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Accueil Nota Bene Cancer V2 Numéro 127 du 13 Mars 2012 Etiologie

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Nota Bene Cancer Numéro 127 du 13 Mars 2012 RSS

Etiologie

Facteurs exogènes : Alcool

A partir des données de 20 études observationnelles, cette méta-analyse évalue l'association entre la consommation d'alcool et le risque de carcinome à cellules rénales

  • Alcohol drinking and risk of renal cell carcinoma: results of a meta-analysis
    Annals of Oncology, sous presse, 2012 (résumé)
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    A partir des données de 20 études observationnelles, cette méta-analyse évalue l'association entre la consommation d'alcool et le risque de carcinome à cellules rénales

    “Alcohol drinking and risk of renal cell carcinoma: results of a meta-analysis”

    • Bellocco, R.;Pasquali, E.;Rota, M.;Bagnardi, V.;Tramacere, I.;Scotti, L.;Pelucchi, C.;Boffetta, P.;Corrao, G.;La Vecchia, C.

    Background: The role of alcohol consumption in relation with renal cell carcinoma is still unclear; a few studies have reported a beneficial effect of moderate levels of alcohol consumption, whereas it remains still under debate whether there is a dose–response association.Materials and methods: Twenty observational studies (4 cohort, 1 pooled and 15 case–control) reporting results on at least three levels of alcohol consumption were selected through a combined search with PubMed and EMBASE of articles published before November 2010. Overall relative risks (RRs) and 95% confidence intervals (CIs) were estimated using random-effects models, and both second-order fractional polynomials and random effect meta-regression models were implemented for the study of dose–risk relation.Results: The estimated RRs were 0.85 (95% CI: 0.80–0.92) for any alcohol drinking, 0.90 (95% CI: 0.83–0.97) for light drinking (0.01–12.49 g/day), 0.79 (95% CI: 0.71–0.88) for moderate drinking ...


Mots clés : Rein; Etiologie (Facteurs exogènes : Alcool)

Facteurs exogènes : Nutrition et activité physique

Menée au Japon auprès de 393 femmes non ménopausées, cette étude analyse l'impact d'une consommation d'alcool, de graisses, de fibres, d'isoflavones de soja, sur le niveau de prolactine et d'hormones sexuelles mesurées dans le sang, et évalue leur rôle dans l'étiologie du cancer du sein

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    Menée au Japon auprès de 393 femmes non ménopausées, cette étude analyse l'impact d'une consommation d'alcool, de graisses, de fibres, d'isoflavones de soja, sur le niveau de prolactine et d'hormones sexuelles mesurées dans le sang, et évalue leur rôle dans l'étiologie du cancer du sein

    “Associations of intakes of fat, dietary fiber, soy isoflavones, and alcohol with levels of sex hormones and prolactin in premenopausal Japanese women”

    • Tsuji, Michiko;Tamai, Yuya;Wada, Keiko;Nakamura, Kozue;Hayashi, Makoto;Takeda, Noriyuki;Yasuda, Keigo;Nagata, Chisato

    Objective Endogenous sex hormones have been implicated in the etiology of breast cancer. Dietary factors such as fat, dietary fiber, soy isoflavones, and alcohol have been suggested to influence endogenous estrogen and other steroid hormone levels. We examined the relationship among these dietary factors and plasma sex hormone levels in premenopausal Japanese women. Methods We measured the plasma concentrations of estradiol, estrone, testosterone, dehydroepiandrosterone sulfate, sex hormone-binding globulin, a follicle-stimulating hormone, a luteinizing hormone, and prolactin among 393 premenopausal women who had regular menstrual cycles fewer than 40 days apart. The dietary intakes were estimated with a validated food frequency questionnaire. Results After controlling for age, BMI, phase of the menstrual cycle, number of births, age at first birth, history of breastfeeding, and smoking status, the saturated fat intake was significantly positively associated with total estradiol and ...


Mots clés : Sein; Etiologie (Facteurs exogènes : Nutrition et activité physique)

Facteurs exogènes : Exposition professionnelle

Menées à partir d'une cohorte incluant 12 315 travailleurs de mines non métalliques, ces deux études évaluent l'association entre une exposition professionnelle à des gaz d'échappement de moteurs diesel et le risque de cancer du poumon

  • The Diesel Exhaust in Miners Study: A Nested Case–Control Study of Lung Cancer and Diesel Exhaust
    Journal of the National Cancer Institute, sous presse, 2012 (article en libre accès)
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    Menées à partir d'une cohorte incluant 12 315 travailleurs de mines non métalliques, ces deux études évaluent l'association entre une exposition professionnelle à des gaz d'échappement de moteurs diesel et le risque de cancer du poumon

    “The Diesel Exhaust in Miners Study: A Nested Case–Control Study of Lung Cancer and Diesel Exhaust”

    • Silverman, Debra T.;Samanic, Claudine M.;Lubin, Jay H.;Blair, Aaron E.;Stewart, Patricia A.;Vermeulen, Roel;Coble, Joseph B.;Rothman, Nathaniel;Schleiff, Patricia L.;Travis, William D.;Ziegler, Regina G.;Wacholder, Sholom;Attfield, Michael D.

    Background Most studies of the association between diesel exhaust exposure and lung cancer suggest a modest, but consistent, increased risk. However, to our knowledge, no study to date has had quantitative data on historical diesel exposure coupled with adequate sample size to evaluate the exposure–response relationship between diesel exhaust and lung cancer. Our purpose was to evaluate the relationship between quantitative estimates of exposure to diesel exhaust and lung cancer mortality after adjustment for smoking and other potential confounders.Methods We conducted a nested case–control study in a cohort of 12 315 workers in eight non-metal mining facilities, which included 198 lung cancer deaths and 562 incidence density–sampled control subjects. For each case subject, we selected up to four control subjects, individually matched on mining facility, sex, race/ethnicity, and birth year (within 5 years), from all workers who were alive before the day the case subject died. ...


  • The Diesel Exhaust in Miners Study: A Cohort Mortality Study With Emphasis on Lung Cancer
    Journal of the National Cancer Institute, sous presse, 2012 (résumé)
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    Menées à partir d'une cohorte incluant 12 315 travailleurs de mines non métalliques, ces deux études évaluent l'association entre une exposition professionnelle à des gaz d'échappement de moteurs diesel et le risque de cancer du poumon

    “The Diesel Exhaust in Miners Study: A Cohort Mortality Study With Emphasis on Lung Cancer”

    • Attfield, Michael D. ; Schleiff, Patricia L. ; Lubin, Jay H. ; Blair, Aaron ; Stewart, Patricia A. ; Vermeulen, Roel ; Coble, Joseph B. ; Silverman, Debra T.

    Background Current information points to an association between diesel exhaust exposure and lung cancer and other mortality outcomes, but uncertainties remain.Methods We undertook a cohort mortality study of 12 315 workers exposed to diesel exhaust at eight US non-metal mining facilities. Historical measurements and surrogate exposure data, along with study industrial hygiene measurements, were used to derive retrospective quantitative estimates of respirable elemental carbon (REC) exposure for each worker. Standardized mortality ratios and internally adjusted Cox proportional hazard models were used to evaluate REC exposure–associated risk. Analyses were both unlagged and lagged to exclude recent exposure such as that occurring in the 15 years directly before the date of death.Results Standardized mortality ratios for lung cancer (1.26, 95% confidence interval [CI] = 1.09 to 1.44), esophageal cancer (1.83, 95% CI = 1.16 to 2.75), and pneumoconiosis (12.20, 95% CI = 6.82 to 20.12) ...


  • The Problem With Diesel
    Journal of the National Cancer Institute, sous presse, 2012 (éditorial)
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    Menées à partir d'une cohorte incluant 12 315 travailleurs de mines non métalliques, ces deux études évaluent l'association entre une exposition professionnelle à des gaz d'échappement de moteurs diesel et le risque de cancer du poumon

    “The Problem With Diesel”

    • Rushton, Lesley


  • Studies Show Exposure to Diesel Exhaust May Increase Lung Cancer Mortality
    Journal of the National Cancer Institute, sous presse, 2012 (communiqué de presse)
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    Menées à partir d'une cohorte incluant 12 315 travailleurs de mines non métalliques, ces deux études évaluent l'association entre une exposition professionnelle à des gaz d'échappement de moteurs diesel et le risque de cancer du poumon

    “Studies Show Exposure to Diesel Exhaust May Increase Lung Cancer Mortality”


Mots clés : Poumon; Etiologie (Facteurs exogènes : Exposition professionnelle)

Menée auprès de 49 884 fermiers masculins de la cohorte "Agricultural Health Study", cette étude analyse l'association entre une exposition professionnelle à des volailles et du bétail et le risque de cancer

  • Poultry and livestock exposure and cancer risk among farmers in the agricultural health study
    Cancer Causes and Control, sous presse, 2012 (résumé)
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    Menée auprès de 49 884 fermiers masculins de la cohorte "Agricultural Health Study", cette étude analyse l'association entre une exposition professionnelle à des volailles et du bétail et le risque de cancer

    “Poultry and livestock exposure and cancer risk among farmers in the agricultural health study”

    • Beane Freeman, Laura;DeRoos, Anneclaire;Koutros, Stella;Blair, Aaron;Ward, Mary;Alavanja, Michael;Hoppin, Jane

    Purpose The purpose of this study is to evaluate cancer risk associated with raising animals as commodities, which is associated with a variety of exposures, such as infectious agents and endotoxins. Methods Information was available for 49,884 male farmers in the Agricultural Health Study, who reported livestock and poultry production at enrollment (1993–1997). Cancer incidence data were obtained through annual linkage to state registries. Using Poisson regression analyses, we evaluated whether the number and type of animals raised on the farm impacted cancer risk. Results Overall, 31,848 (63.8%) male farmers reported raising any animals. Lung cancer risk decreased with increasing number of livestock on the farm ( p trend = 0.04) and with raising poultry (Relative Risk (RR) = 0.6; 95% confidence interval (CI): 0.4–0.97). Raising poultry was associated with an increased risk of colon cancer (RR = 1.4; 95% CI: 0.99–2.0) with further increased with larger flocks ( p trend = 0.02). ...


Mots clés : Cancer (général); Etiologie (Facteurs exogènes : Exposition professionnelle)

Facteurs exogènes : Environnement

A partir des données de 12 registres américains du cancer, cette étude évalue la pertinence de deux estimations du risque de gliome lié à l'usage du téléphone portable (l'étude Interphone et une étude suédoise) pour rendre compte de l'évolution de l'incidence de la maladie entre 1997 et 2008

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    A partir des données de 12 registres américains du cancer, cette étude évalue la pertinence de deux estimations du risque de gliome lié à l'usage du téléphone portable (l'étude Interphone et une étude suédoise) pour rendre compte de l'évolution de l'incidence de la maladie entre 1997 et 2008

    “Mobile phone use and glioma risk: comparison of epidemiological study results with incidence trends in the United States”

    • M P Little;P Rajaraman;R E Curtis;S S Devesa;P D Inskip;D P Check;M S Linet

    Objective In view of mobile phone exposure being classified as a possible human carcinogen by the International Agency for Research on Cancer (IARC), we determined the compatibility of two recent reports of glioma risk (forming the basis of the IARC’s classification) with observed incidence trends in the United States. Design Comparison of observed rates with projected rates of glioma incidence for 1997-2008. We estimated projected rates by combining relative risks reported in the 2010 Interphone study and a 2011 Swedish study by Hardell and colleagues with rates adjusted for age, registry, and sex; data for mobile phone use; and various latency periods. Setting US population based data for glioma incidence in 1992-2008, from 12 registries in the Surveillance, Epidemiology, and End Results (SEER) programme (Atlanta, Detroit, Los Angeles, San Francisco, San Jose-Monterey, Seattle, rural Georgia, Connecticut, Hawaii, Iowa, New Mexico, and Utah). Participants Data for 24 813 ...


Mots clés : Système nerveux central; Etiologie (Facteurs exogènes : Environnement)

Menée dans six provinces du Canada, cette étude (513 cas et 1 506 témoins) évalue l'association entre l'utilisation de produits pesticides, des maladies allergiques et le risque de lymphome non hodgkinien

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    Menée dans six provinces du Canada, cette étude (513 cas et 1 506 témoins) évalue l'association entre l'utilisation de produits pesticides, des maladies allergiques et le risque de lymphome non hodgkinien

    “Pesticide use, immunologic conditions, and risk of non-hodgkin lymphoma in Canadian men in six provinces”

    • Pahwa, Manisha;Harris, Shelley A.;Hohenadel, Karin;McLaughlin, John R.;Spinelli, John J.;Pahwa, Punam;Dosman, James A.;Blair, Aaron

    Pesticide exposures and immune suppression have been independently associated with the risk of non-Hodgkin lymphoma (NHL), but their joint effect has not been well explored. Data from a case-control study of men from six Canadian provinces were used to evaluate the potential effect modification of asthma, allergies, or asthma and allergies and hay fever combined on NHL risk from use of: (1) any pesticide; (2) any organochlorine insecticide; (3) any organophosphate insecticide; (4) any phenoxy herbicide; (5) selected individual pesticides (DDT, malathion, MCPA, mecoprop, and 2,4-D); and, (6) from the number of potentially carcinogenic pesticides. Incident NHL cases (N=513) diagnosed between 1991 and 1994 were recruited from provincial cancer registries and hospitalization records and compared to 1506 controls. A stratified analysis was conducted to calculate odds ratios (ORs) adjusted for age, province, proxy respondent, and diesel oil exposure. Subjects with asthma, allergies, or hay ...


Mots clés : Leucémie; Etiologie (Facteurs exogènes : Environnement)

Facteurs exogènes : THS et contraceptifs

A partir des données de l'essai randomisé "Women's Health Initiative" incluant 10 739 femmes ménopausées, cette étude évalue l'effet de la prise d'œstrogènes équins sur l'incidence de cancer du sein à long terme chez des patientes ayant subi une hystérectomie ainsi que sur la mortalité

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    A partir des données de l'essai randomisé "Women's Health Initiative" incluant 10 739 femmes ménopausées, cette étude évalue l'effet de la prise d'œstrogènes équins sur l'incidence de cancer du sein à long terme chez des patientes ayant subi une hystérectomie ainsi que sur la mortalité

    “Conjugated equine oestrogen and breast cancer incidence and mortality in postmenopausal women with hysterectomy: extended follow-up of the Women's Health Initiative randomised placebo-controlled trial”

    • Anderson, Garnet L.;Chlebowski, Rowan T.;Aragaki, Aaron K.;Kuller, Lewis H.;Manson, JoAnn E.;Gass, Margery;Bluhm, Elizabeth;Connelly, Stephanie;Hubbell, F. Allan;Lane, Dorothy;Martin, Lisa;Ockene, Judith;Rohan, Thomas;Schenken, Robert;Wactawski-Wende, Jean

    By contrast with many observational studies, women in the Women's Health Initiative (WHI) trial who were randomly allocated to receive oestrogen alone had a lower incidence of invasive breast cancer than did those who received placebo. We aimed to assess the influence of oestrogen use on longer term breast cancer incidence and mortality in extended follow-up of this cohort. Between 1993 and 1998, the WHI enrolled 10?739 postmenopausal women from 40 US clinical centres into a randomised, double-masked, placebo-controlled trial. Women aged 50?79 years who had undergone hysterectomy and had expected 3-year survival and mammography clearance were randomly allocated by a computerised, permuted block algorithm, stratified by age group and centre, to receive oral conjugated equine oestrogen (0·625 mg per day; n=5310) or matched placebo (n=5429). The trial intervention was terminated early on Feb 29, 2004, because of an adverse effect on stroke. Follow-up continued until planned termination ...


  • Oestrogen and breast cancer: results from the WHI trial
    The Lancet Oncology, sous presse, 2012 (commentaire)
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    A partir des données de l'essai randomisé "Women's Health Initiative" incluant 10 739 femmes ménopausées, cette étude évalue l'effet de la prise d'œstrogènes équins sur l'incidence de cancer du sein à long terme chez des patientes ayant subi une hystérectomie ainsi que sur la mortalité

    “Oestrogen and breast cancer: results from the WHI trial”

    • Howell, Anthony ; Cuzick, Jack


Mots clés : Sein; Etiologie (Facteurs exogènes : THS et contraceptifs)

Facteurs exogènes : Agents infectieux

Menée aux Etats-Unis, cette étude évalue l'association entre une infection par des variants du type 31 du papillomavirus humain et le risque de néoplasies cervicales intra-épithéliales de grade 2 à 3

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    Menée aux Etats-Unis, cette étude évalue l'association entre une infection par des variants du type 31 du papillomavirus humain et le risque de néoplasies cervicales intra-épithéliales de grade 2 à 3

    “Association of human papillomavirus type 31 variants with risk of cervical intraepithelial neoplasia grades 2-3”

    • Xi, Long Fu;Schiffman, Mark;Koutsky, Laura A.;Hulbert, Ayaka;Lee, Shu-Kuang;DeFilippis, Victor;Shen, Zhenping;Kiviat, Nancy B.

    Although the lineages of human papillomavirus type 31 (HPV31) variants are recognized, their clinical relevance is unknown. The purpose of the present study was to examine risk of cervical intraepithelial neoplasia grades 2-3 (CIN2/3) by HPV31 variants. Study subjects were women who participated in the Atypical Squamous Cells of Undetermined Significance and Low-Grade Squamous Intraepithelial Lesion Triage Study and who had HPV31 infections detected at one or more visits. They were followed semi-annually over 2 years for detection of HPV DNA and cervical lesion. HPV31 isolates were characterized by DNA sequencing and assigned into 1 of 3 variant lineages. CIN2/3 was histologically confirmed in 127 (27.0%) of the 470 HPV31-positive women, 83 diagnosed at the first HPV31-positive visit and 44 thereafter. The odds ratio for the association of 2-year cumulative risk of CIN2/3 was 1.7 (95% CI, 1.0-2.9) for infections with A variants and 2.2 (95% CI, 1.2-3.9) for infections with B variants ...


Mots clés : Col de l'utérus; Etiologie (Facteurs exogènes : Agents infectieux)

Facteurs endogènes

Menée en Allemagne, cette étude de cas incluant 2 410 patientes atteintes d'un cancer du sein évalue l'association entre la densité mammaire et l'expression des récepteurs hormonaux

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    Menée en Allemagne, cette étude de cas incluant 2 410 patientes atteintes d'un cancer du sein évalue l'association entre la densité mammaire et l'expression des récepteurs hormonaux

    “Association of mammographic density with hormone receptors in invasive breast cancers — results from a case-only study”

    • Heusinger, Katharina;Jud, Sebastian M.;Häberle, Lothar;Hack, Carolin;Adamietz, Boris R.;Meier-Meitinger, Martina;Lux, Michael P.;Wagner, Florian;Loehberg, Christian R.;Uder, Michael;Hartmann, Arndt;Schulz-Wendtland, Rüdiger;Beckmann, Matthias W.;Fasching, Peter A.

    Introduction For many breast cancer (BC) risk factors, there is growing evidence concerning molecular subtypes for which the risk factor is specific. With regard to mammographic density (MD), there are inconsistent data concerning its association with estrogen receptor (ER) and progesterone receptor (PR) expression. The aim of this study was to analyze the association between ER and PR expression and MD. Methods In this case-only study, data on BC risk factors, hormone receptor expression, and MD were available for 2410 patients with incident BC. MD was assessed as percent mammographic density (PMD) using a semiautomated method by two readers for every patient. The association of ER/PR and PMD was studied with multifactorial analyses of covariance (ANCOVA) with PMD as the target variable and including well-known factors that are also associated with MD, such as age, parity, use of hormone replacement therapy, and body mass index (BMI). Results In addition to the commonly known ...


Mots clés : Sein; Etiologie (Facteurs endogènes)

A partir des données portant sur 1 034 patientes, cette étude analyse les différents facteurs de risque de cancer du sein par sous-type dans 3 groupes ethniques distincts de l'Asie du sud-est

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    A partir des données portant sur 1 034 patientes, cette étude analyse les différents facteurs de risque de cancer du sein par sous-type dans 3 groupes ethniques distincts de l'Asie du sud-est

    “Incidence and risk factors for breast cancer subtypes in three distinct South-East Asian ethnic groups: Chinese, Malay and natives of Sarawak, Malaysia”

    • Devi, C. R. Beena;Tang, Tieng Swee;Corbex, Marilys

    Introduction: We determined the incidences of the ER, PR and HER2 subtypes among breast cancer cases in Sarawak, Malaysia, and their correlation with various risk factors in the three ethnic groups: Chinese, Malay and native. Methods: Subtype status was ascertained for 1034 cases of female breast cancer (93% of all cases diagnosed since 2003), and the age-standardized incidence rates (ASRs) of each subtype were inferred. Case–case comparisons across subtypes were performed for reproductive risk factors. Results: We found 48% luminal A (ER+/PR+/HER2–), 29% triple-negative (ER–/PR–/HER2–), 12% triple-positive (ER+/PR+/HER2+) and 11% HER2-overexpressing (ER–/PR–/HER2+) subtypes, with ASRs of 10.6, 6.0, 2.8, 2.8 per 100 000, respectively. The proportions of subtypes and ASRs differed significantly by ethnic group: HER2-positive cases were more frequent in Malays (29%; 95% CI [23;35]) than Chinese (22%; [19;26] and natives (21%; [16;26]); triple-negative cases were less ...


Mots clés : Sein; Etiologie (Facteurs endogènes)

Menée à la Barbade, cette étude (963 cas et 941 témoins) évalue l'association entre l'adiposité centrale et le risque de cancer de la prostate dans une population noire

  • Central Adiposity and Prostate Cancer in a Black Population
    Cancer Epidemiology Biomarkers & Prevention, sous presse, 2012 (résumé)
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    Menée à la Barbade, cette étude (963 cas et 941 témoins) évalue l'association entre l'adiposité centrale et le risque de cancer de la prostate dans une population noire

    “Central Adiposity and Prostate Cancer in a Black Population”

    • Nemesure, Barbara;Wu, Suh-Yuh;Hennis, Anselm;Leske, M. Cristina

    Background: The relationship between central adiposity and prostate cancer remains unclear. Methods: This report includes 963 newly diagnosed cases of histologically-confirmed prostate cancer and 941 randomly selected controls ascertained from the population-based Prostate Cancer in a Black Population study conducted between July, 2002 and January, 2011 in Barbados, West Indies. Trained nurse-interviewers obtained data on height, weight, waist and hip circumferences, family and medical history, and lifestyle factors. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess associations between anthropometric measures and prostate cancer. Results: A two-fold increased risk of prostate cancer was found among men in the highest quartile of waist-hip ratio compared to those in the lowest quartile (OR=2.11, 95% CI (1.54, 2.88)). Similarly, men with the largest waist circumferences had an OR of 1.84 (95% CI (1.19, 2.85)) compared to those with the smallest waist sizes. Neither ...


Mots clés : Prostate; Etiologie (Facteurs endogènes)

A partir d'une revue systématique de la littérature (22 études, 3 852 cas et 5 604 témoins), cette méta-analyse évalue l'association entre des polymorphismes du gène UGT1A7 et le risque de cancer

  • The association between UGT1A7 polymorphism and cancer risk: A meta-analysis
    Cancer Epidemiology, sous presse, 2012 (résumé)
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    A partir d'une revue systématique de la littérature (22 études, 3 852 cas et 5 604 témoins), cette méta-analyse évalue l'association entre des polymorphismes du gène UGT1A7 et le risque de cancer

    “The association between UGT1A7 polymorphism and cancer risk: A meta-analysis”

    • Han, Shuang-Xi;Wang, Li;Wu, De-Quan

    Background: studies investigating the associations between UDP-glucuronosyltransferase 1A7 (UGT1A7) gene polymorphisms and various carcinomas risk reported conflicting results. To derive a more precise estimation of the association, we have conducted a meta-analysis. Methods: data were collected from the following electronic databases: PubMed, Medline and Chinese Biomedical Literature Database, with the last report up to September 2011. Case–control studies containing available genotype frequencies of UGT1A7 were chose. The odds ratio (OR) and its 95% confidence interval (95%CI) were used to assess the strength of association. Results: a total of 22 separate case–control studies including 3852 cases and 5604 controls based on the search criteria were involved in this meta-analysis. The combined results based on all studies showed that there was a statistically significant link between UGT1A7*3 allele and cancer risk (OR = 1.31, 95%CI = 1.14–1.50, ...


Mots clés : Cancer (général); Etiologie (Facteurs endogènes)

Interactions gènes-environnement

Cette étude (393 cas et 359 témoins) analyse l'association entre des polymorphismes du gène DR4, une infection par le virus de l'hépatite C et le risque de carcinome hépatocellulaire

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    Cette étude (393 cas et 359 témoins) analyse l'association entre des polymorphismes du gène DR4, une infection par le virus de l'hépatite C et le risque de carcinome hépatocellulaire

    “TRAIL receptor I (DR4) polymorphisms C626G und A638C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients”

    • Korner, Christian;Riesner, Katarina;Kramer, Benjamin;Eisenhardt, Marianne;Glassner, Andreas;Wolter, Franziska;Berg, Thomas;Muller, Tobias;Sauerbruch, Tilman;Nattermann, Jacob;Spengler, Ulrich;Nischalke, Hans Dieter

    BACKGROUND:Tumour surveillance via induction of TRAIL-mediated apoptosis is a key mechanism, how the immune system prevents malignancy. To determine if gene variants in the TRAIL receptor I (DR4) gene affect the risk of hepatitis C virus-(HCV)-induced liver cancer (HCC), we analysed DR4 mutations C626G (rs20575) and A683C (rs20576) in HCV-infected patients with and without HCC.METHODS:Frequencies of DR4 gene polymorphisms were determined by LightSNiP assays in 159 and 234 HCV-infected patients with HCC and without HCC, respectively. 359 healthy controls served as reference population.RESULTS:Distribution of C626G and A683C genotypes were not significantly different between healthy controls and HCV-positive patients without HCC. DR4 variants 626 C and 683A occurred at increased frequencies in patients with HCC. The risk of HCC was linked to carriage of the 626 C allele and the homozygous 683AA genotype, and the simultaneous presence of the two risk variants was confirmed as independent ...


Mots clés : Foie; Etiologie (Interactions gènes-environnement)

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