Lutte contre les cancers

A partir des données des registres européens du cancer portant sur la période 1995-1999, cette étude analayse la qualité de vie, la fatigue et la dépression de survivantes à 5 ans d'un cancer du sein

• Quality of life, fatigue and depression in Italian long-term breast cancer survivors
  • Supportive Care in Cancer, sous presse, 2012 (résumé)
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  A partir des données des registres européens du cancer portant sur la période 1995-1999, cette étude analayse la qualité de vie, la fatigue et la dépression de survivantes à 5 ans d'un cancer du sein

  “Quality of life, fatigue and depression in Italian long-term breast cancer survivors”

  • Romito, Francesca;Cormio, Claudia;Giotta, Francesco;Colucci, Giuseppe;Mattioli, Vittorio

  
  

Mots clés : Sein; Lutte contre les cancers (Qualité de vie, soins de support)

Menée auprès de 185 patients atteints de cancer de stade avancé, cette étude de cohorte prospective analyse leurs symptômes de dystonie neurovégétative et les enjeux de leur prise en charge

• Autonomic dysfunction in patients with advanced cancer; prevalence, clinical correlates and challenges in assessment
  • BMC Palliative Care, Vol. 11 (1), pp. 3, 2012 (article en libre accès)
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  Menée auprès de 185 patients atteints de cancer de stade avancé, cette étude de cohorte prospective analyse leurs symptômes de dystonie neurovégétative et les enjeux de leur prise en charge

  “Autonomic dysfunction in patients with advanced cancer; prevalence, clinical correlates and challenges in assessment”

  • Stone, Carol;Kenny, Rose Anne;Nolan, Brid;Lawlor, Peter

  BACKGROUND:The results of a small number of studies of autonomic function in patients with advanced cancer suggest that autonomic dysfunction (AD) is common. In other disease-specific groups this is associated with decreased survival, falls and symptoms such as postural hypotension, nausea, early satiety and fatigue. The contribution of AD to symptoms in advanced cancer is unknown.METHODS:We conducted a prospective cohort study designed to identify the risk factors for falls in patients with advanced cancer. Ambulant adult patients admitted consecutively to palliative care services were invited to participate. Participants underwent an assessment at baseline which included standard clinical tests of autonomic function, assessment of symptom severity, muscle strength, anthropometric measurements, walking speed, medication use, comorbidities and demographics. Information regarding survival was recorded ten months following cessation of recruitment. The clinical correlates of AD, defined ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

Cette étude américaine (201 cas et 76 témoins) analyse l'état cardiovasculaire de survivants d'un cancer pédiatrique 11 ans (durée médiane) après une exposition à des traitements cardiotoxiques

• Cardiovascular Status of Childhood Cancer Survivors Exposed and Unexposed to Cardiotoxic Therapy
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Cette étude américaine (201 cas et 76 témoins) analyse l'état cardiovasculaire de survivants d'un cancer pédiatrique 11 ans (durée médiane) après une exposition à des traitements cardiotoxiques

  “Cardiovascular Status of Childhood Cancer Survivors Exposed and Unexposed to Cardiotoxic Therapy”

  • Lipshultz, Steven E.;Landy, David C.;Lopez-Mitnik, Gabriela;Lipsitz, Stuart R.;Hinkle, Andrea S.;Constine, Louis S.;French, Carol A.;Rovitelli, Amy M.;Proukou, Cindy;Adams, M. Jacob;Miller, Tracie L.

  Purpose To determine whether cardiovascular abnormalities in childhood cancer survivors are restricted to patients exposed to cardiotoxic anthracyclines and cardiac irradiation and how risk factors for atherosclerotic disease and systemic inflammation contribute to global cardiovascular status.Methods We assessed echocardiographic characteristics and atherosclerotic disease risk in 201 survivors of childhood cancer with and without exposure to cardiotoxic treatments at a median of 11 years after diagnosis (range, 3 to 32 years) and in 76 sibling controls.Results The 156 exposed survivors had below normal left ventricular (LV) mass, wall thickness, contractility, and fractional shortening and above normal LV afterload. The 45 unexposed survivors also had below normal LV mass overall, and females had below normal LV wall thickness. Exposed and unexposed survivors, compared with siblings, had higher levels of N-terminal pro-brain natriuretic peptide (81.7 and 69.0 pg/mL, respectively, v ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

A partir d'une revue systématique de la littérature (57 études conduites aux Etats-Unis sur la période 2000-2011), cette étude fait le point sur les données relatives aux survivants d'un cancer, en termes de qualité de vie et d'effets des traitements à long terme

• A systematic review of large-scale surveys of cancer survivors conducted in North America, 2000–2011
  • Journal of Cancer Survivorship, pp. 1-31, 2012 (résumé)
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  A partir d'une revue systématique de la littérature (57 études conduites aux Etats-Unis sur la période 2000-2011), cette étude fait le point sur les données relatives aux survivants d'un cancer, en termes de qualité de vie et d'effets des traitements à long terme

  “A systematic review of large-scale surveys of cancer survivors conducted in North America, 2000–2011”

  • Lerro, Catherine;Stein, Kevin;Smith, Tenbroeck;Virgo, Katherine

  Introduction Many large surveys collect data on cancer survivors, but few encompass the full spectrum of domains relevant to survivorship ranging from cancer care to quality of life to late- and long-term effects of cancer and its treatment. Here, we review large data sources in North America collecting cancer survivor-reported health information, and catalogue the domains of cancer survivorship each includes. Methods We identified surveys of cancer survivors through a comprehensive web search of federal government agencies, non-profit organizations, and related societies that support health care research or provide health care services, as well as a systematic review of literature indexed on PubMed from 2000–2011. Results A total of 57 surveys were identified, 26 nationally representative surveys and 31 regional, state, or provincial surveys. Thirty-four surveys specifically targeted cancer survivors, and an additional two surveys had supplements or modules targeted at cancer ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

A partir d'une revue de la littérature, cette étude fait le point sur la forme physique et les difficultés cardio-respiratoires de patients atteints de cancer, ainsi que sur l'efficacité d'exercices physiques permettant d'améliorer leur bien-être

• Exercise rehabilitation in patients with cancer
  • Nature Reviews Clinical Oncology, sous presse, 2012 (résumé)
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  A partir d'une revue de la littérature, cette étude fait le point sur la forme physique et les difficultés cardio-respiratoires de patients atteints de cancer, ainsi que sur l'efficacité d'exercices physiques permettant d'améliorer leur bien-être

  “Exercise rehabilitation in patients with cancer”

  • Lakoski, Susan G.;Eves, Neil D.;Douglas, Pamela S.;Jones, Lee W.

  Emerging evidence indicates that patients with cancer have considerable impairments in cardiorespiratory fitness, which is likely to be a result of the direct toxic effects of anticancer therapy as well as the indirect consequences secondary to therapy (for example, deconditioning). This reduced cardiorespiratory fitness is associated with heightened symptoms, functional dependence, and possibly with an increased risk of cardiovascular morbidity and mortality. Current understanding of the complex interaction between the effects of the tumour and cancer-associated therapies on the organ components that govern cardiorespiratory fitness, and the effects of exercise training on these parameters is limited; further research will be critical for further progress of exercise-based rehabilitation in the oncology setting. We assess the current evidence regarding the level, mechanisms, and clinical importance of diminished cardiorespiratory fitness in patients with cancer. The efficacy and ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

A partir des données portant sur 17 753 patients morts de cancer, cette étude en population norvégienne analyse l'utilisation de médicaments antidépresseurs pendant leur dernière année de vie

• Antidepressants to cancer patients during the last year of life—a population-based study
  • Psycho-Oncology, sous presse, 2012 (résumé)
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  A partir des données portant sur 17 753 patients morts de cancer, cette étude en population norvégienne analyse l'utilisation de médicaments antidépresseurs pendant leur dernière année de vie

  “Antidepressants to cancer patients during the last year of life—a population-based study”

  • Brelin, Siri;Loge, Jon Håvard;Skurtveit, Svetlana;Johannesen, Tom Børge;Aass, Nina;Ottesen, Stig;Hjermstad, Marianne Jensen

  Objective Although depression is common among incurable cancer patients, the prescription prevalence of antidepressants (ADs) to these patients is largely unknown. Aims were to examine the prescription prevalence of ADs in the last year of life in a 2-year national cancer death cohort and to examine its associations with sociodemographic and medical variables. Methods Nationwide, 20,627 cancer deaths in adults were identified by combining the Norwegian Central Population and Cancer Registries. Individual prescriptions of ADs in the 12 months prior to death were identified in the Norwegian Prescription Database. The study population consisted of 17,753 patients who died from cancer in 2005 and 2006, after excluding patients assumed to be hospitalized whose prescriptions were not registered in the Norwegian Prescription Database. Results Twenty-two percent (N = 3836) had at least one prescription of ADs in their last year of life (men 19%/women 25%), compared with 6% in the ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

Menée en Californie auprès de 20 987 participantes sino-américaines atteintes d'un cancer du sein de stade précoce, cette étude analyse les associations entre les caractéristiques de la tumeur, le statut socioéconomique des patientes, le réseau hospitalier et le choix thérapeutique (mastectomie, chirurgie conservatrice)

• Patient, hospital, and neighborhood factors associated with treatment of early-stage breast cancer among Asian American women in California
  • Cancer Epidemiology Biomarkers & Prevention, sous presse, 2012 (résumé)
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  Menée en Californie auprès de 20 987 participantes sino-américaines atteintes d'un cancer du sein de stade précoce, cette étude analyse les associations entre les caractéristiques de la tumeur, le statut socioéconomique des patientes, le réseau hospitalier et le choix thérapeutique (mastectomie, chirurgie conservatrice)

  “Patient, hospital, and neighborhood factors associated with treatment of early-stage breast cancer among Asian American women in California”

  • Gomez, Scarlett L.;Press, David J.;Lichtensztajn, Daphne Y.;Keegan, Theresa H.M.;Shema, Sarah J.;Le, Gem M.;Kurian, Allison W.

  Background: Clinical guidelines recommend breast conserving surgery (BCS) with radiation as a viable alternative to mastectomy for treatment of early-stage breast cancer. Yet, Asian Americans (AA) are more likely than other groups to have mastectomy or omit radiation after BCS. Methods: We applied polytomous logistic regression and recursive partitioning (RP) to analyze factors associated with mastectomy, or BCS without radiation, among 20,987 California AAs diagnosed with stage 0-II breast cancer from 1990-2007. Results: The percentage receiving mastectomy ranged from 40% among US-born Chinese to 58% among foreign-born Vietnamese. Factors associated with mastectomy included tumor characteristics such as larger tumor size, patient characteristics such as older age and foreign birthplace among some AA ethnicities, and additional factors including hospital (smaller hospital size, not NCI cancer center, low socioeconomic status (SES) patient composition, and high hospital AA patient ...

  
  

Mots clés : Sein; Lutte contre les cancers (Observation)

Menée en population américaine, cette étude analyse l'impact du niveau socioéconomique et du lieu de vie sur la survie de patients atteints d'un cancer du poumon non à petites cellules

• Neighborhood-level socioeconomic determinants impact outcomes in nonsmall cell lung cancer patients in the Southeastern United States
  • Cancer, sous presse, 2012 (résumé)
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  Menée en population américaine, cette étude analyse l'impact du niveau socioéconomique et du lieu de vie sur la survie de patients atteints d'un cancer du poumon non à petites cellules

  “Neighborhood-level socioeconomic determinants impact outcomes in nonsmall cell lung cancer patients in the Southeastern United States”

  • Erhunmwunsee, Loretta;Joshi, Mary-Beth M.;Conlon, Debbi H.;Harpole, David H.

  BACKGROUND: Studies examining the impact of lower socioeconomic status (SES) on the outcomes of patients with nonsmall cell lung cancer (NSCLC) are inconsistent. The objective of this study was to clearly elucidate the association between SES, education, and clinical outcomes among patients with NSCLC. METHODS: The study population was derived from a consecutive, retrospective cohort of patients with NSCLC who received treatment within the Duke Health System between 1995 and 2007. SES determinants were based on the individual's census tract and corresponding 2000 Census data. Determinants included the percentage of the population living below poverty, the median household income, and the percentages of residents with at least a high school diploma and at least a bachelor's degree. The SES and educational variables were divided into quartiles. Statistical comparisons were performed using the 25th and 75th percentiles. RESULTS: Individuals who resided in areas with a low median ...

  
  

Mots clés : Poumon; Lutte contre les cancers (Observation)

A partir des données des registres suédois du cancer portant sur la période 1960 à 2009, cette étude analyse l'évolution de l'incidence du cancer de l'intestion grêle et constate l'augmentation de l'incidence de l'adénocarcinome duodénal

• Incidence patterns of small bowel cancer in a population-based study in Sweden: Increase in duodenal adenocarcinoma
  • Cancer Epidemiology, sous presse, 2012 (résumé)
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  A partir des données des registres suédois du cancer portant sur la période 1960 à 2009, cette étude analyse l'évolution de l'incidence du cancer de l'intestion grêle et constate l'augmentation de l'incidence de l'adénocarcinome duodénal

  “Incidence patterns of small bowel cancer in a population-based study in Sweden: Increase in duodenal adenocarcinoma”

  • Lu, Yunxia;Fröbom, Robin;Lagergren, Jesper

  Background Increasing incidences of malignant small bowel tumours have been reported, but data from European populations are limited. This study aimed to clarify the incidence patterns of malignant small bowel tumours in Sweden. Methods Patients with a first and primary malignant small bowel tumour were identified from the Swedish Cancer Register during the study period 1960–2009. Sex-specific and age-standardised incidence rates of these tumours were calculated by their anatomical location and histological type in different time periods. Figures were plotted to show the proportions and incidence rates over time, and joinpoint loglinear regression models were estimated to assess any time trends. Results A total of 6604 patients with malignant small bowel tumours were identified. The age-standardised incidence of all malignant small bowel tumours increased from 14.2 to 19.7 per 1,000,000 person-years during the study period. The incidence of duodenal cancer increased more than 3-fold ...

  
  

Mots clés : Appareil digestif (autre); Lutte contre les cancers (Observation)

Menée au Japon sur la période 1980-2005, cette étude de cohorte rétrospective incluant des participants âgés de 30 à 59 ans analyse l'évolution des causes de mortalité de salariés, dont celle par cancer, pendant une période de crise économique

• Trends in cause specific mortality across occupations in Japanese men of working age during period of economic stagnation, 1980-2005: retrospective cohort study
  • British Medical Journal, Vol. 344, 2012 (article en libre accès)
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  Menée au Japon sur la période 1980-2005, cette étude de cohorte rétrospective incluant des participants âgés de 30 à 59 ans analyse l'évolution des causes de mortalité de salariés, dont celle par cancer, pendant une période de crise économique

  “Trends in cause specific mortality across occupations in Japanese men of working age during period of economic stagnation, 1980-2005: retrospective cohort study”

  • Koji Wada;Naoki Kondo;Stuart Gilmour;Yukinobu Ichida;Yoshihisa Fujino;Toshihiko Satoh;Kenji Shibuya

  Objective To assess the temporal trends in occupation specific all causes and cause specific mortality in Japan between 1980 and 2005. Design Longitudinal analysis of individual death certificates by last occupation before death. Data on population by age and occupation were derived from the population census. Setting Government records, Japan. Participants Men aged 30-59. Main outcome measures Age standardised mortality rate for all causes, all cancers, cerebrovascular disease, ischaemic heart disease, unintentional injuries, and suicide. Results Age standardised mortality rates for all causes and for the four leading causes of death (cancers, ischaemic heart disease, cerebrovascular disease, and unintentional injuries) steadily decreased from 1980 to 2005 among all occupations except for management and professional workers, for whom rates began to rise in the late 1990s (P<0.001). During the study period, the mortality rate was lowest in other occupations such as ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Observation)

A partir des données des registres américains du cancer portant sur les périodes 1992–1996 et 2002–2006, cette étude analyse l'évolution de la survie des patients atteints de cancer en fonction de leur origine ethnique

• Changes in survival by ethnicity of patients with cancer between 1992–1996 and 2002–2006: is the discrepancy decreasing?
  • Annals of Oncology, sous presse, 2012 (résumé)
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  A partir des données des registres américains du cancer portant sur les périodes 1992–1996 et 2002–2006, cette étude analyse l'évolution de la survie des patients atteints de cancer en fonction de leur origine ethnique

  “Changes in survival by ethnicity of patients with cancer between 1992–1996 and 2002–2006: is the discrepancy decreasing?”

  • Pulte, D.;Redaniel, M. T.;Brenner, H.;Jeffreys, M.

  Background: Patients of minority race/ethnicity have lower survival after diagnosis with most types of cancer. Little data are available concerning changes in disparity over time. Here, we examine changes in survival by race/ethnicity of patients with common cancers in two recent time periods.Patients and methods: We used modeled period analysis to determine relative survival (RS) for non-Hispanic white (nHw), African–American (AA), and Hispanic patients in the Surveillance, Epidemiology, and End Results database diagnosed with common solid and hematological malignancies.Results: Five-year RS improved overall and for nHw for each tumor examined, ranging from +2% points (pancreatic cancer) to +16.4% points [non-Hodgkin's lymphoma, (NHL)]. Greater improvement was observed for AA and Hispanics than nHw in breast and prostate cancer and NHL. Less improvement was observed for AA and Hispanics than for nHw for lung and pancreatic cancer. No statistically significant improvement was ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Observation)

Menée au Canada, cette étude analyse l'incidence de cancer chez des individus âgés de 15 à 29 ans ainsi que leur survie à 5 ans, en fonction de l'âge et du lieu des traitements

• Surveillance and survival among adolescents and young adults with cancer in Ontario, Canada
  • International Journal of Cancer, sous presse, 2012 (résumé)
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  Menée au Canada, cette étude analyse l'incidence de cancer chez des individus âgés de 15 à 29 ans ainsi que leur survie à 5 ans, en fonction de l'âge et du lieu des traitements

  “Surveillance and survival among adolescents and young adults with cancer in Ontario, Canada”

  • Furlong, William;Rae, Charlene;Greenberg, Mark L.;Barr, Ronald D.

  Gains in survival rates among adolescents and young adults (AYA) are reported from the USA to be lower than in both younger and older patients. Limiting factors include low accrual to clinical trials related to the type of institutional care. This study aimed to determine the incidence of cancer in the 15-29 age group in Ontario, and the 5 year survival of these cases by disease class, age at diagnosis group and highest level of institutional complexity of care. The primary data source was Cancer Care Ontario (CCO). Diseases were classified according to an AYA-specific system. Age at diagnosis was grouped as 15-19, 20-24 and 25-29 years; and institutional site of care was categorized as Pediatric Oncology Group of Ontario (POGO) centers, regional cancer centers (RCC – tertiary care centers associated with CCO), RCC affiliate and satellite institutions, and other institutions having no specialized cancer services. More than 10,000 incident cases were identified during 1990-2001. ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Observation)

A partir des données de deux études cliniques incluant 570 survivants d'un cancer de la tête et du cou, cette étude analyse leurs facteurs de stress et leur détresse émotionnelle

• The burden of stress in head and neck cancer
  • Psycho-Oncology, sous presse, 2012 (résumé)
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  A partir des données de deux études cliniques incluant 570 survivants d'un cancer de la tête et du cou, cette étude analyse leurs facteurs de stress et leur détresse émotionnelle

  “The burden of stress in head and neck cancer”

  • Devins, Gerald M.;Payne, Ada Y. M.;Lebel, Sophie;Mah, Kenneth;Lee, Ruth N. F.;Irish, Jonathan;Wong, Janice;Rodin, Gary M.

  Background Head and neck cancer (HNCa) introduces numerous stressors. We developed the Cancer-Related Stressors Checklist (CRSC), which documents exposure to seven categories of common stressors and emotional distress. We surveyed HNCa survivors and examined associations among exposure to cancer-related stressors, illness intrusiveness (i.e., cancer-induced interference with lifestyles, activities, and interests), and distress. We also investigated whether reported exposure rates differ between self-administered and interviewer-administered measures. Methods Respondents included HNCa survivors, stratified by sex, who participated in one of two clinical studies (N1 = 162; N2 = 408) examining the psychosocial impact of illness intrusiveness. All completed the CRSC, the Center for Epidemiologic Studies Depression Scale, and the Illness Intrusiveness Ratings Scale. Study 1 respondents self-administered the instruments; an interviewer administered them in Study 2. We gathered ...

  
  

Mots clés : Voies aérodigestives supérieures; Lutte contre les cancers (Approches psycho-sociales)

Menée à SIngapour auprès de 43 patientes atteintes d'un cancer du sein, cette étude de cohorte asiatique analyse leurs expériences, leur vécu au quotidien et leurs méthodes pour s'adapter aux effets neurocognitifs de la chimiothérapie

• Cognitive changes in multiethnic Asian breast cancer patients: a focus group study
  • Annals of Oncology, sous presse, 2012 (résumé)
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  Menée à SIngapour auprès de 43 patientes atteintes d'un cancer du sein, cette étude de cohorte asiatique analyse leurs expériences, leur vécu au quotidien et leurs méthodes pour s'adapter aux effets neurocognitifs de la chimiothérapie

  “Cognitive changes in multiethnic Asian breast cancer patients: a focus group study”

  • Cheung, Y. T.;Shwe, M.;Tan, Y. P.;Fan, G.;Ng, R.;Chan, A.

  Background: This study aims to gather descriptions from multiethnic Asian breast cancer patients on their experiences and impact of chemotherapy-associated cognitive changes on their daily lives and their coping strategies.Patients and methods: Forty-three chemotherapy-receiving breast cancer patients participated in eight English or Chinese structured focus group discussions, conducted by trained psychosocial oncologists and medical social workers.Results: Participants were unfamiliar and averse to both English and Chinese-translated equivalent of the term ‘chemobrain’. Participants viewed this phenomenon holistically as a by-product of the physical (fatigue and aging) and psychosocial (anxiety and mood changes) adverse effects associated with chemotherapy. Most participants encountered memory loss, difficulty in decision making and speech problems after receiving chemotherapy. Married participants expressed frustration as cognitive deterioration limited their conservative roles ...

  
  

Mots clés : Sein; Lutte contre les cancers (Approches psycho-sociales)

Menée au Royaume-Uni auprès de 64 patients traités en ambulatoire dans une unité urologique, cette étude analyse l'association entre des caractéristiques d'intelligence émotionnelle et la façon de réagir lors de l'annonce du diagnostic de cancer

• The role of trait emotional intelligence in the diagnostic cancer pathway
  • Supportive Care in Cancer, sous presse, 2012 (résumé)
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  Menée au Royaume-Uni auprès de 64 patients traités en ambulatoire dans une unité urologique, cette étude analyse l'association entre des caractéristiques d'intelligence émotionnelle et la façon de réagir lors de l'annonce du diagnostic de cancer

  “The role of trait emotional intelligence in the diagnostic cancer pathway”

  • Smith, Samuel;Petrides, K.;Green, James;Sevdalis, Nick

  Purpose Trait emotional intelligence (trait EI) has been linked with psychological outcomes in a variety of settings; however, it has received little attention in the healthcare field. We investigated the relationship between trait EI and worry at different stages of the diagnostic cancer pathway. Methods We recruited 64 individuals attending an outpatient urology cancer investigation. Patients completed the Hospital Anxiety and Depression Scale, Trait Emotional Intelligence Questionnaire—Short Form and a single-item measure of arousal/pleasantness. Worry was assessed retrospectively for each stage of the pathway and concurrently for the stage of ‘awaiting the specialist’. Results Trait EI was negatively associated with worry in the early stages of the diagnostic pathway (‘deciding to see’ and ‘awaiting the general practitioner (GP)’; p s < 0.05) and was negatively linked to patients’ worry while ‘seeing the GP’ ( p = 0.051) after controlling for anxiety, ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Approches psycho-sociales)

Menée à partir des données des registres américains du cancer, cette étude analyse l'impact des résultats de l'essai C9343, ayant évalué une radiothérapie adjuvante, sur le recours effectif à la radiothérapie pour des patientes âgées de plus de 70 ans, atteintes d'un cancer du sein et bénéficiant d'une protection sociale

• Assessing the Impact of a Cooperative Group Trial on Breast Cancer Care in the Medicare Population
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Menée à partir des données des registres américains du cancer, cette étude analyse l'impact des résultats de l'essai C9343, ayant évalué une radiothérapie adjuvante, sur le recours effectif à la radiothérapie pour des patientes âgées de plus de 70 ans, atteintes d'un cancer du sein et bénéficiant d'une protection sociale

  “Assessing the Impact of a Cooperative Group Trial on Breast Cancer Care in the Medicare Population”

  • Soulos, Pamela R.;Yu, James B.;Roberts, Kenneth B.;Raldow, Ann C.;Herrin, Jeph;Long, Jessica B.;Gross, Cary P.

  Purpose The Cancer and Leukemia Group B (CALGB) C9343 trial found that adjuvant radiation therapy (RT) provided minimal benefits for older women with breast cancer. Although treatment guidelines were changed to indicate that some women could forego RT, the impact of the C9343 results on clinical practice is unclear.Patients and Methods We used the Surveillance, Epidemiology, and End Results (SEER) –Medicare data set to assess the use of adjuvant RT in a sample of women ≥ 70 years old diagnosed with stage I breast cancer from 2001 to 2007 who fulfilled the C9343 inclusion criteria. We used log-binomial regression to estimate the relation between publication of C9343 and use of RT in the full sample and across strata of patient and health system characteristics.Results Of the 12,925 Medicare beneficiaries in our sample (mean age, 77.7 years), 76.5% received RT. Approximately 79% of women received RT before study publication compared with 75% after (adjusted relative risk of ...

  
  

Mots clés : Sein; Lutte contre les cancers (Analyses économiques et systèmes de soins)

Utilisant un modèle de simulation néerlandais, cette étude analyse et compare le rapport coût-efficacité de deux techniques de dépistage du cancer du col de l'utérus en Europe, l'une basée sur la détection du papillomavirus humain et l'autre sur la cytologie

• Primary screening for human papillomavirus compared with cytology screening for cervical cancer in European settings: cost effectiveness analysis based on a Dutch microsimulation model
  • British Medical Journal, Vol. 344, 2012 (article en libre accès)
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  Utilisant un modèle de simulation néerlandais, cette étude analyse et compare le rapport coût-efficacité de deux techniques de dépistage du cancer du col de l'utérus en Europe, l'une basée sur la détection du papillomavirus humain et l'autre sur la cytologie

  “Primary screening for human papillomavirus compared with cytology screening for cervical cancer in European settings: cost effectiveness analysis based on a Dutch microsimulation model”

  • Inge M C M de Kok;Joost van Rosmalen;Joakim Dillner;Marc Arbyn;Peter Sasieni;Thomas Iftner;Marjolein van Ballegooijen

  Objectives To investigate, using a Dutch model, whether and under what variables framed for other European countries screening for human papillomavirus (HPV) is preferred over cytology screening for cervical cancer, and to calculate the preferred number of examinations over a woman’s lifetime. Design Cost effectiveness analysis based on a Dutch simulation model. Base case analyses investigated the cost effectiveness of more than 1500 different screening policies using the microsimulation model. Subsequently, the policies were compared for five different scenarios that represent different possible scenarios (risk of cervical cancer, previous screening, quality associated test characteristics, costs of testing, and prevalence of HPV). Setting Various European countries. Population Unvaccinated women born between 1939 and 1992. Main outcome measures Optimal screening strategy in terms of incremental cost effectiveness ratios (costs per quality adjusted life years gained) ...

  
  

Mots clés : Col de l'utérus; Lutte contre les cancers (Analyses économiques et systèmes de soins)

Menée au Canada, cette étude analyse les différents facteurs qui permettent la mise en oeuvre et l'utilisation de rapports synoptiques en cancérologie (rapports ou listes de contrôle électroniques normalisés)

• Exploring the interpersonal-, organization-, and system-level factors that influence the implementation and use of an innovation -- synoptic reporting -- in cancer care
  • Implementation Science, Vol. 7 (1), pp. 12, 2012 (article en libre accès)
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  Menée au Canada, cette étude analyse les différents facteurs qui permettent la mise en oeuvre et l'utilisation de rapports synoptiques en cancérologie (rapports ou listes de contrôle électroniques normalisés)

  “Exploring the interpersonal-, organization-, and system-level factors that influence the implementation and use of an innovation -- synoptic reporting -- in cancer care”

  • Urquhart, Robin;Porter, Geoffrey;Grunfeld, Eva;Sargeant, Joan

  BACKGROUND:The dominant method of reporting findings from diagnostic and surgical procedures is the narrative report. In cancer care, this report inconsistently provides the information required to understand the cancer and make informed patient care decisions. Another method of reporting, the synoptic report, captures specific data items in a structured manner and contains only items critical for patient care. Research demonstrates that synoptic reports vastly improve the quality of reporting. However, synoptic reporting represents a complex innovation in cancer care, with implementation and use requiring fundamental shifts in physician behaviour and practice, and support from the organization and larger system. The objective of this study is to examine the key interpersonal, organizational, and system-level factors that influence the implementation and use of synoptic reporting in cancer care.METHODS:This study involves three initiatives in Nova Scotia, Canada, that have implemented ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Analyses économiques et systèmes de soins)

Menée au Royaume-Uni par questionnaire auprès de 30 patients atteints d'un cancer colorectal, cette étude qualitative analyse le rôle du médecin généraliste dans l'aide et le soutien au patient et à sa famille

• A qualitative exploration of the role of primary care in supporting colorectal cancer patients
  • Supportive Care in Cancer, sous presse, 2012 (résumé)
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  Menée au Royaume-Uni par questionnaire auprès de 30 patients atteints d'un cancer colorectal, cette étude qualitative analyse le rôle du médecin généraliste dans l'aide et le soutien au patient et à sa famille

  “A qualitative exploration of the role of primary care in supporting colorectal cancer patients”

  • Hall, Susan;Gray, Nicola;Browne, Susan;Ziebland, Sue;Campbell, Neil

  Purpose To explore experiences and support needs of people with colorectal cancer, with a focus on identifying opportunities for primary care interventions. Methods We conducted a new qualitative analysis of an existing dataset, comprising semi-structured interview transcripts from 39 people with colorectal cancer from across the UK, interviewed in 2001–2002 for www.healthtalkonline.org . Then, we conducted semi-structured interviews with 30 people with colorectal cancer from North East Scotland and Glasgow in 2009 and analysed these new data to explore themes and challenge hypotheses that emerged from the Healthtalkonline data. Results Formal sources of support, including that from primary care, were valued by those who received them, but provision was described as sporadic both in 2002 and in 2009. However, more of the 2009 participants gave descriptions of specialist nurse and community nurse involvement, and telephone contact from general practitioners, which were welcomed. ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Analyses économiques et systèmes de soins)

Menée aux Etats-Unis dans trois structures hospitalières, cette étude analyse la mise en place d'un parcours de soins coordonné dans les services oncologiques pour les patients atteints de cancer du sein ou du colon-rectum

• Patient navigation for breast and colorectal cancer in 3 community hospital settings
  • Cancer, sous presse, 2012 (résumé)
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  Menée aux Etats-Unis dans trois structures hospitalières, cette étude analyse la mise en place d'un parcours de soins coordonné dans les services oncologiques pour les patients atteints de cancer du sein ou du colon-rectum

  “Patient navigation for breast and colorectal cancer in 3 community hospital settings”

  • Donaldson, Elisabeth A.;Holtgrave, David R.;Duffin, Renea A.;Feltner, Frances;Funderburk, William;Freeman, Harold P.

  BACKGROUND: The Ralph Lauren Cancer Center implemented patient navigation programs in sites across the United States building on the model pioneered by Harold P. Freeman, MD. Patient navigation targets medically underserved with the objective of reducing the time interval between an abnormal cancer finding, diagnostic resolution, and treatment initiation. In this study, the authors assessed the incremental cost effectiveness of adding patient navigation to standard cancer care in 3 community hospitals in the United States. METHODS: A decision-analytic model was used to assess the cost effectiveness of a colorectal and breast cancer patient navigation program over the period of 1 year compared with standard care. Data sources included published estimates in the literature and primary costs, aggregate patient demographics, and outcome data from 3 patient navigation programs. RESULTS: After 1 year, compared with standard care alone, it was estimated that offering patient navigation with ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Analyses économiques et systèmes de soins)

A partir d'une enquête en ligne, cette étude américaine analyse le rôle des représentants de patients dans le processus d'élaboration et de sélection des essais cliniques

• Patient advocates' role in clinical trials
  • Cancer, sous presse, 2012 (résumé)
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  A partir d'une enquête en ligne, cette étude américaine analyse le rôle des représentants de patients dans le processus d'élaboration et de sélection des essais cliniques

  “Patient advocates' role in clinical trials”

  • Katz, Mira L.;Archer, Laura E.;Peppercorn, Jeffrey M.;Kereakoglow, Sandra;Collyar, Deborah E.;Burstein, Harold J.;Schilsky, Richard L.;Partridge, Ann H.

  BACKGROUND: Patient advocates are increasingly involved in cooperative group trials, single-institution cancer programs, and peer-review of research applications. The purpose of this study was to evaluate the role and value of patient advocates from the perspective of Cancer and Leukemia Group B (CALGB) advocates and investigators. METHODS: An online survey was sent to current and past (within 5 years) patient advocates and investigators. RESULTS. Response rates were 72.7% (16 of 22) for advocates and 56.4% (102 of 181) for investigators. Patient advocates were more likely than investigators to report the following: the clinical trial process benefited from advocate involvement on committees (100% of advocates vs 72.1% of investigators; P < .05), advocates contribute to protocol development (92.8% vs 33.8%, respectively; P < .001), the cultural appropriateness of protocols (21.4% vs 10.4%, respectively; P < .05), advocates assist with patient accrual (78.6% vs 23.4%, respectively; P < ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Sensibilisation et communication)