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Accueil Nota Bene Cancer V2 Numéro 130 du 03 April 2012 Etiologie

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Nota Bene Cancer Numéro 130 du 03 April 2012 RSS

Etiologie

Facteurs exogènes : Nutrition et activité physique

A partir des données de la cohorte "NIH-AARP Diet and Health Study" incluant 545 771 participants, cette étude américaine analyse l'association entre la consommation de café, de thé et de sodas et le risque de gliome à l'âge adulte

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    A partir des données de la cohorte "NIH-AARP Diet and Health Study" incluant 545 771 participants, cette étude américaine analyse l'association entre la consommation de café, de thé et de sodas et le risque de gliome à l'âge adulte

    “Coffee, tea, soda, and caffeine intake in relation to risk of adult glioma in the NIH-AARP Diet and Health Study”

    • Dubrow, Robert;Darefsky, Amy;Freedman, Neal;Hollenbeck, Albert;Sinha, Rashmi

    Purpose We utilized the large, prospective NIH-AARP Diet and Health Study to further explore the hypothesis, suggested by two recent prospective cohort studies, that increased intake of coffee, tea, soda, and/or caffeine is associated with reduced adult glioma risk. Methods At baseline in 1995–1996, dietary intake, including coffee, tea, and soda, was assessed with a food frequency questionnaire. We used Cox proportional hazards models to calculate adjusted hazard ratios (HR) and 95 % confidence intervals (CI) for glioma risk in relation to beverage intake. Results During follow-up of 545,771 participants through 2006, 904 participants were diagnosed with glioma. We found no trends of decreasing glioma risk with increasing intake of specific beverages or total caffeine. HR patterns for consumption of the caffeinated versus decaffeinated form of each beverage were inconsistent with a specific caffeine effect. HR patterns of reduced glioma risk for most categories of beverage intake ...


Mots clés : Système nerveux central; Etiologie (Facteurs exogènes : Nutrition et activité physique)

Facteurs exogènes : Environnement

Menée aux Etats-Unis, cette étude analyse et compare, pour les les zones urbaines et rurales, l'association entre les niveaux autorisés de substances chimiques dispersées dans les eaux usées et la mortalité par cancer

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    Menée aux Etats-Unis, cette étude analyse et compare, pour les les zones urbaines et rurales, l'association entre les niveaux autorisés de substances chimiques dispersées dans les eaux usées et la mortalité par cancer

    “Permitted water pollution discharges and population cancer and non-cancer mortality: toxicity weights and upstream discharge effects in US rural-urban areas”

    • Hendryx, Michael;Conley, Jamison;Fedorko, Evan;Luo, Juhua;Armistead, Matthew

    BACKGROUND:The study conducts statistical and spatial analyses to investigate amounts and types of permitted surface water pollution discharges in relation to population mortality rates for cancer and non-cancer causes nationwide and by urban-rural setting. Data from the Environmental Protection Agency's (EPA) Discharge Monitoring Report (DMR) were used to measure the location, type, and quantity of a selected set of 38 discharge chemicals for 10,395 facilities across the contiguous US. Exposures were refined by weighting amounts of chemical discharges by their estimated toxicity to human health, and by estimating the discharges that occur not only in a local county, but area-weighted discharges occurring upstream in the same watershed. Centers for Disease Control and Prevention (CDC) mortality files were used to measure age-adjusted population mortality rates for cancer, kidney disease, and total non-cancer causes. Analysis included multiple linear regressions to adjust for ...


Mots clés : Cancer (général); Etiologie (Facteurs exogènes : Environnement)

Facteurs exogènes : Agents infectieux

Menée à Taïwan auprès de 10 000 participantes sur une période de suivi supérieure à 10 ans, cette étude de cohorte évalue l'association entre une infection par le papillomavirus humain, un nombre élevé d'accouchements par voie naturelle et le risque de cancer du col de l'utérus

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    Menée à Taïwan auprès de 10 000 participantes sur une période de suivi supérieure à 10 ans, cette étude de cohorte évalue l'association entre une infection par le papillomavirus humain, un nombre élevé d'accouchements par voie naturelle et le risque de cancer du col de l'utérus

    “Baseline human papillomavirus infection, high vaginal parity, and their interaction on cervical cancer risks after a follow-up of more than 10 years”

    • Liao, Shu-Fen;Lee, Wen-Chung;Chen, Hui-Chi;Chuang, Li-Chung;Pan, Mei-Hung;Chen, Chien-Jen

    Objectives Human papillomavirus (HPV) has been recognized as a major factor for cervical cancer causation. Other factors, relating to reproduction, are also important. This study aims to disentangle the roles of baseline HPV infection, high vaginal parity (defined as having ≥4 vaginal deliveries), and the interaction between the two in predicting cervical cancer risk. Methods The authors apply a newly developed causal-pie modeling technique to analyze a cohort of more than 10,000 women conducted in Taiwan with more than 10 years of follow-up. The rate ratios adjusted by age and menopausal status were further modeled by an additive Poisson regression with non-negative parameters. The index of causal-pie weight (CPW) was calculated to indicate the proportion of cervical cancer cases attributable to a particular class of causal pies. Results It was found that the CPWs are 36.3 % for baseline HPV infection, 35.6 % for baseline HPV infection and high vaginal parity, and 28.1 % for other ...


Mots clés : Col de l'utérus; Etiologie (Facteurs exogènes : Agents infectieux)

Facteurs exogènes : Autres

Cette étude française passe en revue l'ensemble des facteurs impliqués dans l'étiologie du cancer du pomon chez des individus n'ayant jamais fumé

  • Lung cancer in never smokers – A review
    European journal of cancer (Oxford, England : 1990), sous presse, 2012 (résumé)
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    Cette étude française passe en revue l'ensemble des facteurs impliqués dans l'étiologie du cancer du pomon chez des individus n'ayant jamais fumé

    “Lung cancer in never smokers – A review”

    • Couraud, Sébastien;Zalcman, Gérard;Milleron, Bernard;Morin, Franck;Souquet, Pierre-Jean

    An estimated 10–25% of lung cancers worldwide occur in never smokers, i.e. individuals having smoked less than 100 cigarettes in their lifetime. Lung cancer in never smokers (LCINS) is more frequent in women, although large geographic variations are found. Histologically, adenocarcinomas predominate. The mere existence of LCINS suggests that risk factors other than smoking must be present. Exposure to environmental tobacco smoke (particularly in women) and exposure to workplace carcinogens (particularly in men) are the two most important alternative risk factors. However, a history of either is absent in more than a third of LCINS. The large proportion of women in LCINS suggest a hormonal element that may interact with other identified factors such as hereditary risks, a history of respiratory infections or disease, exposure to air pollution, cooking and heating fumes, or exposure to ionising radiation. The study of genomic polymorphisms finds constitutive DNA variations across ...


Mots clés : Poumon; Etiologie (Facteurs exogènes : Autres)

Facteurs endogènes

Menée en Nouvelle-Calédonie, cette étude en population (332 cas et 412 témoins) analyse l'association entre une histoire familiale de maladies malignes et bénignes de la thyroïde et le risque de cancer de la thyroïde

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    Menée en Nouvelle-Calédonie, cette étude en population (332 cas et 412 témoins) analyse l'association entre une histoire familiale de maladies malignes et bénignes de la thyroïde et le risque de cancer de la thyroïde

    “Family history of malignant and benign thyroid diseases and risk of thyroid cancer: a population-based case–control study in New Caledonia”

    • Leux, Christophe;Truong, Thérèse;Petit, Claire;Baron-Dubourdieu, Dominique;Guénel, Pascal

    Purpose Exceptionally high incidence rates of thyroid cancer have been observed in New Caledonia, particularly in Melanesian women, but familial aggregation of thyroid diseases in this population is unknown. We study the association between family history of malignant or benign thyroid diseases and non-medullary thyroid cancer in this country. Methods We conducted a population-based case–control study including 332 cases with papillary or follicular carcinoma diagnosed in 1993–1999 and 412 controls, matched by sex and 5-year age-group. Results Thyroid cancer was associated with a history of thyroid cancer in first-degree relatives (odds ratio (OR), 3.2; 95 % CI, 1.6–6.2) and with a family history of multinodular goiter (OR, 3.6; 95 % CI, 1.9–7.0). The ORs did not change by age at diagnosis and with the number of affected relatives. The study provides evidence that the familial component of thyroid cancer is particularly strong in men. Thyroid cancer was not associated with a ...


Mots clés : Thyroïde; Etiologie (Facteurs endogènes)

A partir des données de 19 études menées dans 10 pays et comprenant 16 895 femmes d'origine caucasienne, cette analyse transversale évalue l'association entre des variants des gènes LSP1 et RAD51L1, la densité mammaire et le risque de cancer du sein

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    A partir des données de 19 études menées dans 10 pays et comprenant 16 895 femmes d'origine caucasienne, cette analyse transversale évalue l'association entre des variants des gènes LSP1 et RAD51L1, la densité mammaire et le risque de cancer du sein

    “Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk”

    • Vachon, Celine M.;Scott, Christopher G.;Fasching, Peter A.;Hall, Per;Tamimi, Rulla M.;Li, Jingmei;Stone, Jennifer;Apicella, Carmel;Odefrey, Fabrice;Gierach, Gretchen L.;Jud, Sebastian M.;Heusinger, Katharina;Beckmann, Matthias W.;Pollan, Marina;Fernandez-Navarro, Pablo;Gonzalez-Neira, Anna;Benítez, Javier;van Gils, Carla H.;Lokate, Mariette A.J.M.;Onland-Moret, N. Charlotte;Peeters, Petra H.M.;Brown, Judith;Leyland, Jean;Varghese, Jajini S.;Easton, Douglas F.;Thompson, Deborah J.;Luben, Robert N.;Warren, Ruth M.;Wareham, Nicholas J.;Loos, Ruth J.F.;Khaw, Kay-Tee;Ursin, Giske;Lee, Eunjung;Gayther, Simon A.;Ramus, Susan J.;Eeles, Rosalind A.;Leach, Martin O.;Kwan-Lim , Gek;Couch, Fergus J.;Giles, Graham G.;Baglietto, Laura;Krishnan, Kavitha;Southey, Melissa C.;Le Marchand, Loic;Kolonel, Laurence N.;Woolcott, Christy;Maskarinec, Gertraud;Haiman, Christopher A.;Walker, Kate;Johnson, Nichola;McCormack, Valerie A.;Biong, Margarethe;Grenaker Alnaes, Grethe;Torhild Gram, Inger;Kristensen, Vessela N.;Borresen-Dale, Anne-Lise;Lindström, Sara;Hankinson, Susan E.;Hunter, David J.;Andrulis, Irene L.;Knight, Julia A.;Boyd, Norman F.;Figueroa, Jonine D.;Lissowska, Jolanta;Wesolowska, Ewa;Peplonska, Beata;Bukowska, Agnieszka;Reszka, Edyta;Liu, Jianjun;Eriksson, Louise;Czene, Kamila;Audley, Tina;Wu, Anna H.;Pankratz, V. Shane;Hopper, John L.;dos Santos Silva, Isabel

    Background: Mammographic density adjusted for age and body mass index (BMI) is a heritable marker of breast cancer susceptibility. Little is known about the biological mechanisms underlying the association between mammographic density and breast cancer risk. We examined whether common low-penetrance breast cancer susceptibility variants contribute to inter-individual differences in mammographic density measures. Methods: We established an international consortium (DENSNP) of 19 studies from 10 countries, comprising 16,895 Caucasian women, to conduct a pooled cross-sectional analysis of common breast cancer susceptibility variants in 14 independent loci and mammographic density measures. Dense and non-dense areas, and percent density, were measured using interactive-thresholding techniques. Mixed linear models were used to assess the association between genetic variants and the square roots of mammographic density measures adjusted for study, age, case status, body mass index (BMI) and ...


Mots clés : Sein; Etiologie (Facteurs endogènes)

Menée auprès de 448 732 participants âgés de 50 à 71 ans, cette étude de cohorte analyse et compare, pour les non-fumeurs, les anciens fumeurs et les fumeurs actifs, l'association entre l'indice de masse corporelle et le risque de cancer du poumon

  • Body Mass Index and Risk of Lung Cancer Among Never, Former, and Current Smokers
    Journal of the National Cancer Institute, sous presse, 2012 (résumé)
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    Menée auprès de 448 732 participants âgés de 50 à 71 ans, cette étude de cohorte analyse et compare, pour les non-fumeurs, les anciens fumeurs et les fumeurs actifs, l'association entre l'indice de masse corporelle et le risque de cancer du poumon

    “Body Mass Index and Risk of Lung Cancer Among Never, Former, and Current Smokers”

    • Smith, Llewellyn;Brinton, Louise A.;Spitz, Margaret R.;Lam, Tram Kim;Park, Yikyung;Hollenbeck, Albert R.;Freedman, Neal D.;Gierach, Gretchen L.

    Background Although obesity has been directly linked to the development of many cancers, many epidemiological studies have found that body mass index (BMI)—a surrogate marker of obesity—is inversely associated with the risk of lung cancer. These studies are difficult to interpret because of potential confounding by cigarette smoking, a major risk factor for lung cancer that is associated with lower BMI.Methods We prospectively examined the association between BMI and the risk of lung cancer among 448 732 men and women aged 50–71 years who were recruited during 1995–1996 for the National Institutes of Health–AARP Diet and Health Study. BMI was calculated based on the participant’s self-reported height and weight on the baseline questionnaire. We identified 9437 incident lung carcinomas (including 415 in never smokers) during a mean follow-up of 9.7 years through 2006. Multivariable Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and ...


Mots clés : Poumon; Etiologie (Facteurs endogènes)

Menée en Espagne, cette étude (879 cas et 803 témoins) évalue l'association entre des polymorphismes de trois gènes MMP, le risque de cancer du poumon et la survie

  • Genetic polymorphisms in MMP 2, 9 and 3 genes modify lung cancer risk and survival
    BMC Cancer, Vol. 12 (1), pp. 121, 2012 (article en libre accès)
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    Menée en Espagne, cette étude (879 cas et 803 témoins) évalue l'association entre des polymorphismes de trois gènes MMP, le risque de cancer du poumon et la survie

    “Genetic polymorphisms in MMP 2, 9 and 3 genes modify lung cancer risk and survival”

    • Gonzalez-Arriaga, Patricia;Pascual, Teresa;Garcia-Alvarez, Arturo;Fernandez-Somoano, Ana;Lopez-Cima, Maria Felicitas;Tardon, Adonina

    BACKGROUND:Matrix metalloproteases (MMPs) are proteolytic enzymes that contribute to all stages of tumour progression, including the later stages of invasion and metastasis. Genetic variants in the MMP genes may influence the biological function of these enzymes and change their role in carcinogenesis and progression. We have investigated the association between the -735 C/T, the -1171 5A/6A, and the -1562 C/T polymorphisms in the MMP2, MMP3 and MMP9 genes, respectively, and the risk and survival of lung cancer.METHODS:The case-control study includes 879 lung cancer patients and 803 controls from a Caucasian population in Spain (CAPUA study). Genotypes were determined by PCR-RFLP. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression. The Kaplan-Meier method, long-rank test and Cox's were used for the survival analysis.RESULTS:The MMP9 -1562 T/T genotype was associated with a statistically significant decreased risk of developing ...


Mots clés : Poumon; Etiologie (Facteurs endogènes)

A partir des données de deux grandes études de cohorte américaines, "Nurses’ Health Study" et "Health Professionals Follow-up Study", cette étude prospective évalue l'association entre l'obésité et le risque de cancers de la peau, mélanome et hors mélanome, dans une population d'origine caucasienne

  • Obesity and the incidence of skin cancer in US Caucasians
    Cancer Causes and Control, sous presse, 2012 (résumé)
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    A partir des données de deux grandes études de cohorte américaines, "Nurses’ Health Study" et "Health Professionals Follow-up Study", cette étude prospective évalue l'association entre l'obésité et le risque de cancers de la peau, mélanome et hors mélanome, dans une population d'origine caucasienne

    “Obesity and the incidence of skin cancer in US Caucasians”

    • Pothiawala, Salma;Qureshi, Abrar;Li, Yunhui;Han, Jiali

    Background Limited information is available on the potential link between obesity and either melanoma or non-melanoma skin cancers. Objective To conduct a prospective study to examine the association between obesity and the risk of both melanoma and non-melanoma skin cancers. Methods Using pooled data from two large national cohorts in the US, the Nurses’ Health Study (NHS) and the Health Professionals Follow-up Study (HPFS), we prospectively examined the incidence of melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) among participants grouped according to body mass index (BMI). Results Compared to participants with an updated BMI in the normal range, those with a BMI in the obese range had a 32 % lower risk of developing SCC, and those with a BMI in the morbidly obese category had a 37 % lower risk of developing SCC. The decrease in SCC risk was limited to women. Compared to participants with a BMI in the normal range, those with a BMI in the obese range had a ...


Mots clés : Peau (hors mélanome); Etiologie (Facteurs endogènes)

Conduite auprès de populations d'Europe du Sud, cette étude (1 639 cas et 1 342 témoins) analyse l'association entre des variants des gènes MC1R, SLC45A2 et TYR et le risque de mélanome

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    Conduite auprès de populations d'Europe du Sud, cette étude (1 639 cas et 1 342 témoins) analyse l'association entre des variants des gènes MC1R, SLC45A2 et TYR et le risque de mélanome

    “MC1R, SLC45A2 and TYR genetic variants involved in melanoma susceptibility in Southern European populations: Results from a Meta-analysis”

    • Ibarrola-Villava, Maider;Hu, Hui-Han;Guedj, Mickaël;Fernandez, Lara P.;Descamps, Vincent;Basset-Seguin, Nicole;Bagot, Martine;Benssussan, Armand;Saiag, Philippe;Fargnoli, Maria Concetta;Peris, Ketty;Aviles, Jose A.;Lluch, Ana;Ribas, Gloria;Soufir, Nadem

    Seven genetic biomarkers previously associated with melanoma were analysed in a meta-analysis conducted in three South European populations: five red hair colour (RHC) MC1R alleles, one SLC45A2 variant (p.Phe374Leu) and one thermosensitive TYR variant (p.Arg402Gln). The study included 1639 melanoma patients and 1342 control subjects. The estimated odds ratio (OR) associated with carrying at least one MC1R RHC variant was 2.18 (95% confidence interval (CI): 1.86–2.55; p-value=1.02×10−21), with an additive effect for carrying two RHC variants (OR: 5.02, 95% CI: 2.88–8.94, p-value=3.91×10−8). The SLC45A2 variant, p.Phe374Leu, was significantly and strongly protective for melanoma in the three South European populations studied, with an overall OR value of 0.41 (95%CI: 0.33–0.50; p-value=3.50×10−17). The association with melanoma of the TYR variant p.Arg402Gln was also statistically significant (OR: 1.50; 95%CI: 1.11–2.04; p-value=0.0089). Adjustment for all clinical ...


Mots clés : Mélanome; Etiologie (Facteurs endogènes)

A partir d'une revue systématique de la littérature (26 études prospectives), cette méta-analyse évalue l'association entre l'excès de poids et le risque de cancer primitif du foie

  • Excess body weight and the risk of primary liver cancer: An updated meta-analysis of prospective studies
    European journal of cancer (Oxford, England : 1990), sous presse, 2012 (résumé)
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    A partir d'une revue systématique de la littérature (26 études prospectives), cette méta-analyse évalue l'association entre l'excès de poids et le risque de cancer primitif du foie

    “Excess body weight and the risk of primary liver cancer: An updated meta-analysis of prospective studies”

    • Chen, Yi;Wang, Xiaolin;Wang, Jianhua;Yan, Zhiping;Luo, Jianjun

    To provide a quantitative assessment of the association between excess body weight (EBW) and the risk of primary liver cancer (PLC), we performed an updated meta-analysis of prospective observational studies. We searched PUBMED and EMBASE for studies of body mass index and the risk of PLC published through 15 th September 2011. Summary relative risks (SRRs) with their corresponding 95% confidence intervals (CIs) were calculated using a random-effects model. The meta-regression and stratified methods were used to examine heterogeneity across studies. A total of 26 prospective studies, including 25,337 PLC cases, were included in this analysis. Overall, excess body weight (EBW: body mass index (BMI)⩾25kg/m2) and obesity (BMI⩾30kg/m2) were associated with an increased risk of PLC, with significant heterogeneity (EBW: SRRs 1.48, 95%CIs 1.31–1.67, Ph<0.001, I2=83.6%; Obesity: SRRs 1.83, 95%CIs 1.59–2.11, Ph<0.001, I2=75.0%). Subgroup analyses revealed that the positive associations ...


Mots clés : Foie; Etiologie (Facteurs endogènes)

Menée en Corée, cette étude (1 771 cas et 4 667 témoins) évalue l'association entre des facteurs de risque métaboliques tels que le stress oxydant, la production d'adipokine, la résistance à l'insuline et le risque de cancer colorectal

  • Association of colorectal adenoma with components of metabolic syndrome
    Cancer Causes and Control, sous presse, 2012 (résumé)
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    Menée en Corée, cette étude (1 771 cas et 4 667 témoins) évalue l'association entre des facteurs de risque métaboliques tels que le stress oxydant, la production d'adipokine, la résistance à l'insuline et le risque de cancer colorectal

    “Association of colorectal adenoma with components of metabolic syndrome”

    • Kim, Byung;Shin, Aesun;Hong, Chang;Sohn, Dae;Han, Kyung;Ryu, Kum;Park, Bum;Nam, Ji;Park, Ji;Chang, Hee;Choi, Hyo;Kim, Jeongseon;Oh, Jae

    Purpose Recently, some studies have shown that diabetes mellitus and metabolic syndrome increase the risk of colorectal neoplasms. Although the mechanism is not known, those have been proposed to contribute to this phenomenon, including insulin resistance, oxidative stress, and adipokine production. The objective of this study was to assess the association between metabolic risk factors and colorectal neoplasm. Methods Study participants visited the National Cancer Center, Korea, for screening (2007–2009). A total of 1,771 diagnosed adenoma patients and 4,667 polyp-free controls were included. The association between risk factors and colorectal neoplasm was evaluated using logistic regression models. Results High waist circumference, blood pressure, and serum triglyceride levels were associated with an increased risk of colorectal adenoma. Metabolic syndrome (MS) was associated with an increased risk of adenoma (OR = 1.44, 95 % CI = 1.23–1.70). The association between MS and ...


Mots clés : Colon-rectum; Etiologie (Facteurs endogènes)

Cette étude en population suédoise (19 756 cas et 147 324 témoins) analyse l'association entre le diabète, l'obésité, un niveau sanguin anormal de lipides et le risque de cancer

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    Cette étude en population suédoise (19 756 cas et 147 324 témoins) analyse l'association entre le diabète, l'obésité, un niveau sanguin anormal de lipides et le risque de cancer

    “Cancer among patients with diabetes, obesity and abnormal blood lipids: a population-based register study in Sweden”

    • Attner, Bo;Landin-Olsson, Mona;Lithman, Thor;Noreen, Dennis;Olsson, Håkan

    Objective To study how the incidence of cancer is related to diabetes, obesity or abnormal blood lipids. Methods Diagnosis of diabetes, obesity or abnormal blood lipids was studied 0-10 years prior to the diagnosis of cancer in 19,756 cases of cancer and in 147,324 controls matched regarding age, sex and domicile. Results Diabetes was significantly more common prior to diagnosis in patients with liver, pancreatic, colon and urinary tract/bladder cancer and in patients with breast cancer diagnosed with diabetes 0–4 years prior to the cancer diagnosis. A lower risk of diabetes was seen in patients with prostate carcinoma among individuals with diabetes diagnosed 5–10 years prior to the cancer diagnosis. The findings remained after adjusting for obesity and high blood lipids. Obesity was significantly more common in patients with endometrial, colon and kidney cancer and with breast cancer above the age of 60 years in those where obesity was diagnosed close to the diagnosis of cancer. ...


Mots clés : Cancer (général); Etiologie (Facteurs endogènes)

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