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Accueil Nota Bene Cancer V2 Numéro 137 du 22 May 2012 Prévention

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Prévention

Nutrition et prévention

A partir d'un questionnaire, cette étude allemande évalue l'association entre la consommation d'aliments riches en phytoestrogènes, en lignanes et en fibres, et le risque de cancer du sein après la ménopause (2 884 cas et 5 509 témoins)

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    A partir d'un questionnaire, cette étude allemande évalue l'association entre la consommation d'aliments riches en phytoestrogènes, en lignanes et en fibres, et le risque de cancer du sein après la ménopause (2 884 cas et 5 509 témoins)

    “The Association Between Dietary Lignans, Phytoestrogen-Rich Foods, and Fiber Intake and Postmenopausal Breast Cancer Risk: A German Case-Control Study”

    • Zaineddin, A. K.;Buck, K.;Vrieling, A.;Heinz, J.;Flesch-Janys, D.;Linseisen, J.;Chang-Claude, J.

    Phytoestrogens are structurally similar to estrogens and may affect breast cancer risk by mimicking estrogenic/antiestrogenic properties. In Western societies, whole grains and possibly soy foods are rich sources of phytoestrogens. A population-based case-control study in German postmenopausal women was used to evaluate the association of phytoestrogen-rich foods and dietary lignans with breast cancer risk. Dietary data were collected from 2,884 cases and 5,509 controls using a validated food-frequency questionnaire, which included additional questions phytoestrogen-rich foods. Associations were assessed using conditional logistic regression. All analyses were adjusted for relevant risk and confounding factors. Polytomous logistic regression analysis was performed to evaluate the associations by estrogen receptor (ER) status. High and low consumption of soybeans as well as of sunflower and pumpkin seeds were associated with significantly reduced breast cancer risk compared to no ...


Mots clés : Sein; Prévention (Nutrition et prévention)

Menée à l'aide de modèles murins présentant une tumeur mammaire "basal-like" ou "claudin-low", cette étude montre que le bilan énergétique alimentaire peut moduler la transition épithélio-mésenchymateuse et la progression tumorale

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    Menée à l'aide de modèles murins présentant une tumeur mammaire "basal-like" ou "claudin-low", cette étude montre que le bilan énergétique alimentaire peut moduler la transition épithélio-mésenchymateuse et la progression tumorale

    “Dietary Energy Balance Modulates Epithelial-To-Mesenchymal Transition and Tumor Progression in Murine Claudin-Low and Basal-Like Mammary Tumor Models”

    • Dunlap, Sarah M.;Chiao, Lucia J.;Nogueira, Leticia;Usary, Jerry;Perou, Charles M.;Varticovski, Lyuba;Hursting, Stephen D.

    Using novel murine models of claudin-low and basal-like breast cancer, we tested the hypothesis that diet-induced obesity (DIO) and calorie restriction (CR) differentially modulate progression of these aggressive breast cancer subtypes. For model development, we characterized two cell lines, "mesenchymal (M)-Wnt" and "epithelial (E)-Wnt," derived from MMTV-Wnt-1 transgenic mouse mammary tumors. M-Wnt, relative to E-Wnt, cells were tumor-initiating cell (TIC)-enriched (62% vs 2.4% CD44high/CD24low), and displayed enhanced aldefluor-positivity, epithelial-to-mesenchymal transition (EMT) marker expression, mammosphere-forming ability, migration, invasion, and tumorigenicity (p<0.001, each parameter). M-Wnt and E-Wnt cells clustered with claudin-low and basal-like breast tumors, respectively, in gene expression profiles, and recapitulated these tumors when orthotopically transplanted into ovariectomized C57BL/6 mice. To assess the effects of energy balance interventions on tumor ...


Mots clés : Sein; Prévention (Nutrition et prévention)

A partir de données d'une étude cas-témoins espagnole (424 cas de cancer colorectal et 401 témoins), de données administratives américaines et d'un questionnaire, cette étude évalue l'association entre une alimentation riche en flavonoïdes et en lignanes, des composés d'origine végétale, et le risque de cancer colorectal

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    A partir de données d'une étude cas-témoins espagnole (424 cas de cancer colorectal et 401 témoins), de données administratives américaines et d'un questionnaire, cette étude évalue l'association entre une alimentation riche en flavonoïdes et en lignanes, des composés d'origine végétale, et le risque de cancer colorectal

    “Association between habitual dietary flavonoid and lignan intake and colorectal cancer in a Spanish case-control study (the Bellvitge Colorectal Cancer Study)”

    • Zamora-Ros, R.;Not, C.;Guino, E.;Lujan-Barroso, L.;Garcia, R. M.;Biondo, S.;Salazar, R.;Moreno, V.

    BACKGROUND: Flavonoid-rich foods, such as fruits, vegetables, and tea, may have a protective effect upon colorectal cancer. However, current epidemiological evidence for a protective effect of flavonoid intake upon colorectal cancer is promising but not conclusive. OBJECTIVE: To examine the relation between dietary flavonoid and lignan intakes and the risk of colorectal cancer within a Spanish population. DESIGN: Data from the Bellvitge Colorectal Cancer Study, a case-control study (424 cases with incident colorectal cancer and 401 hospital-based controls), were used. A reproducible and validated food frequency questionnaire was administered in personal interviews. An ad hoc food composition database on flavonoids and lignans was compiled, mainly using data from the US Department of Agriculture and Phenol-Explorer databases. Adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated using unconditional logistic regression models. RESULTS: An inverse association was ...


Mots clés : Colon-rectum; Prévention (Nutrition et prévention)

Menée sur des rats exposés au 1,2-diméthylhydrazine, cette étude évalue les effets de la consommation d'un extrait de racine de poire de terre (Smallanthus sonchifolius), une plante vivace tubéreuse originaire du Pérou, sur la carcinogenèse du côlon

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    Menée sur des rats exposés au 1,2-diméthylhydrazine, cette étude évalue les effets de la consommation d'un extrait de racine de poire de terre (Smallanthus sonchifolius), une plante vivace tubéreuse originaire du Pérou, sur la carcinogenèse du côlon

    “Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis”

    • de Moura, N. A.;Caetano, B. F.;Sivieri, K.;Urbano, L. H.;Cabello, C.;Rodrigues, M. A.;Barbisan, L. F.

    Yacon (Smallanthus sonchifolius), a tuberous root native to the Andean region of South America, contains high concentration of fructans with potential for colon cancer prevention. This study investigated the potential beneficial of yacon intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4 weeks of DMH-initiation, groups were fed basal diet (G1 and G6) or basal diet containing dried extract of yacon root at 0.5% (G2), 1.0% (G3 and G5) or a synbiotic formulation (G4) (1.0% yacon plus Lactobacillus casei at 2.5 x 10(10) CFU per g diet) for 13 weeks. At week 20, a significant reduction in number and multiplicity of aberrant crypt foci (ACF) and in number of invasive adenocarcinomas was observed in the groups orally treated with 1.0% yacon (G3) or the synbiotic formulation (G4) (0.05 < p < 0.001). Tumor multiplicity (noninvasive plus invasive) was significantly lower in the group fed synbiotic formulation (p< 0.02). A significant reduction in ...


Mots clés : Colon-rectum; Prévention (Nutrition et prévention)

Menée sur une cohorte de 1 000 fumeurs âgés de 25 ans ou plus, cette étude transversale américaine évalue l'association entre la consommation de fruits et de légumes et la dépendance ou l'abstinence au tabac

  • A Longitudinal Evaluation of Fruit and Vegetable Consumption and Cigarette Smoking
    Nicotine & Tobacco Research, sous presse, 2012 (résumé)
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    Menée sur une cohorte de 1 000 fumeurs âgés de 25 ans ou plus, cette étude transversale américaine évalue l'association entre la consommation de fruits et de légumes et la dépendance ou l'abstinence au tabac

    “A Longitudinal Evaluation of Fruit and Vegetable Consumption and Cigarette Smoking”

    • Haibach, Jeffrey P.;Homish, Gregory G.;Giovino, Gary A.

    Introduction: Cross-sectional studies consistently find that cigarette smokers consume fewer fruits and vegetables each day than do nonsmokers. However, there are no published cohort studies on this relationship. This study evaluated the longitudinal relationship between fruit and vegetable consumption (FVC) and cigarette smoking, including measures of dependence and abstinence in a national population-based cohort analysis.Methods: A national random-digit-dialed sample of 1,000 smokers (aged 25 years and older) assessed baseline FVC and indicators of general health orientation. Multivariable analyses were used to assess whether baseline FVC was associated with smoking intensity, time to first cigarette (TTFC), and total score on an abbreviated version of the Nicotine Dependence Syndrome Scale (NDSS), adjusting for age, gender, race/ethnicity, education, and household income. The study also assessed whether baseline FVC predicted 30-day abstinence from all tobacco products at 14-month ...


Mots clés : Cancer (général); Prévention (Nutrition et prévention)

Chimioprévention

Cet article passe en revue les études récentes concernant l'utilisation conjointe de catéchines du thé vert et d'agents anti-cancer pour inhiber la croissance tumorale et prévenir le risque de récidive

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    Cet article passe en revue les études récentes concernant l'utilisation conjointe de catéchines du thé vert et d'agents anti-cancer pour inhiber la croissance tumorale et prévenir le risque de récidive

    “Green Tea: An effective synergist with anticancer drugs for tertiary cancer prevention”

    • Fujiki, Hirota;Suganuma, Masami

    Green tea is now an acknowledged cancer preventive in Japan. Based on evidence that colorectal adenomas and prostate cancer in humans have been prevented, we review here the concept that the combination of anticancer drugs with green tea catechin synergistically induces apoptosis of human cancer cells, inhibits tumor formation in mice, and enhances inhibition of tumor growth in xenograft mouse models. As a molecular mechanism by the combination, the induction of growth arrest and DNA damage-inducible 153 (GADD153, CHOP) gene expression is discussed in relation to death receptor 5 and TRAIL-apoptotic pathway. The combination of anticancer drugs with green tea could be a new cancer therapeutic strategy in humans.


Mots clés : Cancer (général); Prévention (Chimioprévention)

Politiques et programmes de prévention

A partir d'une revue de la littérature (13 études), cet article analyse l'efficacité et les composantes structurelles et socio-culturelles de programmes de prévention et de sevrage tabagiques ciblant les adolescents appartenant à une minorité ethnique

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    A partir d'une revue de la littérature (13 études), cet article analyse l'efficacité et les composantes structurelles et socio-culturelles de programmes de prévention et de sevrage tabagiques ciblant les adolescents appartenant à une minorité ethnique

    “A Review of Culturally Targeted/Tailored Tobacco Prevention and Cessation Interventions for Minority Adolescents”

    • Kong, Grace;Singh, Nisha;Krishnan-Sarin, Suchitra

    Aim: Emerging racial/ethnic disparities in tobacco use behaviors and resulting long-term health outcomes highlight the importance of developing culturally tailored/targeted tobacco prevention and cessation interventions. This manuscript describes the efficacy and the components of prevention and cessation interventions developed for minority adolescents.Methods: Thirteen studies focused on culturally tailoring and targeting tobacco prevention/cessation interventions were selected and information on intervention design (type, number of sessions), setting (school or community), theoretical constructs, culture-specific components (surface/deep structures), and treatment outcomes were extracted.Results: Of the 13 studies, 5 focused on prevention, 4 on cessation, and 4 combined prevention and cessation, and most of the studies were primarily school-based, while a few used community locations. Although diverse minority groups were targeted, a majority of the studies (n = 6) worked with ...


Mots clés : Cancer (général); Prévention (Politiques et programmes de prévention)

Ressources et infrastructures (Prévention)

Mené en Chine sur 248 fumeurs en bonne santé, cet essai randomisé contrôlé multicentrique évalue l'efficacité du bupropion à libération prolongée, utilisé durant 8 semaines, pour arrêter de fumer

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    Mené en Chine sur 248 fumeurs en bonne santé, cet essai randomisé contrôlé multicentrique évalue l'efficacité du bupropion à libération prolongée, utilisé durant 8 semaines, pour arrêter de fumer

    “Sustained-Release Bupropion for Smoking Cessation in a Chinese Sample: A Double-Blind, Placebo-Controlled Randomized Trial”

    • Sheng, Li-xia;Tang, Yi-lang;Jiang, Zuo-ning;Yao, Chong-hua;Gao, Jun-yu;Xu, Guo-Zhu;Tong, Xin-yuan

    Introduction: Bupropion is a first-line pharmacological aid for smoking cessation; however, no clinical trials have been conducted in a Chinese population.Methods: We enrolled 248 smokers in a hospital-based, randomized, smoking cessation trial conducted at four outpatient centers in Beijing. A total of 123 participants received an 8-week course of sustained-release bupropion (Bup-SR) and 125 participants received 8 weeks of placebo. All participants received brief education and counseling on smoking cessation. We determined rates of abstinence and smoking reduction based on chemical verification and self-report at 8 and 12 weeks.Results: At the end of the medication treatment (8 weeks) and at the end of the trial (12 weeks), the abstinence rates for Bup-SR were 29.3% and 39.8%, respectively, and 10.4% and 8.0% for placebo, respectively (both p < .001). Bup-SR was also superior to placebo in reducing cigarettes per day and urinary cotinine levels.Conclusion: Bup-SR is efficacious for ...


Mots clés : Cancer (général); Prévention (Ressources et infrastructures (Prévention))

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