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Accueil Nota Bene Cancer V2 Numéro 126 du 06 Mars 2012 Lutte contre les cancers

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Nota Bene Cancer Numéro 126 du 06 Mars 2012 RSS

Lutte contre les cancers

Qualité de vie, soins de support

A partir de données portant sur 76 600 patients atteints d'un cancer de la prostate, cette étude suédoise analyse l'incidence de fractures osseuses induites par une hormonothérapie

  • Incidence of fractures causing hospitalisation in prostate cancer patients: Results from the population-based PCBaSe Sweden
    European journal of cancer (Oxford, England : 1990), sous presse, 2012 (résumé)
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    A partir de données portant sur 76 600 patients atteints d'un cancer de la prostate, cette étude suédoise analyse l'incidence de fractures osseuses induites par une hormonothérapie

    “Incidence of fractures causing hospitalisation in prostate cancer patients: Results from the population-based PCBaSe Sweden”

    • Thorstenson, Andreas;Bratt, Ola;Akre, Olof;Hellborg, Henrik;Holmberg, Lars;Lambe, Mats;Bill-Axelson, Anna;Stattin, Pär;Adolfsson, Jan

    Background: Prostate cancer patients have an increased risk of fractures as a consequence of skeletal metastases and osteoporosis induced by endocrine treatment. Data on incidence of fractures and risks in subgroups of men with prostate cancer are sparse. Our aim with this study is to report the risk of fractures among men with prostate cancer in a nationwide population-based study. Patients and methods: We identified 76,600 Swedish men diagnosed with prostate cancer 1997–2006 in the Prostate Cancer Data Base (PCBaSe) Sweden and compared the occurrence of fractures requiring hospitalisation with the Swedish male population. Results: Only men treated with gonadotropin releasing-hormone (GnRH) agonists or orchiectomy had increased incidence and increased relative risk of fractures requiring hospitalisation. Men treated with GnRH agonists had 9.8 and 6.3/1000 person-years higher incidence of any fracture and hip fracture requiring hospitalisation than the general population. The ...


Mots clés : Prostate; Lutte contre les cancers (Qualité de vie, soins de support)

Menée au Canada auprès de participants âgés de plus de 65 ans, cette étude de cohorte transversale analyse les prescriptions d'opioïdes pour gérer la douleur de patients atteints d'un cancer et traités en ambulatoire

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    Menée au Canada auprès de participants âgés de plus de 65 ans, cette étude de cohorte transversale analyse les prescriptions d'opioïdes pour gérer la douleur de patients atteints d'un cancer et traités en ambulatoire

    “Opioid Prescription After Pain Assessment: A Population-Based Cohort of Elderly Patients With Cancer”

    • Barbera, Lisa;Seow, Hsien;Husain, Amna;Howell, Doris;Atzema, Clare;Sutradhar, Rinku;Earle, Craig;Sussman, Jonathan;Liu, Ying;Dudgeon, Deborah

    Purpose The purpose of this study was to measure opioid prescription (OP) rates in elderly cancer outpatients around the time of assessment for pain and to evaluate factors associated with receiving OPs for those with severe pain.Patients and Methods The cross-sectional cohort includes all patients with cancer in Ontario older than age 65 years who completed a pain assessment as part of a provincial initiative of systematic symptom screening. Patients were assigned to mutually exclusive categories by pain score severity: 0, 1 to 3 (mild), 4 to 6 (moderate), and 7 to 10 (severe). We linked multiple provincial health databases to examine the proportion of patients with an OP within 7 days after or 30 days before the assessment date. We examined factors associated with OPs for patients with pain scores of 7 to 10.Results The proportion of patients with an OP increased as pain score severity increased: 10% of those with no pain, 24% of those with mild pain, 45% of those with moderate ...


Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

Observation

Menée en Chine sur la période 1999-2008, cette étude transversale analyse la typologie des cancers du sein et les caractéristiques de 4 211 patientes traitées en hôpital

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    Menée en Chine sur la période 1999-2008, cette étude transversale analyse la typologie des cancers du sein et les caractéristiques de 4 211 patientes traitées en hôpital

    “The pathologic characteristics of breast cancer in China and its shift during 1999-2008: A national-wide multicenter cross-sectional image over 10 years”

    • Zheng, Shan;Bai, Jing-Qiao;Li, Jing;Fan, Jin-Hu;Pang, Yi;Song, Qing-Kun;Huang, Rong;Yang, Hong-Jian;Xu, Feng;Lu, Ning;Qiao, You-Lin

    In China, breast cancer is currently the most common malignancy and the sixth leading cause of cancer death in women. But the characteristics of breast cancer in the whole population are not determined. The aim of this study was to perform a detailed study on pathologic characteristics of breast cancer representing the whole population in China during 1999 to 2008 and to compare the difference in invasive breast cancer between the Western and Chinese. We randomly collected 4211 inpatient at seven hospitals in representative geographical regions of China during 1999 to 2008. All the hospitals had the ability of comprehensive cancer treatment. The pathologic characters including ER, PR and HER2 status were surveyed. The shift of pathologic characters was evaluated and the data from China were also compared with those of the Western, both using Chi-square test. We found as follow. (i) The median age of the patients was 48 years and showed the similar characters of Asia. (ii) Breast ...


Mots clés : Sein; Lutte contre les cancers (Observation)

A partir des données du registre néerlandais du cancer entre 1989 et 2009, cette étude analyse l'évolution de l'incidence du cancer du rein, des traitements, de la survie relative et de la mortalité

  • Modest improvement in 20 years of kidney cancer care in the Netherlands
    European journal of cancer (Oxford, England : 1990), sous presse, 2012 (résumé)
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    A partir des données du registre néerlandais du cancer entre 1989 et 2009, cette étude analyse l'évolution de l'incidence du cancer du rein, des traitements, de la survie relative et de la mortalité

    “Modest improvement in 20 years of kidney cancer care in the Netherlands”

    • van de Schans, Saskia A. M.;Aben, Katja K. H.;Mulders, Peter F. A.;Haanen, John B. A. G.;van Herpen, Carla;Verhoeven, Rob H. A.;Karim-Kos, Henrike E.;Oosterwijk, Egbert;Kiemeney, Lambertus A. L. M.

    For an evaluation of the progress achieved in the field of kidney cancer care in the Netherlands in the last decades, we described trends in incidence, treatment, mortality and relative survival. All adult patients newly diagnosed with kidney cancer between 1989 and 2009 (N=32,545) were selected from the Netherlands Cancer Registry. Age-standardised incidence and mortality rates were calculated. Follow-up was completed until January 2010. In order to assess trends estimated annual percentages of change (EAPC) were estimated. The incidence of kidney cancer has been fairly stable between 1989 and 2001 with a European Standardised Rate of approximately 11 per 100,000 person years (PY). Since 2001 the incidence increased to 13 per 100,000 PY in 2009 (EAPC: 2.4%; 95%confidence interval (CI): 1.5 to 3.4%). The mortality rate decreased slightly over time, from 6.2 per 100,000 PY in 1989 to 5.6 in 2010. No changes in treatment were observed, except for the introduction of targeted therapies ...


Mots clés : Rein; Lutte contre les cancers (Observation)

Menée en Australie auprès de 301 patients atteints d'un carcinome épidermoïde de l'œsophage, cette étude analyse l'impact de facteurs démographiques et comportementaux (tels que tabagisme et consommation d'alcool) sur la survie des patients

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    Menée en Australie auprès de 301 patients atteints d'un carcinome épidermoïde de l'œsophage, cette étude analyse l'impact de facteurs démographiques et comportementaux (tels que tabagisme et consommation d'alcool) sur la survie des patients

    “The influence of prediagnostic demographic and lifestyle factors on esophageal squamous cell carcinoma survival”

    • Thrift, Aaron P.;Nagle, Christina M.;Fahey, Paul P.;Russell, Anne;Smithers, Bernard M.;Watson, David I.;Whiteman, David C.;for the Australian Cancer Study Clinical Follow-Up, Study

    Demographic and lifestyle factors, in particular tobacco smoking and alcohol, are well established causes of esophageal squamous cell carcinoma (ESCC); however, little is known about the effect of these factors on survival. We included all 301 patients with incident ESCC, recruited into a population-based case–control study of esophageal cancer in Australia. Detailed information about demographic and lifestyle factors was obtained at diagnosis, and deaths were identified using the National Death Index. Median follow-up for all-cause mortality was 6.4 years. Hazard ratios (HRs) and 95% confidence intervals (95% CI) were calculated from Cox proportional hazards models, adjusted for age, sex, pretreatment AJCC tumor stage, treatment and presence of comorbidities. Two hundred and thirteen patients (71%) died during follow-up. High lifetime alcohol consumption was independently associated with poor survival. Relative to life-long nondrinkers and those consuming <1 drink/week, the HRs for ...


Mots clés : Oesophage; Lutte contre les cancers (Observation)

Ce rapport de l'Institut national de veille sanitaire présente l'évolution de l’incidence du mélanome cutané infiltrant en France sur la période 1998-2005

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    Ce rapport de l'Institut national de veille sanitaire présente l'évolution de l’incidence du mélanome cutané infiltrant en France sur la période 1998-2005

    “Mélanome cutané infiltrant en France : évolution de l’incidence en fonction des facteurs histopronostiques sur la période 1998-2005 ”

    • Binder-Foucard F;Coutard L;Belot A;Danzon A;Guizard A-V;et le réseau français des registres de cancer, Francim

    Contexte : en 2005, l’incidence du mélanome cutané se situe au 9e rang des cancers en France. En augmentation depuis 1980, son incidence connaît toutefois un ralentissement après 2000. Selon des études internationales, cette variation d’incidence n’affecte pas de la même manière les différents types histologiques de mélanomes. Objectifs : décrire à partir des données de registres de cancer français, l’évolution de 1998 à 2005 de l’incidence des mélanomes cutanés infiltrants (mélanomes invasifs) selon la forme anatomo-clinique et l’indice de Breslow (i.e. épaisseur de la tumeur). Méthode : les cas incidents de mélanomes cutanés invasifs (MCI) ont été identifiés par 11 registres généraux de cancer métropolitains du réseau Francim. Les cas correspondaient aux codes topographiques C44 et histologiques 8 720 à 8 780 (comportement /3) de la Classification internationale des maladies appliquée à l’oncologie – 3e édition (CIM-O-3). Les taux ...


Mots clés : Mélanome; Lutte contre les cancers (Observation)

A partir des données de 89 registres européens des cancers entre 1978 et 2002, cette étude analyse l'incidence et la prévalence des tumeurs endocrines, ainsi que la survie des patients

  • Carcinoma of endocrine organs: Results of the RARECARE project
    European journal of cancer (Oxford, England : 1990), sous presse, 2012 (résumé)
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    A partir des données de 89 registres européens des cancers entre 1978 et 2002, cette étude analyse l'incidence et la prévalence des tumeurs endocrines, ainsi que la survie des patients

    “Carcinoma of endocrine organs: Results of the RARECARE project”

    • van der Zwan, Jan Maarten;Mallone, Sandra;van Dijk, Boukje;Bielska-Lasota, Magdalena;Otter, Renée;Foschi, Roberto;Baudin, Eric;Links, Thera P.

    The rarity or the asymptomatic character of endocrine tumours results in a lack of epidemiological studies on their incidence and survival patterns. The aim of this study was to describe the incidence, prevalence and survival of endocrine tumours using a large database, which includes cancer patients diagnosed from 1978 to 2002, registered in 89 population-based cancer registries (CRs) with follow-up until 31st December 2003. These data give an unique overview of the burden of endocrine carcinomas in Europe. A list of tumour entities based on the third International Classification of Diseases for Oncology was provided by the project Surveillance of rare cancer in Europe (RARECARE) project. Over 33,594 cases of endocrine carcinomas were analysed in this study. Incidence rates increased with age and were highest in patients 65 years of age or older. In 2003, more than 315,000 persons in the EU (27 countries) were alive with a past diagnosis of a carcinoma of endocrine organs. The ...


Mots clés : Glande endocrine (autre); Lutte contre les cancers (Observation)

A partir des données du registre californien des cancers entre 1998 et 2002, cette étude analyse les caractéristiques de l'incidence du cancer de l'estomac dans la population hispanique

  • Gastric cancer incidence among Hispanics in California: patterns by time, nativity, and neighborhood characteristics
    Cancer Epidemiology Biomarkers & Prevention, sous presse, 2012 (résumé)
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    A partir des données du registre californien des cancers entre 1998 et 2002, cette étude analyse les caractéristiques de l'incidence du cancer de l'estomac dans la population hispanique

    “Gastric cancer incidence among Hispanics in California: patterns by time, nativity, and neighborhood characteristics”

    • Chang, Ellen T.;Gomez, Scarlett L.;Fish, Kari;Schupp, Clayton W.;Parsonnet, Julie;DeRouen, Mindy C.;Keegan, Theresa H.M.;Clarke, Christina A.;Glaser, Sally

    Background: Better understanding about gastric cancer incidence patterns among Hispanics by birthplace, socioeconomic status (SES) and acculturation can improve preventive strategies and disease models. Methods: Incidence rates, rate ratios, and estimated annual percent change (EAPC) in rates of anatomic and histologic subtype-specific gastric cancer were calculated by age, sex, and nativity among Hispanics using California Cancer Registry data from 1988 through 2004. Incidence rates in 1998-2002 were compared by neighborhood SES and Hispanic enclave status according to 2000 US Census data. Results: Incidence rates of diffuse gastric cancer increased from 1988 through 2004 among foreign-born Hispanic men (EAPC: 3.5%, 95% CI: 1.5%-5.5%) and US-born Hispanic women (EAPC: 3.0%, 95% CI: 0.7%-5.3%). During the same time period, incidence rates of intestinal gastric cancer declined significantly and both cardia and non-cardia gastric cancer were steady or declined among foreign-born and ...


Mots clés : Estomac; Lutte contre les cancers (Observation)

Menée dans une région espagnole entre 1990 et 2005, cette étude analyse les disparités spatio-temporelles dans l'évolution de l'incidence du cancer colorectal chez les femmes et les hommes

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    Menée dans une région espagnole entre 1990 et 2005, cette étude analyse les disparités spatio-temporelles dans l'évolution de l'incidence du cancer colorectal chez les femmes et les hommes

    “Gender-specific spatio-temporal patterns of colorectal cancer incidence in Navarre, Spain (1990–2005)”

    • Ugarte, M. D.;Etxeberria, J.;Goicoa, T.;Ardanaz, E.

    Introduction: In the last ten to twenty years, a stabilization or decline in colorectal cancer (CRC) incidence has been observed in some countries across the world but not in Spain. Our objective here is to assess the gender-specific CRC spatio-temporal pattern in the health areas of Navarre, a Spanish province, during the period 1990–2005. Methods: For each gender, a model with spatio-temporal CAR (Conditional Autoregressive) distributions is used for smoothing the incidence risks. Smoothing is carried out in two dimensions: space and time, allowing for a different time evolution in each health area. An estimated incidence trend curve for each health area and the corresponding confidence bands are obtained. To analyze the evolution of the geographical patterns of CRC incidence risks, maps are also provided. Results: In both genders, CRC shows an increasing trend in most of the areas. In the second half of the period 1998–2005 most of the areas have risks above one although not ...


Mots clés : Colon-rectum; Lutte contre les cancers (Observation)

Cette étude observationnelle britannique évalue l'impact d'une maladie héréditaire monogénique, telle qu'une neurofibromatose ou une polypose recto-colique familiale, sur le developpement de tumeurs malignes et la survie des patients

  • Life expectancy in hereditary cancer predisposing diseases: an observational study
    Journal of Medical Genetics, sous presse, 2012 (résumé)
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    Cette étude observationnelle britannique évalue l'impact d'une maladie héréditaire monogénique, telle qu'une neurofibromatose ou une polypose recto-colique familiale, sur le developpement de tumeurs malignes et la survie des patients

    “Life expectancy in hereditary cancer predisposing diseases: an observational study”

    • Wilding, Anna;Ingham, Sarah Louise;Lalloo, Fiona;Clancy, Tara;Huson, Susan M;Moran, Anthony;Evans, D Gareth

    Background Neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), familial adenomatous polyposis (FAP), von Hippel-Lindau syndrome (VHL), and Gorlin syndrome (GS) are single gene diseases that predispose to early onset tumours. Few studies have assessed the effect of these diseases on life expectancy. This study's aim was to assess this effect, and to test the hypothesis that genetic registers increase survival.Method NF1, NF2, VHL, FAP, and GS patients were identified through the North West Regional Genetic Register Service and the North West Cancer Intelligence Service. Information on benign and malignant tumours, and deaths were obtained. Kaplan–Meier curves were used to show actuarial survival rates for each disease, compared to the local population, and in patients diagnosed pre/post the regional genetic register. Log rank (Mantel–Cox) tests were used to compare survival between groups.Results Life expectancies were significantly reduced for all diseases investigated compared ...


Mots clés : Cancer (général); Lutte contre les cancers (Observation)

A partir des données de l'Organisation mondiale de la santé, cette étude présente une estimation de la mortalité par cancer dans l'Union européenne pour l'année 2012

  • European cancer mortality predictions for the year 2012
    Annals of Oncology, sous presse, 2012 (résumé)
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    A partir des données de l'Organisation mondiale de la santé, cette étude présente une estimation de la mortalité par cancer dans l'Union européenne pour l'année 2012

    “European cancer mortality predictions for the year 2012”

    • Malvezzi, M.;Bertuccio, P.;Levi, F.;La Vecchia, C.;Negri, E.

    Background: Estimating current cancer mortality figures is important for defining priorities for prevention and treatment.Materials and methods: Using logarithmic Poisson count data joinpoint models on mortality and population data from the World Health Organization database, we estimated numbers of deaths and age-standardized rates in 2012 from all cancers and selected cancer sites for the whole European Union (EU) and its six more populated countries.Results: Cancer deaths in the EU in 2012 are estimated to be 1 283 101 (717 398 men and 565 703 women) corresponding to standardized overall cancer death rates of 139/100 000 men and 85/100 000 women. The fall from 2007 was 10% in men and 7% in women. In men, declines are predicted for stomach (−20%), leukemias (−11%), lung and prostate (−10%) and colorectal (−7%) cancers, and for stomach (−23%), leukemias (−12%), uterus and colorectum (−11%) and breast (−9%) in women. Almost stable rates are expected for ...


Mots clés : Cancer (général); Lutte contre les cancers (Observation)

Menée en Angleterre sur la période 2006-2009 à partir des données de 31 122 patients, cette étude analyse les variations dans le stade au diagnostic d'un cancer du sein ou du poumon

  • Variation in advanced stage at diagnosis of lung and female breast cancer in an English region 2006-2009
    British Journal of Cancer, sous presse, 2012 (article en libre accès)
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    Menée en Angleterre sur la période 2006-2009 à partir des données de 31 122 patients, cette étude analyse les variations dans le stade au diagnostic d'un cancer du sein ou du poumon

    “Variation in advanced stage at diagnosis of lung and female breast cancer in an English region 2006-2009”

    • Lyratzopoulos, G.;Abel, G. A.;Barbiere, J. M.;Brown, C. H.;Rous, B. A.;Greenberg, D. C.

    Background: Understanding variation in stage at diagnosis can inform interventions to improve the timeliness of diagnosis for patients with different cancers and characteristics. Methods: We analysed population-based data on 17 836 and 13 286 East of England residents diagnosed with (female) breast and lung cancer during 2006–2009, with stage information on 16 460 (92%) and 10 435 (79%) patients, respectively. Odds ratios (ORs) of advanced stage at diagnosis adjusted for patient and tumour characteristics were derived using logistic regression. Results: We present adjusted ORs of diagnosis in stages III/IV compared with diagnosis in stages I/II. For breast cancer, the frequency of advanced stage at diagnosis increased stepwise among old women (ORs: 1.21, 1.46, 1.68 and 1.78 for women aged 70–74, 75–79, 80–84 and 85, respectively, compared with those aged 65–69 , P<0.001). In contrast, for lung cancer advanced stage at diagnosis was less frequent in old patients (ORs: ...


Mots clés : Cancer (général); Lutte contre les cancers (Observation)

Approches psycho-sociales

Menée en Italie auprès de 167 survivantes d'un cancer du sein, cette étude analyse leurs difficultés d'ordre psychologique et sexuel sur le long terme

  • Psychological and sexual disorders in long-term breast cancer survivors
    Cancer Management and Research, Vol. 4 , pp. 61 - 65, 2012 (résumé)
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    Menée en Italie auprès de 167 survivantes d'un cancer du sein, cette étude analyse leurs difficultés d'ordre psychologique et sexuel sur le long terme

    “Psychological and sexual disorders in long-term breast cancer survivors”

    • Pumo V;Milone G;Iacono M;Rametta Giuliano S;Di Mari A;Lopiano C;Bordonaro S;Tralongo P

    Background: The progressive increase in the number of patients surviving long term after a diagnosis of malignant disease has led to a focus on the early and late complications of the disease and its treatment. The aim of this study was to investigate the prevalence of complications which may worsen quality of life and shorten long-term survival. Methods: We identified 306 cancer patients who had been disease-free without treatment for at least three years. Of these, 167 with breast cancer were enrolled in this study. A detailed questionnaire-based interview was undertaken to investigate the characteristics of the patients (age, gender, marital status, education), the tumor (date of diagnosis, histology), and treatment. We also used the Beck Depression Inventory to screen for depression, Spitzer’s Quality of Life Index to assess quality of life, and the International Index of Erectile Function and the Female Sexual Function Index to get precise information on sexual ...


Mots clés : Sein; Lutte contre les cancers (Approches psycho-sociales)

Cette étude cas-témoins américaine analyse les capacités neuropsychologiques de 1 509 survivantes d'un cancer du sein 20 ans après leur chimiothérapie adjuvante

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    Cette étude cas-témoins américaine analyse les capacités neuropsychologiques de 1 509 survivantes d'un cancer du sein 20 ans après leur chimiothérapie adjuvante

    “Neuropsychological Performance in Survivors of Breast Cancer More Than 20 Years After Adjuvant Chemotherapy”

    • Koppelmans, Vincent;Breteler, Monique M.B.;Boogerd, Willem;Seynaeve, Caroline;Gundy, Chad;Schagen, Sanne B.

    Purpose Adjuvant chemotherapy for breast cancer can have adverse effects on cognition shortly after administration. Whether chemotherapy has any long-term effects on cognition is largely unknown, yet it becomes increasingly relevant because of the widespread use of chemotherapy for early-stage breast cancer and the improved survival. We investigated whether cyclophosphamide, methotrexate, and fluorouracil (CMF) chemotherapy for breast cancer is associated with worse cognitive performance more than 20 years after treatment.Patients And methods This case-cohort study compared the cognitive performance of patients with breast cancer who had a history of adjuvant CMF chemotherapy treatment (six cycles; average time since treatment, 21 years; n = 196) to that of a population-based sample of women never diagnosed with cancer (n = 1,509). Participants were between 50 and 80 years of age. Exclusion criteria were ever use of adjuvant endocrine therapy, secondary malignancy, recurrence, and/or ...


Mots clés : Sein; Lutte contre les cancers (Approches psycho-sociales)

Menée aux Pays-Bas auprès de 70 patientes atteintes d'un cancer du sein, cette étude analyse l'efficacité d'une intervention psychologique relative à la gestion du stress pour des patientes devant être opérées

  • Stress management training for breast cancer surgery patients
    Psycho-Oncology, sous presse, 2012 (résumé)
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    Menée aux Pays-Bas auprès de 70 patientes atteintes d'un cancer du sein, cette étude analyse l'efficacité d'une intervention psychologique relative à la gestion du stress pour des patientes devant être opérées

    “Stress management training for breast cancer surgery patients”

    • Garssen, Bert;Boomsma, Martijn F.;de Jager Meezenbroek, Eltica;Porsild, Terry;Berkhof, Johannes;Berbee, Monique;Visser, Adriaan;Meijer, Sybren;Beelen, Rob H. J.

    Objective This study evaluated the psychological effects of a pre-surgical stress management training (SMT) in cancer patients. Methods Stress management training comprised four sessions in total: on 5 days and 1 day pre-surgery and on 2 days and 1 month post-surgery. Patients also received audio CDs with relaxation and coping skills exercises. Patients were randomly assigned to the SMT (N= 34) or a regular care condition (N =36). Depression, anxiety, quality of life, perception of control, fatigue, pain, sleep problems, and surgery-related somatic symptoms were measured at Day 6 and Day 1 pre-surgery, and Day 2, 5, 30 and 90 post-surgery. Results Depression and fatigue decreased in the intervention group and increased in the control group, leading to significant group differences at Day 2 (fatigue) and Day 5 post-surgery (fatigue and depression). It also appeared that surgery-related symptoms had increased more in the control group 3 months post-surgery than in the SMT group. ...


Mots clés : Sein; Lutte contre les cancers (Approches psycho-sociales)

Menée en Autriche auprès de 23 participantes, cette étude qualitative analyse les symptômes physiques et psychosociaux de patientes atteintes d'un cancer de l'ovaire et recevant une chimiothérapie

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    Menée en Autriche auprès de 23 participantes, cette étude qualitative analyse les symptômes physiques et psychosociaux de patientes atteintes d'un cancer de l'ovaire et recevant une chimiothérapie

    “Monitoring physical and psychosocial symptom trajectories in ovarian cancer patients receiving chemotherapy”

    • Meraner, Verena;Gamper, Eva-Maria;Grahmann, Anna;Giesinger, Johannes;Wiesbauer, Petra;Sztankay, Monika;Zeimet, Alain;Sperner-Unterweger, Barbara;Holzner, Bernhard

    BACKGROUND:Diagnosis and treatment of ovarian cancer (OC) entail severe symptom burden and a significant loss of quality of life (QOL). Somatic and psychological impairments may persist well beyond active therapy. Although essential for optimal symptom management as well as for the interpretation of treatment outcomes, knowledge on the course of QOL-related issues is scarce. This study aimed at assessing the course of depressive symptoms, anxiety, fatigue and QOL in patients with OC over the course of chemotherapy until early aftercare.METHODS:23 patients were assessed longitudinally (eight time points) with regard to symptom burden (depression, anxiety, fatigue, and QOL) by means of patient-reported outcome instruments (HADS, MFI-20, EORTC QLQ-C30/ -OV28) and clinician ratings (HAMA/D) at each chemotherapy cycle and at the first two aftercare visits.RESULTS:Statistically significant decrease over time was found for depressive symptoms and anxiety as well as for all fatigue scales. ...


Mots clés : Ovaire; Lutte contre les cancers (Approches psycho-sociales)

Menée au Canada, cette étude analyse l'efficacité d'un groupe de support en ligne pour la prise en charge de la détresse psychologique et des problématiques sexuelles de patientes atteintes d'un cancer gynécologique

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    Menée au Canada, cette étude analyse l'efficacité d'un groupe de support en ligne pour la prise en charge de la détresse psychologique et des problématiques sexuelles de patientes atteintes d'un cancer gynécologique

    “Psychosexual distress in women with gynecologic cancer: a feasibility study of an online support group”

    • Classen, Catherine C.;Chivers, Meredith L.;Urowitz, Sara;Barbera, Lisa;Wiljer, David;O'Rinn, Susan;Ferguson, Sarah E.

    Objectives The psychosexual concerns of gynecologic cancer patients are often unaddressed and there are limited resources available for women to deal with this highly sensitive topic. This feasibility study examines the participation rates and preliminary outcomes for an online support group designed specifically for women who are sexually distressed subsequent to gynecologic cancer treatment Methods A 12-week online intervention was developed to address the psychosexual impact of gynecologic cancer. This intervention included a professionally moderated, asynchronous discussion forum as well as the provision of psycho-educational materials addressing the psychosexual impact of gynecologic cancer. Each week, a new topic was introduced and relevant material was posted on the website. Women were encouraged to share their experiences related to the topic. Twenty-seven, sexually distressed, remitted gynecologic cancer patients were randomly assigned to immediate treatment or a waitlist ...


Mots clés : Cancer (général); Lutte contre les cancers (Approches psycho-sociales)

Cet essai randomisé américain évalue l'efficacité d'une psychothérapie destinée à améliorer le bien-être de120 patients atteints d'un cancer de stade avancé

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    Cet essai randomisé américain évalue l'efficacité d'une psychothérapie destinée à améliorer le bien-être de120 patients atteints d'un cancer de stade avancé

    “Pilot Randomized Controlled Trial of Individual Meaning-Centered Psychotherapy for Patients With Advanced Cancer”

    • Breitbart, William;Poppito, Shannon;Rosenfeld, Barry;Vickers, Andrew J.;Li, Yuelin;Abbey, Jennifer;Olden, Megan;Pessin, Hayley;Lichtenthal, Wendy;Sjoberg, Daniel;Cassileth, Barrie R.

    Purpose Spiritual well-being and sense of meaning are important concerns for clinicians who care for patients with cancer. We developed Individual Meaning-Centered Psychotherapy (IMCP) to address the need for brief interventions targeting spiritual well-being and meaning for patients with advanced cancer.Patients and Methods Patients with stage III or IV cancer (N = 120) were randomly assigned to seven sessions of either IMCP or therapeutic massage (TM). Patients were assessed before and after completing the intervention and 2 months postintervention. Primary outcome measures assessed spiritual well-being and quality of life; secondary outcomes included anxiety, depression, hopelessness, symptom burden, and symptom-related distress.Results Of the 120 participants randomly assigned, 78 (65%) completed the post-treatment assessment and 67 (56%) completed the 2-month follow-up. At the post-treatment assessment, IMCP participants demonstrated significantly greater improvement than the ...


Mots clés : Cancer (général); Lutte contre les cancers (Approches psycho-sociales)

Analyses économiques et systèmes de soins

Cette étude américaine évalue le rapport coût-efficacité de diverses stratégies thérapeutiques en prévention de fractures osseuses pour des patientes ménopausées atteintes d'un cancer du sein de stade précoce et traitées avec des inhibiteurs de l'aromatase

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    Cette étude américaine évalue le rapport coût-efficacité de diverses stratégies thérapeutiques en prévention de fractures osseuses pour des patientes ménopausées atteintes d'un cancer du sein de stade précoce et traitées avec des inhibiteurs de l'aromatase

    “Cost Effectiveness of Fracture Prevention in Postmenopausal Women Who Receive Aromatase Inhibitors for Early Breast Cancer”

    • Ito, Kouta;Blinder, Victoria S.;Elkin, Elena B.

    Purpose Aromatase inhibitors (AIs) increase the risk of osteoporosis and related fractures in postmenopausal women who receive adjuvant AIs for hormone receptor (HR) –positive early breast cancer (EBC). We compared the cost effectiveness of alternative screening and treatment strategies for fracture prevention.Methods We developed a Markov state transition model to simulate clinical practice and outcomes in a hypothetical cohort of women age 60 years with HR-positive EBC starting a 5-year course of AI therapy after primary surgery for breast cancer. Outcomes were quality-adjusted life-years (QALYs), lifetime cost, and incremental cost-effectiveness ratio (ICER). We compared the following strategies: no intervention; one-time bone mineral density (BMD) screening and selective bisphosphonate therapy in women with osteoporosis or osteopenia; annual BMD screening and selective bisphosphonate therapy in women with osteoporosis or osteopenia; and universal bisphosphonate therapy.Results ...


  • Screening for Osteoporosis in Postmenopausal Women With Breast Cancer Receiving Aromatase Inhibitors: Less Is More?
    Journal of Clinical Oncology, sous presse, 2012 (éditorial en libre accès)
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    Cette étude américaine évalue le rapport coût-efficacité de diverses stratégies thérapeutiques en prévention de fractures osseuses pour des patientes ménopausées atteintes d'un cancer du sein de stade précoce et traitées avec des inhibiteurs de l'aromatase

    “Screening for Osteoporosis in Postmenopausal Women With Breast Cancer Receiving Aromatase Inhibitors: Less Is More?”

    • Dhesy-Thind, Sukhbinder K.


Mots clés : Sein; Lutte contre les cancers (Analyses économiques et systèmes de soins)

A partir d'une revue de la littérature, cette étude analayse le rapport coût-efficacité de diverses techniques d'identification de biomarqueurs de la réponse à des thérapies ciblées chez des patients atteints d'un cancer du poumon

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    A partir d'une revue de la littérature, cette étude analayse le rapport coût-efficacité de diverses techniques d'identification de biomarqueurs de la réponse à des thérapies ciblées chez des patients atteints d'un cancer du poumon

    “The cost-effectiveness of screening lung cancer patients for targeted drug sensitivity markers”

    • Atherly, A. J.;Camidge, D. R.

    Background: New oncology drugs are being developed in conjunction with companion diagnostics with approval restricting their use to certain biomarker-positive subgroups. We examined the impact of different predictive biomarker screening techniques and population enrichment criteria on the cost-effectiveness of targeted drugs in lung cancer, using ALK and crizotinib to build the initial model. Methods: Health economic modeling of cost per Quality Adjusted Life Year was based on literature review and expert opinion. The modeled population represented advanced non-small cell lung cancer (NSCLC), eligible for predictive biomarker screening with prescribing restricted to biomarker-positive patients. Results: For assays costing $1400 per person, cost per quality-adjusted life year (QALY) gained for ALK screening all advanced NSCLC, excluding treatment cost, is $106 707. This falls to $4756 when only a highly enriched population is screened (increasing biomarker frequency from 1.6 to ...


Mots clés : Poumon; Lutte contre les cancers (Analyses économiques et systèmes de soins)

Menée aux Pays-Bas, cette étude en population analyse l'efficacité d'une organisation centralisée des soins pour améliorer la survie des patientes atteintes d'un carcinome de la vulve

  • Successful centralisation of patients with vulvar carcinoma: A population-based study in The Netherlands
    European journal of cancer (Oxford, England : 1990), sous presse, 2012 (résumé)
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    Menée aux Pays-Bas, cette étude en population analyse l'efficacité d'une organisation centralisée des soins pour améliorer la survie des patientes atteintes d'un carcinome de la vulve

    “Successful centralisation of patients with vulvar carcinoma: A population-based study in The Netherlands”

    • van den Einden, Loes C. G.;Aben, Katja K. H.;Massuger, Leon F. A. G.;van Spronsen, Dick Johan;de Hullu, Joanne A.

    In general, centralisation of care for patients with rare malignancies is advised in order to improve outcome with respect to prognosis and treatment related morbidity. Therefore, centralisation of women with vulvar squamous cell carcinoma (SCC), which is an extremely rare tumour, has been advocated by the national guidelines of the Dutch Society of Obstetrics and Gynaecology in 2000. The objective of this study was to determine whether this advice has been adapted and has led to improved survival. All patients diagnosed with vulvar malignancies between 1989 and 2008 in the Eastern part of the Netherlands were retrieved from the population-based cancer registry held by the Comprehensive Cancer Centre, The Netherlands. Patient- and tumour characteristics and vital status until January 2011 were retrieved. Data of patients diagnosed in two periods (before and after release of the guideline; 1989–1999 and 2000–2008) were compared. Relative survival rates were calculated as a good ...


Mots clés : Organe génital (autre); Lutte contre les cancers (Analyses économiques et systèmes de soins)

Cette étude présente une simulation numérique du rapport coût-efficacité des stratégies préventives et thérapeutiques des cancers du sein, du col de l'utérus et du colon-rectum dans les pays d'Afrique sub-saharienne et d'Asie du sud-est

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    Cette étude présente une simulation numérique du rapport coût-efficacité des stratégies préventives et thérapeutiques des cancers du sein, du col de l'utérus et du colon-rectum dans les pays d'Afrique sub-saharienne et d'Asie du sud-est

    “Cost effectiveness of strategies to combat breast, cervical, and colorectal cancer in sub-Saharan Africa and South East Asia: mathematical modelling study”

    • D Chisholm;R Baltussen;D B Evans;G Ginsberg;J A Lauer;S Lim;M Ortegon;J Salomon;A Stanciole;T Tan-Torres Edejer

    Objective: To determine the costs and health effects of interventions to combat breast, cervical, and colorectal cancers in order to guide resource allocation decisions in developing countries. Setting : Two World Health Organization sub-regions of the world: countries in sub-Saharan Africa with very high adult and high child mortality (AfrE); and countries in South East Asia with high adult and high child mortality (SearD). Design : Cost effectiveness analysis of prevention and treatment strategies for breast, cervical, and colorectal cancer, using mathematical modelling based on a lifetime population model. Data sources: Demographic and epidemiological data were taken from the WHO mortality and global burden of disease databases. Estimates of intervention coverage, effectiveness, and resource needs were based on clinical trials, treatment guidelines, and expert opinion. Unit costs were taken from the WHO-CHOICE price database. Main outcome measures: Cost per disability adjusted ...


  • Cost effectiveness of interventions to tackle non-communicable diseases
    British Medical Journal, Vol. 344, 2012 (éditorial)
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    Cette étude présente une analyse du rapport coût-efficacité des stratégies préventives et thérapeutiques des cancers du sein, du col de l'utérus et du colon-rectum dans les pays d'Afrique sub-saharienne et d'Asie du sud-est

    “Cost effectiveness of interventions to tackle non-communicable diseases”

    • Paul Revill ; Mark Sculpher


Mots clés : Cancer (général); Lutte contre les cancers (Analyses économiques et systèmes de soins)

Sensibilisation et communication

Menée au Canada auprès de 204 survivants d'un cancer du testicule, cette étude transversale analyse leurs besoins de santé et leur utilisation des outils d'aide et de conseils en ligne

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    Menée au Canada auprès de 204 survivants d'un cancer du testicule, cette étude transversale analyse leurs besoins de santé et leur utilisation des outils d'aide et de conseils en ligne

    “Testicular cancer survivors' supportive care needs and use of online support: a cross-sectional survey”

    • Bender, Jacqueline;Wiljer, David;To, Matthew;Bedard, Philippe;Chung, Peter;Jewett, Michael;Matthew, Andrew;Moore, Malcolm;Warde, Padraig;Gospodarowicz, Mary

    Introduction The supportive care needs of testicular cancer survivors have not been comprehensively studied. Likewise, there is limited research on their use of the Internet or social media applications—tools that are popular among young adults and which could be used to address their needs. Methods Two hundred and four testicular cancer patients receiving care at an urban cancer center completed a questionnaire assessing supportive care needs and the use and preferences for online support. We examined the associations between patient characteristics and met or unmet supportive care needs and the use of testicular cancer online communities. Results Respondents had more met (median 8.0, interquartile range (IQR) 10.0) than unmet (median 2.0, IQR 7.0) needs. The majority (62.5%) reported at least one unmet need, most commonly (25%) concerning financial support, body image, stress, being a cancer survivor, and fear of recurrence. Patients who were younger, had nonseminoma testicular ...


Mots clés : Testicule; Lutte contre les cancers (Sensibilisation et communication)

Ressources et infrastructures (Lutte contre les cancers)

A partir de l'exemple du registre suédois des leucémies aiguës, cette étude plaide pour la nécessité et l'importance de développer des registres du cancer de qualité

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    A partir de l'exemple du registre suédois des leucémies aiguës, cette étude plaide pour la nécessité et l'importance de développer des registres du cancer de qualité

    “Acute myeloid leukemia in the real world: why population-based registries are needed”

    • Juliusson, Gunnar;Lazarevic, Vladimir Lj;Hörstedt, Ann-Sofi;Hagberg, Oskar;Hoglund, Martin

    Population-based registries may provide data complementary to that from basic science and clinical intervention studies, all of which essential for establishing recommendations for the management of patients in the real world. The same quality criteria apply for the evidence-based label, and both high representation and good data quality are crucial in registry studies. Registries with high coverage of the target population reduce the impact of selection on outcome and the subsequent problem with extrapolating data to non-studied populations. Thus data, useful for clinical decision in situations not well covered by clinical studies, can be provided. The potential clinical impact of data from population-based studies is exemplified with analyses from the Swedish Acute Leukemia Registry containing over 3300 AML patients diagnosed 1997-2006 with a median follow-up of 6.2 years on (i) the role of intensive combination chemotherapy for older patients with AML, (ii) the impact of allogeneic ...


Mots clés : Leucémie; Lutte contre les cancers (Ressources et infrastructures (Lutte contre les cancers))

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