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Accueil Nota Bene Cancer V2 Numéro 135 du 10 May 2012 Etiologie

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Etiologie

Facteurs exogènes : Alcool

Menée entre 1992 et 2007 sur une cohorte de 143 124 femmes et hommes âgés de 50 à 74 ans, cette étude prospective américaine évalue l'association entre la consommation d'alcool et le risque de sous-types de lymphome non hodgkinien (1 991 cas) en fonction du sexe, du type de boisson et de la fréquence de consommation

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    Menée entre 1992 et 2007 sur une cohorte de 143 124 femmes et hommes âgés de 50 à 74 ans, cette étude prospective américaine évalue l'association entre la consommation d'alcool et le risque de sous-types de lymphome non hodgkinien (1 991 cas) en fonction du sexe, du type de boisson et de la fréquence de consommation

    “Alcohol Intake and the Incidence of Non-Hodgkin Lymphoid Neoplasms in the Cancer Prevention Study II Nutrition Cohort”

    • Gapstur, Susan M.;Diver, W. Ryan;McCullough, Marjorie L.;Teras, Lauren R.;Thun, Michael J.;Patel, Alpa V.

    Although several studies have shown a lower risk of non-Hodgkin lymphoma (NHL) in alcohol drinkers compared with nondrinkers, the dose-response relation and potential differences between former and current drinking and across beverage types and subtypes are unclear. The authors examined associations of alcohol intake with risk of NHL and NHL subtypes in the Cancer Prevention Study II Nutrition Cohort, a prospective study of US men and women aged 50–74 years. Between 1992 and 2007, there were 1,991 incident NHL cases among 143,124 participants. Multivariable-adjusted relative risks and 95% confidence intervals were computed using Cox proportional hazards regression. Compared with nondrinkers, the relative risk of NHL associated with former drinking was 0.90 (95% confidence interval (CI): 0.75, 1.10); the relative risks associated with current intakes of <1, 1–2, and >2 drinks/day were 0.93 (95% CI: 0.83, 1.03), 0.91 (95% CI: 0.78, 1.06), and 0.78 (95% CI: 0.65, 0.93), respectively. ...


Mots clés : Lymphome; Etiologie (Facteurs exogènes : Alcool)

Facteurs exogènes : Nutrition et activité physique

Menée dans trois états américains (Maine, New Hampshire et Vermont) à partir de données de registres médicaux portant sur la période 2001 - 2004 et à l'aide d'un questionnaire, cette étude évalue l'association entre la consommation de viande, de fruits, de légumes ou de micronutriments et le risque de cancer de la vessie (1 171 cas, 1 418 témoins)

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    Menée dans trois états américains (Maine, New Hampshire et Vermont) à partir de données de registres médicaux portant sur la période 2001 - 2004 et à l'aide d'un questionnaire, cette étude évalue l'association entre la consommation de viande, de fruits, de légumes ou de micronutriments et le risque de cancer de la vessie (1 171 cas, 1 418 témoins)

    “Dietary intake of meat, fruits, vegetables, and selective micronutrients and risk of bladder cancer in the New England region of the United States”

    • Wu, J. W.;Cross, A. J.;Baris, D.;Ward, M. H.;Karagas, M. R.;Johnson, A.;Schwenn, M.;Cherala, S.;Colt, J. S.;Cantor, K. P.;Rothman, N.;Silverman, D. T.;Sinha, R.

    Background : Despite many studies on diet and bladder cancer, there are areas that remain unexplored including meat mutagens, specific vegetable groups, and vitamins from diet. Methods : We conducted a population-based case–control study of bladder cancer in Maine, New Hampshire, and Vermont. A total of 1171 cases were ascertained through hospital pathology records and cancer registries from 2001 to 2004. Overall, 1418 controls were identified from the Department of Motor Vehicles (<65 years) and Center for Medicaid and Medicare Services (65–79 years) and were frequency-matched to cases by state, sex, and age (within 5 years). Diet was assessed with a self-administered Diet History Questionnaire. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results : Processed meat intake was positively associated with bladder cancer (highest vs lowest quartile OR: 1.28; 95% CI: 1.00–1.65; Ptrend=0.035), with a stronger association ...


Mots clés : Vessie; Etiologie (Facteurs exogènes : Nutrition et activité physique)

A partir d'une revue de la littérature (21 études, dont 16 cas-témoins et 5 études de cohorte), cette méta-analyse évalue l'association entre la consommation de viande rouge, de viandes transformées et le risque d'adénome colorectal

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    A partir d'une revue de la littérature (21 études, dont 16 cas-témoins et 5 études de cohorte), cette méta-analyse évalue l'association entre la consommation de viande rouge, de viandes transformées et le risque d'adénome colorectal

    “Red and processed meat intake and risk of colorectal adenomas: A meta-analysis of observational studies”

    • Xu, Xiaodong;Yu, Enda;Gao, Xianhua;Song, Ning;Liu, Lianjie;Wei, Xubiao;Zhang, Wei;Fu, Chuangang

    Inconsistent results regarding the association between red and processed meat intake and the risk of colorectal adenoma (CRA), the precursor of colorectal cancer (CRC), have been reported. To provide a quantitative assessment of this association, we summarized the evidence from observational studies. Relevant studies were identified in MEDLINE and EMBASE until December 31, 2011. Summary relative risks (SRRs) with 95% confidence intervals (CIs) were pooled with a random-effects model. Between-study heterogeneity was assessed using the Cochran's Q and I2 statistics. A total of 21 studies (16 case-control studies and 5 cohort/nested case control studies) were included in this meta-analysis. The SRRs of CRA were 1.36 (95% CI: 1.17–1.58) for every 100 g/day increase in red meat intake, and 1.24 (95% CI: 1.12-1.36) for the highest vs the lowest level of red meat intake. Non-linear dose-response meta-analysis indicated that CRA risk increased approximately linearly with increasing intake ...


Mots clés : Colon-rectum; Etiologie (Facteurs exogènes : Nutrition et activité physique)

Facteurs exogènes : Exposition professionnelle

Menée sur une cohorte de 4 825 femmes travaillant dans l'industrie automobile, cette étude rétrospective évalue l'association entre une exposition professionnelle aux fluides de coupe et le risque de cancer

  • Metalworking fluid exposure and cancer risk in a retrospective cohort of female autoworkers
    Cancer Causes and Control, sous presse, 2012 (résumé)
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    Menée sur une cohorte de 4 825 femmes travaillant dans l'industrie automobile, cette étude rétrospective évalue l'association entre une exposition professionnelle aux fluides de coupe et le risque de cancer

    “Metalworking fluid exposure and cancer risk in a retrospective cohort of female autoworkers”

    • Friesen, Melissa;Betenia, Nicole;Costello, Sadie;Eisen, Ellen

    Objectives Metalworking fluids (MWFs) have been associated with cancer of several sites, but the risks have been primarily examined in men or in studies that adjusted for gender in analyses. To evaluate whether risks were similar in women, we report cancer mortality risk among 4,825 female autoworkers within the united autoworkers–general motors autoworkers cohort. Methods Standardized mortality rates (SMRs) were calculated based on Michigan death rates (1980–2004). Internal comparisons (1941–2004) were examined using Cox regression for straight, soluble, and synthetic MWFs, and their corresponding oil- and water-based fractions. Results MWF exposure levels in the female cohort were generally less than two-third the MWF levels in the male cohort. Female autoworkers had an excess of cancer from all sites (SMR, 1.10; 95 % confidence interval (CI), 0.98–1.22) and lung cancer (SMR, 2.08; 95 % CI, 1.71–2.52). Colon cancer risk increased with straight (mineral oil) MWF exposure ...


Mots clés : Cancer (général); Etiologie (Facteurs exogènes : Exposition professionnelle)

Facteurs exogènes : Environnement

Menée à Singapour, cette étude (541 cas et 830 témoins) évalue l'association entre une exposition solaire et le risque de lymphome

  • Sun exposure and risk of lymphoid neoplasms in Singapore
    Cancer Causes and Control, sous presse, 2012 (résumé)
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    Menée à Singapour, cette étude (541 cas et 830 témoins) évalue l'association entre une exposition solaire et le risque de lymphome

    “Sun exposure and risk of lymphoid neoplasms in Singapore”

    • Wong, Kin-Yoke;Tai, Bee-Choo;Chia, Sin-Eng;Kuperan, Ponnudurai;Lee, Khai-Mun;Lim, Soon-Thye;Loong, Susan;Mow, Benjamin;Ng, Siok-Bian;Tan, Leonard;Tan, Soo-Yong;Tan, Suat-Hoon;Tao, Miriam;Wong, Alvin;Wong, Gee-Chuan;Seow, Adeline

    Background Epidemiologic studies have reported an inverse association between sun exposure and non-Hodgkin lymphoma (NHL), but these have been almost exclusively conducted in Western populations residing in temperate locations. We evaluated the association between personal outdoor sun exposure and risk of malignant lymphomas in Singapore. Methods A hospital-based case–control study of 541 incident cases of lymphoid neoplasms and 830 controls were recruited during 2004–2008. Participants were interviewed regarding recreational or occupational outdoor activities during childhood and in adulthood. Basic demographics and potential confounders were also collected. Odds ratios (OR) and 95 % confidence intervals (CI) were calculated using unconditional logistic regression analysis. Results Compared with individuals who did not have regular sun exposure, a lower risk of NHL was observed for those who reported regular exposure on non-school days during childhood [OR, 0.62; 95 % CI, ...


Mots clés : Lymphome; Etiologie (Facteurs exogènes : Environnement)

Cette étude néerlandaise évalue l'association entre la consommation de 5 mutagènes contenus dans la viande, la présence de polymorphismes à simple nucléotide sur des gènes codant pour des enzymes impliquées dans le métabolisme des xénobiotiques et le risque d'adénome avancé (1 205 cas et 1 387 témoins) ou de cancer colorectal (370 cas et 401 témoins)

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    Cette étude néerlandaise évalue l'association entre la consommation de 5 mutagènes contenus dans la viande, la présence de polymorphismes à simple nucléotide sur des gènes codant pour des enzymes impliquées dans le métabolisme des xénobiotiques et le risque d'adénome avancé (1 205 cas et 1 387 témoins) ou de cancer colorectal (370 cas et 401 témoins)

    “Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer”

    • Gilsing, Anne;Berndt, Sonja;Ruder, Elizabeth;Graubard, Barry;Ferrucci, Leah;Burdette, Laurie;Weissfeld, Joel;Cross, Amanda;Sinha, Rashmi

    Meat mutagens, including heterocyclic amines (HCAs), polycyclic aromatic hydrocarbons (PAHs), and N–nitroso compounds (NOCs), may be involved in colorectal carcinogenesis depending on their activation or detoxification by phase I and II xenobiotic metabolizing enzymes (XME). Using unconditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI), we examined the intake of five meat mutagens and >300 single nucleotide polymorphisms (SNPs) in 18 XME genes in relation to advanced colorectal adenoma (1,205 cases; 1,387 controls), and colorectal cancer (370 cases; 401 controls) within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Dietary intake of meat mutagens was assessed using a food frequency questionnaire (FFQ) with a detailed meat-cooking module. An interaction was observed between 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) intake and the NAT1 polymorphism rs6586714 in the adenoma study (Pinteraction = 0.001). Among ...


Mots clés : Colon-rectum; Etiologie (Facteurs exogènes : Environnement)

Facteurs exogènes : THS et contraceptifs

A partir des données de la cohorte "NIH-AARP Diet and Health study" incluant 68 419 participantes ménopausées, cette étude évalue l'association entre un traitement hormonal substitutif de la ménopause combinant estrogènes et progestatifs et le risque de cancer de l'endomètre

  • Is estrogen plus progestin menopausal hormone therapy safe with respect to endometrial cancer risk?
    International Journal of Cancer, sous presse, 2012 (résumé)
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    A partir des données de la cohorte "NIH-AARP Diet and Health study" incluant 68 419 participantes ménopausées, cette étude évalue l'association entre un traitement hormonal substitutif de la ménopause combinant estrogènes et progestatifs et le risque de cancer de l'endomètre

    “Is estrogen plus progestin menopausal hormone therapy safe with respect to endometrial cancer risk?”

    • Trabert, Britton;Wentzensen, Nicolas;Yang, Hannah P.;Sherman, Mark E.;Hollenbeck, Albert R.;Park, Yikyung;Brinton, Louise A.

    Given the strong link between use of unopposed estrogens and development of endometrial cancers, estrogens are usually prescribed with a progestin, particularly for women with intact uteri. Some studies suggest that sequential use of progestins may increase risk, but the moderating effects of usage patterns or patient characteristics, including body mass index (BMI) are unknown. We evaluated menopausal hormone use and incident endometrial cancer (n=885) in 68,419 postmenopausal women with intact uteri enrolled in the NIH-AARP Diet and Health study. Participants completed a risk factor questionnaire in 1996-1997 and were followed through 2006. Hazard rate ratios (RR) and 95% confidence intervals (CI) were estimated using Cox regression. Among 19,131 women reporting exclusive estrogen plus progestin use, 176 developed endometrial cancer [RR 0.88; 95% CI: 0.74, 1.06]. Long duration (≥10 years) sequential (<15 days progestin/month) estrogen plus progestin use was positively associated ...


Mots clés : Corps de l'utérus; Etiologie (Facteurs exogènes : THS et contraceptifs)

Facteurs exogènes : Autres

A partir d'une revue de la littérature publiée jusqu'en août 2011 (16 études, 1 692 863 participants, 7 807 cas), cette méta-analyse évalue l'association entre l'utilisation de statines et le risque de cancer du pancréas

  • Statin use and risk of pancreatic cancer: a meta-analysis
    Cancer Causes and Control, sous presse, 2012 (résumé)
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    A partir d'une revue de la littérature publiée jusqu'en août 2011 (16 études, 1 692 863 participants, 7 807 cas), cette méta-analyse évalue l'association entre l'utilisation de statines et le risque de cancer du pancréas

    “Statin use and risk of pancreatic cancer: a meta-analysis”

    • Cui, Xiaobing;Xie, Yue;Chen, Min;Li, Jun;Liao, Xiaoming;Shen, Jian;Shi, Meng;Li, Wenjing;Zheng, Haoxuan;Jiang, Bo

    Purpose Statins are commonly prescribed medications that potently reduce cholesterol levels and the risk of cardiovascular events. Preclinical studies suggested statins also possess cancer chemopreventive properties. However, the clinical studies provided contradictory results as to whether statins influence the risk of pancreatic cancer. Herein, we present this meta-analysis to assess the association between statin use and risk of pancreatic cancer. Methods We conducted a comprehensive search up to August 2011 for the eligible studies. Pooled relative risk (RR) estimates and corresponding 95 % confidence intervals (CIs) were calculated using the inverse-variance-weighted random-effects model. Subgroup analyses were conducted where data were available. Heterogeneity was assessed by the Cochran’s Q test and the I 2 statistic. Results We included 16 studies that involving 1,692,863 participants and 7,807 pancreatic cancer cases. Pooled results only indicated a non-significant decrease ...


Mots clés : Pancréas; Etiologie (Facteurs exogènes : Autres)

A partir des données du registre danois du cancer, cette étude de cohorte (13 602 patients) évalue l'association entre la prise d'antibiotiques et le risque de lymphomes non hodgkiniens en fonction de leur sous-type

  • Antibiotic use and risk of non-Hodgkin lymphomas
    International Journal of Cancer, sous presse, 2012 (résumé)
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    A partir des données du registre danois du cancer, cette étude de cohorte (13 602 patients) évalue l'association entre la prise d'antibiotiques et le risque de lymphomes non hodgkiniens en fonction de leur sous-type

    “Antibiotic use and risk of non-Hodgkin lymphomas”

    • Rasmussen, M. L. H.;Hjalgrim, H.;Mølgaard-Nielsen, D.;Wohlfahrt, J.;Melbye, M.

    Clinical case-reports have suggested that specific bacterial infections are associated with certain non-Hodgkin lymphoma (NHL) subtypes. Epidemiological case-control studies have been conducted using antibiotics as a proxy for bacterial infections, but with inconclusive results. The aim of this study was, in a cohort design, based on the unique nationwide Danish registers, to investigate the association between use of antibiotics and the risk of NHL subtypes. Based on the Civil Registration System, we established a cohort of the entire adult (≥15y) Danish population. Information on use of antibiotics came from the Danish Drug Prescription Registry and lymphoma diagnosis from the Danish Cancer Registry. Associations were assessed by adjusted rate ratios (RR). In total, 13,602 patients were diagnosed with one of the NHL subtypes during 51.6 million person-years of follow-up (1995-2008). We observed positive associations between use of antibiotics and plasma cell myeloma (PCM) ...


Mots clés : Lymphome; Etiologie (Facteurs exogènes : Autres)

Facteurs endogènes

A partir des données de deux études cas-témoins indépendantes incluant au total 1 432 patientes atteintes d'un cancer du sein sporadique ou familial et 1 934 témoins, cette étude chinoise montre qu'un polymorphisme à simple nucléotide, localisé sur la séquence mature du micro-ARN-608, peut contribuer à augmenter le risque de cancer du sein HER2+ mais pas celui des autres sous-types

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    A partir des données de deux études cas-témoins indépendantes incluant au total 1 432 patientes atteintes d'un cancer du sein sporadique ou familial et 1 934 témoins, cette étude chinoise montre qu'un polymorphisme à simple nucléotide, localisé sur la séquence mature du micro-ARN-608, peut contribuer à augmenter le risque de cancer du sein HER2+ mais pas celui des autres sous-types

    “Polymorphism rs4919510:C>G in Mature Sequence of Human MicroRNA-608 Contributes to the Risk of HER2-Positive Breast Cancer but Not Other Subtypes”

    • Huang, A. Ji;Yu, Ke-Da;Li, Jing;Fan, Lei;Shao, Zhi-Ming

    Background: A few polymorphisms are located in the mature microRNA sequences. Such polymorphisms could directly affect the binding of microRNA to hundreds of target mRNAs. It remains unknown whether rs4919510:C>G located in the mature miR-608 alters breast cancer susceptibility. Methods: The association of rs4919510:C>G with risk and pathologic features of breast cancer were investigated in two independent case-control studies, the first set including 1,138 sporadic breast cancer patients (including 927 invasive ductal carcinoma patients, 777 of them with known subtypes: 496 luminal-like, 133 HER2-positive, and 148 triple-negative) and 1,434 community-based controls, and the second set including 294 familial/early-onset breast cancer patients and 500 hospital-based cancer-free controls. Odds ratios (ORs) were estimated by logistic regression. Predicted targets of miR-608 and complementary sequences containing rs4919510:C>G were surveyed to reveal potential pathological ...


Mots clés : Sein; Etiologie (Facteurs endogènes)

A partir de données taÏwanaises portant sur la période 1996-2009, cette étude rétrospective de cohorte évalue l'association entre un diabète mellitus de type 2 et le risque de divers types de cancer (895 434 cas et 895 434 témoins)

  • Modest increase in risk of specific types of cancer types in type 2 diabetes mellitus patients
    International Journal of Cancer, sous presse, 2012 (résumé)
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    A partir de données taÏwanaises portant sur la période 1996-2009, cette étude rétrospective de cohorte évalue l'association entre un diabète mellitus de type 2 et le risque de divers types de cancer (895 434 cas et 895 434 témoins)

    “Modest increase in risk of specific types of cancer types in type 2 diabetes mellitus patients”

    • Lo, Sui-Foon;Chang, Shih-Ni;Muo, Chih-Hsin;Chen, Shih-Yin;Liao, Fang-Yin;Dee, Shu-Wei;Chen, Pei-Chun;Sung, Fung-Chang

    Most studies associated diabetes mellitus (DM) with risk of cancer have focused on the Caucasian population and only a few types of cancer. Therefore, a large and comprehensive nationwide retrospective cohort study involving an Asian population was conducted to evaluate the risk of several major types of cancer among Type 2 DM patients. The study analyzed the nationwide population-based database from 1996 to 2009 released by the National Health Research Institute in Taiwan. Incidence and hazard ratios (HRs) were calculated for specific types of cancer. The overall risk of cancers was significantly greater in the DM cohort [N = 895,434; HR = 1.19, 95% confidence interval (CI) = 1.17–1.20], compared with non-DM controls (N = 895,434). Several organs in the digestive and urogenital systems showed increased risk of cancer. The three highest HRs were obtained from cancers of the liver (HR = 1.78, 95% CI = 1.73–1.84), pancreatic (HR = 1.52, 95% CI = 1.40–1.65), and uterus and corpus ...


Mots clés : Cancer (général); Etiologie (Facteurs endogènes)

Menées chacune sur plus de 50 000 participants, ces deux études mettent en évidence un mosaïcisme clonal en association avec un risque de cancer

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    Menées chacune sur plus de 50 000 participants, ces deux études mettent en évidence un mosaïcisme clonal en association avec un risque de cancer

    “Detectable clonal mosaicism from birth to old age and its relationship to cancer”

    • Laurie, Cathy C.;Laurie, Cecelia A.;Rice, Kenneth;Doheny, Kimberly F.;Zelnick, Leila R.;McHugh, Caitlin P.;Ling, Hua;Hetrick, Kurt N.;Pugh, Elizabeth W.;Amos, Chris;Wei, Qingyi;Wang, Li-e;Lee, Jeffrey E.;Barnes, Kathleen C.;Hansel, Nadia N.;Mathias, Rasika;Daley, Denise;Beaty, Terri H.;Scott, Alan F.;Ruczinski, Ingo;Scharpf, Rob B.;Bierut, Laura J.;Hartz, Sarah M.;Landi, Maria Teresa;Freedman, Neal D.;Goldin, Lynn R.;Ginsburg, David;Li, Jun;Desch, Karl C.;Strom, Sara S.;Blot, William J.;Signorello, Lisa B.;Ingles, Sue A.;Chanock, Stephen J.;Berndt, Sonja I.;Le Marchand, Loic;Henderson, Brian E.;Monroe, Kristine R.;Heit, John A.;de Andrade, Mariza;Armasu, Sebastian M.;Regnier, Cynthia;Lowe, William L.;Hayes, M. Geoffrey;Marazita, Mary L.;Feingold, Eleanor;Murray, Jeffrey C.;Melbye, Mads;Feenstra, Bjarke;Kang, Jae H.;Wiggs, Janey L.;Jarvik, Gail P.;McDavid, Andrew N.;Seshan, Venkatraman E.;Mirel, Daniel B.;Crenshaw, Andrew;Sharopova, Nataliya;Wise, Anastasia;Shen, Jess;Crosslin, David R.;Levine, David M.;Zheng, Xiuwen;Udren, Jenna I.;Bennett, Siiri;Nelson, Sarah C.;Gogarten, Stephanie M.;Conomos, Matthew P.;Heagerty, Patrick;Manolio, Teri;Pasquale, Louis R.;Haiman, Christopher A.;Caporaso, Neil;Weir, Bruce S.

    We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for genome-wide association studies. This detection method requires a relatively high frequency of cells with the same abnormal karyotype (>5–10%; presumably of clonal origin) in the presence of normal cells. The frequency of detectable clonal mosaicism in peripheral blood is low (<0.5%) from birth until 50 years of age, after which it rapidly rises to 2–3% in the elderly. Many of the mosaic anomalies are characteristic of those found in hematological cancers and identify common deleted regions with genes previously associated with these cancers. Although only 3% of subjects with detectable clonal mosaicism had any record of hematological cancer before DNA sampling, those without a previous diagnosis have an estimated tenfold higher risk of a subsequent hematological cancer (95% confidence interval = 6–18).


  • Detectable clonal mosaicism and its relationship to aging and cancer
    Nature Genetics, sous presse, 2012 (résumé)
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    Menées chacune sur plus de 50 000 participants, ces deux études mettent en évidence un mosaïcisme clonal en association avec un risque de cancer

    “Detectable clonal mosaicism and its relationship to aging and cancer”

    • Jacobs, Kevin B. ; Yeager, Meredith ; Zhou, Weiyin ; Wacholder, Sholom ; Wang, Zhaoming ; Rodriguez-Santiago, Benjamin ; Hutchinson, Amy ; Deng, Xiang ; Liu, Chenwei ; Horner, Marie-Josephe ; Cullen, Michael ; Epstein, Caroline G. ; Burdett, Laurie ; Dean, Michael C. ; Chatterjee, Nilanjan ; Sampson, Joshua ; Chung, Charles C. ; Kovaks, Joseph ; Gapstur, Susan M. ; Stevens, Victoria L. ; Teras, Lauren T. ; Gaudet, Mia M. ; Albanes, Demetrius ; Weinstein, Stephanie J. ; Virtamo, Jarmo ; Taylor, Philip R. ; Freedman, Neal D. ; Abnet, Christian C. ; Goldstein, Alisa M. ; Hu, Nan ; Yu, Kai ; Yuan, Jian-Min ; Liao, Linda ; Ding, Ti ; Qiao, You-Lin ; Gao, Yu-Tang ; Koh, Woon-Puay ; Xiang, Yong-Bing ; Tang, Ze-Zhong ; Fan, Jin-Hu ; Aldrich, Melinda C. ; Amos, Christopher ; Blot, William J. ; Bock, Cathryn H. ; Gillanders, Elizabeth M. ; Harris, Curtis C. ; Haiman, Christopher A. ; Henderson, Brian E. ; Kolonel, Laurence N. ; Le Marchand, Loic ; McNeill, Lorna H. ; Rybicki, Benjamin A. ; Schwartz, Ann G. ; Signorello, Lisa B. ; Spitz, Margaret R. ; Wiencke, John K. ; Wrensch, Margaret ; Wu, Xifeng ; Zanetti, Krista A. ; Ziegler, Regina G. ; Figueroa, Jonine D. ; Garcia-Closas, Montserrat ; Malats, Nuria ; Marenne, Gaelle ; Prokunina-Olsson, Ludmila ; Baris, Dalsu ; Schwenn, Molly ; Johnson, Alison ; Landi, Maria Teresa ; Goldin, Lynn ; Consonni, Dario ; Bertazzi, Pier Alberto ; Rotunno, Melissa ; Rajaraman, Preetha ; Andersson, Ulrika ; Freeman, Laura E. Beane ; Berg, Christine D. ; Buring, Julie E. ; Butler, Mary A. ; Carreon, Tania ; Feychting, Maria ; Ahlbom, Anders ; Gaziano, J. Michael ; Giles, Graham G. ; Hallmans, Goran ; Hankinson, Susan E. ; Hartge, Patricia ; Henriksson, Roger ; Inskip, Peter D. ; Johansen, Christoffer ; Landgren, Annelie ; McKean-Cowdin, Roberta ; Michaud, Dominique S. ; Melin, Beatrice S. ; Peters, Ulrike ; Ruder, Avima M. ; Sesso, Howard D. ; Severi, Gianluca ; Shu, Xiao-Ou ; Visvanathan, Kala ; White, Emily ; Wolk, Alicja ; Zeleniuch-Jacquotte, Anne ; Zheng, Wei ; Silverman, Debra T. ; Kogevinas, Manolis ; Gonzalez, Juan R. ; Villa, Olaya ; Li, Donghui ; Duell, Eric J. ; Risch, Harvey A. ; Olson, Sara H. ; Kooperberg, Charles ; Wolpin, Brian M. ; Jiao, Li ; Hassan, Manal ; Wheeler, William ; Arslan, Alan A. ; Bueno-de-Mesquita, H. Bas ; Fuchs, Charles S. ; Gallinger, Steven ; Gross, Myron D. ; Holly, Elizabeth A. ; Klein, Alison P. ; LaCroix, Andrea ; Mandelson, Margaret T. ; Petersen, Gloria ; Boutron-Ruault, Marie-Christine ; Bracci, Paige M. ; Canzian, Federico ; Chang, Kenneth ; Cotterchio, Michelle ; Giovannucci, Edward L. ; Goggins, Michael ; Bolton, Judith A. Hoffman ; Jenab, Mazda ; Khaw, Kay-Tee ; Krogh, Vittorio ; Kurtz, Robert C. ; McWilliams, Robert R. ; Mendelsohn, Julie B. ; Rabe, Kari G. ; Riboli, Elio ; Tjonneland, Anne ; Tobias, Geoffrey S. ; Trichopoulos, Dimitrios ; Elena, Joanne W. ; Yu, Herbert ; Amundadottir, Laufey ; Stolzenberg-Solomon, Rachael Z. ; Kraft, Peter ; Schumacher, Fredrick ; Stram, Daniel ; Savage, Sharon A. ; Mirabello, Lisa ; Andrulis, Irene L. ; Wunder, Jay S. ; Garcia, Ana Patino ; Sierrasesumaga, Luis ; Barkauskas, Donald A. ; Gorlick, Richard G. ; Purdue, Mark ; Chow, Wong-Ho ; Moore, Lee E. ; Schwartz, Kendra L. ; Davis, Faith G. ; Hsing, Ann W. ; Berndt, Sonja I. ; Black, Amanda ; Wentzensen, Nicolas ; Brinton, Louise A. ; Lissowska, Jolanta ; Peplonska, Beata ; McGlynn, Katherine A. ; Cook, Michael B. ; Graubard, Barry I. ; Kratz, Christian P. ; Greene, Mark H. ; Erickson, Ralph L. ; Hunter, David J. ; Thomas, Gilles ; Hoover, Robert N. ; Real, Francisco X. ; Fraumeni, Joseph F. ; Caporaso, Neil E. ; Tucker, Margaret ; Rothman, Nathaniel ; Perez-Jurado, Luis A. ; Chanock, Stephen J.

    In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10−8). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free ...


Mots clés : Cancer (général); Etiologie (Facteurs endogènes)

Interactions gènes-environnement

Menée auprès de 380 cas et de 355 témoins sains, cette étude analyse la relation entre des polymorphismes des gènes NOXA and MCL1 et le risque de carcinome épidermoïde de la tête et du cou associé à une infection par le papillomavirus humain de type 16

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    Menée auprès de 380 cas et de 355 témoins sains, cette étude analyse la relation entre des polymorphismes des gènes NOXA and MCL1 et le risque de carcinome épidermoïde de la tête et du cou associé à une infection par le papillomavirus humain de type 16

    “Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck”

    • Zhou, ZiYuan;Sturgis, Eric;Liu, ZhenSheng;Wang, Li-E;Wei, QingYi;Li, GuoJun

    BACKGROUND:The cooperation between phorbol 12-myristate 13-acetate induced protein 1 (NOXA) and myeloid cell leukemia 1 (MCL1) is critical in the intrinsic apoptotic pathway. Human papillomavirus 16 (HPV16), by inducing p53 and pRb-E2F degradation, may play an essential role in development of squamous cell carcinoma of the head and neck (SCCHN) through NOXA-MCL1 axis-mediated apoptosis. Therefore, genetic variants of NOXA and MCL1 may modify the SCCHN risk associated with HPV16 seropositivity. Patients and methods: HPV16 serology was obtained by immunoadsorption assay. Four functional SNPs in the promoter of NOXA (rs9957673, rs4558496) and MCL1 (rs9803935, rs3738485) were genotyped for 380 cases and 335 frequency-matched cancer-free controls of non-Hispanic whites. Results: Associations between the four polymorphisms and SCCHN risk were not significant, while we observed a significantly synergistic effect on SCCHN risk between the polymorphisms and HPV16 seropositivity. Notably, this ...


Mots clés : Voies aérodigestives supérieures; Etiologie (Interactions gènes-environnement)

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