Lutte contre les cancers

A partir des données de 2 essais cliniques, cette étude analyse et compare la qualité de vie de patients atteints de cancer colorectal et traités avec ou sans panitumumab

• Health-related quality of life in patients with metastatic colorectal cancer treated with panitumumab in first- or second-line treatment
  • British Journal of Cancer, sous presse, 2011 (résumé)
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  A partir des données de 2 essais cliniques, cette étude analyse et compare la qualité de vie de patients atteints de cancer colorectal et traités avec ou sans panitumumab

  “Health-related quality of life in patients with metastatic colorectal cancer treated with panitumumab in first- or second-line treatment”

  • Bennett, L.;Zhao, Z.;Barber, B.;Zhou, X.;Peeters, M.;Zhang, J.;Xu, F.;Wiezorek, J.;Douillard, J. Y.

  Background: Panitumumab in combination with chemotherapy was evaluated in two pivotal clinical trials in first- and second-line treatment of metastatic colorectal cancer (mCRC), respectively. This analysis compared the health-related quality of life (HRQoL) of patients with or without panitumumab in the two trials. Methods: Patients with mCRC were randomised to FOLFOX (first-line trial) or FOLFIRI (second-line trial)±panitumumab. The EuroQoL 5-Dimensions Health State Index (EQ-5D HSI) and Visual Analogue Scale (EQ-5D VAS) were assessed at baseline and monthly follow-up until disease progression. Patients with wild-type KRAS mCRC with baseline and post-baseline HRQoL scores were included. Difference in change from baseline between treatment groups was evaluated using linear mixed and pattern-mixture models. Results: In the first-line trial, 576 patients with wild-type KRAS mCRC (284 panitumumab+FOLFOX4 and 292 FOLFOX4 alone) were included in the HRQoL analyses. In the second-line ...

  
  

Mots clés : Colon-rectum; Lutte contre les cancers (Qualité de vie, soins de support)

Cette étude en population française (542 cas et 1 181 témoins) évalue la qualité de vie de survivants à long terme d'un cancer colorectal

• Health-Related Quality of Life Among Long-Term Survivors of Colorectal Cancer: A Population-Based Study
  • The Oncologist, sous presse, 2011 (résumé)
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  Cette étude en population française (542 cas et 1 181 témoins) évalue la qualité de vie de survivants à long terme d'un cancer colorectal

  “Health-Related Quality of Life Among Long-Term Survivors of Colorectal Cancer: A Population-Based Study”

  • Caravati-Jouvenceaux, Agnès;Launoy, Guy;Klein, Delphine;Henry-Amar, Michel;Abeilard, Edwige;Danzon, Arlette;Pozet, Astrid;Velten, Michel;Mercier, Mariette

  Abstract Background. The number of long-term colorectal cancer survivors is increasing. Cancer and its treatment can cause physical and psychological complications, but little is known about how it impacts quality of life (QOL) over the long term—5, 10, and 15 years after diagnosis.Methods. Cancer survivors were randomly selected from three tumor registries in France, diagnosed in 1990 (±1 year), 1995 (±1 year), and 2000 (±1 year). Controls were randomly selected from electoral rolls, stratifying on gender, age group, and residence area. Participants completed two QOL questionnaires, a fatigue questionnaire, an anxiety questionnaire, and a life conditions questionnaire. An analysis of variance was used to compare QOL scores of cancer survivors by period of diagnosis (5, 10, and 15 years) with those of controls, adjusted for sociodemographic data and comorbidities.Results. We included 344 colon cancer and 198 rectal cancer survivors and 1,181 controls. In a global analysis, ...

  
  

Mots clés : Colon-rectum; Lutte contre les cancers (Qualité de vie, soins de support)

Cette étude transversale brésilienne menée auprès de 202 participantes analyse la fatigue de survivantes d'un cancer du sein après leur traitement et son impact sur leur qualité de vie

• Fatigue after treatment in breast cancer survivors: prevalence, determinants and impact on health-related quality of life
  • Supportive Care in Cancer, pp. 1-9, 2011 (résumé)
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  Cette étude transversale brésilienne menée auprès de 202 participantes analyse la fatigue de survivantes d'un cancer du sein après leur traitement et son impact sur leur qualité de vie

  “Fatigue after treatment in breast cancer survivors: prevalence, determinants and impact on health-related quality of life”

  • Cavalli Kluthcovsky, Ana;Urbanetz, Almir;de Carvalho, Denise;Pereira Maluf, Eliane;Schlickmann Sylvestre, Geovana;Bonatto Hatschbach, Sergio

  Purpose Fatigue is a phenomenon that may persist for years after completion of adjuvant therapy, and is one of the most frequent symptoms associated with breast cancer survivors. The purposes of this study were to investigate the occurrence of fatigue in disease-free breast cancer survivors after treatment, to identify variables associated with fatigue, and to evaluate the impact of fatigue on health-related quality of life. Methods A cross-sectional study was conducted on 202 consecutive women diagnosed with in-situ to Stage III breast cancer attending in outpatient facilities of two large hospitals, one year or more after diagnosis. They completed the Piper Fatigue Scale-Revised and the European Organization for Research and Treatment of Cancer QLQ-C30. Multiple logistic regression models were used to identify predictive factors associated with fatigue. EORTC QLQC-30 scores for fatigued survivors were compared to non-fatigued survivors. Results The prevalence of fatigue reported by ...

  
  

Mots clés : Sein; Lutte contre les cancers (Qualité de vie, soins de support)

Cette étude de cohorte américaine incluant 404 participants évalue l'impact de la consommation d'alcool sur l'appétit, le poids corporel et la survie des patients atteints d'un cancer du poumon

• The Purported Effects of Alcohol on Appetite and Weight in Lung Cancer Patients
  • Nutrition and Cancer, sous presse, 2011 (résumé)
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  Cette étude de cohorte américaine incluant 404 participants évalue l'impact de la consommation d'alcool sur l'appétit, le poids corporel et la survie des patients atteints d'un cancer du poumon

  “The Purported Effects of Alcohol on Appetite and Weight in Lung Cancer Patients”

  • Jatoi, Aminah;Qi, Yingwei;Wampfler, Jason A.;Busta, Allan J.;Yang, Ping;Mandrekar, Sumithra

  Loss of appetite and weight predict poor outcomes in patients with advanced cancer. Effective and affordable palliative strategies are lacking; but because an emerging non-cancer literature suggests that alcohol can increase appetite and weight, this study explored associations between alcohol and clinical outcomes in lung cancer patients. Among 404 consecutive lung cancer patients enrolled in the Mayo Clinic Lung Cancer Cohort between 2004 and 2008, alcohol consumption (within 6 mo of diagnosis) was as follows: 199 (49%) used none, 158 (14%) were moderate users (7 drinks per wk or less), and 47 (12%) were heavier consumers (more than 7 drinks per wk). Only heavier consumers had a lower likelihood of anorexia (odds ratio: 0.49; 95% CI: 0.25, 0.94; P = 0.03) and weight loss (odds ratio: 0.43; 95% CI: 0.20, 0.91; P = 0.03) compared to those who consumed no alcohol. These conclusions were sustained in multivariate analyses. Neither moderate nor heavier consumption was associated with ...

  
  

Mots clés : Poumon; Lutte contre les cancers (Qualité de vie, soins de support)

Menée en Turquie auprès de 43 participants, cette étude prospective analyse la qualité de vie et les fonctions neurocognitives de patients atteints d'un gliome de bas grade

• Prospective assessment of health-related quality of life in patients with low-grade glioma
  • Supportive Care in Cancer, pp. 1-10, 2011 (résumé)
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  Menée en Turquie auprès de 43 participants, cette étude prospective analyse la qualité de vie et les fonctions neurocognitives de patients atteints d'un gliome de bas grade

  “Prospective assessment of health-related quality of life in patients with low-grade glioma”

  • Yavas, Cagdas;Zorlu, Faruk;Ozyigit, Gokhan;Gurkaynak, Murat;Yavas, Guler;Yuce, Deniz;Cengiz, Mustafa;Yildiz, Ferah;Akyol, Fadil

  Purpose The assessment of Health-Related Quality of Life (HRQoL) in cancer patients has become increasingly important during the past decades. The aim of this study was to evaluate the HRQoL in patients treated for low-grade glioma (LGG). Methods and Materials Forty-three adult patients with LGG were evaluated prospectively between September 2006 and December 2010. We assessed HRQoL at baseline (after surgery before radiotherapy), at the end of radiotherapy and during follow-up (every 3 months for the first 2 years and every 6 months between 2 and 5 years), using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC-C30), Brain Cancer Module-20 (BN-20), Mini Mental State Examination (MMSE) and Hospital Anxiety and Depression Scale (HADS). Results We demonstrated changes in global score ( p = 0.004), and future uncertainty ( p < 0.001), communication deficit ( p = 0.007), headache ( p < 0.001), drowsiness ( p = 0.002) and hair loss ...

  
  

Mots clés : Système nerveux central; Lutte contre les cancers (Qualité de vie, soins de support)

Menée aux Etats-Unis auprès de 190 participants, cette étude analyse la qualité de vie et les besoins en termes d'éducation pour la santé de survivants d'un cancer âgés de plus de 70 ans

• Quality of Life and Perceived Educational Needs among Older Cancer Survivors
  • Journal of Cancer Education, pp. 1-6, 2011 (résumé)
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  Menée aux Etats-Unis auprès de 190 participants, cette étude analyse la qualité de vie et les besoins en termes d'éducation pour la santé de survivants d'un cancer âgés de plus de 70 ans

  “Quality of Life and Perceived Educational Needs among Older Cancer Survivors”

  • Schlairet, Maura;Benton, Melissa

  The purpose of this study was to evaluate perceived educational needs regarding nutrition and exercise in older cancer survivors. One hundred ninety survivors, age 70.7 (7.5), completed a Survey of Needs developed from the City of Hope Quality of Life model. Fifty percent reported distress related to poor appetite, 60% reported distress related to weight change, 64% reported distress related to balance/walking/mobility difficulty, and 79% reported distress related to fatigue. Weight change, poor appetite, balance/walking/mobility difficulty, and fatigue were significantly associated with distress related to (a) managing household activities, (b) caring for family, (c) maintaining a sense of well-being, (d) coping with grief and loss, and (e) managing stress. Despite distress associated with weight change, poor appetite, mobility difficulty, and fatigue, respondents did not recognize a need for education regarding nutrition and exercise. Findings suggest that evaluating older ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

A partir d'une revue systématique de la littérature, cette méta-analyse (21 études) évalue la morbidité psychologique et la qualité de vie de patients atteints de cancer et appartenant à des minorités ethniques

• Psychological morbidity and quality of life of ethnic minority patients with cancer: a systematic review and meta-analysis
  • The Lancet Oncology, sous presse, 2011 (résumé)
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  A partir d'une revue systématique de la littérature, cette méta-analyse (21 études) évalue la morbidité psychologique et la qualité de vie de patients atteints de cancer et appartenant à des minorités ethniques

  “Psychological morbidity and quality of life of ethnic minority patients with cancer: a systematic review and meta-analysis”

  • Luckett, Tim;Goldstein, David;Butow, Phyllis N.;Gebski, Val;Aldridge, Lynley J.;McGrane, Joshua;Ng, Weng;King, Madeleine T.

  Ethnic minority is associated with higher cancer incidence and poorer survival than is being in the majority group. We did a systematic review and meta-analysis to assess whether psychological morbidity and health-related quality of life (HRQoL) were affected by minority status. We searched Medline, AMED, PsycINFO, Embase, CENTRAL, CINAHL, PubMed, Sociological Abstracts, and Web of Science for English-language articles published between Jan 1, 1995, and October, 2009. Articles were eligible if they reported original data on anxiety, depression, distress (for psychological morbidity), or HRQoL in minority and majority cancer patients or survivors. Minority status was defined as being an immigrant or having an ethnic, linguistic, or religious background different to the majority of the population in the country where the research was done. We excluded African Americans and indigenous groups. Eligible articles were rated for quality of reporting, external validity, internal validity, ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

A partir des données de 12 essais randomisés menés aux Etats-Unis entre 1977 et 2002 et incluant 14 611 patients, cette étude analyse et compare la survie des patients, blancs et noirs, atteints d'un cancer du colon de stade 2 ou 3 et recevant une chimiothérapie

• Outcomes Among Black Patients With Stage II and III Colon Cancer Receiving Chemotherapy: An Analysis of ACCENT Adjuvant Trials
  • Journal of the National Cancer Institute, sous presse, 2011 (résumé)
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  A partir des données de 12 essais randomisés menés aux Etats-Unis entre 1977 et 2002 et incluant 14 611 patients, cette étude analyse et compare la survie des patients, blancs et noirs, atteints d'un cancer du colon de stade 2 ou 3 et recevant une chimiothérapie

  “Outcomes Among Black Patients With Stage II and III Colon Cancer Receiving Chemotherapy: An Analysis of ACCENT Adjuvant Trials”

  • Yothers, Greg;Sargent, Daniel J.;Wolmark, Norman;Goldberg, Richard M.;O’Connell, Michael J.;Benedetti, Jacqueline K.;Saltz, Leonard B.;Dignam, James J.;Blackstock, A. William;on behalf of the ACCENT Collaborative Group

  Background Among patients with resected colon cancer, black patients have worse survival than whites. We investigated whether disparities in survival and related endpoints would persist when patients were treated with identical therapies in controlled clinical trials.Methods We assessed 14 611 patients (1218 black and 13 393 white) who received standardized adjuvant treatment in 12 randomized controlled clinical trials conducted in North America for resected stage II and stage III colon cancer between 1977 and 2002. Individual patient data on covariates and outcomes were extracted from the Adjuvant Colon Cancer ENdpoinTs (ACCENT) database. The endpoints examined in this meta-analysis were overall survival (time to death), recurrence-free survival (time to recurrence or death), and recurrence-free interval (time to recurrence). Cox models were stratified by study and controlled for sex, stage, age, and treatment to determine the effect of race. Kaplan–Meier estimates were ...

  
  
• Race and Subset Analyses in Clinical Trials: Time to Get Serious About Data Integration
  • Journal of the National Cancer Institute, sous presse, 2011 (éditorial en libre accès)
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  A partir des données de 12 essais randomisés menés aux Etats-Unis entre 1977 et 2002 et incluant 14 611 patients, cette étude analyse et compare la survie des patients, blancs et noirs, atteints d'un cancer du colon de stade 2 ou 3 et recevant une chimiothérapie

  “Race and Subset Analyses in Clinical Trials: Time to Get Serious About Data Integration”

  • Polite, Blase N. ; Sylvester, Brooke E. ; Olopade, Olufunmilayo I.

  
  
• Survival Disparities Between African-American and White Colo-rectal Cancer Patients
  • Journal of the National Cancer Institute, sous presse, 2011 (communiqué de presse)
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  A partir des données de 12 essais randomisés menés aux Etats-Unis entre 1977 et 2002 et incluant 14 611 patients, cette étude analyse et compare la survie des patients, blancs et noirs, atteints d'un cancer du colon de stade 2 ou 3 et recevant une chimiothérapie

  “Survival Disparities Between African-American and White Colo-rectal Cancer Patients”

  
  

Mots clés : Colon-rectum; Lutte contre les cancers (Observation)

Cette étude de cohorte en population suédoise (415 participants) analyse les déterminants de la survie des patients atteints d'un cancer colorectal et évalue l'impact d'un second cancer primitif sur le calcul du critère de survie sans maladie

• Survival endpoints in colorectal cancer and the effect of second primary other cancer on disease free survival
  • BMC Cancer, Vol. 11 (1), pp. 438, 2011 (article en libre accès)
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  Cette étude de cohorte en population suédoise (415 participants) analyse les déterminants de la survie des patients atteints d'un cancer colorectal et évalue l'impact d'un second cancer primitif sur le calcul du critère de survie sans maladie

  “Survival endpoints in colorectal cancer and the effect of second primary other cancer on disease free survival”

  • Birgisson, Helgi;Wallin, Ulrik;Holmberg, Lars;Glimelius, Bengt

  BACKGROUND:In cancer research the selection and definitions of survival endpoints are important and yet they are not used consistently. The aim of this study was to compare different survival endpoints in patients with primary colorectal cancer (CRC) and to understand the effect of second primary other cancer on disease-free survival (DFS) calculations. METHODS:A population-based cohort of 415 patients with CRC, 332 of whom were treated with curative intention between the years 2000-2003, was analysed. Events such as locoregional recurrence, distant metastases, second primary cancers, death, cause of death and loss to follow-up were recorded. Different survival endpoints, including DFS, overall survival, cancer-specific survival, relapse-free survival, time to treatment failure and time to recurrence were compared and DFS was calculated with and without inclusion of second primary other cancers. RESULTS:The events that occurred most often in patients treated with curative intention ...

  
  

Mots clés : Colon-rectum; Lutte contre les cancers (Observation)

A partir des données des registres américains du cancer et celles de la base Medicare entre 1994 et 2005, cette étude de cohorte (incluant 57 839 patients âgés de plus de 69 ans et bénéficiaires du système Medicare) analyse les facteurs prédictifs et la prévalence d'un cancer colorectal de l'intervalle

• Prevalence and predictors of interval colorectal cancers in Medicare beneficiaries
  • Cancer, sous presse, 2011 (résumé)
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  A partir des données des registres américains du cancer et celles de la base Medicare entre 1994 et 2005, cette étude de cohorte (incluant 57 839 patients âgés de plus de 69 ans et bénéficiaires du système Medicare) analyse les facteurs prédictifs et la prévalence d'un cancer colorectal de l'intervalle

  “Prevalence and predictors of interval colorectal cancers in Medicare beneficiaries”

  • Cooper, Gregory S.;Xu, Fang;Barnholtz Sloan, Jill S.;Schluchter, Mark D.;Koroukian, Siran M.

  BACKGROUND: After a colonoscopy that is negative for cancer, a subset of patients may be diagnosed with colorectal cancer, also termed interval cancer. The frequency and predictors have not been well studied in a population-based US cohort. METHODS: The authors used the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database to identify 57,839 patients aged ≥69 years who were diagnosed with colorectal cancer between 1994 and 2005 and who underwent colonoscopy within 6 months of cancer diagnosis. Colonoscopy performed between 6 and 36 months before cancer diagnosis was a proxy for interval cancer. RESULTS: By using the case definition, 7.2% of patients developed interval cancers. Factors that were associated with interval cancers included proximal tumor location (distal colon: multivariable odds ratio [OR], 0.42; 95% confidence interval [CI], 0.390-0.46; rectum: OR, 0.47; 95% CI, 0.42-0.53), increased comorbidity (OR, 1.89; 95% CI, 1.68 2.14 for ≥3 ...

  
  

Mots clés : Colon-rectum; Lutte contre les cancers (Observation)

Menée aux Etats-Unis auprès de 1 915 participants, cette étude analyse l'incidence de maladies thrombo-emboliques chez des patients atteints de cancer invasif du pancréas

• Analysis of incidence and clinical outcomes in patients with thromboembolic events and invasive exocrine pancreatic cancer
  • Cancer, sous presse, 2011 (résumé)
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  Menée aux Etats-Unis auprès de 1 915 participants, cette étude analyse l'incidence de maladies thrombo-emboliques chez des patients atteints de cancer invasif du pancréas

  “Analysis of incidence and clinical outcomes in patients with thromboembolic events and invasive exocrine pancreatic cancer”

  • Epstein, Andrew S.;Soff, Gerald A.;Capanu, Marinela;Crosbie, Christopher;Shah, Manish A.;Kelsen, David P.;Denton, Brian;Gardos, Stuart;O'Reilly, Eileen M.

  BACKGROUND: Pancreatic adenocarcinoma is among the most common malignancies associated with thromboembolic events (TEs); however, reported incidence figures vary significantly and contain small patient cohorts. Pancreatic cancer-specific thrombosis studies examining the correlation between clinical variables, including thrombosis timing and the impact of thrombosis on survival, have not been reported. METHODS: Survival analyses were performed relating to the development and timing of a TE in 1915 patients administered chemotherapy at Memorial Sloan-Kettering Cancer Center with invasive exocrine pancreatic cancer from January 1, 2000 to December 31, 2009. TE timing, relative to clinical parameters including laboratory data, erythropoietin-stimulating agent use, and body mass index (BMI), were also analyzed. RESULTS: A thrombosis was identified in 690 (36%) patients. After adjusting for patients with pancreatic surgery and thrombosis (n = 127), developing a TE significantly increased ...

  
  

Mots clés : Pancréas; Lutte contre les cancers (Observation)

Menée en Suède auprès de 73 159 participants âgés de 25 à 74 ans, cette étude analyse l'association entre le fait d'habiter dans une zone économiquement défavorisée et la mortalité des patients atteints d'un cancer de la prostate

• Neighborhood deprivation and prostate cancer mortality: a multilevel analysis from Sweden
  • Prostate Cancer Prostatic Diseases, sous presse, 2011 (résumé)
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  Menée en Suède auprès de 73 159 participants âgés de 25 à 74 ans, cette étude analyse l'association entre le fait d'habiter dans une zone économiquement défavorisée et la mortalité des patients atteints d'un cancer de la prostate

  “Neighborhood deprivation and prostate cancer mortality: a multilevel analysis from Sweden”

  • Li, X.;Sundquist, K.;Sundquist, J.

  The objective was to analyze the association between neighborhood deprivation and prostate cancer mortality, after adjusting for individual characteristics. Methods: This study was designed as a follow-up study of prostate cancer mortality between 1 January 1990 and 31 December 2008 in patients aged 25–74 years (a total of 73159 patients). Multilevel logistic regression analyses were performed with individual-level characteristics at the first level and level of neighborhood deprivation at the second level. Results: The age-standardized prostate cancer mortality rate was 1.5 times higher in men living in high-deprivation neighborhoods than in those living in the most affluent neighborhoods. Mortality rates were also associated with certain individual-level characteristics, that is, age, marital status, family income, educational attainment, immigration status, urban/rural status, mobility and comorbidity. For example, there was a strong relationship between prostate cancer mortality ...

  
  

Mots clés : Prostate; Lutte contre les cancers (Observation)

Menée aux Etats-Unis auprès de 166 participantes, cette étude analyse les disparités ethniques dans la qualité de vie et les symptômes et déficiences physiques de patientes atteintes d'un cancer du sein après leur traitement chirurgical

• Racial disparities in physical and functional domains in women with breast cancer
  • Supportive Care in Cancer, pp. 1-9, 2011 (résumé)
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  Menée aux Etats-Unis auprès de 166 participantes, cette étude analyse les disparités ethniques dans la qualité de vie et les symptômes et déficiences physiques de patientes atteintes d'un cancer du sein après leur traitement chirurgical

  “Racial disparities in physical and functional domains in women with breast cancer”

  • Morehead-Gee, Alicia;Pfalzer, Lucinda;Levy, Ellen;McGarvey, Charles;Springer, Barbara;Soballe, Peter;Gerber, Lynn;Stout, Nicole

  Introduction African-American women are more likely than white women to have functional impairments after breast cancer (BC) surgery; however, no differences were found in self-reported health status surveys at 12+ months postsurgery. Purpose This analysis compared white and African-American BC survivors’ (BCS) health status, health-related quality of life, and the occurrence of physical impairments after BC treatment. Methods One hundred sixty-six women (130 white, 28 African-American, 8 other) were assessed for impairments preoperatively and at 1, 3, 6, 9, and 12+ months postsurgery. Health status was assessed at 12+ months using the Short Form Health Survey (SF36v2™). Analysis of variance estimated differences between groups for health status and impairment occurrence. Results No differences were found between groups for BC type, stage, grade, or tumor size; surgery type; or number of lymph nodes sampled. African-American BCS had more estrogen/progesterone receptor-negative ...

  
  

Mots clés : Sein; Lutte contre les cancers (Observation)

Cette étude de cohorte américaine incluant 778 de patients opérés d'un cancer de l'œsophage évalue l'impact de l'indice de masse corporelle et du tabagisme sur leur survie

• Prognostic Impact of Body Mass Index Stratified by Smoking Status in Patients With Esophageal Adenocarcinoma
  • Journal of Clinical Oncology, sous presse, 2011 (résumé)
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  Cette étude de cohorte américaine incluant 778 de patients opérés d'un cancer de l'œsophage évalue l'impact de l'indice de masse corporelle et du tabagisme sur leur survie

  “Prognostic Impact of Body Mass Index Stratified by Smoking Status in Patients With Esophageal Adenocarcinoma”

  • Yoon, Harry H.;Lewis, Mark A.;Shi, Qian;Khan, Maliha;Cassivi, Stephen D.;Diasio, Robert B.;Sinicrope, Frank A.

  Purpose Given that smoking affects body mass index (BMI) and survival, stratification by smoking status may be required to determine the true prognostic impact of BMI. Although obesity increases risk for developing esophageal adenocarcinoma (EAC), the prognostic influence of obesity and its potential modification by smoking status is unknown in this disease.Patients and Methods All patients (N = 778) underwent potentially curative esophagectomy. BMI was calculated using measured height and weight at surgery and categorized as obese (≥ 30 kg/m2), overweight (25 to 29.9 kg/m2), or normal (18.5 to 24.9 kg/m2). Cigarette smoking was categorized as never or ever. The association of BMI with disease-specific survival (DSS), disease-free survival (DFS), and overall survival (OS) was determined by Cox regression.Results Excess BMI was significantly associated with DSS in a manner that differed substantially by smoking status (P for interaction = .023). Among never smokers, obesity was ...

  
  

Mots clés : Oesophage; Lutte contre les cancers (Observation)

Cette étude française (16 cas et 21 témoins) analyse les effets cérébraux et fonctionnels, en particulier sur la mémoire autobiographique, d'une histoire de cancer du sein

• Breast Cancer Affects Both the Hippocampus Volume and the Episodic Autobiographical Memory Retrieval
  • PLoS ONE, Vol. 6 (10), pp. e25349, 2011 (résumé)
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  Cette étude française (16 cas et 21 témoins) analyse les effets cérébraux et fonctionnels, en particulier sur la mémoire autobiographique, d'une histoire de cancer du sein

  “Breast Cancer Affects Both the Hippocampus Volume and the Episodic Autobiographical Memory Retrieval”

  • Bergouignan, Loretxu;Lefranc, Jean Pierre;Chupin, Marie;Morel, Nastassja;Spano, Jean Philippe;Fossati, Philippe

  Neuroimaging studies show the hippocampus is a crucial node in the neural network supporting episodic autobiographical memory retrieval. Stress-related psychiatric disorders, namely Major Depression and Post Traumatic Stress Disorder (PTSD), are related to reduced hippocampus volume. However, this is not the case for remitted breast cancer patients with co-morbid stress-related psychiatric disorders. This exception may be due to the fact that, consequently to the cancer experience as such, this population might already be characterized by a reduced hippocampus with an episodic autobiographical memory deficit.

  We scanned, with a 3T Siemens TRIO, 16 patients who had lived through a “standard experience of breast cancer” (breast cancer and a standard treatment in remission since 18 month) in the absence of any associated stress-related psychiatric or neurological disorder and 21 matched controls. We then assessed their episodic ...

  
  

Mots clés : Sein; Lutte contre les cancers (Approches psycho-sociales)

Menée auprès de 437 participantes, cette étude américaine évalue l'efficacité de la détection précoce des symptômes et troubles psychiatriques chez des patientes nouvellement diagnostiquées avec un cancer du sein

• Is screening effective in detecting untreated psychiatric disorders among newly diagnosed breast cancer patients?
  • Cancer, sous presse, 2011 (résumé)
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  Menée auprès de 437 participantes, cette étude américaine évalue l'efficacité de la détection précoce des symptômes et troubles psychiatriques chez des patientes nouvellement diagnostiquées avec un cancer du sein

  “Is screening effective in detecting untreated psychiatric disorders among newly diagnosed breast cancer patients?”

  • Palmer, Steven C.;Taggi, Alison;DeMichele, Angela;Coyne, James C.

  BACKGROUND: A key purpose of routine distress screening is to ensure that cancer patients receive appropriate mental health care. Most studies validating screening instruments overestimate the effectiveness of screening by not differentiating between patients with untreated disorders and patients who are already being treated. This study adopts the novel strategy of evaluating the effectiveness of screening after correcting for disorder for which treatment is already being provided. METHODS: A total of 437 recently diagnosed breast cancer patients received in-clinic distress screening and telephone-based psychiatric interviews. Analyses were conducted using receipt of psychotropic medication for mental health difficulties in the context of a psychiatric disorder as a proxy for identification and treatment. RESULTS: Rates of elevated distress (33%), major depressive disorder (8%), minor depression (6%), dysthymia (2%), or generalized anxiety disorder (3%) were similar to those in other ...

  
  

Mots clés : Sein; Lutte contre les cancers (Approches psycho-sociales)

Menée auprès de 167 femmes porteuses de mutations BRCA1 et 2, cette étude observationnelle analyse les effets à long terme de la connaissance des résultats d'un test génétique sur leurs comportements de santé et le soutien de leur famille

• Long-Term Reactions to Genetic Testing for BRCA1 and BRCA2 Mutations: Does Time Heal Women's Concerns?
  • Journal of Clinical Oncology, sous presse, 2011 (résumé)
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  Menée auprès de 167 femmes porteuses de mutations BRCA1 et 2, cette étude observationnelle analyse les effets à long terme de la connaissance des résultats d'un test génétique sur leurs comportements de santé et le soutien de leur famille

  “Long-Term Reactions to Genetic Testing for BRCA1 and BRCA2 Mutations: Does Time Heal Women's Concerns?”

  • Hughes Halbert, Chanita;Stopfer, Jill E.;McDonald, Jasmine;Weathers, Benita;Collier, Aliya;Troxel, Andrea B.;Domchek, Susan

  Purpose Short-term reactions to BRCA1 and BRCA2 (BRCA1/2) genetic test results have been described in several reports, but the long-terms effects of testing have not been examined extensively.Methods We conducted an observational study to characterize the long-term impact of genetic testing for BRCA1/2 mutations in 167 women who had received genetic test results at least 4 years ago. We also evaluated the relationship between genetic testing–specific reactions and breast and ovarian cancer screening to determine the behavioral significance of adverse reactions.Results Seventy-four percent of women were not experiencing any distress regarding their test result, 41% were not experiencing any uncertainty, and 51% had a score for positive experiences that was suggestive of low levels of adverse reactions in terms of family support and communication. Mutation carriers (odds ratio, 3.96; 95% CI, 1.44 to 10.89; P = .01) were most likely to experience distress. Only less time since ...

  
  

Mots clés : Sein; Lutte contre les cancers (Approches psycho-sociales)

Menée en Australie auprès de 51 patientes atteintes d'un cancer du sein, cette étude analyse l'impact d'une activité de loisir avec un défi à relever, ici une longue randonnée à moto, sur leur détresse psychologique et leur bien-être

• Motorcycles and breast cancer: The influence of peer support and challenge on distress and posttraumatic growth
  • Supportive Care in Cancer, pp. 1-10, 2011 (résumé)
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  Menée en Australie auprès de 51 patientes atteintes d'un cancer du sein, cette étude analyse l'impact d'une activité de loisir avec un défi à relever, ici une longue randonnée à moto, sur leur détresse psychologique et leur bien-être

  “Motorcycles and breast cancer: The influence of peer support and challenge on distress and posttraumatic growth”

  • Morris, B.;Chambers, S.;Campbell, M.;Dwyer, M.;Dunn, J.

  Purpose Peer support programs based on exercise or challenge activities may have potential to improve well-being for women diagnosed with breast cancer. The current study investigated the role of social comparison and social identity based on group membership on posttraumatic growth (PTG) and distress. Methods Fifty-one women diagnosed with breast cancer who participated in a 1,000 mi group motorcycle ride completed pre- and post-ride surveys. Participants had a mean age of 49.82 years ( SD = 7.04) and their average time since diagnosis was 6.39 years ( SD = 3.89). Results Cancer-related distress significantly decreased after the ride. PTG did not significantly differ after the ride, which may have been a result of a ceiling effect on this measure. Hierarchical regression analyses showed that pre-ride PTG ( p < 0.01) and upward social comparison during the ride ( p < 0.05) were related to post-ride PTG. Pre-ride distress was the only variable to remain significantly related to ...

  
  

Mots clés : Sein; Lutte contre les cancers (Approches psycho-sociales)

Menée en Australie, cette étude pilote évalue l'efficacité d'une psychothérapie cognitive de couple pour aider les patients nouvellement diagnostiqués avec un cancer de la prostate et leur partenaire

• Cognitive Existential Couple Therapy for newly diagnosed prostate cancer patients and their partners: a descriptive pilot study
  • Psycho-Oncology, sous presse, 2011 (résumé)
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  Menée en Australie, cette étude pilote évalue l'efficacité d'une psychothérapie cognitive de couple pour aider les patients nouvellement diagnostiqués avec un cancer de la prostate et leur partenaire

  “Cognitive Existential Couple Therapy for newly diagnosed prostate cancer patients and their partners: a descriptive pilot study”

  • Collins, Anna L.;Love, Anthony W.;Bloch, Sidney;Street, Annette F.;Duchesne, Gillian M.;Dunai, Judy;Couper, Jeremy W.

  Objective This paper aims to describe ‘Cognitive Existential Couple Therapy’ (CECT), a novel couples-based intervention for men with early stage prostate cancer (PCa) and their partners, and to report preliminary findings from a pilot study that investigated the acceptability and feasibility of the intervention and the measures to be used in a subsequent randomised controlled trial. Methods A manualised CECT programme was delivered to 12 couples facing a diagnosis of PCa within the previous 12 months by psychiatrists and clinical psychologists. Participants completed measures of psychological distress, marital function and coping pattern before and after CECT. Semi-structured interviews were conducted with nine couples shortly after the completion of CECT. Results The application of CECT was both feasible and acceptable as indicated by favourable participant compliance (10 of the 12 couples attended all six designated sessions), completion of measures before and after CECT and ...

  
  

Mots clés : Prostate; Lutte contre les cancers (Approches psycho-sociales)

Menée auprès de 682 survivants à long terme d'un lymphome non hodgkinien, cette étude analyse leurs symptômes de stress post-traumatique

• Post-Traumatic Stress Symptoms in Long-Term Non-Hodgkin's Lymphoma Survivors: Does Time Heal?
  • Journal of Clinical Oncology, sous presse, 2011 (résumé)
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  Menée auprès de 682 survivants à long terme d'un lymphome non hodgkinien, cette étude analyse leurs symptômes de stress post-traumatique

  “Post-Traumatic Stress Symptoms in Long-Term Non-Hodgkin's Lymphoma Survivors: Does Time Heal?”

  • Smith, Sophia K.;Zimmerman, Sheryl;Williams, Christianna S.;Benecha, Habtamu;Abernethy, Amy P.;Mayer, Deborah K.;Edwards, Lloyd J.;Ganz, Patricia A.

  Purpose Little is known about the trajectory of post-traumatic stress disorder (PTSD) symptoms in cancer survivors, despite the fact that such knowledge can guide treatment. Therefore, this study examined changes in PTSD symptoms among long-term survivors of non-Hodgkin's lymphoma (NHL) and identified demographic, clinical, and psychosocial predictors and correlates of PTSD symptomatology.Patients and Methods Surveys were mailed to 682 NHL survivors who participated in an earlier survey and now were at least 7 years postdiagnosis. Information was obtained regarding PTSD symptoms, positive and negative perceptions of the cancer experience (ie, impact of cancer), and other potential correlates of PTSD.Results A total of 566 individuals participated (83% response rate) with a median of 12.9 years since diagnosis; respondents were 52% female and 87% white. Although half (51%) of the respondents reported no PTSD symptoms and 12% reported a resolution of symptoms, more than one-third (37%) ...

  
  

Mots clés : Lymphome; Lutte contre les cancers (Approches psycho-sociales)

Menée aux Etats-Unis auprès de 1 516 survivants d'un cancer, cette étude analyse leurs besoins psychosociaux et en termes d'information de santé

• Needs assessment of cancer survivors in Connecticut
  • Journal of Cancer Survivorship, pp. 1-10, 2011 (résumé)
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  Menée aux Etats-Unis auprès de 1 516 survivants d'un cancer, cette étude analyse leurs besoins psychosociaux et en termes d'information de santé

  “Needs assessment of cancer survivors in Connecticut”

  • Tish Knobf, M.;Ferrucci, Leah;Cartmel, Brenda;Jones, Beth;Stevens, Denise;Smith, Maureen;Salner, Andrew;Mowad, Linda

  Introduction There are knowledge gaps regarding the needs of cancer survivors in Connecticut and their utilization of supportive services. Methods A convenience sample of cancer survivors residing in Connecticut were invited to complete a self-administered (print or online) needs assessment (English or Spanish). Participants identified commonly occurring problems and completed a modified version of the Supportive Care Needs Survey Short Form (SNCS-SF34) assessing needs across five domains (psychosocial, health systems/information, physical/daily living, patient care /support, and sexuality). Results The majority of the 1,516 cancer survivors (76.4%) were women, 47.5% had completed high school or some college, 66.1% were diagnosed ≤5 years ago, and 87.7% were non-Hispanic white. The breast was the most common site (47.6%), followed by the prostate, colorectal, lung, and melanoma. With multivariate adjustment, need on the SCNS-SF34 was greatest among women, younger survivors, those ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Approches psycho-sociales)

Cet article plaide pour la prise en compte des critères économiques dans le développement des thérapies médicamenteuses personnalisées

• Personalized cancer medicine-advances and socio-economic challenges
  • Nature Reviews Clinical Oncology, sous presse, 2011 (résumé)
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  Cet article plaide pour la prise en compte des critères économiques dans le développement des thérapies médicamenteuses personnalisées

  “Personalized cancer medicine-advances and socio-economic challenges”

  • Jackson, David B.;Sood, Anil K.

  It was Hippocrates, the father of Western medicine, who first emphasized the patient as the most important determinant of therapeutic efficacy. Although the principle of adjusting treatment to specific patient characteristics has since been the strategy of physicians, this is undermined by a population-biased approach to drug development. Therefore, it is generally true to say that our current evidential approach to cancer treatment is driven more by drug-regulation requirements and market considerations than the specific needs of an individual patient. But, with cancer drug costs now spiraling out of control and the modest efficacy typically seen in patients, the community is again turning to Hippocrates' ancient paradigm—this time with emphasis on molecular considerations. Rapidly evolving technologies are empowering us to describe the molecular 'nature' of a patient and/or tumor and with this has come the beginning of truly personalized medicine, with maximized efficacy, cost ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Analyses économiques et systèmes de soins)

Cette étude en population britannique incluant 1 515 participantes âgées de plus de 30 ans analyse les disparités ethniques dans leurs connaissances liées aux symptômes et au cancer du sein

• Breast cancer awareness and barriers to symptomatic presentation among women from different ethnic groups in East London
  • British Journal of Cancer, sous presse, 2011 (article en libre accès)
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  Cette étude en population britannique incluant 1 515 participantes âgées de plus de 30 ans analyse les disparités ethniques dans leurs connaissances liées aux symptômes et au cancer du sein

  “Breast cancer awareness and barriers to symptomatic presentation among women from different ethnic groups in East London”

  • Forbes, L. J. L.;Atkins, L.;Thurnham, A.;Layburn, J.;Haste, F.;Ramirez, A. J.

  Background: During 2001 to 2005, 1-year breast cancer survival was low in ethnically diverse East London. We hypothesised that this was due to low breast cancer awareness and barriers to symptomatic presentation, leading to late stage at diagnosis in women from ethnic minorities. We examined ethnic differences in breast cancer awareness and barriers to symptomatic presentation in East London. Methods: We carried out a population-based survey of 1515 women aged 30+ using the Cancer Research UK Breast Cancer Awareness Measure. We analysed the data using logistic regression adjusting for age group and level of deprivation. Results: South Asian and black women had lower breast cancer awareness than white women. South Asian women, but not black women, reported more emotional barriers to seeking medical help than white women. White women were more likely than non-white women to report worry about wasting the doctor's time as a barrier to symptomatic presentation. Conclusion: ...

  
  

Mots clés : Sein; Lutte contre les cancers (Sensibilisation et communication)

Par comparaison avec les campagnes de sensibilisation sur le cancer du poumon et de la prostate, cette étude américaine analyse l'impact de la campagne annuelle de sensibilisation relative au cancer du sein se déroulant chaque mois d'octobre sur l'activité de recherche via internet

• The effect of breast cancer awareness month on internet search activity - a comparison with awareness campaigns for lung and prostate cancer
  • BMC Cancer, Vol. 11 (1), pp. 442, 2011 (article en libre accès)
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  Par comparaison avec les campagnes de sensibilisation sur le cancer du poumon et de la prostate, cette étude américaine analyse l'impact de la campagne annuelle de sensibilisation relative au cancer du sein se déroulant chaque mois d'octobre sur l'activité de recherche via internet

  “The effect of breast cancer awareness month on internet search activity - a comparison with awareness campaigns for lung and prostate cancer”

  • Glynn, Ronan;Kelly, John;Coffey, Norma;Sweeney, Karl;Kerin, Michael

  BACKGROUND:This work aimed to assess the effects of the annual breast cancer awareness campaign on internet search activity, and to compare these effects with those of similar campaigns in prostate and lung cancer. We further aimed to assess overall levels of online activity relating to all three neoplasms between 2004 and 2009. METHODS:Google Insights for Search was employed to examine search trends for the term "breast cancer", across all Google domains between January 2004 and December 2009 (6 years). Search trends for both "prostate cancer" and "lung cancer" across all domains were also analysed for the same period, and these trends were compared with those for "breast cancer". Repeated measures ANOVA and Tukey post-hoc analyses were performed to assess for significant differences in activity. RESULTS:Increased levels of online activity relating to breast cancer are consistently generated each October. There is a significantly higher level of background activity in breast cancer ...

  
  

Mots clés : Sein; Lutte contre les cancers (Sensibilisation et communication)

Menée en France auprès de 836 participants, cette étude analyse les perceptions des fumeurs face au packaging des paquets de cigarette, en comparant les éditions régulières ou limitées

• Consumer perceptions of cigarette pack design in France: a comparison of regular, limited edition and plain packaging
  • Tobacco Control, sous presse, 2011 (résumé)
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  Menée en France auprès de 836 participants, cette étude analyse les perceptions des fumeurs face au packaging des paquets de cigarette, en comparant les éditions régulières ou limitées

  “Consumer perceptions of cigarette pack design in France: a comparison of regular, limited edition and plain packaging”

  • Gallopel-Morvan, Karine;Moodie, Crawford;Hammond, David;Eker, Figen;Beguinot, Emmanuelle;Martinet, Yves

  Background In the face of comprehensive bans on the marketing of tobacco products, packaging has become an increasingly important promotional tool for the tobacco industry. A ban on the use of branding on tobacco packaging, known as ‘plain’ packaging, has emerged as a promising regulatory strategy. The current study sought to examine perceptions of cigarette packaging among adults in France.Methods Adult smokers and non-smokers (N=836) were surveyed using computer-assisted personal interviewing to assess perceptions of pack design by comparing ‘regular’ branded packs and ‘limited edition’ packs (with novel designs or innovations) with ‘plain’ versions of these packs with all branding, including colour, removed.Results Plain packs (PP) were less likely than regular packs, and particularly limited edition packs, to be considered attractive, attention grabbing and likely to motivate youth purchase. PPs were also rated as the most effective in convincing non-smokers not to ...

  
  

Mots clés : Poumon; Lutte contre les cancers (Sensibilisation et communication)

Menée au Bangladesh, en Chine, en Egypte, en Inde, en Indonesie, au Mexique, aux Philippines, en Russie, en Turquie et au Vietnam, cette étude de cohorte incluant 2 399 fumeurs âgés de 18 à 34 ans analyse l'efficacité des messages publicitaires télévisuels relatifs aux dangers du tabac

• Smokers' responses to television advertisements about the serious harms of tobacco use: pre-testing results from 10 low- to middle-income countries
  • Tobacco Control, sous presse, 2011 (résumé)
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  Menée au Bangladesh, en Chine, en Egypte, en Inde, en Indonesie, au Mexique, aux Philippines, en Russie, en Turquie et au Vietnam, cette étude de cohorte incluant 2 399 fumeurs âgés de 18 à 34 ans analyse l'efficacité des messages publicitaires télévisuels relatifs aux dangers du tabac

  “Smokers' responses to television advertisements about the serious harms of tobacco use: pre-testing results from 10 low- to middle-income countries”

  • Wakefield, Melanie;Bayly, Megan;Durkin, Sarah;Cotter, Trish;Mullin, Sandra;Warne, Charles;for the International Anti-Tobacco Advertisement Rating Study Team

  Background While television advertisements (ads) that communicate the serious harms of smoking are effective in prompting quitting-related thoughts and actions, little research has been conducted among smokers in low- to middle-income countries to guide public education efforts.Method 2399 smokers aged 18–34 years in 10 low- to middle-income countries (Bangladesh, China, Egypt, India, Indonesia, Mexico, Philippines, Russia, Turkey and Vietnam) viewed and individually rated the same five anti-smoking ads on a standard questionnaire and then engaged in a structured group discussion about each ad. Multivariate logistic regression analysis, with robust SEs to account for the same individual rating multiple ads, was performed to compare outcomes (message acceptance, perceived personalised effectiveness, feel uncomfortable, likelihood of discussing the ad) across ads and countries, adjusting for covariates. Ads by country interactions were examined to assess consistency of ratings ...

  
  

Mots clés : Poumon; Lutte contre les cancers (Sensibilisation et communication)

A partir d'une revue systématique de la littérature, cette étude analyse la souffrance et la détresse psychologique en fin de vie

• Suffering and distress at the end-of-life
  • Psycho-Oncology, sous presse, 2011 (résumé)
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  A partir d'une revue systématique de la littérature, cette étude analyse la souffrance et la détresse psychologique en fin de vie

  “Suffering and distress at the end-of-life”

  • Krikorian, Alicia;Limonero, Joaquín T.;Maté, Jorge

  Objective Suffering frequently occurs in the context of chronic and progressive medical illnesses and emerges with great intensity at end-of-life. A review of the literature on suffering and distress-related factors was conducted to illustrate the integrative nature of suffering in this context. We hope it will result in a comprehensive approach, centered in the patient-family unit, which will alleviate or eliminate unnecessary suffering and provide well-being, when possible. Methods An extensive search of the literature on suffering and distress in end-of-life patients was conducted. While the present review is not a systematic one, an in-depth search using the terms ‘Suffering’, ‘Distress’, End-of-Life’, ‘Palliative Care’, and ‘Terminal illness’ was conducted using search engines such as PubMed, PsycINFO, MEDLINE, EBSCO-Host, OVID, and SciELO. Results Taking into account the comprehensive and integrative nature of suffering, factors related to the physical, ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Soins palliatifs)

Menée auprès de 422 participants, cette étude rétrospective analyse et compare, en Belgique et aux Pays-Bas, les soins de fin de vie et les circonstances du décès de patients atteints de cancer

• End-of-Life Care and Circumstances of Death in Patients Dying As a Result of Cancer in Belgium and the Netherlands: A Retrospective Comparative Study
  • Journal of Clinical Oncology, sous presse, 2011 (résumé)
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  Menée auprès de 422 participants, cette étude rétrospective analyse et compare, en Belgique et aux Pays-Bas, les soins de fin de vie et les circonstances du décès de patients atteints de cancer

  “End-of-Life Care and Circumstances of Death in Patients Dying As a Result of Cancer in Belgium and the Netherlands: A Retrospective Comparative Study”

  • Meeussen, Koen;Van den Block, Lieve;Echteld, Michael A.;Boffin, Nicole;Bilsen, Johan;Van Casteren, Viviane;Abarshi, Ebun;Donker, Gé;Onwuteaka-Philipsen, Bregje;Deliens, Luc

  Purpose To examine and compare end-of-life care in patients with cancer dying in Belgium and the Netherlands.Patients and Methods A mortality follow-back study was undertaken in 2008 via representative nationwide sentinel networks of general practitioners (GPs) in Belgium and the Netherlands. By using similar standardized procedures, GPs reported on aspects of end-of-life care and the circumstances of nonsudden death of patients with cancer in their practice.Results Of the 422 reported patients with cancer, most resided at home during the last year of life (Belgium, 91%; the Netherlands, 95%). Death occurred at home in 34% (Belgium) and 61% (the Netherlands) and in the hospital in 29% (Belgium) and 19% (the Netherlands). In the last month of life, end-of-life issues were more often discussed in the Netherlands (88%) than in Belgium (68%). In both countries, physical problems were discussed most often (Belgium, 49%; the Netherlands, 78%) and spiritual issues least often (Belgium, 20%; ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Soins palliatifs)