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Agence nationale sanitaire et scientifique en cancérologie

Accueil Nota Bene Cancer V2 Numéro 125 du 28 February 2012 Lutte contre les cancers BREADCRUMB PUBLICATION

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The contrasting age-incidence patterns of bone tumours in teenagers and young adults: Implications for aetiology

A partir des données du registre anglais des cancers entre 1979 et 2003, cette étude analyse l'incidence de divers types de tumeurs osseuses chez des adolescents et jeunes adultes (9 146 cas)

  • International Journal of Cancer, sous presse, 2012 (résumé)

Résumé en anglais :
Bone tumours comprise 0.2% of cancers overall but 5.7% in 15–24 year olds. To explore the relationship with adolescence we have analysed age-incidence patterns of bone tumours in a large national dataset. Data on incident cases of bone tumours in 0–84 year olds in England, 1979–2003, were extracted from national cancer registration data. Incidence rates per million person-years by 5-year age-group, sex, morphology and primary site were calculated and adjusted to the world standard population. Nine thousand one hundred forty-six cases were identified giving an overall age-standardized rate of 7.19 per million person-years. The distribution by morphology was: osteosarcoma, 34.2%; chondrosarcoma, 27.2%; Ewing sarcoma, 19.3%; other, 19.4%. The distribution varied by age. Ewing sarcoma was most common in 0–9 year olds, osteosarcoma in 10–29 year olds and chondrosarcoma in 30–84 year olds. 29.2% of all tumours occurred in 0–24 year olds. Highest incidence of osteosarcoma and Ewing sarcoma in females was in 10–14 year olds. In males, peak incidence occurred at 15–19 years and exceeded that in females. Chondrosarcoma incidence steadily increased with age. The proportions of Ewing sarcomas occurring in respective bones were consistent with those of the adult skeleton by weight. In osteosarcoma tumours of long bones of lower limb were markedly over-represented in the adolescent peak, being six times more than at any other site. Variation in incidence patterns with age and site suggests pubertal bone growth to be a key factor in osteosarcoma while different biological pathways could be relevant for Ewing sarcoma.

NBC n° 125 du 28 February 2012

Mots clés : Os; Lutte contre les cancers (Observation)

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