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Accueil Nota Bene Cancer V2 Numéro 126 du 06 Mars 2012 Prévention

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Nota Bene Cancer Numéro 126 du 06 Mars 2012 RSS

Prévention

Comportements individuels

Menée aux Etats-Unis auprès d'un échantillon d'une population âgée de 50 à 75 ans, cette étude évalue l'impact d'un indice de masse corporelle élévé ou d'obésité sur les comportements de dépistage du cancer colorectal

  • Body mass index and screening for colorectal cancer: Gender and attitudinal factors
    Cancer Epidemiology, sous presse, 2012 (résumé)
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    Menée aux Etats-Unis auprès d'un échantillon d'une population âgée de 50 à 75 ans, cette étude évalue l'impact d'un indice de masse corporelle élévé ou d'obésité sur les comportements de dépistage du cancer colorectal

    “Body mass index and screening for colorectal cancer: Gender and attitudinal factors”

    • Messina, Catherine R.;Lane, Dorothy S.;Anderson, Joseph C.

    Background: Overweight/obese women and men are at increased risk for colorectal cancer (CRC) incidence and mortality. Research examining body mass index (BMI) and CRC screening has had mixed results. A clearer understanding of the extent to which high-BMI subgroups are screened for CRC is needed to inform planning for CRC screening promotions targeting BMI. Methods: Data were obtained from a random, population-based sample of women and men at average-risk for CRC (aged 50–75 years) during 2004 (n = 1098). Multiple logistic regression analyses were conducted to evaluate whether BMI category was significantly associated with the probability of reporting recent CRC screening and with the probability of agreeing with statements denoting attitudes/perceptions about CRC and screening. Attitudes/perceptions about CRC and screening were evaluated as potential mediators and moderators of the association between BMI category and CRC screening. Results: After controlling for ...


Mots clés : Colon-rectum; Prévention (Comportements individuels)

Nutrition et prévention

Menée sur 69 635 participants (durée moyenne de suivi : 5,84 ans), cette étude de cohorte prospective évalue l'association entre la consommation de vitamine A ou de caroténoïdes et le risque de mélanome

  • Association of Vitamin A and Carotenoid Intake with Melanoma Risk in a Large Prospective Cohort
    Journal of Investigative Dermatology, sous presse, 2012 (résumé)
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    Menée sur 69 635 participants (durée moyenne de suivi : 5,84 ans), cette étude de cohorte prospective évalue l'association entre la consommation de vitamine A ou de caroténoïdes et le risque de mélanome

    “Association of Vitamin A and Carotenoid Intake with Melanoma Risk in a Large Prospective Cohort”

    • Asgari, Maryam M.;Brasky, Theodore M.;White, Emily

    Laboratory data suggest that intake of vitamin A and carotenoids may have chemopreventive benefits against melanoma, but epidemiological studies examining the association have yielded conflicting results. We examined whether dietary and supplemental vitamin A and carotenoid intake was associated with melanoma risk among 69,635 men and women who were participants of the VITamins And Lifestyle (VITAL) cohort study in western Washington. After an average of 5.84 years of follow-up, 566 incident melanomas were identified. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of melanoma associated with dietary, supplemental, and total vitamin A and carotenoid intake after adjusting for melanoma risk factors. Baseline use of individual retinol supplements was associated with a significant reduction in melanoma risk (HR: 0.60; 95% CI: 0.41–0.89). High-dose (>1,200  μg per day) supplemental retinol was also ...


Mots clés : Mélanome; Prévention (Nutrition et prévention)

Chimioprévention

Cet article passe en revue les études concernant les effets chimiopréventifs de phytosubstances sur la carcinogenèse de la cavité buccale induite par des dérivés réactifs de l'oxygène

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    Cet article passe en revue les études concernant les effets chimiopréventifs de phytosubstances sur la carcinogenèse de la cavité buccale induite par des dérivés réactifs de l'oxygène

    “Pleiotrophic effects of natural products in ROS-induced carcinogenesis: The role of plant-derived natural products in oral cancer chemoprevention”

    • Ziech, D.;Anestopoulos, I.;Hanafi, R.;Voulgaridou, G. P.;Franco, R.;Georgakilas, A. G.;Pappa, A.;Panayiotidis, M. I.

    Cancer is a multistage process where each stage involves different molecular, biochemical and cellular events all of which, however, contribute to malignant transformation. Over the last years, substantial scientific evidence has promoted the hypothesis that ROS-induced cellular damage underlies key steps during development of the malignant phenotype including evasion of apoptosis, limitless proliferation, angiogenesis, tissue invasion and metastasis etc. On the other hand, natural products hold great promise as anti-cancer compounds in preventing against carcinogenesis both in vitro and in vivo. Throughout this article, we aim to review the evidence as to how some of these natural products exert their chemopreventive effects in human carcinogenesis. For this reason, we have placed particular emphasis on oral cancer where significant efforts have been made in alternative therapeutic strategies such as the use of plant-derived natural products. This is of paramount importance given the ...


Mots clés : Voies aérodigestives supérieures; Prévention (Chimioprévention)

Menée sur un modèle murin de carcinogenèse du sein, cette étude montre que les tocophérols d'origine alimentaire (vitamine E) inhibent la prolifération cellulaire, régulent l'expression de ERα, PPARγ, et Nrf2 et induisent une diminution du niveau sérique des biomarqueurs de l'inflammation durant le développement d'une hyperplasie mammaire

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    Menée sur un modèle murin de carcinogenèse du sein, cette étude montre que les tocophérols d'origine alimentaire (vitamine E) inhibent la prolifération cellulaire, régulent l'expression de ERα, PPARγ, et Nrf2 et induisent une diminution du niveau sérique des biomarqueurs de l'inflammation durant le développement d'une hyperplasie mammaire

    “Dietary tocopherols inhibit cell proliferation, regulate expression of ERα, PPARγ, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia”

    • Smolarek, Amanda K.;So, Jae Young;Thomas, Paul E.;Lee, Hong Jin;Paul, Shiby;Dombrowski, Anne;Wang, Chung-Xiou;Saw, Constance Lay-Lay;Khor, Tin Oo;Kong, Ah-Ng Tony;Reuhl, Kenneth;Lee, Mao-Jung;Yang, Chung S.;Suh, Nanjoo

    Previous clinical and epidemiological studies of vitamin E have used primarily α-tocopherol for the prevention of cancer. However, γ-tocopherol has demonstrated greater anti-inflammatory and anti-tumor activity than α-tocopherol in several animal models of cancer. This study assessed the potential chemopreventive activities of a tocopherol mixture containing 58% γ-tocopherol (γ-TmT) in an established rodent model of mammary carcinogenesis. Female ACI rats were utilized due to their sensitivity to 17β-estradiol (E2) to induce mammary hyperplasia and neoplasia. The rats were implanted subcutaneously with sustained release E2 pellets and given dietary 0.3% or 0.5% γ-TmT for 2 or 10 wk. Serum E2 levels were significantly reduced by the treatment with 0.5% γ-TmT. Serum levels of inflammatory markers, prostaglandin E2 and 8-isoprostane, were suppressed by γ-TmT treatment. Histology of mammary glands showed evidence of epithelial hyperplasia in E2-treated rats. Immunohistochemical ...


Mots clés : Sein; Prévention (Chimioprévention)

Cet article passe en revue les études concernant l'utilisation de l'exémestane dans la chimioprévention du cancer du sein

  • Exemestane in the prevention setting
    Therapeutic Advances in Medical Oncology, sous presse, 2012 (résumé)
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    Cet article passe en revue les études concernant l'utilisation de l'exémestane dans la chimioprévention du cancer du sein

    “Exemestane in the prevention setting”

    • Keating Litton, Jennifer;Bevers, Therese B.;Arun, Banu K.

    Aromatase inhibitors are well-established therapies in the neoadjuvant, adjuvant and metastatic settings for breast cancer. In adjuvant trials, this class of drugs has shown preventative properties by decreasing the rate of contralateral breast cancer. Recently, the National Cancer Institute of Canada Clinical Trials Group MAP.3 study evaluated exemestane as a breast cancer prevention agent for women with specified higher risks of developing breast cancer. We review the history of exemestane and evaluate the available evidence of its use for breast cancer prevention.


Mots clés : Sein; Prévention (Chimioprévention)

Menée sur des lignées cellulaires de cancer du poumon, cette étude montre que la tanshinone I, une phytosubstance extraite de la plante chinoise Salvia miltiorrhiza, inhibe la croissance des cellules tumorales en partie par l'intermédiaire d'une régulation négative de la protéine kinase Aurora A

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    Menée sur des lignées cellulaires de cancer du poumon, cette étude montre que la tanshinone I, une phytosubstance extraite de la plante chinoise Salvia miltiorrhiza, inhibe la croissance des cellules tumorales en partie par l'intermédiaire d'une régulation négative de la protéine kinase Aurora A

    “Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function”

    • Li, Yanli;Gong, Yi;Li, Linglin;Abdolmaleky, Hamid M.;Zhou, Jin-Rong

    Lung cancer is the leading cause of cancer death in the world, and the searching for novel efficacious and safe agents for lung cancer prevention remains the top priority of lung cancer research. In the present study, we evaluated the effect of bioactive tanshinones from a Chinese herb Salvia miltiorrhiza, cryptotanshinone (CT), tanshinone I (T1) and tanshinone IIA (T2A), on the proliferation inhibition of lung cancer cell lines. Tanshinones inhibited the lung cancer cell proliferation in vitro, with T1 the most potent, via cell cycle arrest and apoptosis induction. Gene function assay showed that Aurora A knockdown by siRNA dramatically eliminated the T1 activity in vitro, suggesting that Aurora A is an important functional target for T1. We further evaluated the effectiveness of T1 on the growth of H1299 nonsmall lung cancer cell in a mouse model. Tanshinone I inhibited the growth of H1299 lung tumor in a dose-dependent manner. Tanshinone I at 200 mg/kg body weight significantly ...


Mots clés : Poumon; Prévention (Chimioprévention)

Cet article passe en revue les études concernant les effets chimiopréventifs de composés alimentaires sur la carcinogenèse de la peau et fait le point sur les mécanismes immunologiques impliqués et les perspectives thérapeutiques offertes par ces molécules

  • Invited Review Dietary Agents in Cancer Prevention: an Immunological Perspective(dagger)
    Photochemistry and photobiology, sous presse, 2012 (résumé)
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    Cet article passe en revue les études concernant les effets chimiopréventifs de composés alimentaires sur la carcinogenèse de la peau et fait le point sur les mécanismes immunologiques impliqués et les perspectives thérapeutiques offertes par ces molécules

    “Invited Review Dietary Agents in Cancer Prevention: an Immunological Perspective(dagger)”

    • Zheng, Y. Y.;Viswanathan, B.;Kesarwani, P.;Mehrotra, S.

    Skin cancer is the most common form of cancer diagnosed in the United States. Exposure to solar ultraviolet (UV) radiations is believed to be the primary cause for skin cancer. Excessive UV radiation can lead to genetic mutations and damage in the skin's cellular DNA that in turn can lead to skin cancer. Lately, chemoprevention by administering naturally occurring non-toxic dietary compounds has proven to be a potential strategy to prevent the occurrence of tumors. Attention has been drawn towards several natural dietary agents such as resveratrol, one of the major components found in grapes, red wines, berries and peanuts, proanthocyanidins from grape seeds, (-)-epigallocatechin-3-gallate (EGCG) from green tea etc. However, the effect these dietary agents have on the immune system and the immunological mechanisms involved there in are still being explored. In this review we shall focus on the role of key chemopreventive agents on various immune cells and discuss their potential as ...


Mots clés : Peau (hors mélanome); Prévention (Chimioprévention)

Ressources et infrastructures (Prévention)

A partir des données de l'étude "Partnership for Health-2" collectées entre 2005 et 2008, cette étude analyse les modalités d'utilisation d'internet chez les jeunes adultes atteints d'un cancer ou ayant développé la maladie durant l'enfance afin d'étudier l'intérêt d'un programme de sevrage tabagique en ligne

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    A partir des données de l'étude "Partnership for Health-2" collectées entre 2005 et 2008, cette étude analyse les modalités d'utilisation d'internet chez les jeunes adultes atteints d'un cancer ou ayant développé la maladie durant l'enfance afin d'étudier l'intérêt d'un programme de sevrage tabagique en ligne

    “Internet use among childhood and young adult cancer survivors who smoke : implications for cessation interventions”

    • Nagler, Rebekah;Puleo, Elaine;Sprunck-Harrild, Kim;Emmons, Karen

    Objective To identify patterns of Internet use among childhood and young adult cancer survivors who smoke. Methods Baseline assessment data were collected from 2005 to 2008 for the Partnership for Health-2 (PFH-2) study, a web-based smoking cessation intervention for childhood and young adult cancer survivors. Participants were surveyed about their Internet access and use. Sociodemographic, clinical, and psychosocial data also were collected. Results Internet access and use was widespread among PFH-2 participants. However, older, less-educated, and female survivors reported less frequent Internet use, even when they had access to the Internet at home and/or at work. These associations were significant in multivariable analyses. Conclusions Although the digital divide is narrowing, Internet use and engagement remains socially patterned. web-based prevention interventions are a promising method of reaching this geographically dispersed, high-risk population, but certain ...


Mots clés : Poumon; Prévention (Ressources et infrastructures (Prévention))

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