Margarita;Abal-Arca, Jose;Tojo-Castro, Marta

Background: Lung cancer is an important public health problem and tobacco the main risk factor followed by residential radon exposure. Recommended exposure levels have been progressively lowered. Galicia, the study area, has high residential radon concentrations. We aim: 1) to assess the risk of lung cancer linked to airborne residential radon exposure, 2) to ascertain whether tobacco modifies radon risk and, 3) to know whether there is a lung cancer histological type more susceptible to radon. Methods: A hospital-based case-control design was performed in two Spanish hospitals. Consecutive cases with histological diagnosis of lung cancer and controls undergoing trivial surgery not tobacco-related were included. Residential radon was measured using standard procedures. Results were obtained using logistic regression. Results: 349 cases and 513 controls were included. Radon exposure posed a risk even with a low exposure, with those exposed to 50-100 Bq/m3 having an OR of 1.87 (CI95% ...

Mots clés : Poumon; Etiologie (Facteurs exogènes : Environnement)

Menée sur 1 009 patients atteints d'un lymphome non hodgkinien nouvellement diagnostiqué et 1 233 témoins, cette étude évalue l'association entre une exposition solaire précoce, des variants génétiques associés au métabolisme de la vitamine D et le risque de développer la maladie

Early life sun exposure, vitamin D-related gene variants, and risk of non-Hodgkin lymphoma
• Cancer Causes and Control, sous presse, 2012 (résumé)

Détails

Fermer
Menée sur 1 009 patients atteints d'un lymphome non hodgkinien nouvellement diagnostiqué et 1 233 témoins, cette étude évalue l'association entre une exposition solaire précoce, des variants génétiques associés au métabolisme de la vitamine D et le risque de développer la maladie

“Early life sun exposure, vitamin D-related gene variants, and risk of non-Hodgkin lymphoma”

• Kelly, Jennifer;Drake, Matthew;Fredericksen, Zachary;Asmann, Yan;Liebow, Mark;Shanafelt, Tait;Feldman, Andrew;Ansell, Stephen;Macon, William;Herr, Megan;Wang, Alice;Nowakowski, Grzegorz;Call, Timothy;Habermann, Thomas;Slager, Susan;Witzig, Thomas;Cerhan, James

Purpose It has been hypothesized that vitamin D mediates the inverse relationship between sun exposure and non-Hodgkin lymphoma (NHL) risk reported in several recent studies. We evaluated the association of self-reported sun exposure at ages <13, 13–21, 22–40, and 41+ years and 19 single nucleotide polymorphisms (SNPs) from 4 candidate genes relevant to vitamin D metabolism ( RXR, VDR , CYP24A1, CYP27B1 ) with NHL risk. Methods This analysis included 1,009 newly diagnosed NHL cases and 1,233 frequency-matched controls from an ongoing clinic-based study. Odds ratios (OR), 95 % confidence intervals (CI), and tests for trend were estimated using unconditional logistic regression. Results There was a significant decrease in NHL risk with increased sun exposure at ages 13–21 years (OR ≥15 vs. ≤3 h/week = 0.68; 95 % CI, 0.43–1.08; p trend = 0.0025), which attenuated for older ages at exposure. We observed significant main effect associations for 3 SNPs in VDR and 1 SNP in ...

Mots clés : Lymphome; Etiologie (Facteurs exogènes : Environnement)

Facteurs exogènes : Autres

Menée sur une cohorte de 377 649 patients recevant un traitement antihypertenseur (durée médiane de suivi après le début du traitement : 4,6 ans), cette étude évalue l'association entre l'utilisation de bloqueurs des récepteurs de l'angiotensine et le risque global de cancer (20 203 cas)

Angiotensin receptor blockers and risk of cancer: cohort study among people receiving antihypertensive drugs in UK General Practice Research Database
• British Medical Journal, Vol. 344, 2012 (résumé)

Détails

Fermer
Menée sur une cohorte de 377 649 patients recevant un traitement antihypertenseur (durée médiane de suivi après le début du traitement : 4,6 ans), cette étude évalue l'association entre l'utilisation de bloqueurs des récepteurs de l'angiotensine et le risque global de cancer (20 203 cas)

“Angiotensin receptor blockers and risk of cancer: cohort study among people receiving antihypertensive drugs in UK General Practice Research Database”

• Krishnan Bhaskaran;Ian Douglas;Stephen Evans;Tjeerd van Staa;Liam Smeeth

Objectives : To investigate whether there is an association between use of angiotensin receptor blockers and risk of cancer. Design : Cohort study of risk of cancer in people treated with angiotensin receptor blockers compared with angiotensin converting enzyme (ACE) inhibitors. Effects were explored with time updated covariates in Cox models adjusted for age, sex, body mass index (BMI), diabetes and metformin/insulin use, hypertension, heart failure, statin use, socioeconomic status, alcohol, smoking, and calendar year. Absolute changes in risk were predicted from a Poisson model incorporating the strongest determinants of risk from the main analysis. Setting : UK primary care practices contributing to the General Practice Research Database. Participants : 377 649 new users of angiotensin receptor blockers or ACE inhibitors with at least one year of initial treatment. Main outcome : measures Adjusted hazard ratios for all cancer and major site specific cancers (breast, lung, colon, ...

Mots clés : Cancer (général); Etiologie (Facteurs exogènes : Autres)

Facteurs endogènes

Menée sur 757 patients atteints d'une tumeur de Wilms et 1 879 témoins, cette étude d'association sur le génome entier identifie plusieurs loci de susceptibilité à cette forme de cancer rénal chez l'enfant

A genome-wide association study identifies susceptibility loci for Wilms tumor
• Nature Genetics, sous presse, 2012 (résumé)

Détails

Fermer
Menée sur 757 patients atteints d'une tumeur de Wilms et 1 879 témoins, cette étude d'association sur le génome entier identifie plusieurs loci de susceptibilité à cette forme de cancer rénal chez l'enfant

“A genome-wide association study identifies susceptibility loci for Wilms tumor”

• Turnbull, Clare;Perdeaux, Elizabeth R.;Pernet, David;Naranjo, Arlene;Renwick, Anthony;Seal, Sheila;Munoz-Xicola, Rosa Maria;Hanks, Sandra;Slade, Ingrid;Zachariou, Anna;Warren-Perry, Margaret;Ruark, Elise;Gerrard, Mary;Hale, Juliet;Hewitt, Martin;Kohler, Janice;Lane, Sheila;Levitt, Gill;Madi, Mabrook;Morland, Bruce;Neefjes, Veronica;Nicholdson, James;Picton, Susan;Pizer, Barry;Ronghe, Milind;Stevens, Michael;Traunecker, Heidi;Stiller, Charles A.;Pritchard-Jones, Kathy;Dome, Jeffrey;Grundy, Paul;Rahman, Nazneen

Wilms tumor is the most common renal malignancy of childhood. To identify common variants that confer susceptibility to Wilms tumor, we conducted a genome-wide association study in 757 individuals with Wilms tumor (cases) and 1,879 controls. We evaluated ten SNPs in regions significantly associated at P < 5 × 10−5 in two independent replication series from the UK (769 cases and 2,814 controls) and the United States (719 cases and 1,037 controls). We identified clear significant associations at 2p24 (rs3755132, P = 1.03 × 10−14; rs807624, P = 1.32 × 10−14) and 11q14 (rs790356, P = 4.25 × 10−15). Both regions contain genes that are plausibly related to Wilms tumorigenesis. We also identified candidate association signals at 5q14, 22q12 and Xp22.

Mots clés : Rein; Etiologie (Facteurs endogènes)

A partir des données de deux études indépendantes incluant 312 patients atteints d'un cancer du poumon non à petites cellules, cette étude évalue l'association entre 12 variants génétiques situés sur les chromosomes 15q25 et 5p15, l'expression des gènes correspondant dans les cellules tumorales et le risque de développer la maladie

Association of the 15q25 and 5p15 lung cancer susceptibility regions with gene expression in lung tumour tissue
• Cancer Epidemiology Biomarkers & Prevention, sous presse, 2012 (résumé)

Détails

Fermer
A partir des données de deux études indépendantes incluant 312 patients atteints d'un cancer du poumon non à petites cellules, cette étude évalue l'association entre 12 variants génétiques situés sur les chromosomes 15q25 et 5p15, l'expression des gènes correspondant dans les cellules tumorales et le risque de développer la maladie

“Association of the 15q25 and 5p15 lung cancer susceptibility regions with gene expression in lung tumour tissue”

• Fehringer, Gordon;Liu, Geoffrey;Pintilie, Melania;Sykes, Jenna;Cheng, Dangxiao;Liu, Ni;Chen, Zhuo;Seymour, Lesley;Der, Sandy D.;Shepherd, Frances A.;Tsao, Ming-Sound;Hung, Rayjean

Background: Genome-wide association studies have identified two independent lung cancer susceptibility loci at chromosome 15q25 and one locus at 5p15. We examined the association of genetic variants in these regions with gene expression in lung tumor tissue, in an effort to elucidate carcinogeneic mechanisms by which these variants influence lung cancer risk. Methods: We used data from two independent studies of non-small cell lung cancer patients: the JBR.10 clinical trial (n=131) and a University Health Network (UHN) patient sample in Toronto (n=181). We genotyped seven 15q25 and five 5p15 variants and examined their association with expression profiles of genes in the corresponding regions, measured by Affymetrix HG-U133A. Results: The minor allele (C) of a variant representing one of the two loci at 15q25 (rs2036534) was associated with increased IREB2 (iron-responsive element binding protein 2) expression in both studies (JBR.10 P=0.042; UHN P=0.002). An FDR≤0.05 in the UHN ...

Mots clés : Poumon; Etiologie (Facteurs endogènes)

A partir d'une revue de la littérature publiée jusqu'en novembre 2011 (27 études, 9 663 cas, 11 348 témoins), cette méta-analyse évalue l'association entre le polymorphisme Ser326Cys du gène OGG1 et le risque de cancer du poumon

The Association between OGG1 Ser326Cys Polymorphism and Lung Cancer Susceptibility: A Meta-Analysis of 27 Studies
• PLoS ONE, Vol. 7 (4), pp. e35970, 2012 (article en libre accès)

Détails

Fermer
A partir d'une revue de la littérature publiée jusqu'en novembre 2011 (27 études, 9 663 cas, 11 348 témoins), cette méta-analyse évalue l'association entre le polymorphisme Ser326Cys du gène OGG1 et le risque de cancer du poumon

“The Association between OGG1 Ser326Cys Polymorphism and Lung Cancer Susceptibility: A Meta-Analysis of 27 Studies”

• Duan, Wei-Xun;Hua, Rui-Xi;Yi, Wei;Shen, Li-Jun;Jin, Zhen-Xiao;Zhao, Yu-Hong;Yi, Ding-Hua;Chen, Wen-Sheng;Yu, Shi-Qiang

Background : Numerous studies have investigated association of OGG1 Ser326Cys polymorphism with lung cancer susceptibility; however, the findings are inconsistent. Therefore, we performed a meta-analysis based on 27 publications encompass 9663 cases and 11348 controls to comprehensively evaluate such associations. Methods : We searched publications from MEDLINE and EMBASE which were assessing the associations between OGG1 Ser326Cys polymorphism and lung cancer risk. We calculated pooled odds ratio (OR) and 95% confidence interval (CI) by using either fixed-effects or random-effects model. We used genotype based mRNA expression data from HapMap for SNP rs1052133 in normal cell lines among 270 subjects with four different ethnicities. Results : The results showed that individuals carrying the Cys/Cys genotype did not have significantly increased risk for lung cancer (OR = 1.15, 95% CI = 0.98–1.36) when compared with the Ser/Ser genotype; similarly, no significant association was found ...

Mots clés : Poumon; Etiologie (Facteurs endogènes)

Menée sur la cohorte "Genes, Environment and Melanoma", incluant 65 parents au premier degré de patients atteints d'un mélanome avec mutations du gène CDKN2A et 3 537 parents au premier degré de patients atteints d'un mélanome sans mutations de ce gène, cette étude évalue le risque d'un cancer autre que le mélanome associé au fait d'être parent au premier degré d'un patient atteint d'un mélanome avec mutations du gène CDKN2A

Risk of Non-Melanoma Cancers in First-Degree Relatives of CDKN2A Mutation Carriers
• Journal of the National Cancer Institute, sous presse, 2012 (résumé)

Détails

Fermer
Menée sur la cohorte "Genes, Environment and Melanoma", incluant 65 parents au premier degré de patients atteints d'un mélanome avec mutations du gène CDKN2A et 3 537 parents au premier degré de patients atteints d'un mélanome sans mutations de ce gène, cette étude évalue le risque d'un cancer autre que le mélanome associé au fait d'être parent au premier degré d'un patient atteint d'un mélanome avec mutations du gène CDKN2A

“Risk of Non-Melanoma Cancers in First-Degree Relatives of CDKN2A Mutation Carriers”

• Mukherjee, Bhramar;DeLancey, John Oliver;Raskin, Leon;Everett, Jessica;Jeter, Joanne;Begg, Colin B.;Orlow, Irene;Berwick, Marianne;Armstrong, Bruce K.;Kricker, Anne;Marrett, Loraine D.;Millikan, Robert C.;Culver, Hoda Anton;Rosso, Stefano;Zanetti, Roberto;Kanetsky, Peter A.;From, Lynn;Gruber, Stephen B.;for the GEM Study Investigators

The purpose of this study was to quantify the risk of cancers other than melanoma among family members of CDKN2A mutation carriers using data from the Genes, Environment and Melanoma study. Relative risks (RRs) of all non-melanoma cancers among first-degree relatives (FDRs) of melanoma patients with CDKN2A mutations (n = 65) and FDRs of melanoma patients without mutations (n = 3537) were calculated as the ratio of estimated event rates (number of cancers/total person-years) in FDRs of carriers vs noncarriers with exact Clopper–Pearson-type tests and 95% confidence intervals (CIs). All statistical tests were two-sided. There were 56 (13.1%) non-melanoma cancers reported among 429 FDRs of mutation carriers and 2199 (9.4%) non-melanoma cancers in 23 452 FDRs of noncarriers. The FDRs of carriers had an increased risk of any cancer other than melanoma (56 cancers among 429 FDRs of carrier probands vs 2199 cancers among 23 452 FDRs of noncarrier probands; RR = 1.5, 95% CI = 1.2 to ...

Mots clés : Mélanome; Etiologie (Facteurs endogènes)

A partir de données médicales et de données en population, cette étude évalue l'association entre l'âge des parents, le nombre de frères et sœurs et le risque de leucémie aiguë durant l'enfance ou la vie adulte (2 660 cas pédiatriques, 4 412 cas adultes et 28 288 témoins)

Parental age, family size, and offspring's risk of childhood and adult acute leukemia
• Cancer Epidemiology Biomarkers & Prevention, sous presse, 2012 (résumé)

Détails

Fermer
A partir de données médicales et de données en population, cette étude évalue l'association entre l'âge des parents, le nombre de frères et sœurs et le risque de leucémie aiguë durant l'enfance ou la vie adulte (2 660 cas pédiatriques, 4 412 cas adultes et 28 288 témoins)

“Parental age, family size, and offspring's risk of childhood and adult acute leukemia”

• Larfors, Gunnar;Hallbook, Helene;Simonsson, Bengt

Background: An association between childhood acute leukemia and advanced parental age was observed more than fifty years ago, and the association has been repeated in several, but not all, subsequent studies. In contrast to the many studies addressing childhood leukemia, few have included adult patients. Methods: In this register-based case-control study we examined the association between parental age and incidence of acute leukemia in 2660 childhood cases and 4412 adult cases of acute leukemia, compared to 28288 age-matched controls selected from a population-based register. Relative risks were estimated with conditional logistic regression. Results: We found a small increased risk of childhood ALL with increasing paternal age (adjusted odds ratio 1.05 per five year increase in age). Risk estimates were similar for childhood AML, whereas no association was found with adult leukemia. Meanwhile, we observed a decreased risk of adult AML with increasing number of siblings, both older ...

Mots clés : Leucémie; Etiologie (Facteurs endogènes)

Menée sur une cohorte de 2 033 patients atteints d'un cancer colorectal et 9 640 témoins, cette étude évalue l'association entre 24 polymorphismes à simple nucléotide, le risque d'obésité et le risque de cancer colorectal

Susceptibility variants for obesity and colorectal cancer risk: The multiethnic cohort and PAGE studies
• International Journal of Cancer, sous presse, 2012 (résumé)

Détails

Fermer
Menée sur une cohorte de 2 033 patients atteints d'un cancer colorectal et 9 640 témoins, cette étude évalue l'association entre 24 polymorphismes à simple nucléotide, le risque d'obésité et le risque de cancer colorectal

“Susceptibility variants for obesity and colorectal cancer risk: The multiethnic cohort and PAGE studies”

• Lim, Unhee;Wilkens, Lynne R.;Monroe, Kristine R.;Caberto, Christian;Tiirikainen, Maarit;Cheng, Iona;Park, Sungshim Lani;Stram, Daniel O.;Henderson, Brian E.;Kolonel, Laurence N.;Haiman, Christopher A.;Le Marchand, Loïc

Obesity is a leading contributor to colorectal cancer risk. We investigated whether the risk variants identified in genome-wide association studies of body mass index (BMI) and waist size are associated with colorectal cancer risk, independently of the effect of obesity phenotype due to a shared etiology. Twenty-four single nucleotide polymorphisms (SNPs) in 15 loci (BDNF, FAIM2, FTO, GNPDA2, KCTD15, LYPLAL1, MC4R, MSRA, MTCH2, NEGR1, NRXN3, SEC16B, SH2B1, TFAP2B and TMEM18) were genotyped in a case–control study of 2,033 colorectal cancer cases and 9,640 controls nested within the multiethnic cohort study, as part of the population architecture using genomics and epidemiology consortium. Risk alleles for two obesity SNPs were associated with colorectal cancer risk—KCTD15 rs29941 [odds ratio (OR) for C allele = 0.90, 95% confidence interval (CI) 0.83–0.98; p = 0.01] and MC4R rs17782313 (OR for C allele = 1.12, 95% CI 1.02–1.22; p = 0.02). These associations were independent of ...

Mots clés : Colon-rectum; Etiologie (Facteurs endogènes)

A partir des données de l'assurance maladie taïwanaise portant sur 24 066 patients, cette étude évalue l'association entre des troubles de l'anxiété et le risque de cancer

A Nationwide Population-Based Cohort Study: Will Anxiety Disorders Increase Subsequent Cancer Risk?
• PLoS ONE, Vol. 7 (4), pp. e36370, 2012 (article en libre accès)

Détails

Fermer
A partir des données de l'assurance maladie taïwanaise portant sur 24 066 patients, cette étude évalue l'association entre des troubles de l'anxiété et le risque de cancer

“A Nationwide Population-Based Cohort Study: Will Anxiety Disorders Increase Subsequent Cancer Risk?”

• Liang, Ji-An;Sun, Li-Min;Su, Kuan-Pin;Chang, Shih-Ni;Sung, Fung-Chang;Muo, Chih-Hsin;Kao, Chia-Hung

Background : The aim of this study was to evaluate a possible association between malignancy and anxiety disorders (AD) in Taiwan. Methods : We employed data from the National Health Insurance system of Taiwan. The AD cohort contained 24,066 patients with each patient randomly frequency matched according to age and sex with 4 individuals from the general population without AD. Cox's proportional hazard regression analysis was conducted to estimate the influence of AD on the risk of cancer. Results : Among patients with AD, the overall risk of developing cancer was only 1% higher than among subjects without AD, and the difference was not significant (hazard ratio [HR] = 1.01, 95% confidence interval [95% CI] = 0.95–1.07). With regard to individual types of cancer, the risk of developing prostate cancer among male patients with AD was significantly higher (HR = 1.32, 95% CI = 1.02–1.71). On the other hand, the risk of cervical cancer among female patients with AD was marginally ...

Mots clés : Cancer (général); Etiologie (Facteurs endogènes)

A partir de données d'un registre américain du cancer et d'une étude de cohorte incluant 115 686 enfants nés entre 1996 et 2005, cette étude évalue l'association entre des malformations congénitales et le risque de cancer durant l'enfance (2 351 cas)

Are Children With Birth Defects at Higher Risk of Childhood Cancers?
• American Journal of Epidemiology, sous presse, 2012 (résumé)

Détails

Fermer
A partir de données d'un registre américain du cancer et d'une étude de cohorte incluant 115 686 enfants nés entre 1996 et 2005, cette étude évalue l'association entre des malformations congénitales et le risque de cancer durant l'enfance (2 351 cas)

“Are Children With Birth Defects at Higher Risk of Childhood Cancers?”

• Carozza, Susan E.;Langlois, Peter H.;Miller, Eric A.;Canfield, Mark

Birth defects may influence the risk of childhood cancer development through a variety of mechanisms. The rarity of both birth defects and childhood cancers makes it challenging to study these associations, particularly for the very rare instances of each. To address this limitation, the authors conducted a record linkage-based cohort study among Texas children born between 1996 and 2005. Birth defects in the cohort were identified through the Texas Birth Defects Registry, and children who developed cancer were identified by using record linkage with Texas Cancer Registry data. Over 3 million birth records were included; 115,686 subjects had birth defects, and there were 2,351 cancer cases. Overall, children with a birth defect had a 3-fold increased risk of developing cancer (incidence rate ratio (IRR) = 3.05, 95% confidence interval (CI): 2.65, 3.50), with germ cell tumors (IRR = 5.19, 95% CI: 2.67, 9.41), retinoblastomas (IRR = 2.34, 95% CI: 1.21, 4.16), soft-tissue sarcomas (IRR = ...