Mitochondrial remodeling in cancer metabolism and survival: Potential for new therapies

Cet article passe en revue les travaux récents sur le rôle des anomalies de fonctionnement des mitochondries dans les cellules tumorales

• Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, sous presse, 2012 (résumé)

Résumé en anglais :
Mitochondria are semi-autonomous organelles that play essential roles in cellular metabolism and programmed cell death pathways. Genomic, functional and structural mitochondrial alterations have been associated with cancer. Some of those alterations may provide a selective advantage to cells, allowing them to survive and grow under stresses created by oncogenesis. Due to the specific alterations that occur in cancer cell mitochondria, these organelles may provide promising targets for cancer therapy. The development of drugs that specifically target metabolic and mitochondrial alterations in tumor cells has become a matter of interest in recent years, with several molecules undergoing clinical trials. This review focuses on the most relevant mitochondrial alterations found in tumor cells, their contribution to cancer progression and survival, and potential usefulness for stratification and therapy.

NBC n° 134 du 03 May 2012

Mots clés : Cancer (général); Biologie (Progression et métastases)