Lutte contre les cancers

Menée auprès de 41 participants, cette étude évalue les effets à long terme d'une radiothérapie combinée ou non à une chimiothérapie sur le fonctionnement de la glande salivaire de patients atteints d'un cancer de la tête et du cou

• Long-term oral effects in patients treated with radiochemotherapy for head and neck cancer
  • Supportive Care in Cancer, sous presse, 2012 (résumé)
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  Menée auprès de 41 participants, cette étude évalue les effets à long terme d'une radiothérapie combinée ou non à une chimiothérapie sur le fonctionnement de la glande salivaire de patients atteints d'un cancer de la tête et du cou

  “Long-term oral effects in patients treated with radiochemotherapy for head and neck cancer”

  • Deboni, Aline;Giordani, Adelmo;Lopes, Nilza;Dias, Rodrigo;Segreto, Roberto;Jensen, Siri;Segreto, Helena

  Purpose The purpose of this study is to assess the late oral complications and the role of salivary gland hypofunction in the severity of mucosal reaction in nonsurgical head and neck cancer patients, submitted to radiotherapy with or without chemotherapy. Methods and materials Five hundred fifteen charts from patients treated between 2005 and 2009 were reviewed, and 41 patients met the inclusion criteria. Salivary gland function was assessed using a simplified grading system (GSX) and sialometry. Late effects were assessed using the Common Toxicity Criteria (CTC Version 2.0). Results The average follow-up was 17.1 (4–51) months. A statistical correlation was found for whole salivary flow rates and the average CTC grades for the mucous membrane. Both unstimulated/stimulated whole salivary flow rates (<0.09 mL/min) were identified as potential risk factors ( p < 0.05) and an independent predictor for late mucous membrane toxicity (≥grade 2). A significant correlation was also ...

  
  

Mots clés : Voies aérodigestives supérieures; Lutte contre les cancers (Qualité de vie, soins de support)

Menée aux Etats-Unis auprès de 115 dyades constituées du patient et de son soignant, cette étude analyse la convergence entre les symptômes déclarés par le patient atteint de tumeurs cérébrales et ceux rapportés par le soignant ainsi que le dégré de sévérité de ces symptômes

• Congruence of primary brain tumor patient and caregiver symptom report
  • Cancer, sous presse, 2012 (résumé)
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  Menée aux Etats-Unis auprès de 115 dyades constituées du patient et de son soignant, cette étude analyse la convergence entre les symptômes déclarés par le patient atteint de tumeurs cérébrales et ceux rapportés par le soignant ainsi que le dégré de sévérité de ces symptômes

  “Congruence of primary brain tumor patient and caregiver symptom report”

  • Armstrong, Terri S.;Wefel, Jeffrey S.;Gning, Ibrahima;Acquaye, Alvina;Vera-Bolanos, Elizabeth;Gilbert, Mark R.;Cleeland, Charles S.;Mendoza, Tito

  BACKGROUND: Evaluating the severity of symptoms in patients with primary brain tumors (PBTs) is important in clinical care and research but may be difficult due to patient neurocognitive (NC) impairment. This study was conducted to evaluate the congruence of symptom reporting in patient and caregiver dyads, examining potential impact of NC impairment and Karnofsky performance status (KPS). METHODS: PBT patients undergoing NC testing and their caregivers were included in this study. These dyads (paired patient and caregiver group) completed the MD Anderson Symptom Inventory-Brain Tumor Module prior to testing, and impairment was categorized based on NC test scores. Concordance and equivalency was then assessed using Bland-Altman analysis and 2 one-sided techniques. RESULTS: A total of 115 dyads participated. Median patient and caregiver age was 49 and 51 years, respectively, and 63% of patients were male (73% female caregivers). Most patients had a good KPS (≥90, 66%) but were ...

  
  

Mots clés : Système nerveux central; Lutte contre les cancers (Qualité de vie, soins de support)

Menée auprès de 15 femmes présentant un lymphoedème et 15 témoins, cette étude analyse les effets indésirables d'une séance de massage lymphatique et d'une compression du bras pour traiter le lymphoedème suivant un cancer du sein

• Change in extracellular fluid and arm volumes as a consequence of a single session of lymphatic massage followed by rest with or without compression
  • Supportive Care in Cancer, sous presse, 2012 (résumé)
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  Menée auprès de 15 femmes présentant un lymphoedème et 15 témoins, cette étude analyse les effets indésirables d'une séance de massage lymphatique et d'une compression du bras pour traiter le lymphoedème suivant un cancer du sein

  “Change in extracellular fluid and arm volumes as a consequence of a single session of lymphatic massage followed by rest with or without compression”

  • Maher, J.;Refshauge, K.;Ward, L.;Paterson, R.;Kilbreath, S.

  Purpose This study evaluated the acute effect of massage and compression components of lymphoedema treatment in women with and without arm lymphoedema secondary to breast cancer from a single treatment session. Methods Women with ( n = 15) and without ( n = 15) lymphoedema underwent a single session of lymphatic massage. Following the session, women were randomised to receive or not receive a compression sleeve. Measurements were taken prior to, during, and following the massage as well as 30 min after completion of the massage. Bioimpedance spectrometry (BIS) was used to measure changes in extracellular fluid volume of all limbs as well as 10-cm segments within the upper limbs; perometry was used to measure changes in total upper limb volume as well as 10-cm segments within the limb. Results There were no significant changes after massage with or without compression. The median (and interquartile range) BIS ratios (unaffected:affected) for the whole upper limb for women with ...

  
  

Mots clés : Sein; Lutte contre les cancers (Qualité de vie, soins de support)

Menée auprès de 633 survivantes d'un cancer du sein (âge médian : 56 ans), cette étude analyse leur fatigue associée à une inflammation et évalue les effets d'une consommation d'acides gras oméga 3 sur la diminution de l'inflammation

• Fatigue, Inflammation, and ω-3 and ω-6 Fatty Acid Intake Among Breast Cancer Survivors
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Menée auprès de 633 survivantes d'un cancer du sein (âge médian : 56 ans), cette étude analyse leur fatigue associée à une inflammation et évalue les effets d'une consommation d'acides gras oméga 3 sur la diminution de l'inflammation

  “Fatigue, Inflammation, and ω-3 and ω-6 Fatty Acid Intake Among Breast Cancer Survivors”

  • Alfano, Catherine M.;Imayama, Ikuyo;Neuhouser, Marian L.;Kiecolt-Glaser, Janice K.;Wilder Smith, Ashley;Meeske, Kathleen;McTiernan, Anne;Bernstein, Leslie;Baumgartner, Kathy B.;Ulrich, Cornelia M.;Ballard-Barbash, Rachel

  Purpose Evidence suggests that inflammation may drive fatigue in cancer survivors. Research in healthy populations has shown reduced inflammation with higher dietary intake of ω-3 polyunsaturated fatty acids (PUFAs), which could potentially reduce fatigue. This study investigated fatigue, inflammation, and intake of ω-3 and ω-6 PUFAs among breast cancer survivors.Methods Six hundred thirty-three survivors (mean age, 56 years; stage I to IIIA) participating in the Health, Eating, Activity, and Lifestyle Study completed a food frequency/dietary supplement questionnaire and provided a blood sample assayed for C-reactive protein (CRP) and serum amyloid A (30 months after diagnosis) and completed the Piper Fatigue Scale and Short Form-36 (SF-36) vitality scale (39 months after diagnosis). Analysis of covariance and logistic regression models tested relationships between inflammation and fatigue, inflammation and ω-3 and ω-6 PUFA intake, and PUFA intake and fatigue, controlling for ...

  
  

Mots clés : Sein; Lutte contre les cancers (Qualité de vie, soins de support)

Menée en Australie auprès de 135 patients (âge médian : 7,7 ans), cette étude transversale analyse l'efficacité et la mise en oeuvre d'un programme destiné à traiter la douleur des enfants atteints de cancer

• Comfort First: an evaluation of a procedural pain management programme for children with cancer
  • Psycho-Oncology, sous presse, 2012 (résumé)
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  Menée en Australie auprès de 135 patients (âge médian : 7,7 ans), cette étude transversale analyse l'efficacité et la mise en oeuvre d'un programme destiné à traiter la douleur des enfants atteints de cancer

  “Comfort First: an evaluation of a procedural pain management programme for children with cancer”

  • McCarthy, Maria;Glick, Ron;Green, Jessica;Plummer, Karin;Peters, Kari;Johnsey, Lydia;DeLuca, Cinzia

  Background The Comfort First Program (CFP) provides children and their caregivers with early procedural pain management intervention to reduce procedural pain and distress. This study evaluated whether the CFP was meeting its goals and effectively implementing the Royal Australasian College of Physicians paediatric pain management guidelines. Methods The study was conducted as a single-site cross-sectional audit. One hundred and thirty-five patients (mean age 7.7 years) receiving treatment at the Royal Children's Hospital, Melbourne, Children's Cancer Centre Day Oncology Unit were observed. Procedural aspects related to the treatment room, carer and staff behaviour, child distress and use of pharmacologic and nonpharmacologic interventions were recorded using an audit tool developed for the study. Results The procedure room was regularly quiet and prepared before the child entered. Median procedure duration was 8 min. Median procedure wait time was 54 min. At least one carer was ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

Menée auprès de 210 participants chinois, cette étude analyse et compare les besoins en soins de support de patientes atteintes d'un cancer du sein et de patients atteints de cancer colorectal

• Interpreting differences in patterns of supportive care needs between patients with breast cancer and patients with colorectal cancer
  • Psycho-Oncology, sous presse, 2012 (résumé)
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  Menée auprès de 210 participants chinois, cette étude analyse et compare les besoins en soins de support de patientes atteintes d'un cancer du sein et de patients atteints de cancer colorectal

  “Interpreting differences in patterns of supportive care needs between patients with breast cancer and patients with colorectal cancer”

  • Li, Wylie W. Y.;Lam, Wendy W. T.;Au, Angel H. Y.;Ye, Michelle;Law, Wai Lun;Poon, Jensen;Kwong, Ava;Suen, Dacita;Tsang, Janice;Girgis, Afaf;Fielding, Richard

  Background Understanding cancer patients' supportive care needs can help optimize health-care systems and inform services development. We therefore examined the prevalence of supportive care needs in Chinese breast (BC) and colorectal cancer (CRC) patients to identify prevalence and correlates of unmet needs. Methods We assessed supportive care needs (Supportive Care Needs Survey—Short Form), psychological distress (the Hospital Anxiety and Depression Scale), symptom distress (The Memorial Symptom Assessment Scale—Short Form), and satisfaction with care (Patient Satisfaction Questionnaire) among 210 Chinese BC (97) or CRC (104) outpatient clinic attendees. Results Breast cancer patients (89.7%) reported more unmet needs (χ2 = 4.409, p = 0.027), but both CRC and BC samples ranked unmet needs prevalence similarly, with health system and information needs reported as the most common. Younger patients reported higher health system and information and sexuality needs. After ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

Menée sur la période 1991 à 2008, cette étude analyse l'incidence du cancer de la thyroïde après l'accident nucléaire de Tchernobyl

• Radiation-epidemiological studies of thyroid cancer incidence in Russia after Chernobyl accident (estimation of radiatino risks, 1991-2008 follow-up period)
  • Radiation Protection Dosimetry, sous presse, 2012 (résumé)
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  Menée sur la période 1991 à 2008, cette étude analyse l'incidence du cancer de la thyroïde après l'accident nucléaire de Tchernobyl

  “Radiation-epidemiological studies of thyroid cancer incidence in Russia after Chernobyl accident (estimation of radiatino risks, 1991-2008 follow-up period)”

  • Ivanov, V. K.;Kashcheev, V. V.;Chekin, S. Yu.;Maksioutov, M. A.;Tumanov, K. A.;Vlasov, O. K.;Shchukina, N. V.;Tsyb, A. F.

  This study presents an analysis of the thyroid cancer incidence in the population of the most contaminated territories of Bryansk, Kaluga, Oryol and Tula oblasts affected by the Chernobyl accident. The follow-up period is 1991–2008, and the cohort size is 309 130 people. For that period 978 thyroid cancer cases were detected. The excess relative risk per 1 Gy (ERR/Gy) is found to be statistically significant for children and adolescents (0–17 y of age) at the time of the Chernobyl accident (ERR/Gy=3.22; 95 % confidence interval (1.56; 5.81). In boys, the ERR/Gy was higher than in girls –6.54 and 2.24, respectively. A statistically significant decrease in ERR/Gy with time since exposure, by a factor of 0.37 per 10 y, was observed for the whole cohort and for boys separately, but not for girls. No radiation risks of a thyroid cancer among people of 18 y of age at exposure and older were found.

  
  

Mots clés : Thyroïde; Lutte contre les cancers (Observation)

Menée sur la période 1991-1995 à partir des données des registres belges de la mortalité, cette étude analyse l'association entre des facteurs reproductifs, le niveau d'éducation et la mortalité par cancer du sein, chez des femmes ménopausées ou non

• Does birth history account for educational differences in breast cancer mortality? A comparison of pre- and postmenopausal women in Belgium
  • International Journal of Cancer, sous presse, 2012 (résumé)
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  Menée sur la période 1991-1995 à partir des données des registres belges de la mortalité, cette étude analyse l'association entre des facteurs reproductifs, le niveau d'éducation et la mortalité par cancer du sein, chez des femmes ménopausées ou non

  “Does birth history account for educational differences in breast cancer mortality? A comparison of pre- and postmenopausal women in Belgium”

  • Gadeyne, Sylvie;Deboosere, Patrick;Vandenheede, Hadewijch;Neels, Karel

  This study investigates the impact of reproductive factors on the association between education and breast cancer mortality in Belgium. The role of reproductive factors has been investigated in several studies, with mixed results. Reproductive factors are either completely or partially responsible for the association between education and breast cancer mortality. The data consist of the 1991 census linked to registration data on cause-specific mortality during the period 1991-1995, including all breast cancer deaths in Belgium during the observation period. The study population includes all women aged 35 to 79 at time of the census. Age-standardised mortality rates and mortality rate ratios (Poisson regression) are computed for educational groups with and without control for reproductive factors. The population is stratified according to age (women aged 35-49 and 50-79) and according to nulliparity. The relationship between education and breast cancer is significant among ...

  
  

Mots clés : Sein; Lutte contre les cancers (Observation)

A partir de données des registres américains du cancer et de la base Medicare portant sur 20 027 femmes, cette étude analyse le taux de récidive de cancer du sein chez des patientes ayant terminé complètement leur premier traitement (durée de suivi 10 ans)

• Hazard of Recurrence among Women after Primary Breast Cancer Treatment - A 10-Year Follow-Up Using Data from SEER-Medicare
  • Cancer Epidemiology Biomarkers & Prevention, sous presse, 2012 (résumé)
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  A partir de données des registres américains du cancer et de la base Medicare portant sur 20 027 femmes, cette étude analyse le taux de récidive de cancer du sein chez des patientes ayant terminé complètement leur premier traitement (durée de suivi 10 ans)

  “Hazard of Recurrence among Women after Primary Breast Cancer Treatment - A 10-Year Follow-Up Using Data from SEER-Medicare”

  • Cheng, Lee;Swartz, Michael;Zhao, Hui;Kapadia, Asha;Lai, Dejian;Rowan, Paul;Buchholz, Thomas A.;Giordano, Sharon

  Few studies have used SEER-Medicare data to describe recurrence of breast cancer after completion of primary treatment for US women. Methods We used SEER-Medicare data to estimate the annual hazard rate (HR) of recurrence for women with breast cancer between 1991 and 1997 with 10 years of follow-up. The Kaplan-Meier method was used to derive the HR. Multivariate Cox proportional hazards model was used to estimate the relative hazard of the recurrence associated prognostic factors. Results Of 20,027 women, 36.8% had recurrence within 10 years, with most of these recurrences (81.9%) occurring within 5 years after diagnosis. Women with stage III cancer showed the highest HR peak and largest magnitude compared with women with stage I or II disease (both P<0.01) within the first 5 years. Women with negative tumor hormone receptor status had a higher peak hazard of developing recurrence within the first 5 years (P<0.01), but the hazards were remarkably lower beyond 5 years of follow-up ...

  
  

Mots clés : Sein; Lutte contre les cancers (Observation)

Cette étude américaine évalue l'impact de la diminution du tabagisme sur la mortalité par cancer du poumon entre 1975 et 2000

• Impact of Reduced Tobacco Smoking on Lung Cancer Mortality in the United States During 1975–2000
  • Journal of the National Cancer Institute, sous presse, 2012 (article en libre accès)
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  Cette étude américaine évalue l'impact de la diminution du tabagisme sur la mortalité par cancer du poumon entre 1975 et 2000

  “Impact of Reduced Tobacco Smoking on Lung Cancer Mortality in the United States During 1975–2000”

  • Moolgavkar, Suresh H.;Holford, Theodore R.;Levy, David T.;Kong, Chung Yin;Foy, Millenia;Clarke, Lauren;Jeon, Jihyoun;Hazelton, William D.;Meza, Rafael;Schultz, Frank;McCarthy, William;Boer, Robert;Gorlova, Olga;Gazelle, G. Scott;Kimmel, Marek;McMahon, Pamela M.;de Koning, Harry J.;Feuer, Eric J.

  Background Considerable effort has been expended on tobacco control strategies in the United States since the mid-1950s. However, we have little quantitative information on how changes in smoking behaviors have impacted lung cancer mortality. We quantified the cumulative impact of changes in smoking behaviors that started in the mid-1950s on lung cancer mortality in the United States over the period 1975–2000.Methods A consortium of six groups of investigators used common inputs consisting of simulated cohort-wise smoking histories for the birth cohorts of 1890 through 1970 and independent models to estimate the number of US lung cancer deaths averted during 1975–2000 as a result of changes in smoking behavior that began in the mid-1950s. We also estimated the number of deaths that could have been averted had tobacco control been completely effective in eliminating smoking after the Surgeon General’s first report on Smoking and Health in 1964.Results Approximately 795 851 US ...

  
  
• The 795 Thousand and Ending a Century of Tobacco
  • Journal of the National Cancer Institute, sous presse, 2012 (éditorial en libre accès)
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  Cette étude américaine évalue l'impact de la diminution du tabagisme sur la mortalité par cancer du poumon entre 1975 et 2000

  “The 795 Thousand and Ending a Century of Tobacco”

  • Glynn, Thomas J.

  
  
• Declines in Smoking and Lung Cancer Mortality in the U.S.: 1975–2000
  • Journal of the National Cancer Institute, sous presse, 2012 (communiqué de presse)
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  Cette étude américaine évalue l'impact de la diminution du tabagisme sur la mortalité par cancer du poumon entre 1975 et 2000

  “Declines in Smoking and Lung Cancer Mortality in the U.S.: 1975–2000”

  
  

Mots clés : Poumon; Lutte contre les cancers (Observation)

Menée en Australie à partir des données du registre des cancers de Queensland, cette étude analyse la survie à 20 ans de patients diagnostiqués avec un mélanome fin (inférieur à 1 mm)

• Population-Based 20-Year Survival Among People Diagnosed With Thin Melanomas in Queensland, Australia
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Menée en Australie à partir des données du registre des cancers de Queensland, cette étude analyse la survie à 20 ans de patients diagnostiqués avec un mélanome fin (inférieur à 1 mm)

  “Population-Based 20-Year Survival Among People Diagnosed With Thin Melanomas in Queensland, Australia”

  • Green, Adèle C.;Baade, Peter;Coory, Michael;Aitken, Joanne F.;Smithers, Mark

  Purpose The 20-year survival rates are unknown for the majority of melanoma patients—those with thin melanomas. We determined 20-year survival rates of patients diagnosed with thin melanomas (≤ 1.00 mm) in the general population and also determined the main prognostic factors.Patients and Methods Available clinical and histologic data from the Queensland Cancer Registry were obtained for all patients diagnosed with a single thin invasive melanoma from 1982 to 2006 and matched against national death registration data. Melanoma-specific survival estimates to December 31, 2007, were assessed, and subgroup differences in prognosis were determined by fitting multivariate Cox proportional hazard models.Results Among 26,736 people in the state of Queensland diagnosed with thin melanomas, the 20-year survival was 96%. The most influential determinants of prognosis were tumor thickness ≥ 0.75 mm (adjusted hazard ratio [HR], 4.33; 95% CI, 2.8 to 6.8 compared with tumors < 0.25 mm) and ...

  
  

Mots clés : Mélanome; Lutte contre les cancers (Observation)

Menée sur la période 1990 à 2005, cette étude américaine analyse l'évolution de la survie des enfants et adolescents atteints de leucémie lymphoblastique aiguë

• Improved Survival for Children and Adolescents With Acute Lymphoblastic Leukemia Between 1990 and 2005: A Report From the Children's Oncology Group
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Menée sur la période 1990 à 2005, cette étude américaine analyse l'évolution de la survie des enfants et adolescents atteints de leucémie lymphoblastique aiguë

  “Improved Survival for Children and Adolescents With Acute Lymphoblastic Leukemia Between 1990 and 2005: A Report From the Children's Oncology Group”

  • Hunger, Stephen P.;Lu, Xiaomin;Devidas, Meenakshi;Camitta, Bruce M.;Gaynon, Paul S.;Winick, Naomi J.;Reaman, Gregory H.;Carroll, William L.

  Purpose To examine population-based improvements in survival and the impact of clinical covariates on outcome among children and adolescents with acute lymphoblastic leukemia (ALL) enrolled onto Children's Oncology Group (COG) clinical trials between 1990 and 2005.Patients and Methods In total, 21,626 persons age 0 to 22 years were enrolled onto COG ALL clinical trials from 1990 to 2005, representing 55.8% of ALL cases estimated to occur among US persons younger than age 20 years during this period. This period was divided into three eras (1990-1994, 1995-1999, and 2000-2005) that included similar patient numbers to examine changes in 5- and 10-year survival over time and the relationship of those changes in survival to clinical covariates, with additional analyses of cause of death.Results Five-year survival rates increased from 83.7% in 1990-1994 to 90.4% in 2000-2005 (P < .001). Survival improved significantly in all subgroups (except for infants age ≤ 1 year), including males ...

  
  

Mots clés : Leucémie; Lutte contre les cancers (Observation)

A partir des données des registres américains du cancer et de la base Medicare, cette étude analyse l'association entre des critères ethniques, des comorbidités et la survie de patientes atteintes d'un cancer de l'endomètre

• The impact of race and comorbidity on survival in endometrial cancer
  • Cancer Epidemiology Biomarkers & Prevention, sous presse, 2012 (résumé)
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  A partir des données des registres américains du cancer et de la base Medicare, cette étude analyse l'association entre des critères ethniques, des comorbidités et la survie de patientes atteintes d'un cancer de l'endomètre

  “The impact of race and comorbidity on survival in endometrial cancer”

  • Olson, Sara H.;Atoria, Coral L.;Cote, Michele L.;Cook, Linda S.;Rastogi, Radhai;Soslow, Robert A.;Brown, Carol L.;Elkin, Elena B.

  Background: Poorer survival from endometrial cancer in blacks than in whites is well-documented. The aims of this study were to determine whether diabetes, hypertension, or other conditions influence survival and whether accounting for these conditions reduces this racial disparity. Methods: Using the SEER-Medicare database, we investigated the influence of diabetes, hypertension, and other comorbid conditions on survival in black and white women age >66 with endometrial cancer. We used Cox proportional hazards regression to evaluate the influence of comorbidities on survival for blacks and whites separately and to study survival differences between blacks and whites after adjustment for diabetes, hypertension, and other medical conditions, as well as for demographics, tumor characteristics, and treatment. Results: In both racial subgroups, women with diabetes or other conditions had poorer overall survival, while hypertensive black women experienced better survival (hazard ratio ...

  
  

Mots clés : Corps de l'utérus; Lutte contre les cancers (Observation)

A partir des données d'un programme de santé publique nord-américain (Etats-Unis et Canada), cette étude analyse l'incidence des hyperplasies de l'endomètre, de cancer de l'endomètre et des hystérectomies sur la période 1980 à 2003

• Incidence rates of endometrial hyperplasia, endometrial cancer and hysterectomy from 1980 to 2003 within a large prepaid health plan
  • International Journal of Cancer, sous presse, 2012 (résumé)
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  A partir des données d'un programme de santé publique nord-américain (Etats-Unis et Canada), cette étude analyse l'incidence des hyperplasies de l'endomètre, de cancer de l'endomètre et des hystérectomies sur la période 1980 à 2003

  “Incidence rates of endometrial hyperplasia, endometrial cancer and hysterectomy from 1980 to 2003 within a large prepaid health plan”

  • Lacey, James V.;Chia, Victoria M.;Rush, Brenda B.;Carreon, Danny J.;Richesson, Douglas A.;Ioffe, Olga B.;Ronnett, Brigitte M.;Chatterjee, Nilanjan;Langholz, Bryan;Sherman, Mark E.;Glass, Andrew G.

  Obesity strongly increases the risk of endometrial cancer and is projected to increase current and future endometrial cancer incidence. In order to fully understand endometrial cancer incidence, one should also examine both hysterectomy, which eliminates future risk of endometrial cancer, and endometrial hyperplasia (EH), a precursor that prompts treatment (including hysterectomy). Hysterectomy and EH are more common than endometrial cancer, but data on simultaneous temporal trends of EH, hysterectomy and endometrial cancer are lacking. We used linked pathology, tumor registry, surgery and administrative datasets at the Kaiser Permanente Northwest Health Plan to calculate age-adjusted and age-specific rates, 1980–2003, of EH only (N = 5,990), EH plus hysterectomy (N = 904), hysterectomy without a diagnosis of EH or cancer (N = 14,926) and endometrial cancer (N = 1,208). Joinpoint regression identified inflection points and quantified annual percentage changes (APCs). The EH APCs ...

  
  

Mots clés : Corps de l'utérus; Lutte contre les cancers (Observation)

Menée aux Etats-Unis auprès de 74 patients atteints d'un cancer de la prostate, cette étude longitudinale analyse l'association entre l'évolution de leur image corporelle au cours de la maladie et leur qualité de vie

• Body image predicts quality of life in men with prostate cancer
  • Psycho-Oncology, sous presse, 2012 (résumé)
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  Menée aux Etats-Unis auprès de 74 patients atteints d'un cancer de la prostate, cette étude longitudinale analyse l'association entre l'évolution de leur image corporelle au cours de la maladie et leur qualité de vie

  “Body image predicts quality of life in men with prostate cancer”

  • Taylor-Ford, Megan;Meyerowitz, Beth E.;D'Orazio, Lina M.;Christie, Kysa M.;Gross, Mitchell E.;Agus, David B.

  Objective Most men diagnosed with prostate cancer in the USA will survive. Of the many aspects of survivorship affected by prostate cancer, body image receives limited attention despite some indication that it may be important to men with the disease. The present study investigated how body image changes over time and the relations between changes in body image and quality of life (QOL) in men with prostate cancer. Methods In a longitudinal design, patients (N = 74) completed questionnaires before treatment (T1) and at 1 month (T2) and 2 years (T3) following treatment completion. Results Growth curve modeling indicated that there was no significant change over time in group-level body image scores. However, hormone treatment was associated with a negative trajectory of change over 2 years. Also, analysis of individual difference scores indicated that ≥50% of patients demonstrated change of at least 0.5 standard deviation between time points. Hierarchical regression ...

  
  

Mots clés : Prostate; Lutte contre les cancers (Approches psycho-sociales)

Le Journal of Clinical Oncology présente plusieurs études relatives aux besoins et aux soins psychosociaux des patients atteints de cancer

• Psychosocial Care of Adolescent and Young Adult Patients With Cancer and Survivors
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Le Journal of Clinical Oncology présente plusieurs études relatives aux besoins et aux soins psychosociaux des patients atteints de cancer

  “Psychosocial Care of Adolescent and Young Adult Patients With Cancer and Survivors”

  • Zebrack, Brad;Isaacson, Sinéad

  The delivery of quality care for adolescent and young adult (AYA) patients with cancer and survivors requires an understanding of the unique qualities of this group—the shared norms, attitudes, and beliefs that determine their behavior as well as the unique stresses they face on a day-to-day basis. All AYAs have typical concerns about being comfortable with who they are and who they want to become (identity development, including sexual identity), their bodies (body image), initiating intimate and emotional relationships, separating from parents, and making independent decisions about future goals such as career, higher education, and/or family (autonomy). Yet efforts of AYA patients with cancer and survivors to mature are often confounded by restrictions and limitations placed on them by their disease and treatment. This article promotes understanding of psychosocial challenges faced by AYAs when diagnosed with and treated for cancer. It reviews evidence-based psychosocial support ...

  
  
• Web-Based Tailored Education Program for Disease-Free Cancer Survivors With Cancer-Related Fatigue: A Randomized Controlled Trial
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Le Journal of Clinical Oncology présente plusieurs études relatives aux besoins et aux soins psychosociaux des patients atteints de cancer

  “Web-Based Tailored Education Program for Disease-Free Cancer Survivors With Cancer-Related Fatigue: A Randomized Controlled Trial”

  • Yun, Young Ho ; Lee, Keun Seok ; Kim, Young-Woo ; Park, Sang Yoon ; Lee, Eun Sook ; Noh, Dong-Young ; Kim, Sung ; Oh, Jae Hwan ; Jung, So Youn ; Chung, Ki-Wook ; Lee, You Jin ; Jeong, Seung-Yong ; Park, Kyu Joo ; Shim, Young Mog ; Zo, Jae Ill ; Park, Ji Won ; Kim, Young Ae ; Shon, En Jung ; Park, Sohee

  Purpose To determine whether an Internet-based tailored education program is effective for disease-free cancer survivors with cancer-related fatigue (CRF).Patients and Methods We randomly assigned patients who had completed primary cancer treatment within the past 24 months in any of four Korean hospitals and had reported moderate to severe fatigue for at least 1 week to participate in a 12-week, Internet-based, individually tailored CRF education program or to receive routine care. We based the program on the CRF guidelines of the National Comprehensive Cancer Network (NCCN) and incorporated the transtheoretic model (TTM). At baseline and 12 weeks, we used the Brief Fatigue Inventory (BFI) and Fatigue Severity Scale (FSS) as primary outcomes and the Hospital Anxiety and Depression Scale (HADS) and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) for secondary outcomes.Results We recruited 273 participants and randomly ...

  
  
• Evidence-Based Treatment of Anxiety in Patients With Cancer
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Le Journal of Clinical Oncology présente plusieurs études relatives aux besoins et aux soins psychosociaux des patients atteints de cancer

  “Evidence-Based Treatment of Anxiety in Patients With Cancer”

  • Traeger, Lara ; Greer, Joseph A. ; Fernandez-Robles, Carlos ; Temel, Jennifer S. ; Pirl, William F.

  Anxiety is a dynamic response to perceived threat that is common among patients with cancer and fluctuates at critical points in the disease trajectory. A substantial minority of patients may experience clinically significant anxiety resulting from a range of potential etiologic factors. This review summarizes evidence-based recommendations for treatment of anxiety in oncology settings. Recommendations are based on the nature and time course of anxiety and the results of meta-analyses, systematic reviews, and individual trials in cancer populations. The evidence-based literature supports the use of psychosocial and psychopharmacologic treatments to prevent or alleviate anxiety symptoms. Conclusions are tempered by study heterogeneity and methodologic limitations and a lack of trials that included patients with clinically significant anxiety. In oncology settings, accessibility and acceptability of evidence-based treatments vary, and patients may seek a variety of resources to manage ...

  
  
• What Happens Now? Psychosocial Care for Cancer Survivors After Medical Treatment Completion
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Le Journal of Clinical Oncology présente plusieurs études relatives aux besoins et aux soins psychosociaux des patients atteints de cancer

  “What Happens Now? Psychosocial Care for Cancer Survivors After Medical Treatment Completion”

  • Stanton, Annette L.

  The growing population of adults living with a history of cancer in the United States mandates attention to quality of life and health in this group, as well as to the implementation of evidence-based interventions to address psychosocial and physical concerns at completion of medical treatments and beyond. The goals of this article are to document the need for attention to psychosocial domains during the re-entry and later phases of the cancer survivor trajectory, offer an overview of current evidence on efficacy of psychosocial interventions during those phases, and offer suggestions for application and research regarding post-treatment psychosocial care.

  
  
• Evidence-Based Treatment of Depression in Patients With Cancer
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Le Journal of Clinical Oncology présente plusieurs études relatives aux besoins et aux soins psychosociaux des patients atteints de cancer

  “Evidence-Based Treatment of Depression in Patients With Cancer”

  • Li, Madeline ; Fitzgerald, Peter ; Rodin, Gary

  Purpose Depression is a common condition in patients with cancer, although there has been a relative paucity of research on the effectiveness of treatment in this population. This review summarizes the psychosocial and pharmacologic treatment of depression in patients with cancer based on a consideration of evidence regarding etiologic factors and treatment outcomes.Methods A review of the evidence base for psychosocial and pharmacologic interventions for depression in patients with cancer was performed, including original studies, systematic reviews, and meta-analytic studies in the literature.Results Recent evidence from randomized controlled trials has demonstrated the efficacy of psychosocial and pharmacologic treatments to alleviate depression in patients with cancer. Further research is needed to establish their relative and combined efficacy and their role in the treatment of depression that is less severe and occurs in association with more advanced disease. First-line ...

  
  
• A New Quality Standard: The Integration of Psychosocial Care Into Routine Cancer Care
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Le Journal of Clinical Oncology présente plusieurs études relatives aux besoins et aux soins psychosociaux des patients atteints de cancer

  “A New Quality Standard: The Integration of Psychosocial Care Into Routine Cancer Care”

  • Jacobsen, Paul B. ; Wagner, Lynne I.

  There is a growing consensus that psychosocial care should be integrated into the routine care of patients with cancer. This consensus is consistent with the considerable body of evidence about the deleterious effects of allowing psychosocial needs to remain unmet and the growing body of evidence about the beneficial effects of providing psychosocial services to address unmet needs. Despite this evidence, available data suggest that a considerable portion of the population of patients with cancer does not receive needed psychosocial care. Three lines of professional activity initiated in recent years have the potential to address this issue in fundamental ways: the formulation of standards of cancer care that address the psychosocial component of care, the issuance of clinical practice guidelines for psychosocial care of patients with cancer, and the development and implementation of measurable indicators of the quality of psychosocial care in oncology settings. This article provides ...

  
  
• Caring for the Whole Patient: The Science of Psychosocial Care
  • Journal of Clinical Oncology, sous presse, 2012 (article en libre accès)
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  Le Journal of Clinical Oncology présente plusieurs études relatives aux besoins et aux soins psychosociaux des patients atteints de cancer

  “Caring for the Whole Patient: The Science of Psychosocial Care”

  • Jacobsen, Paul B. ; Holland, Jimmie C. ; Steensma, David P.

  This Journal of Clinical Oncology Special Series relates to the science of psychosocial care. This series is designed to provide oncology professionals with the most recent information about the psychological, psychiatric, and social aspects of cancer care. The emergence of the field of psychosocial care reflects growing public and professional awareness of the potential for cancer and its treatment to have profound effects on many aspects of life. A principal goal of psychosocial care is to recognizeandaddress the effects that cancer and its treatment have on the mental status and emotional well-being of patients, their family members, and their professional caregivers. In addition to improving emotional well-being and mental health, provision of psychosocial care has been shown to yield better management of common disease-related symptoms and adverse effects of treatment, such as pain and fatigue.

  
  
• Integrating Psychosocial Care Into Cancer Services
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Le Journal of Clinical Oncology présente plusieurs études relatives aux besoins et aux soins psychosociaux des patients atteints de cancer

  “Integrating Psychosocial Care Into Cancer Services”

  • Fann, Jesse R. ; Ell, Kathleen ; Sharpe, Michael

  Despite substantial evidence that patients with cancer commonly have significant psychosocial problems, for which we have evidence-based treatments, many patients still do not receive adequate psychosocial care. This means that we risk prolonging life without adequately addressing the quality of that life. There are many challenges to improving the current situation, the major one of which is organizational. Many cancer centers lack a system of psychosocial care that is integrated with the cancer care of the patient. Psychosocial care encompasses a range of problems (emotional, social, palliative, and logistical). The integration must occur with the cancer care of the patient at all stages (from screening to palliative care) and across all clinical sites of care (inpatient and outpatient cancer services as well as primary care). In this article, we consider the challenges we face if we are to provide such integrated psychosocial services. We focus on the collaborative care service ...

  
  
• Screening for Distress and Unmet Needs in Patients With Cancer: Review and Recommendations
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Le Journal of Clinical Oncology présente plusieurs études relatives aux besoins et aux soins psychosociaux des patients atteints de cancer

  “Screening for Distress and Unmet Needs in Patients With Cancer: Review and Recommendations”

  • Carlson, Linda E. ; Waller, Amy ; Mitchell, Alex J.

  Purpose This review summarizes the need for and process of screening for distress and assessing unmet needs of patients with cancer as well as the possible benefits of implementing screening.Methods Three areas of the relevant literature were reviewed and summarized using structured literature searches: psychometric properties of commonly used distress screening tools, psychometric properties of relevant unmet needs assessment tools, and implementation of distress screening programs that assessed patient-reported outcomes (PROs).Results Distress and unmet needs are common problems in cancer settings, and programs that routinely screen for and treat distress are feasible, particularly when staff are supported and links with specialist psychosocial services exist. Many distress screening and unmet need tools have been subject to preliminary validation, but few have been compared head to head in independent centers and in different stages of cancer. Research investigating the overall ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Approches psycho-sociales)

A partir des données du registre irlandais des cancers, cette étude analyse l'impact du stress associé aux difficultés financières engendrées par la maladie sur le bien-être psychologique des patients atteints de cancer

• Associations between cancer-related financial stress and strain and psychological well-being among individuals living with cancer
  • Psycho-Oncology, sous presse, 2012 (résumé)
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  A partir des données du registre irlandais des cancers, cette étude analyse l'impact du stress associé aux difficultés financières engendrées par la maladie sur le bien-être psychologique des patients atteints de cancer

  “Associations between cancer-related financial stress and strain and psychological well-being among individuals living with cancer”

  • Sharp, Linda;Carsin, Anne-Elie;Timmons, Aileen

  Background Cancer places a financial and economic burden on individuals, but relatively little is known about the consequences. We investigated associations between cancer-related financial stress and strain and psychological well-being. Methods Individuals >6 months post-diagnosis with breast, prostate and lung cancer, identified from the National Cancer Registry Ireland, completed a postal questionnaire. Financial stress was assessed by the impact of the cancer diagnosis on household ability to make ends meet, financial strain by feelings about household financial situation since the cancer diagnosis and psychological well-being (depression, anxiety and distress) by the Depression Anxiety Stress Scales-21. Logistic regression was used to identify associations between financial stress and strain and depression, anxiety and distress of (a) any severity and (b) severe or worse. Results The response rate was 54%. Of 654 respondents, 49% reported increased financial stress and 32% ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Approches psycho-sociales)

Cet article passe en revue les causes et conséquences d'un épuisement professionnel chez les oncologues

• Oncologist Burnout: Causes, Consequences, and Responses
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Cet article passe en revue les causes et conséquences d'un épuisement professionnel chez les oncologues

  “Oncologist Burnout: Causes, Consequences, and Responses”

  • Shanafelt, Tait;Dyrbye, Lotte

  Although the practice of oncology can be extremely rewarding, it is also one of the most demanding and stressful areas of medicine. Oncologists are faced with life and death decisions on a daily basis, administer incredibly toxic therapies with narrow therapeutic windows, must keep up with the rapid pace of scientific and treatment advances, and continually walk a fine line between providing palliation and administering treatments that lead to excess toxicity. Personal distress precipitated by such work-related stress may manifest in a variety of ways including depression, anxiety, fatigue, and low mental quality of life. Burnout also seems to be one of the most common manifestations of distress among physicians, with studies suggesting a prevalence of 35% among medical oncologists, 38% among radiation oncologists, and 28% to 36% among surgical oncologists. Substantial evidence suggests that burnout can impact quality of care in a variety of ways and has potentially profound personal ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Approches psycho-sociales)

Le Journal of Clinical Oncology présente plusieurs études relatives aux besoins et aux soins psychosociaux des patients atteints de cancer

• Psychosocial Care for Family Caregivers of Patients With Cancer
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Le Journal of Clinical Oncology présente plusieurs études relatives aux besoins et aux soins psychosociaux des patients atteints de cancer

  “Psychosocial Care for Family Caregivers of Patients With Cancer”

  • Northouse, Laurel;Williams, Anna-leila;Given, Barbara;McCorkle, Ruth

  Purpose To understand family caregivers' needs for better preparation and care, this state-of-the-science review examines the effect of caregiving on the health and well-being of caregivers, the efficacy of research-tested interventions on patient and caregiver outcomes, implications of the research on policy and practice, and recommendations for practice and future research.Methods We reviewed research that described the multiple effects of cancer on caregivers' well-being. Five meta-analyses were analyzed to determine the effect of interventions with caregivers on patient and caregiver outcomes. In addition, we reviewed legislation such as the Affordable Care Act and the Family Leave Act along with current primary care practice to determine whether family caregivers' needs have been addressed.Results Research findings indicate that caregiver stress can lead to psychological and sleep disturbances and changes in caregivers' physical health, immune function, and financial well-being. ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Approches psycho-sociales)

Menée auprès de 523 survivants d'un cancer et âgés de 15 à 39 ans, cette étude multicentrique en population américaine analyse les effets psychosociaux, négatifs et positifs, d'un diagnostic de cancer

• Positive and negative psychosocial impact of being diagnosed with cancer as an adolescent or young adult
  • Cancer, sous presse, 2012 (résumé)
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  Menée auprès de 523 survivants d'un cancer et âgés de 15 à 39 ans, cette étude multicentrique en population américaine analyse les effets psychosociaux, négatifs et positifs, d'un diagnostic de cancer

  “Positive and negative psychosocial impact of being diagnosed with cancer as an adolescent or young adult”

  • Bellizzi, Keith M.;Smith, Ashley;Schmidt, Steven;Keegan, Theresa H. M.;Zebrack, Brad;Lynch, Charles F.;Deapen, Dennis;Shnorhavorian, Margarett;Tompkins, Bradley J.;Simon, Michael;and the, Adolescent;Young Adult Health, Outcomes;Patient Experience Study Collaborative, Group

  BACKGROUND: The objective of this study was to explore the psychosocial impact of cancer on newly diagnosed adolescent and young adult (AYA) cancer patients. METHODS: This was a population-based, multicenter study of 523 newly diagnosed AYA survivors (ages 15-39 years) of germ cell cancer (n = 204), non-Hodgkin lymphoma (n = 131), Hodgkin lymphoma (n = 142), acute lymphocytic leukemia (n = 21), or sarcoma (n = 25) from 7 National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) registries. Age at diagnosis was categorized into 3 groups (ages 15-20 years, 21-29 years, and 30-39 years). RESULTS: Respondents (43% response rate), on average (±standard deviation), were aged 29 = 6.7 years, and most patients (80.1%) were not receiving treatment at the time the completed the survey. With modest differences between the age groups, the most prevalent areas of life impacted in a negative way were financial, body image, control over life, work plans, relationship with ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Approches psycho-sociales)

A partir des données des registres américains du cancer, cette étude analyse les coûts médicaux directs des traitements du cancer du pancréas dans une population disposant de la couverture sociale Medicare et âgée de plus de 66 ans

• Costs and trends in pancreatic cancer treatment
  • Cancer, sous presse, 2012 (résumé)
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  A partir des données des registres américains du cancer, cette étude analyse les coûts médicaux directs des traitements du cancer du pancréas dans une population disposant de la couverture sociale Medicare et âgée de plus de 66 ans

  “Costs and trends in pancreatic cancer treatment”

  • O'Neill, Caitriona B.;Atoria, Coral L.;O'Reilly, Eileen M.;LaFemina, Jennifer;Henman, Martin C.;Elkin, Elena B.

  BACKGROUND: Pancreatic cancer poses a substantial morbidity and mortality burden in the United States, and predominantly affects older adults. The objective of this study was to estimate the direct medical costs of pancreatic cancer treatment in a population-based cohort of Medicare beneficiaries, and the contribution of different treatment modalities and health care services to the total cost of care and trends in costs over time. METHODS: In the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database, pancreatic cancer patients were identified who were aged 66 years or older and who were diagnosed from 2000 to 2007. Total direct medical costs were estimated from Medicare payments overall and within categories of care. Costs attributable to pancreatic cancer were estimated by subtracting the costs of medical care in a matched cohort of cancer-free beneficiaries. RESULTS: A total of 15,037 patients were identified, of whom 97% were observed from diagnosis until ...

  
  

Mots clés : Pancréas; Lutte contre les cancers (Analyses économiques et systèmes de soins)

A partir des données d'un registre américain du cancer, cette étude en population analyse les facteurs de risque de difficultés financières et de non adhésion aux traitements pour des patients atteints d'un cancer du colon et recevant une chimiothérapie adjuvante

• Risk Factors for Financial Hardship in Patients Receiving Adjuvant Chemotherapy for Colon Cancer: A Population-Based Exploratory Analysis
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  A partir des données d'un registre américain du cancer, cette étude en population analyse les facteurs de risque de difficultés financières et de non adhésion aux traitements pour des patients atteints d'un cancer du colon et recevant une chimiothérapie adjuvante

  “Risk Factors for Financial Hardship in Patients Receiving Adjuvant Chemotherapy for Colon Cancer: A Population-Based Exploratory Analysis”

  • Shankaran, Veena;Jolly, Sanjay;Blough, David;Ramsey, Scott D.

  Purpose Characteristics that predispose patients to financial hardship during cancer treatment are poorly understood. We therefore conducted a population-based exploratory analysis of potential factors associated with financial hardship and treatment nonadherence during and following adjuvant chemotherapy for colon cancer.Patients and Methods Patients diagnosed with stage III colon cancer between 2008 and 2010 were identified from a population-based cancer registry representing 13 counties in Washington state. Patients were asked to complete a comprehensive survey on treatment-related costs. Patients were considered to have experienced financial hardship if they accrued debt, sold or refinanced their home, borrowed money from friends or family, or experienced a 20% or greater decline in their annual income as a result of treatment-related expenses. Logistic regression analysis was used to investigate factors associated with financial hardship and treatment nonadherence.Results A total ...

  
  
• Financial Hardship: A Consequence of Survivorship?
  • Journal of Clinical Oncology, sous presse, 2012 (éditorial en libre accès)
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  A partir des données d'un registre américain du cancer, cette étude en population analyse les facteurs de risque de difficultés financières et de non adhésion aux traitements pour des patients atteints d'un cancer du colon et recevant une chimiothérapie adjuvante

  “Financial Hardship: A Consequence of Survivorship?”

  • Bradley, Cathy J.

  
  

Mots clés : Colon-rectum; Lutte contre les cancers (Analyses économiques et systèmes de soins)

Menée en Angleterre, cette étude qualitative analyse les besoins de 19 aidants de patients atteints d'un cancer de la prostate et les difficultés rencontrées pour les satisfaire, qu'il s'agisse de besoins en information ou de soutien psychologique

• The needs of carers of men with prostate cancer and barriers and enablers to meeting them: a qualitative study in England
  • European Journal of Cancer Care, sous presse, 2012 (résumé)
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  Menée en Angleterre, cette étude qualitative analyse les besoins de 19 aidants de patients atteints d'un cancer de la prostate et les difficultés rencontrées pour les satisfaire, qu'il s'agisse de besoins en information ou de soutien psychologique

  “The needs of carers of men with prostate cancer and barriers and enablers to meeting them: a qualitative study in England”

  • Sinfield, P.;Baker, R.;Ali, S.;Richardson, A.

  The aim of this study was to explore the needs of carers of men with prostate cancer and to identify barriers and enablers to meeting these needs. Carers were recruited to focus groups or interviews. These were recorded, transcribed and analysed by two researchers using Nvivo QSR6 and the Framework approach to index, chart and analyse data to identify emergent themes of the needs of carers, and barriers and enablers to meeting these needs. Fifteen carers took part in focus groups and 19 were interviewed. Carers' needs varied and were often unmet because of barriers to existing services. Carers needed: information; emotional support; practical support; effective medical care for the patient. Barriers to carers meeting their needs included: lack of awareness of sources of help; lack of understanding of information; reluctance to ask for help; prioritising the patient's needs. Enablers included better signposting to information and sources of support, and assessment of their needs. ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Analyses économiques et systèmes de soins)

A partir d'une revue de la littérature (239 articles), cette étude analyse les besoins d'information des patients atteints de cancer colorectal, pendant et après leurs traitements

• Information needs across the colorectal cancer care continuum: scoping the literature
  • European Journal of Cancer Care, sous presse, 2012 (résumé)
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  A partir d'une revue de la littérature (239 articles), cette étude analyse les besoins d'information des patients atteints de cancer colorectal, pendant et après leurs traitements

  “Information needs across the colorectal cancer care continuum: scoping the literature”

  • Van Mossel, C.;Leitz, L.;Scott, S.;Daudt, H.;Dennis, D.;Watson, H.;Alford, M.;Mitchell, A.;Payeur, N.;Cosby, C.;Levi-Milne, R.;Purkis, M. E.

  Because cancer care requires a multifaceted approach, providing useful and timely information to people with colorectal cancer may be fragmented and inconsistent. Our interest was in examining what has and has not captured the attention of researchers speaking to the information needs of people with colorectal cancer. We followed Arksey and O'Malley's framework for the methodology of scoping review. Focusing solely on colorectal cancer, we analysed 239 articles to get a picture of which information needs and sources of information, as well as the timing of providing information, were attended to. Treatment-related information received the most mentions (26%). Healthcare professionals (49%) were mentioned as the most likely source of information. Among articles focused on one stage of the care continuum, post-treatment (survivorship) received the most attention (16%). Only 27% of the articles consulted people with colorectal cancer and few attended to diet/nutrition and bowel ...

  
  

Mots clés : Colon-rectum; Lutte contre les cancers (Sensibilisation et communication)

Menée en Espagne auprès de 169 patients atteints d'un cancer de la prostate, de la vessie ou du rein, cette étude transversale analyse les caractéristiques liées à l'utilisation d'internet pour rechercher de l'information en santé

• Factors related to use of the Internet as a source of health information by urological cancer patients
  • Supportive Care in Cancer, sous presse, 2012 (résumé)
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  Menée en Espagne auprès de 169 patients atteints d'un cancer de la prostate, de la vessie ou du rein, cette étude transversale analyse les caractéristiques liées à l'utilisation d'internet pour rechercher de l'information en santé

  “Factors related to use of the Internet as a source of health information by urological cancer patients”

  • Valero-Aguilera, Beatriz;Bermúdez-Tamayo, Clara;García-Gutiérrez, José;Jiménez-Pernett, Jaime;Vázquez-Alonso, Fernando;Suárez-Charneco, Armando;Guerrero-Tejada, Rosario;Cózar-Olmo, José

  Aims The aims of this study were to describe the profile of urological cancer patients who look for health information on the Internet and to analyse the factors related to use of the Internet as a source of health information. Methodology A cross-sectional descriptive study using individual, semi-structured, questionnaire-based interviews was carried out in oncology clinics in a hospital in Granada (Spain) in a sample group of 169 patients with prostate, bladder and kidney cancer. The dependent variable was use of the Internet as a source of health information. The independent variables were sociodemographic variables, health status, relationship with healthcare services, patient’s role in decision-making process, satisfaction with healthcare, Internet use, Internet skills and attitude. Data analyses include descriptive, bivariate and multivariate analyses. Results Of the patients in the sample group, 72.2 % had prostate cancer, 19.4 % had bladder cancer and 8.3 % had kidney ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Sensibilisation et communication)

A partir d'une revue de la littérature, cette méta-analyse fait le point sur les formations destinées aux professionnels de l'oncologie en matière de communication avec le patient

• Communication Skills Training for Oncology Professionals
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  A partir d'une revue de la littérature, cette méta-analyse fait le point sur les formations destinées aux professionnels de l'oncologie en matière de communication avec le patient

  “Communication Skills Training for Oncology Professionals”

  • Kissane, David W.;Bylund, Carma L.;Banerjee, Smita C.;Bialer, Philip A.;Levin, Tomer T.;Maloney, Erin K.;D'Agostino, Thomas A.

  Purpose To provide a state-of-the-art review of communication skills training (CST) that will guide the establishment of a universal curriculum for fellows of all cancer specialties undertaking training as oncology professionals today.Methods Extensive literature review including meta-analyses of trials, conceptual models, techniques, and potential curricula provides evidence for the development of an appropriate curriculum and CST approach. Examples from the Memorial Sloan-Kettering Cancer Center CST program are incorporated.Results A core curriculum embraces CST modules in breaking bad news and discussing unanticipated adverse events, discussing prognosis, reaching a shared treatment decision, responding to difficult emotions, coping with survivorship, running a family meeting, and transitioning to palliative care and end of life. Achievable outcomes are growth in clinician's self-efficacy, uptake of new communication strategies and skills, and transfer of these strategies and ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Sensibilisation et communication)

A partit d'une revue systématique de la littérature (725 études), cette étude fait le point sur les divers outils permettant de mesurer la survie, les besoins, la qualité de vie de patients traités dans des unités de soins palliatifs

• Outcome assessment instruments in palliative and hospice care—a review of the literature
  • Supportive Care in Cancer, sous presse, 2012 (résumé)
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  A partit d'une revue systématique de la littérature (725 études), cette étude fait le point sur les divers outils permettant de mesurer la survie, les besoins, la qualité de vie de patients traités dans des unités de soins palliatifs

  “Outcome assessment instruments in palliative and hospice care—a review of the literature”

  • Stiel, Stephanie;Pastrana, T.;Balzer, C.;Elsner, F.;Ostgathe, C.;Radbruch, L.

  Background As different definitions for PC have been used across the last three decades, a common terminology is lacking. To ensure quality of care, (a) a consensus on outcome criteria and indicators and (b) validated and applicable outcome assessment instruments are necessary. The aim of this study is to systematically review instrument for outcome assessment that have been used or proposed for research and clinical practice in palliative care. Method A systematic literature search in electronic databases Cinahl, MEDLINE, EMBASE, and PsychoINFO until December 2009 was conducted to identify articles describing outcome assessment in palliative care. Following extraction of relevant publications, the outcome assessment instruments were categorized in outcome domains and target groups. Results The literature search resulted in 8,607 hits. Deduplication and exclusion of irrelevant or unavailable publications allowed for 725 publications which were analyzed in detail. At least 528 ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Soins palliatifs)

A partir d'une revue systématique de la littérature, cette étude analyse le recours à la sédation palliative dans les soins aux patients atteints de cancer en phase terminale et son impact sur la survie des patients

• Palliative Sedation in End-of-Life Care and Survival: A Systematic Review
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  A partir d'une revue systématique de la littérature, cette étude analyse le recours à la sédation palliative dans les soins aux patients atteints de cancer en phase terminale et son impact sur la survie des patients

  “Palliative Sedation in End-of-Life Care and Survival: A Systematic Review”

  • Maltoni, Marco;Scarpi, Emanuela;Rosati, Marta;Derni, Stefania;Fabbri, Laura;Martini, Francesca;Amadori, Dino;Nanni, Oriana

  Purpose Palliative sedation is a clinical procedure aimed at relieving refractory symptoms in patients with advanced cancer. It has been suggested that sedative drugs may shorten life, but few studies exist comparing the survival of sedated and nonsedated patients. We present a systematic review of literature on the clinical practice of palliative sedation to assess the effect, if any, on survival.Methods A systematic review of literature published between January 1980 and December 2010 was performed using MEDLINE and EMBASE databases. Search terms included palliative sedation, terminal sedation, refractory symptoms, cancer, neoplasm, palliative care, terminally ill, end-of-life care, and survival. A manual search of the bibliographies of electronically identified articles was also performed.Results Eleven published articles were identified describing 1,807 consecutive patients in 10 retrospective or prospective nonrandomized studies, 621 (34.4%) of whom were sedated. One case-control ...

  
  
• Palliative Sedation: When and How?
  • Journal of Clinical Oncology, sous presse, 2012 (éditorial en libre accès)
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  A partir d'une revue systématique de la littérature, cette étude analyse le recours à la sédation palliative dans les soins aux patients atteints de cancer en phase terminale et son impact sur la survie des patients

  “Palliative Sedation: When and How?”

  • Bruera, Eduardo

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Soins palliatifs)

Cet article plaide pour la prise en compte des travaux en recherche épidémiologique sur l'étiologie des cancers dans les études relatives à la vie des patients après les traitements

• Converting epidemiological studies of cancer etiology to survivorship studies: approaches and challenges
  • Cancer Epidemiology Biomarkers & Prevention, sous presse, 2012 (résumé)
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  Cet article plaide pour la prise en compte des travaux en recherche épidémiologique sur l'étiologie des cancers dans les études relatives à la vie des patients après les traitements

  “Converting epidemiological studies of cancer etiology to survivorship studies: approaches and challenges”

  • Berrington de Gonzalez, Amy;Morton, Lindsay M.

  There are nearly 12 million cancer survivors living in the US and the number continues to rise with ongoing improvements in treatment and screening. Assuring the long-term health of these patients poses both clinical and public health concerns. Survivorship research covers multiple aspects of life after a cancer diagnosis including quality of life, acute and late effects of cancer treatment and mortality. Answering these questions requires a wide array of data, including information on the outcomes of interest, treatment history, and lifestyle. One potentially efficient approach to studying late effects and survivorship is to convert or extend existing epidemiologic studies of cancer etiology. In this article we evaluate the different potential approaches for doing this and the challenges this entails. Our evaluation highlights the combinations of research topic and design most likely to succeed. We show that any question that relates to the existing information including ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Ressources et infrastructures (Lutte contre les cancers))