Lutte contre les cancers

Cette étude américaine menée auprès de 3 013 participants évalue l'association entre l'activité physique, l'indice de masse corporelle et la qualité de vie de survivantes d'un cancer d'un sein, en fonction de leur appartenance ethnique

• Associations among physical activity, body mass index, and health-related quality of life by race/ethnicity in a diverse sample of breast cancer survivors
  • Cancer, sous presse, 2012 (résumé)
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  Cette étude américaine menée auprès de 3 013 participants évalue l'association entre l'activité physique, l'indice de masse corporelle et la qualité de vie de survivantes d'un cancer d'un sein, en fonction de leur appartenance ethnique

  “Associations among physical activity, body mass index, and health-related quality of life by race/ethnicity in a diverse sample of breast cancer survivors”

  • Paxton, Raheem J.;Phillips, Karon L.;Jones, Lovell A.;Chang, Shine;Taylor, Wendell C.;Courneya, Kerry S.;Pierce, John P.

  BACKGROUND: Health-related quality of life (HRQOL), body mass index (BMI), and physical activity (PA) levels have all been associated with prognosis following breast cancer and may explain partially the higher mortality for breast cancer in certain racial/ethnic subgroups. In this study, associations between PA, BMI, and HRQOL by race were examined in a sample of breast cancer survivors. METHODS: Measures of PA, BMI, and HRQOL as well as demographic and medical characteristics of women (N = 3013, 13% nonwhite) who participated in the Women's Healthy Eating and Living Study were assessed at baseline. Analysis of covariance was used to examine the relationship between PA and obesity with HRQOL outcomes. Statistical tests were 2-sided. RESULTS: African American women were less likely to meet guidelines for PA and more likely to be obese than women from other ethnic groups (P < .05). In adjusted models, women who met guidelines for PA reported significantly higher physical health ...

  
  

Mots clés : Sein; Lutte contre les cancers (Qualité de vie, soins de support)

Menée à partir de questionnaires auprès de participants atteints d'un cancer localisé de la prostate à faible risque de récidive, cette étude compare les effets d'une surveillance active de la maladie, d'une radiothérapie et d'une prostatectomie radicale sur l'activité sexuelle des patients

• Sexual function with localized prostate cancer: active surveillance vs radical therapy
  • British Journal of Urology International, sous presse, 2012 (résumé)
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  Menée à partir de questionnaires auprès de participants atteints d'un cancer localisé de la prostate à faible risque de récidive, cette étude compare les effets d'une surveillance active de la maladie, d'une radiothérapie et d'une prostatectomie radicale sur l'activité sexuelle des patients

  “Sexual function with localized prostate cancer: active surveillance vs radical therapy”

  • van den Bergh, Roderick C. N.;Korfage, Ida J.;Roobol, Monique J.;Bangma, Chris H.;de Koning, Harry J.;Steyerberg, Ewout W.;Essink-Bot, Marie-Louise

  Study Type – Outcomes (cohort sample)Level of Evidence 2bWhat's known on the subject? and What does the study add?The study compares the sexual function of men with low-risk prostate cancer who chose active surveillance (expectant management) with similar men who received radiation therapy or radical prostatectomy. The first group appeared to be sexually active more frequently and had less erectile dysfunction. The study was non-randomized.No other studies exist on the effect of active surveillance on sexual function vs other treatment methods. OBJECTIVE * •To compare sexual function of men with localized prostate cancer (PCa) on active surveillance (AS) with similar patients who received radical therapy. PATIENTS AND METHODS * •Two groups of men with screening-detected localized PCa were compared. The first were men on AS within the prospective protocol-based Prostate Cancer Research International: Active Surveillance study. The second were men participating in the European ...

  
  

Mots clés : Prostate; Lutte contre les cancers (Qualité de vie, soins de support)

Menée auprès de 262 hommes âgés de moins de 60 ans et ayant subi une protonthérapie pour un cancer de la prostate, cette étude analyse leurs fonctions érectiles, leur incontinence et d'autres facteurs associés à la qualité de vie et à la survie

• Erectile function, incontinence, and other quality of life outcomes following proton therapy for prostate cancer in men 60 years old and younger
  • Cancer, sous presse, 2012 (résumé)
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  Menée auprès de 262 hommes âgés de moins de 60 ans et ayant subi une protonthérapie pour un cancer de la prostate, cette étude analyse leurs fonctions érectiles, leur incontinence et d'autres facteurs associés à la qualité de vie et à la survie

  “Erectile function, incontinence, and other quality of life outcomes following proton therapy for prostate cancer in men 60 years old and younger”

  • Hoppe, Bradford S.;Nichols, Romaine C.;Henderson, Randal H.;Morris, Christopher G.;Williams, Christopher R.;Costa, Joseph;Marcus, Robert B.;Mendenhall, William M.;Li, Zuofeng;Mendenhall, Nancy P.

  BACKGROUND: This study sought to evaluate patient-reported health-related quality of life following proton therapy for prostate cancer in men ≤60 years old. METHODS: Between August 2006 and January 2010, 262 hormone-naive men ≤60 years old were treated with definitive proton therapy for prostate cancer. Before treatment and every 6 months after treatment, patients filled out the Expanded Prostate Index Composite (EPIC) and the International Index of Erectile Function (IIEF) questionnaires. Potency was defined as successful sexual intercourse in the prior month or an EPIC sexual summary (SS) score ≥60. RESULTS: Median follow-up was 24 months; 90% of men completed follow-up EPIC forms within the last year. For EPIC urinary, bowel, and hormone subscales, the average decline from baseline to 2 years was ≤5 points, except for bowel function (5.2 points). SS scores declined 12.6 points after 2 years. Potency rates declined by 11% from baseline at 2 years, but 94% of men were potent ...

  
  

Mots clés : Prostate; Lutte contre les cancers (Qualité de vie, soins de support)

A partir d'une revue systématique de la littérature (37 études), cette méta-analyse fait le point sur les interventions de nature psycho-sociale destinées à réduire la douleur de patients atteints de cancer

• Meta-Analysis of Psychosocial Interventions to Reduce Pain in Patients With Cancer
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  A partir d'une revue systématique de la littérature (37 études), cette méta-analyse fait le point sur les interventions de nature psycho-sociale destinées à réduire la douleur de patients atteints de cancer

  “Meta-Analysis of Psychosocial Interventions to Reduce Pain in Patients With Cancer”

  • Sheinfeld Gorin, Sherri;Krebs, Paul;Badr, Hoda;Janke, Elizabeth Amy;Jim, Heather S.L.;Spring, Bonnie;Mohr, David C.;Berendsen, Mark A.;Jacobsen, Paul B.

  Purpose Pain is one of the most common, burdensome, and feared symptoms experienced by patients with cancer. American Pain Society standards for pain management in cancer recommend both pharmacologic and psychosocial approaches. To obtain a current, stable, and comprehensive estimate of the effect of psychosocial interventions on pain—an important clinical topic—we conducted a meta-analysis of randomized controlled studies among adult patients with cancer published between 1966 and 2010.Methods Three pairs of raters independently reviewed 1,681 abstracts, with a systematic process for reconciling disagreement, yielding 42 papers, of which 37 had sufficient data for meta-analysis. Studies were assessed for quality using a modified seven-item Physiotherapy Evidence Database (PEDro) coding scheme. Pain severity and interference were primary outcome measures.Results Study participants (N = 4,199) were primarily women (66%) and white (72%). The weighted averaged effect size across ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

Cette étude (289 cas et 262 témoins) menée en population américaine et britannique analyse et compare la santé et la qualité de vie de survivants d'un cancer par rapport à la population générale

• A comparative analysis of the health and well-being of cancer survivors to the general population
  • Supportive Care in Cancer, pp. 1-8, 2012 (résumé)
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  Cette étude (289 cas et 262 témoins) menée en population américaine et britannique analyse et compare la santé et la qualité de vie de survivants d'un cancer par rapport à la population générale

  “A comparative analysis of the health and well-being of cancer survivors to the general population”

  • Santin, Olinda;Mills, Moyra;Treanor, Charlene;Donnelly, Michael

  Background The population of people surviving cancer is continually increasing and currently cancer survivors represent approximately 3.7% of the American population and 3% of the UK population. There is limited and inconclusive empirical evidence regarding the long-term health and well-being of cancer survivors. Methods Two hundred eighty-nine cancer survivors and 262 matched-age and sex patients from the same group of General (primary care) Practices completed postal questionnaires measuring health and well-being, health service utilisation and satisfaction and health care needs. Main Results Cancer survivors reported poorer health and well-being and health service utilisation than the general population. Despite this poorer health, the majority of cancer survivors reported satisfaction with services and almost two-thirds of the survivors did not report any needs. Conclusions The majority of cancer survivors do not appear to require additional support services. There is, however, a ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

A partir d'une revue systématique de la littérature (15 études), cette étude analyse l'efficacité de la pratique du qigong comme soin de support destiné à améliorer la qualité de vie de patients atteints de cancer

• A systematic review of the effectiveness of qigong exercise in supportive cancer care
  • Supportive Care in Cancer, pp. 1-13, 2012 (résumé)
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  A partir d'une revue systématique de la littérature (15 études), cette étude analyse l'efficacité de la pratique du qigong comme soin de support destiné à améliorer la qualité de vie de patients atteints de cancer

  “A systematic review of the effectiveness of qigong exercise in supportive cancer care”

  • Chan, Cecilia;Wang, Chong-Wen;Ho, Rainbow;Ng, Siu-Man;Chan, Jessie;Ziea, Eric;Wong, Vivian

  Qigong as a complementary and alternative modality of traditional Chinese medicine is often used by cancer patients to manage their symptoms. The aim of this systematic review is to critically evaluate the effectiveness of qigong exercise in cancer care. Methods Thirteen databases were searched from their inceptions through November 2010. All controlled clinical trials of qigong exercise among cancer patients were included. The strength of the evidence was evaluated for all included studies using the Oxford Centre for Evidence-based Medicine Levels of Evidence. The validity of randomized controlled trials (RCTs) was also evaluated using the Jadad Scale. Results Twenty-three studies including eight RCTs and fifteen non-randomized controlled clinical trials (CCTs) were identified. The effects of qigong on physical and psychosocial outcomes were examined in 14 studies and the effects on biomedical outcomes were examined in 15 studies. For physical and psychosocial outcomes, it is ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

A partir des données du registre américain du cancer portant sur 1 317 patients, cette étude en population analyse la qualité des soins et la survie des patients atteints d'un cancer de la tête et du cou et traités dans un hôpital de proximité

• A population-based study of therapy and survival for patients with head and neck cancer treated in the community
  • Cancer, sous presse, 2012 (résumé)
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  A partir des données du registre américain du cancer portant sur 1 317 patients, cette étude en population analyse la qualité des soins et la survie des patients atteints d'un cancer de la tête et du cou et traités dans un hôpital de proximité

  “A population-based study of therapy and survival for patients with head and neck cancer treated in the community”

  • Dansky Ullmann, Claudio;Harlan, Linda C.;Shavers, Vickie L.;Stevens, Jennifer L.

  BACKGROUND: The objective of this study was to examine patterns of care and survival in a population-based sample of patients with head and neck cancer (HNC) who were treated in the community or in hospitals that had residency training programs. METHODS: Data from the National Cancer Institute's Surveillance, Epidemiology, and End Results Program were used to sample 1317 patients aged ≥20 years with invasive squamous HNC who were diagnosed during 2004 and who had vital status available through 2008. RESULTS: Treatment and survival were influenced by tumor site and disease stage. Patients who had stage I/II cancer of the oral cavity generally underwent surgery; patients with stage III oral cavity disease underwent surgery and received radiation; and patients with stage IV oral cavity disease underwent surgery and received chemoradiation. Patients with early stage cancer of the oropharynx either underwent surgery or received radiation and chemotherapy, and patients with late/unstaged ...

  
  

Mots clés : Voies aérodigestives supérieures; Lutte contre les cancers (Observation)

A partir des données des registres américains du cancer sur la période 1999-2007, cette étude passe en revue les caractéristiques du cancer insulaire de la thyroïde et la survie des patients

• Insular thyroid cancer
  • Cancer, sous presse, 2012 (résumé)
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  A partir des données des registres américains du cancer sur la période 1999-2007, cette étude passe en revue les caractéristiques du cancer insulaire de la thyroïde et la survie des patients

  “Insular thyroid cancer”

  • Kazaure, Hadiza S.;Roman, Sanziana A.;Sosa, Julie A.

  BACKGROUND: Insular thyroid cancer (ITC) is an uncommon, poorly differentiated thyroid malignancy. To date, there have been no population-level studies of the characteristics and outcomes of patients with ITC. METHODS: The authors used the Surveillance, Epidemiology, and End Results (SEER) database from 1999 to 2007 to compare the characteristics and prognosis of patients who had ITC with those of patients who had well differentiated thyroid cancer (WDTC) and anaplastic thyroid cancer (ATC). Data analyses were performed using chi-square tests, analyses of variance, log-rank tests, and multivariate regression. RESULTS: There were 114 patients with ITC, 497 patients with ATC, and 34,021 patients with WDTC. The mean age of patients with ITC was 62.1 years versus 48.1 years for patients with WDTC and 69.5 years for patients with ATC (P < .001). The mean ITC tumor size was 5.9 cm versus 2.0 cm for WDTC and 6.4 cm for ATC (P < .001). Distant metastasis occurred in 31% of patients with ITC ...

  
  

Mots clés : Thyroïde; Lutte contre les cancers (Observation)

Menée aux Etats-Unis, cette étude analyse les pratiques et le recours à la radiothérapie à la fin de la vie de patients atteints d'un cancer incurable du poumon non à petites cellules

• Radiation therapy at the end of life in patients with incurable nonsmall cell lung cancer
  • Cancer, sous presse, 2012 (résumé)
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  Menée aux Etats-Unis, cette étude analyse les pratiques et le recours à la radiothérapie à la fin de la vie de patients atteints d'un cancer incurable du poumon non à petites cellules

  “Radiation therapy at the end of life in patients with incurable nonsmall cell lung cancer”

  • Kapadia, Nirav S.;Mamet, Rizvan;Zornosa, Carrie;Niland, Joyce C.;D'Amico, Thomas A.;Hayman, James A.

  BACKGROUND: Receipt of chemotherapy at the end of life (EOL) is considered an indicator of poor quality of care for medical oncology. The objective of this study was to characterize the use of radiotherapy (RT) in patients with nonsmall cell lung cancer (NSCLC) during the same period. METHODS: Treatment characteristics of patients with incurable NSCLC who received RT at the EOL, defined as within 14 days of death, were analyzed from the National Comprehensive Cancer Network NSCLC Outcomes Database. RESULTS: Among 1098 patients who died, 10% had received EOL RT. Patients who did and did not receive EOL RT were similar in terms of sex, race, comorbid disease, and Eastern Cooperative Oncology Group performance status. On multivariable logistic regression analysis, independent predictors of receiving EOL RT included stage IV disease (odds ratio [OR], 2.04; 95% confidence interval [CI], 1.09-3.83) or multiorgan involvement (OR, 1.75; 95% CI, 1.08-2.84) at diagnosis, age <65 years at ...

  
  

Mots clés : Poumon; Lutte contre les cancers (Observation)

A partir des données de patients inclus dans 4 essais randomisés américains, cette étude analyse la survie des adolescents et jeunes adultes atteints d'un ostéosarcome

• Outcome for adolescent and young adult patients with osteosarcoma
  • Cancer, sous presse, 2012 (résumé)
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  A partir des données de patients inclus dans 4 essais randomisés américains, cette étude analyse la survie des adolescents et jeunes adultes atteints d'un ostéosarcome

  “Outcome for adolescent and young adult patients with osteosarcoma”

  • Janeway, Katherine A.;Barkauskas, Donald A.;Krailo, Mark D.;Meyers, Paul A.;Schwartz, Cindy L.;Ebb, David H.;Seibel, Nita L.;Grier, Holcombe E.;Gorlick, Richard;Marina, Neyssa

  BACKGROUND: There are conflicting data regarding age as a prognostic factor in osteosarcoma. The authors conducted a study evaluating the impact of age on prognosis in children and young adults with osteosarcoma enrolled on North American cooperative group trials. METHODS: Patients with high-grade osteosarcoma of any site enrolled on North American cooperative group trials CCG-7943, POG-9754, INT-0133, and AOST0121 were included in this study. Primary tumor site, age, sex, ethnicity, histologic response, and presence of metastatic disease at diagnosis were evaluated for their impact on overall survival (OS) and event-free survival (EFS). RESULTS: A total of 1054 patients were eligible and had complete data available for the study. Age was not significantly associated with any other presenting covariate analyzed except sex. Age 18 or older was associated with a statistically significant poorer EFS (P = .019) and OS (P = .043). The 10-year EFS and OS in patients <10, 10 to 17, and ≥18 ...

  
  

Mots clés : Os; Lutte contre les cancers (Observation)

Menée en Angleterre, cette étude analyse l'évolution de l'incidence des tumeurs à cellules germinales, gonadiques et extragonadiques, sur la période 1979-2003

• Comparative incidence patterns and trends of gonadal and extragonadal germ cell tumors in England, 1979 to 2003
  • Cancer, sous presse, 2012 (résumé)
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  Menée en Angleterre, cette étude analyse l'évolution de l'incidence des tumeurs à cellules germinales, gonadiques et extragonadiques, sur la période 1979-2003

  “Comparative incidence patterns and trends of gonadal and extragonadal germ cell tumors in England, 1979 to 2003”

  • Arora, Ramandeep S.;Alston, Robert D.;Eden, Tim O. B.;Geraci, Marco;Birch, Jillian M.

  BACKGROUND: It is believed that gonadal and extragonadal germ cell tumors (GCTs) arise from primordial germ cells and may have similar etiopathogenesis. Unlike testicular GCTs, there has been limited comprehensive population-based analysis of ovarian and extragonadal GCTs. METHODS: All malignant GCTs and all central nervous system (CNS) GCTs with benign and uncertain behavior that were registered in England in the age group 0 to 84 years from 1979 to 2003 were included in the current study. Incidence rates were calculated and adjusted to the world standard population. RESULTS: There were 33,364 GCTs (92.5% testes, 3.9% ovary, 3.2% extragonadal) in individuals aged 0 to 84 years. The CNS was the most common extragonadal site. An initial peak in incidence at ages 0 to 4 years of nongerminomas was observed at all sites except ovary. Second incidence peaks between ages 10 to 39 years that were more marked among males also were observed at all sites. The ages at these incidence peaks ...

  
  

Mots clés : Organe génital (autre); Lutte contre les cancers (Observation)

Ces deux études analysent l'évolution de la distribution et de la prévalence de l'obésité parmi les enfants, les adolescents et les adultes américains, sur la période 1999-2012

• Prevalence of Obesity and Trends in Body Mass Index Among US Children and Adolescents, 1999-2010
  • JAMA: The Journal of the American Medical Association, sous presse, 2012 (résumé)
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  Ces deux études analysent l'évolution de la distribution et de la prévalence de l'obésité parmi les enfants, les adolescents et les adultes américains, sur la période 1999-2012

  “Prevalence of Obesity and Trends in Body Mass Index Among US Children and Adolescents, 1999-2010”

  • Ogden, Cynthia L.;Carroll, Margaret D.;Kit, Brian K.;Flegal, Katherine M.

  Context The prevalence of childhood obesity increased in the 1980s and 1990s but there were no significant changes in prevalence between 1999-2000 and 2007-2008 in the United States.Objectives To present the most recent estimates of obesity prevalence in US children and adolescents for 2009-2010 and to investigate trends in obesity prevalence and body mass index (BMI) among children and adolescents between 1999-2000 and 2009-2010.Design, Setting, and Participants Cross-sectional analyses of a representative sample (N = 4111) of the US child and adolescent population (birth through 19 years of age) with measured heights and weights from the National Health and Nutrition Examination Survey 2009-2010.Main Outcome Measures Prevalence of high weight-for-recumbent length (≥95th percentile on the growth charts) among infants and toddlers from birth to 2 years of age and obesity (BMI ≥95th percentile of the BMI-for-age growth charts) among children and adolescents aged 2 through 19 ...

  
  
• Prevalence of Obesity and Trends in the Distribution of Body Mass Index Among US Adults, 1999-2010
  • JAMA: The Journal of the American Medical Association, sous presse, 2012 (résumé)
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  Ces deux études analysent l'évolution de la distribution et de la prévalence de l'obésité parmi les enfants, les adolescents et les adultes américains, sur la période 1999-2012

  “Prevalence of Obesity and Trends in the Distribution of Body Mass Index Among US Adults, 1999-2010”

  • Flegal, Katherine M. ; Carroll, Margaret D. ; Kit, Brian K. ; Ogden, Cynthia L.

  Context Between 1980 and 1999, the prevalence of adult obesity (body mass index [BMI] ≥30) increased in the United States and the distribution of BMI changed. More recent data suggested a slowing or leveling off of these trends.Objective To estimate the prevalence of adult obesity from the 2009-2010 National Health and Nutrition Examination Survey (NHANES) and compare adult obesity and the distribution of BMI with data from 1999-2008.Design, Setting, and Participants NHANES includes measured heights and weights for 5926 adult men and women from a nationally representative sample of the civilian noninstitutionalized US population in 2009-2010 and for 22 847 men and women in 1999-2008.Main Outcome Measures The prevalence of obesity and mean BMI.Results In 2009-2010 the age-adjusted mean BMI was 28.7 (95% CI, 28.3-29.1) for men and also 28.7 (95% CI, 28.4-29.0) for women. Median BMI was 27.8 (interquartile range [IQR], 24.7-31.7) for men and 27.3 (IQR, 23.3-32.7) for women. The ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Observation)

Menée en Belgique auprès de 67 patients atteints d'un cancer du poumon de stade avancé, cette étude longitudinale analyse leur désir d'information et leur volonté de prendre part à la décision concernant les soins de fin de vie

• Changing preferences for information and participation in the last phase of life: a longitudinal study among newly diagnosed advanced lung cancer patients
  • Supportive Care in Cancer, pp. 1-10, 2012 (résumé)
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  Menée en Belgique auprès de 67 patients atteints d'un cancer du poumon de stade avancé, cette étude longitudinale analyse leur désir d'information et leur volonté de prendre part à la décision concernant les soins de fin de vie

  “Changing preferences for information and participation in the last phase of life: a longitudinal study among newly diagnosed advanced lung cancer patients”

  • Pardon, Koen;Deschepper, R.;Vander Stichele, R.;Bernheim, J.;Mortier, F.;Bossuyt, N.;Schallier, D.;Germonpré, P.;Galdermans, D.;Van Kerckhoven, W.;Deliens, L.;on behalf of the Eolic-consortium

  Purpose The objective is to explore changes over time in the information and participation preferences of newly diagnosed stage IIIb/IV non-small-cell lung cancer patients. Methods Patients were recruited by physicians in 13 hospitals and interviewed every 2 months until the fourth and every 4 months until the sixth interview. Results Sixty-seven patients were interviewed three times. Over a period of 4 months from diagnosis, half of patients changed their information preferences for palliative care and end-of-life decisions with a possible or certain life-shortening effect (ELDs, e.g., non-treatment decisions) in both directions, from not wanting to wanting the information, but also—and as much—from wanting to no longer wanting it. The latter were more likely to be in a better physical condition. Preferences for participation in medical decision making also changed: 50% to 78%, depending on the type of decision (general, treatment, transfer or ELD), changed their preference ...

  
  

Mots clés : Poumon; Lutte contre les cancers (Approches psycho-sociales)

Cette étude japonaise analyse l'efficacité d'un outil permettant de mesurer le niveau de stress des infirmières dispensant des soins palliatifs dans des services de médecine générale

• Creation of a questionnaire to measure stress among nurses engaged in palliative care on general wards
  • Supportive Care in Cancer, pp. 1-8, 2012 (résumé)
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  Cette étude japonaise analyse l'efficacité d'un outil permettant de mesurer le niveau de stress des infirmières dispensant des soins palliatifs dans des services de médecine générale

  “Creation of a questionnaire to measure stress among nurses engaged in palliative care on general wards”

  • Terakado, Ako;Watanabe, Takako

  Purpose This study was conducted to create a questionnaire that measures stress among nurses engaged in palliative care on general wards. Methods Nurses with at least 3 years of experience involved in palliative care on a general ward in six facilities in Japan were the subjects from September 7 to October 4, 2004. A draft questionnaire on stress factors and conditions of stress in nurses engaged in end-of-life care was created, and question items and content meaning were revised to produce 32 question items, with a four-point Likert scale for the responses. Two pretests were conducted. Internal validity was investigated and resulted in 31 question items. Factor analysis using the principal factor method (Varimax rotation) was performed, and Cronbach’s coefficient alpha was used to evaluate internal consistency and check reliability. Results The survey response rate was 94%, with a valid response rate of 98%. Analysis was conducted using responses from 269 participants, of whom ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Approches psycho-sociales)

Menée à Taïwan en milieu hospitalier auprès de 152 patientes atteintes d'un cancer du sein avant la ménopause, cette étude rétrospective analyse le rapport coût-efficacité de la goséréline en traitement adjuvant

• Cost-utility analysis of adjuvant goserelin (Zoladex) and adjuvant chemotherapy in premenopausal women with breast cancer
  • BMC Cancer, Vol. 12 (1), pp. 33, 2012 (article en libre accès)
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  Menée à Taïwan en milieu hospitalier auprès de 152 patientes atteintes d'un cancer du sein avant la ménopause, cette étude rétrospective analyse le rapport coût-efficacité de la goséréline en traitement adjuvant

  “Cost-utility analysis of adjuvant goserelin (Zoladex) and adjuvant chemotherapy in premenopausal women with breast cancer”

  • Cheng, Tsui Fen;Wang, Jung Der;Uen, Wu Ching

  BACKGROUND:Increased health care costs have made it incumbent on health-care facilities and physicians to demonstrate both clinical and cost efficacy when recommending treatments. Though studies have examined the cost-effectiveness of adjuvant goserelin with radiotherapy for locally advanced prostate cancer, few have compared the cost-effectiveness of adjuvant goserelin to adjuvant chemotherapy alone in premenopausal breast cancer.METHODS:In this retrospective study at one hospital, the records of 152 patients with stage Ia to IIIa ER + breast cancer who received goserelin or chemotherapy were reviewed. Survival analysis was assessed by the Kaplan-Meier method. Patients were interviewed to evaluate their quality of life using the European Organization for Research and Treatment Quality of Life questionnaire (EORTC-QLQ-C30, version 4.0), and to obtain the utility value by the standard gamble (SG) and visual scale (VS) methods. Total medical cost was assessed from the (National Health ...

  
  

Mots clés : Sein; Lutte contre les cancers (Analyses économiques et systèmes de soins)

Cet article présente les programmes américains de parcours personnalisés de suivi et de soins après cancer, et leur mise en oeuvre sur le terrain

• Survivorship care plans in research and practice
  • CA: A Cancer Journal for Clinicians, sous presse, 2012 (résumé)
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  Cet article présente les programmes américains de parcours personnalisés de suivi et de soins après cancer, et leur mise en oeuvre sur le terrain

  “Survivorship care plans in research and practice”

  • Salz, Talya;Oeffinger, Kevin C.;McCabe, Mary S.;Layne, Tracy M.;Bach, Peter B.

  The Institute of Medicine (IOM) recommends the use of survivorship care plans (SCPs) for all cancer survivors. Developing useful SCPs requires understanding what survivors and their providers need and how SCPs can be implemented in practice. Published studies investigating the perspectives of stakeholders (survivors, primary care providers, and oncology providers) were reviewed regarding the content and use of SCPs. All National Cancer Institute (NCI)-designated cancer centers were surveyed concerning the extent to which SCPs for survivors of breast and colorectal cancers are in use, their concordance with the IOM's recommendation, and details about SCP delivery. Survivors and primary care providers typically lack the information the IOM suggested should be included in SCPs. Oncology providers view SCPs favorably but express concerns about the feasibility of their implementation. Fewer than one-half (43%) of NCI-designated cancer centers deliver SCPs to their breast or colorectal ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Analyses économiques et systèmes de soins)

Menée auprès de 80 participants, cette étude américaine analyse l'efficacité et la pertinence d'un outil vidéo éducatif pour aider les patients atteints d'un cancer de stade avancé à faire des choix de fin de vie

• Augmenting advance care planning in poor prognosis cancer with a video decision aid
  • Cancer, sous presse, 2012 (résumé)
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  Menée auprès de 80 participants, cette étude américaine analyse l'efficacité et la pertinence d'un outil vidéo éducatif pour aider les patients atteints d'un cancer de stade avancé à faire des choix de fin de vie

  “Augmenting advance care planning in poor prognosis cancer with a video decision aid”

  • Volandes, Angelo E.;Levin, Tomer T.;Slovin, Susan;Carvajal, Richard D.;O'Reilly, Eileen M.;Keohan, Mary Louise;Theodoulou, Maria;Dickler, Maura;Gerecitano, John F.;Morris, Michael;Epstein, Andrew S.;Naka-Blackstone, Anastazia;Walker-Corkery, Elizabeth S.;Chang, Yuchiao;Noy, Ariela

  BACKGROUND: The authors tested whether an educational video on the goals of care in advanced cancer (life-prolonging care, basic care, or comfort care) helped patients understand these goals and had an impact on their preferences for resuscitation. METHODS: A survey of 80 patients with advanced cancer was conducted before and after they viewed an educational video. The outcomes of interest included changes in goals of care preference and knowledge and consistency of preferences with code status. RESULTS: Before viewing the video, 10 patients (13%) preferred life-prolonging care, 24 patients (30%) preferred basic care, 29 patients (36%) preferred comfort care, and 17 patients (21%) were unsure. Preferences did not change after the video, when 9 patients (11%) chose life-prolonging care, 28 patients (35%) chose basic care, 29 patients (36%) chose comfort care, and, 14 patients (18%) were unsure (P = .28). Compared with baseline, after the video presentation, more patients did not want ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Sensibilisation et communication)

Menée au Royaume-Uni auprès de 261 patients, cette étude analyse l'information relative à la chimiothérapie disponible sur internet et son impact sur les connaissances et comportements des patients et des professionnels de santé

• Internet chemotherapy information: impact on patients and health professionals
  • British Journal of Cancer, sous presse, 2012 (résumé)
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  Menée au Royaume-Uni auprès de 261 patients, cette étude analyse l'information relative à la chimiothérapie disponible sur internet et son impact sur les connaissances et comportements des patients et des professionnels de santé

  “Internet chemotherapy information: impact on patients and health professionals”

  • Davies, E.;Yeoh, K. W.

  Background: Reliable information can improve patients’ knowledge of chemotherapy. As internet chemotherapy information (ICI) is increasingly viewed as a valuable patient education tool, we investigated the impact of ICI on patient care and analysed health professionals’ (HPs’) attitudes towards ICI. Methods: The following questionnaires were distributed: (1) self-administered questionnaire randomly given to 261 patients receiving chemotherapy (80% returned); and (2) separate questionnaire given to 58 HPs at the same UK Oncology Centre (83% returned). Results: Just over half of the patient respondents accessed the internet regularly. They were younger, with higher incomes and qualifications. Key search topics included chemotherapy modes of action, symptom management and treatment success, and most considered ICI useful. More than half wanted to discuss ICI with HPs but most did not get the opportunity. Although the majority of HP respondents supported the need for patients to ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Sensibilisation et communication)

Menée au Japon auprès de 72 participants, cette étude rétrospective analyse la qualité des soins de fin de vie dispensés à des patients atteints d'un cancer métastatique du poumon non à petites cellules, selon qu'ils sont traités dans des unités de soins palliatifs ou dans des services de médecine générale

• Quality of end-of-life care for patients with metastatic non-small-cell lung cancer in general wards and palliative care units in Japan
  • Supportive Care in Cancer, pp. 1-6, 2012 (résumé)
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  Menée au Japon auprès de 72 participants, cette étude rétrospective analyse la qualité des soins de fin de vie dispensés à des patients atteints d'un cancer métastatique du poumon non à petites cellules, selon qu'ils sont traités dans des unités de soins palliatifs ou dans des services de médecine générale

  “Quality of end-of-life care for patients with metastatic non-small-cell lung cancer in general wards and palliative care units in Japan”

  • Nakano, Kikuo;Yoshida, Takashi;Furutama, Junko;Sunada, Shoji

  Purpose Patients with lung cancer in Japan often receive aggressive care near the end of life and die in an acute care hospital. We describe the differences in end-of-life care for metastatic non-small-cell lung cancer (NSCLC) patients between general wards and a palliative care unit (PCU). Methods A retrospective analysis was conducted using data from patients who received at least second-line chemotherapy between 2002 and 2007 in a single institute. Among 72 eligible patients, we categorised patients into two groups, those who died in general wards ( n = 57) and those who died in the PCU ( n = 15), and examined end-of-life care including chemotherapy, do-not-resuscitate (DNR) decision making and treatment in the last 48 h of life. Results Mean number of days between the last chemotherapy and death was shorter in general wards than in the PCU ( P = 0.019). Furthermore, 25% of patients in general wards received chemotherapy within the last 2 weeks of life. Rates of multiple ...

  
  

Mots clés : Poumon; Lutte contre les cancers (Soins palliatifs)

Cette étude analyse l'efficacité et la compatibilité chimique de mélanges binaires ou ternaires à base de morphine et de méthadone, combinés ou non avec d'autres médicaments, en administration parentérale dans le cadre des soins palliatifs

• Physical compatibility of binary and ternary mixtures of morphine and methadone with other drugs for parenteral administration in palliative care
  • Supportive Care in Cancer, pp. 1-9, 2012 (résumé)
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  Cette étude analyse l'efficacité et la compatibilité chimique de mélanges binaires ou ternaires à base de morphine et de méthadone, combinés ou non avec d'autres médicaments, en administration parentérale dans le cadre des soins palliatifs

  “Physical compatibility of binary and ternary mixtures of morphine and methadone with other drugs for parenteral administration in palliative care”

  • Destro, Massimo;Ottolini, Luca;Vicentini, Lorenza;Boschetti, Silvia

  The parenteral administration of combinations of drugs is often necessary in palliative medicine, particularly in the terminal stage of life, when patients are no longer able to take medication orally. The use of infusers to administer continuous subcutaneous infusions is a well-established practice in the palliative care setting and enables several drugs to be given simultaneously, avoiding the need for repeated administrations and the effects of peaks and troughs in the doses of medication. The method is also appreciated by patients and caregivers in the home care setting because the devices and infusion sites are easy to manage. Despite their frequent use, however, the mixtures of drugs adopted in clinical practice are sometimes not supported by reliable data concerning their chemical and physical compatibility. The present study investigates the chemical compatibility of binary mixtures (morphine with ketorolac) and the physical compatibility of binary (morphine or methadone with ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Soins palliatifs)