Lutte contre les cancers

Menée aux Etats-Unis auprès de 54 patients (âge médian au diagnostic: 8,8 ans), cette étude analyse la qualité de vie à long terme de patients pédiatriques ayant été opérés d'un gliome de haut grade (durée médiane de suivi : 15,1 ans)

• Long-Term Follow-Up of Children Treated for High-Grade Gliomas: Children's Oncology Group L991 Final Study Report
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Menée aux Etats-Unis auprès de 54 patients (âge médian au diagnostic: 8,8 ans), cette étude analyse la qualité de vie à long terme de patients pédiatriques ayant été opérés d'un gliome de haut grade (durée médiane de suivi : 15,1 ans)

  “Long-Term Follow-Up of Children Treated for High-Grade Gliomas: Children's Oncology Group L991 Final Study Report”

  • Sands, Stephen Alan;Zhou, Tianni;O'Neil, Sharon Helene;Patel, Sunita K.;Allen, Jeffrey;McGuire Cullen, Patsy;Kaleita, Thomas A.;Noll, Robert;Sklar, Charles;Finlay, Jonathan Lester

  Purpose High-grade gliomas of the CNS are characterized by poor treatment response and prognosis for long-term survival. The Children's Oncology Group (COG) L991 study investigated the neuropsychological, behavioral, and quality of life (QoL) outcomes after treatment on the Children's Cancer Group (CCG) trial for high-grade gliomas (CCG-945).Patients and Methods Fifty-four patients (29 males, 25 females) with a median age of 8.8 years at diagnosis (range, 0.2 to 19.5 years) were enrolled at 25 institutions in North America, representing 81% of available survivors; median length of follow-up was 15.1 years (range, 9.5 to 19.2 years), and median age at study evaluation was 23.6 years (range, 11.3 to 36 years). Standardized tests of neuropsychological functioning and QoL were performed. Descriptive statistics summarized principal findings, and one-way analysis of variance identified potential predictors of outcomes.Results With an average follow-up time of 15 years, survivors ...

  
  

Mots clés : Système nerveux central; Lutte contre les cancers (Qualité de vie, soins de support)

Menée en Italie auprès de 20 patientes atteintes de cancer et souffrant d'une alopécie induite par la chimiothérapie, cette étude qualitative analyse leur expérience et leur vécu lors de leur participation à un programme de soins esthétiques

• ‘My wig has been my journey's companion’: perceived effects of an aesthetic care programme for Italian women suffering from chemotherapy-induced alopecia
  • European Journal of Cancer Care, sous presse, 2012 (résumé)
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  Menée en Italie auprès de 20 patientes atteintes de cancer et souffrant d'une alopécie induite par la chimiothérapie, cette étude qualitative analyse leur expérience et leur vécu lors de leur participation à un programme de soins esthétiques

  “‘My wig has been my journey's companion’: perceived effects of an aesthetic care programme for Italian women suffering from chemotherapy-induced alopecia”

  • Zannini, L.;Verderame, F.;Cucchiara, G.;Zinna, B.;Alba, A.;Ferrara, M.

  This study explored the perceived effects of an aesthetic care/wig programme for Italian women suffering from chemotherapy-induced alopecia. Despite advances in the treatment of many side effects of chemotherapy, alopecia remains difficult to resolve. Literature suggests that patients' reactions to alopecia and camouflaging strategies depend on their gender, individual characteristics, social context, and culture. A qualitative study was designed involving 20 patients from Sicily (Italy), who participated in an aesthetic care programme. Data were collected through semi-structured interviews, and an Interpretative Phenomenological Analysis was conducted on transcriptions. Our findings showed that, even if expected, alopecia is experienced as a traumatic event that challenges a woman's femininity, as reported by many other enquiries. Diverging from other studies, the wig is perceived as very helpful, since it camouflages baldness and reduces the ‘sick aspect’ related to alopecia. ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

Menée en Suède sur 251 patients atteints de cancer et recevant des soins palliatifs, cette étude analyse l'association entre la densité calorique des aliments et l'apport énergétique en fonction des caractéristiques des patients

• Dietary energy density is associated with energy intake in palliative care cancer patients
  • Supportive Care in Cancer, sous presse, 2012 (résumé)
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  Menée en Suède sur 251 patients atteints de cancer et recevant des soins palliatifs, cette étude analyse l'association entre la densité calorique des aliments et l'apport énergétique en fonction des caractéristiques des patients

  “Dietary energy density is associated with energy intake in palliative care cancer patients”

  • Wallengren, Ola;Bosaeus, Ingvar;Lundholm, Kent

  Purpose Diet energy density (ED) is associated with energy intake (EI) in cancer patients. There is limited information on the influence of patient characteristics on this association, potentially hampering individual tailoring of dietary treatment in clinical practice. Methods We studied the relation between ED (kcal/g) and EI (kcal/kg body weight per day), using a mixed linear model estimating both overall and individual intercept and slopes with patient characteristics as covariates. Age, sex, body mass index (BMI), tumor type, tertiles of survival, weight loss, hypermetabolism, low muscle mass, low serum albumin, inflammation, handgrip strength, and fatigue were entered in the model, and significant effects were retained ( p < 0.05). Dietary intake was obtained from 251 food records (995 days) in a group of unselected palliative care cancer patients. ED and EI were calculated for each day including all food and beverages. Results Mean EI was 25.8 kcal/kg/day. Age, BMI, fatigue, ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

Menée aux Etats-Unis auprès de 181 survivantes d'un cancer incluses dans 4 cohortes, cette étude analyse l'efficacité d'un outil permettant de mesurer les troubles de la fonction sexuelle dans un contexte de cancer

• Psychometric validation of the Female Sexual Function Index (FSFI) in cancer survivors
  • Cancer, sous presse, 2012 (résumé)
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  Menée aux Etats-Unis auprès de 181 survivantes d'un cancer incluses dans 4 cohortes, cette étude analyse l'efficacité d'un outil permettant de mesurer les troubles de la fonction sexuelle dans un contexte de cancer

  “Psychometric validation of the Female Sexual Function Index (FSFI) in cancer survivors”

  • Baser, Raymond E.;Li, Yuelin;Carter, Jeanne

  BACKGROUND: The Female Sexual Function Index (FSFI) is the most commonly used self-report instrument to measure sexual functioning among women cancer survivors. Despite this, the validity and reliability of the FSFI for use in cancer populations has not been established. METHODS: Data were combined from 3 separate institutional review board-approved studies of the psychosexual adjustment of women cancer survivors conducted at Memorial Sloan-Kettering Cancer Center. Psychometric analysis was applied to the FSFI responses from 181 women comprising 4 cohorts, including survivors of: gynecologic cancer (all types; 2 cohorts), malignancies requiring bone-marrow/stem cell transplantation, and early stage cervical cancer. RESULTS: A factor analysis supported the subscale structure of the FSFI, yielding results nearly identical to those from the original FSFI validation study. Internal consistency reliability was 0.94 for the FSFI total score and ranged from 0.85 to 0.94 for the domain ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Qualité de vie, soins de support)

Menée auprès de 2 448 patientes atteintes d'un cancer du sein triple négatif, cette étude rétrospective analyse l'incidence de tumeurs cérébrales lors de la récidive de leur cancer

• Incidence of brain metastases as a first site of recurrence among women with triple receptor–negative breast cancer
  • Cancer, sous presse, 2012 (résumé)
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  Menée auprès de 2 448 patientes atteintes d'un cancer du sein triple négatif, cette étude rétrospective analyse l'incidence de tumeurs cérébrales lors de la récidive de leur cancer

  “Incidence of brain metastases as a first site of recurrence among women with triple receptor–negative breast cancer”

  • Dawood, Shaheenah;Lei, Xiudong;Litton, Jennifer K.;Buchholz, Thomas A.;Hortobagyi, Gabriel N.;Gonzalez-Angulo, Ana M.

  BACKGROUND: This retrospective study sought to define the incidence of brain metastases as a first site of recurrence among women with triple receptor–negative breast cancer (TNBC). METHODS: A total of 2448 patients with stage I through III TNBC who were diagnosed between 1990 and 2010 were identified. We computed the cumulative incidence of developing brain metastases as a first site of recurrence at 2 and 5 years. Cox proportional hazards models were fitted to determine factors that could predict for the development of brain metastases as a first site of recurrence. The Kaplan-Meier product limit method was used to compute survival following a diagnosis of brain metastases. RESULTS: At a median follow-up of 39 months, 115 (4.7%) patients had developed brain metastases as a first site of recurrence. The cumulative incidence at 2 and 5 years was 3.7% (95% confidence interval [CI] = 2.9%-4.5%) and 5.4% (95% CI = 4.4%-6.5%), respectively. Among patients with stage I, II, and III ...

  
  

Mots clés : Sein; Lutte contre les cancers (Observation)

A partir des données du registre néerlandais du cancer sur la période 1989 à 2009, cette étude analyse les évolutions dans l'incidence du cancer du rein, les traitements et la survie des patients

• Modest improvement in 20 years of kidney cancer care in the Netherlands
  • European journal of cancer (Oxford, England : 1990), sous presse, 2012 (résumé)
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  A partir des données du registre néerlandais du cancer sur la période 1989 à 2009, cette étude analyse les évolutions dans l'incidence du cancer du rein, les traitements et la survie des patients

  “Modest improvement in 20 years of kidney cancer care in the Netherlands”

  • van de Schans, Saskia A. M.;Aben, Katja K. H.;Mulders, Peter F. A.;Haanen, John B. A. G.;van Herpen, Carla;Verhoeven, Rob H. A.;Karim-Kos, Henrike E.;Oosterwijk, Egbert;Kiemeney, Lambertus A. L. M.

  For an evaluation of the progress achieved in the field of kidney cancer care in the Netherlands in the last decades, we described trends in incidence, treatment, mortality and relative survival. All adult patients newly diagnosed with kidney cancer between 1989 and 2009 (N=32,545) were selected from the Netherlands Cancer Registry. Age-standardised incidence and mortality rates were calculated. Follow-up was completed until January 2010. In order to assess trends estimated annual percentages of change (EAPC) were estimated. The incidence of kidney cancer has been fairly stable between 1989 and 2001 with a European Standardised Rate of approximately 11 per 100,000 person years (PY). Since 2001 the incidence increased to 13 per 100,000 PY in 2009 (EAPC: 2.4%; 95%confidence interval (CI): 1.5 to 3.4%). The mortality rate decreased slightly over time, from 6.2 per 100,000 PY in 1989 to 5.6 in 2010. No changes in treatment were observed, except for the introduction of targeted therapies ...

  
  

Mots clés : Rein; Lutte contre les cancers (Observation)

Menée en Corée auprès de 1 487 patients opérés pour un carcinome à cellules rénales, cette étude analyse l'impact de l'indice de masse corporelle sur leur survie

• Impact of body mass index in Korean patients with renal cell carcinoma
  • Cancer Causes and Control, sous presse, 2012 (résumé)
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  Menée en Corée auprès de 1 487 patients opérés pour un carcinome à cellules rénales, cette étude analyse l'impact de l'indice de masse corporelle sur leur survie

  “Impact of body mass index in Korean patients with renal cell carcinoma”

  • Sung, Hyun;Jeon, Seong;Park, Seo;Jeong, Byong;Seo, Seong;Lee, Hyun;Choi, Han-Yong

  Objective The aim of the current study was to examine the impact of preoperative body mass index (BMI) in Korean patients with surgically treated renal cell carcinoma (RCC). Methods From 1994 to 2008, a total of 1,487 patients underwent nephrectomy for RCC. All patients were classified into three groups according to Asian BMI classification by Asia Cohort Consortium: <18.5, 18.5 to <25, and 25 kg/m 2 or greater group, which represents the underweight ( n = 42, 2.8%), normal ( n = 833, 56.0%), and obesity ( n = 612, 41.2%) group, respectively. Survival analyses and predictive factors for cancer-specific survival among the three groups were evaluated. Subgroup survival analysis of organ-confined and advanced disease was performed. Results An overall median follow-up was 54.8 months. Mean ± SE estimated cancer-specific survival in all patients at 5 and 10 years was 88.0 ± 1.0% and 81.4 ± 1.4%, respectively. In the multivariate model after adjusting preoperative and postoperative ...

  
  

Mots clés : Rein; Lutte contre les cancers (Observation)

A partir des données des registres néerlandais du cancer, cette étude analyse l'évolution de l'incidence du carcinome épidermoïde cutané sur la période 1989 à 2008, ainsi que la mortalité et la survie des patients

• Trends of cutaneous squamous cell carcinoma in the Netherlands: Increased incidence rates, but stable relative survival and mortality 1989–2008
  • European journal of cancer (Oxford, England : 1990), sous presse, 2012 (résumé)
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  A partir des données des registres néerlandais du cancer, cette étude analyse l'évolution de l'incidence du carcinome épidermoïde cutané sur la période 1989 à 2008, ainsi que la mortalité et la survie des patients

  “Trends of cutaneous squamous cell carcinoma in the Netherlands: Increased incidence rates, but stable relative survival and mortality 1989–2008”

  • Hollestein, L. M.;de Vries, E.;Nijsten, T.

  Incidence rates of cutaneous squamous cell carcinoma (SCC) are increasing in many countries, though detailed information is scarce. To describe detailed trends in incidence rates, relative survival and estimate mortality rates of SCC in the Netherlands. Information on newly diagnosed SCC patients between 1989 and 2008 was obtained from the Netherlands Cancer Registry (NCR). Information of non-melanoma skin cancer (NMSC) mortality was obtained from Statistics Netherlands. European Standardised Rates (ESR) and Estimated Annual Percentage Change (EAPC) were calculated. Incidence rates were fitted to two different models and predicted by the best fitted model. Cohort-based and multivariate survival analyses were performed to assess changes over time. The ESR increased from 22.2 to 35.4 per 100,000 inhabitants for males and from 7.8 to 20.5 for females. The EAPC was 6.9% (95% confidence interval: 5.8–8.7) for males and 9.2% (95%CI: 7.5–11.0) for females. Incidence rates increased for ...

  
  

Mots clés : Peau (hors mélanome); Lutte contre les cancers (Observation)

A partir des données du registre anglais des cancers entre 1979 et 2003, cette étude analyse l'incidence de divers types de tumeurs osseuses chez des adolescents et jeunes adultes (9 146 cas)

• The contrasting age-incidence patterns of bone tumours in teenagers and young adults: Implications for aetiology
  • International Journal of Cancer, sous presse, 2012 (résumé)
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  A partir des données du registre anglais des cancers entre 1979 et 2003, cette étude analyse l'incidence de divers types de tumeurs osseuses chez des adolescents et jeunes adultes (9 146 cas)

  “The contrasting age-incidence patterns of bone tumours in teenagers and young adults: Implications for aetiology”

  • Arora, Ramandeep S.;Alston, Robert D.;Eden, Tim O. B.;Geraci, Marco;Birch, Jillian M.

  Bone tumours comprise 0.2% of cancers overall but 5.7% in 15–24 year olds. To explore the relationship with adolescence we have analysed age-incidence patterns of bone tumours in a large national dataset. Data on incident cases of bone tumours in 0–84 year olds in England, 1979–2003, were extracted from national cancer registration data. Incidence rates per million person-years by 5-year age-group, sex, morphology and primary site were calculated and adjusted to the world standard population. Nine thousand one hundred forty-six cases were identified giving an overall age-standardized rate of 7.19 per million person-years. The distribution by morphology was: osteosarcoma, 34.2%; chondrosarcoma, 27.2%; Ewing sarcoma, 19.3%; other, 19.4%. The distribution varied by age. Ewing sarcoma was most common in 0–9 year olds, osteosarcoma in 10–29 year olds and chondrosarcoma in 30–84 year olds. 29.2% of all tumours occurred in 0–24 year olds. Highest incidence of osteosarcoma and ...

  
  

Mots clés : Os; Lutte contre les cancers (Observation)

Cette étude de cohorte en population américaine (783 participants) analyse les modes de vie et les facteurs sociodémographiques influençant la survie de patients atteints d'un adénocarcinome de l'œsophage ou d'un adénocarcinome de la jonction œsogastrique

• Predictors of survival among patients diagnosed with adenocarcinoma of the esophagus and gastroesophageal junction
  • Cancer Causes and Control, sous presse, 2012 (résumé)
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  Cette étude de cohorte en population américaine (783 participants) analyse les modes de vie et les facteurs sociodémographiques influençant la survie de patients atteints d'un adénocarcinome de l'œsophage ou d'un adénocarcinome de la jonction œsogastrique

  “Predictors of survival among patients diagnosed with adenocarcinoma of the esophagus and gastroesophageal junction”

  • Thrift, Aaron;Nagle, Christina;Fahey, Paul;Smithers, Bernard;Watson, David;Whiteman, David

  Purpose Patients diagnosed with esophageal adenocarcinoma (EAC) or gastroesophageal junction adenocarcinoma (GEJAC) have poor survival. We investigated the possible influence of pre-morbid lifestyle factors on survival for these lethal cancers. Methods This study included a population-based cohort of patients with EAC ( n = 362) and GEJAC ( n = 421) tumors. Detailed information about demographic and lifestyle factors was obtained around the time of diagnosis, and deaths were identified using the National Death Index. Hazard ratios (HR) and 95% confidence intervals (95% CI) were calculated from Cox proportional hazards models, adjusted for age, sex, pre-treatment American Joint Committee on Cancer tumor stage, treatment and presence of comorbidities. Results Median follow-up for mortality was 6.4 years. Five-year survival rates were 27 and 33% for EAC and GEJAC, respectively. As expected, tumor and treatment characteristics were the strongest predictors of survival for both cancer ...

  
  

Mots clés : Oesophage; Lutte contre les cancers (Observation)

A partir des données des registres américains du cancer, cette étude analyse la survie des patients atteints d'un mélanome malin ou d'un carcinome à cellules de Merkel et ayant eu une histoire de leucémie lymphocytaire chronique ou de lymphome non hodgkinien

• Chronic Lymphocytic Leukemia Is Associated With Decreased Survival of Patients With Malignant Melanoma and Merkel Cell Carcinoma in a SEER Population-Based Study
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  A partir des données des registres américains du cancer, cette étude analyse la survie des patients atteints d'un mélanome malin ou d'un carcinome à cellules de Merkel et ayant eu une histoire de leucémie lymphocytaire chronique ou de lymphome non hodgkinien

  “Chronic Lymphocytic Leukemia Is Associated With Decreased Survival of Patients With Malignant Melanoma and Merkel Cell Carcinoma in a SEER Population-Based Study”

  • Brewer, Jerry D.;Shanafelt, Tait D.;Otley, Clark C.;Roenigk, Randall K.;Cerhan, James R.;Kay, Neil E.;Weaver, Amy L.;Call, Timothy G.

  Purpose To delineate outcomes of malignant melanoma (MM) and Merkel cell carcinoma (MCC) in patients with chronic lymphocytic leukemia (CLL) or non-Hodgkin’s lymphoma (NHL).Patients and Methods We identified patients with MM or MCC reported to the Surveillance, Epidemiology, and End Results program and analyzed the effects of history of CLL/NHL on overall (OS) and cause-specific survival after MM or MCC. Expected survival was derived from patients with MM or MCC without CLL/NHL.Results From 1990 to 2006, 212,245 patients with MM and 3,613 patients with MCC were identified, of whom 1,246 with MM and 90 with MCC had a prior diagnosis of CLL/NHL. Patients with MM and a history of CLL/NHL had worse-than-expected OS as measured by standardized mortality ratio (SMR; SMR for CLL, 2.6; 95% CI, 2.3 to 3.0; SMR for NHL, 2.3; 95% CI, 2.1 to 2.6). MM cause-specific survival was worse than expected for patients with a history of CLL (SMR, 2.8; 95% CI, 2.2 to 3.4) or NHL (SMR, 2.1; 95% CI, 1.7 to ...

  
  

Mots clés : Leucémie; Lutte contre les cancers (Observation)

Menée au Danemark auprès de 6 325 patients atteints de cancer et âgés de plus de 70 ans, cette étude en population analyse les comorbidités associées à la mortalité par cancer

• Comorbidity in elderly cancer patients in relation to overall and cancer-specific mortality
  • British Journal of Cancer, sous presse, 2012 (résumé)
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  Menée au Danemark auprès de 6 325 patients atteints de cancer et âgés de plus de 70 ans, cette étude en population analyse les comorbidités associées à la mortalité par cancer

  “Comorbidity in elderly cancer patients in relation to overall and cancer-specific mortality”

  • Jorgensen, T. L.;Hallas, J.;Friis, S.;Herrstedt, J.

  Background: Aims of this study were to describe the prevalence of comorbidity in newly diagnosed elderly cancer cases compared with the background population and to describe its influence on overall and cancer mortality. Methods: Population-based study of all 70+ year-olds in a Danish province diagnosed with breast, lung, colorectal, prostate, or ovarian cancer from 1 January 1996 to 31 December 2006. Comorbidity was measured according to Charlson's comorbidity index (CCI). Prevalence of comorbidity in newly diagnosed cancer patients was compared with a control group by conditional logistic regression, and influence of comorbidity on mortality was analysed by Cox proportional hazards method. Results: A total of 6325 incident cancer cases were identified. Elderly lung and colorectal cancer patients had significantly more comorbidity than the background population. Severe comorbidity was associated with higher overall mortality in the lung, colorectal, and prostate cancer patients, ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Observation)

A partir des données de plusieurs registres européens des cancers entre 1995 et 2002, cette étude estime l'incidence et la prévalence de tumeurs embryonnaires (neuroblastomes, néphroblastomes, rétinoblastomes, hépatoblastomes, ...) ainsi que la survie des patients

• Embryonal cancers in Europe
  • European journal of cancer (Oxford, England : 1990), sous presse, 2012 (résumé)
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  A partir des données de plusieurs registres européens des cancers entre 1995 et 2002, cette étude estime l'incidence et la prévalence de tumeurs embryonnaires (neuroblastomes, néphroblastomes, rétinoblastomes, hépatoblastomes, ...) ainsi que la survie des patients

  “Embryonal cancers in Europe”

  • Gatta, Gemma;Ferrari, Andrea;Stiller, Charles A.;Pastore, Guido;Bisogno, Gianni;Trama, Annalisa;Capocaccia, Riccardo

  Embryonal cancers are a heterogeneous group of rare cancers which mainly occur in children and adolescents. The aim of the present study was to estimate the burden (incidence, prevalence, survival and proportion of cured) for the principal embryonal cancers in Europe (EU27), using population-based data from cancer registries (CRs) participating in RARECARE. We identified 3322 cases diagnosed from 1995 to 2002 (latest period for which data are available): 44% neuroblastoma, 35% nephroblastoma, 13% retinoblastoma and 6% hepatoblastoma. Very few cases of pulmonary blastoma (43 cases) and pancreatoblastoma (seven cases) were diagnosed. About 2000 new embryonal cancers were estimated every year in EU27, for an annual incidence rate of 4 per million (1.8 neuroblastoma, 1.4 nephroblastoma, and 0.5 retinoblastoma); 91% of cases occurred in patients under 15years. Five-year relative survival for all embryonal cancers was 80% (99% retinoblastoma, 90% nephroblastoma, 71% hepatoblastoma and 68% ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Observation)

Menée aux Etats-Unis, au Mexique et en Jordanie, cette étude rétrospective multicentrique évalue l'impact d'une infection par le virus pandémique de la grippe A (H1N1) sur la morbidité et la survie de patients atteints de tumeurs solides

• A multicenter study of pandemic influenza a (H1N1) infection in patients with solid tumors in 3 countries
  • Cancer, sous presse, 2012 (résumé)
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  Menée aux Etats-Unis, au Mexique et en Jordanie, cette étude rétrospective multicentrique évalue l'impact d'une infection par le virus pandémique de la grippe A (H1N1) sur la morbidité et la survie de patients atteints de tumeurs solides

  “A multicenter study of pandemic influenza a (H1N1) infection in patients with solid tumors in 3 countries”

  • Chemaly, Roy F.;Vigil, Karen J.;Saad, Mustafa;Vilar-Compte, Diana;Cornejo-Juarez, Patricia;Perez-Jimenez, Carolina;Mubarak, Sawsan;Salhab, Mohammed;Jiang, Ying;Granwehr, Bruno;Adachi, Javier A.;Raad, Issam I.

  Pandemic influenza A (hereafter 2009/H1N1) caused significant morbidity and mortality during the 2009 pandemia. Patients with chronic medical conditions and immunosuppressive diseases had a greater risk of complications. However, data regarding the characteristics and outcome of 2009/H1N1 infection in patients with solid tumors are nonexistent. Herein, the authors describe a series of influenza 2009/H1N1 in patients with solid malignancies at 3 major cancer hospitals worldwide. METHODS: The authors retrospectively reviewed the records of patients with solid organ malignancies and 2009/H1N1 from The University of Texas M. D. Anderson Cancer Center in Houston, Texas; the Mexican National Cancer Institute, Federal District of Mexico; and King Hussein Cancer Center in Amman, Jordan from the period of the 2009 H1N1 pandemia. Data on demographics, disease characteristics, and outcome were extracted. RESULTS: In total, 115 cases were identified during the pandemic influenza among the 3 ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Observation)

Menée en Allemagne auprès de 1 761 patients traités dans 38 hôpitaux, cette étude analyse les aspects psychologiques affectant la qualité de vie de patients atteints d'un carcinome épidermoïde de la sphère oto-rhino-laryngée ainsi que leurs besoins en soins de support psychologique

• Psychological aspects affect quality of life in patients with oral squamous cell carcinomas
  • Psycho-Oncology, sous presse, 2012 (résumé)
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  Menée en Allemagne auprès de 1 761 patients traités dans 38 hôpitaux, cette étude analyse les aspects psychologiques affectant la qualité de vie de patients atteints d'un carcinome épidermoïde de la sphère oto-rhino-laryngée ainsi que leurs besoins en soins de support psychologique

  “Psychological aspects affect quality of life in patients with oral squamous cell carcinomas”

  • Handschel, Jörg;Naujoks, Christian;Hofer, Matthias;Krüskemper, Gertrud

  Quality of life (QoL) in head and neck cancer patients has been of increasing interest for some years. Unfortunately, only poor data exist regarding the impact of professional psychological support on QoL. Objectives The purpose of this study was to investigate psychological aspects of QoL as well as the potential need for additional psychological treatment. Material and methods A total collective of 1761 patients from 38 hospitals yielding 1652 patients' questionnaires containing 147 items was evaluated. QoL, impairments and psychological and surgical treatment were evaluated. Results Most patients had no psychological interview, and the majority of those who had an interview did not even want one. However, 17% of those patients who did not receive an interview wished to have one. When a psychological interview was performed, most patients (77.5%) evaluated this as helpful. Patients who wished to have a psychological interview but did not receive one showed a significantly worse QoL ...

  
  

Mots clés : Voies aérodigestives supérieures; Lutte contre les cancers (Approches psycho-sociales)

Menée au Royaume-Uni auprès de 37 participants, cette étude transversale évalue le stress de parents d'un enfant atteint de tumeurs cérébrales

• Predicting parenting stress in caregivers of children with brain tumours
  • Psycho-Oncology, sous presse, 2012 (résumé)
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  Menée au Royaume-Uni auprès de 37 participants, cette étude transversale évalue le stress de parents d'un enfant atteint de tumeurs cérébrales

  “Predicting parenting stress in caregivers of children with brain tumours”

  • Bennett, Emily;English, Martin William;Rennoldson, Michael;Starza-Smith, Arleta

  Objective The purpose of the study was to identify factors that contribute to parenting stress in caregivers of children diagnosed with brain tumours. Methods The study was cross-sectional and recruited 37 participants from a clinical database at a specialist children's hospital. Parents were sent questionnaires, which were used to measure factors related to stress in caregivers of children diagnosed with a brain tumour. Stress levels were measured using the Parenting Stress Index—Short Form (PSI/SF). Correlation analysis and multiple linear regression were used to examine the associations between parenting stress and coping styles, locus of control, parent-perceived child disability and time since diagnosis. Results Results revealed that 51% of parents were experiencing clinically significant levels of stress. The mean stress level of parents in the study was significantly higher than the PSI/SF norms (t = 4.7, p < .001). Regression analysis revealed that external locus of ...

  
  

Mots clés : Système nerveux central; Lutte contre les cancers (Approches psycho-sociales)

Menée aux Pays-Bas, cette étude rétrospective (113 887 cas et 121 395 témoins) analyse les prescriptions de médicaments psychotropes (anxiolytiques, neuroleptiques, antidépresseurs) aux patients atteints de cancer

• Prescription patterns for psychotropic drugs in cancer patients; a large population study in the Netherlands
  • Psycho-Oncology, sous presse, 2012 (résumé)
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  Menée aux Pays-Bas, cette étude rétrospective (113 887 cas et 121 395 témoins) analyse les prescriptions de médicaments psychotropes (anxiolytiques, neuroleptiques, antidépresseurs) aux patients atteints de cancer

  “Prescription patterns for psychotropic drugs in cancer patients; a large population study in the Netherlands”

  • Guan, Ng Chong;Boks, Marco P. M.;Smeets, Hugo Matthias;Zainal, Nor Zuraida;de Wit, Niek J.

  Background Psychotropic drugs are commonly prescribed for various psychological complaints in cancer patients. We aim to examine the prescription pattern in cancer patients of three common psychotropic drugs: benzodiazepine, antidepressant and antipsychotic. Methods This is a retrospective case-control study. Data were extracted from the Agis Health Database. This insurance database contains the healthcare consumption of 1.3 million inhabitants of the Netherlands. We analyzed the use of psychotropics in cancer patients and an equally sized randomly selected control group of noncancer patients from 2006 to 2008. Odds ratio (OR) were adjusted for age, gender, immigrant status, neighborhood socio-economic status, and premorbid medical condition. Additionally, the numbers of new user in the 3 months after cancer was diagnosed and in the 3 months before death were compared. Results A total of 113 887 cancer patients and 121 395 control subjects were included. Cancer patients were ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Approches psycho-sociales)

Menée en Suède par questionnaire, cette étude analyse l'état psychologique d'individus dont un frère ou une soeur est décédé des suites d'un cancer deux à neuf ans plus tôt

• Psychological health in siblings who lost a brother or sister to cancer 2 to 9 years earlier
  • Psycho-Oncology, sous presse, 2012 (résumé)
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  Menée en Suède par questionnaire, cette étude analyse l'état psychologique d'individus dont un frère ou une soeur est décédé des suites d'un cancer deux à neuf ans plus tôt

  “Psychological health in siblings who lost a brother or sister to cancer 2 to 9 years earlier”

  • Eilegård, Alexandra;Steineck, Gunnar;Nyberg, Tommy;Kreicbergs, Ulrika

  Background The objective of this study was to assess long-term psychological distress in siblings who lost a brother or sister to cancer 2 to 9 years earlier, as compared with a control group of non-bereaved siblings from the general population. Methods During 2009, we conducted a nationwide follow-up study in Sweden by using an anonymous study-specific questionnaire. Siblings who had lost a brother or sister to cancer between the years 2000 and 2007 and also a control group of non-bereaved siblings from the general population were invited to participate. The Hospital Anxiety and Depression Scale (HADS) was used to measure psychological distress, and to test for differences in the ordinal outcome responses between the groups, we used Wilcoxon–Mann–Whitney rank-sum test. Results Among the bereaved siblings, 174/240 (73%) participated and 219/293 (75%) among the non-bereaved. Self-assessed low self-esteem (p = 0.002), difficulties falling asleep (p = 0.005), and low level ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Approches psycho-sociales)

Cette étude analyse le rapport coût-efficacité de deux tests génomiques (MammaPrint et Oncotype Dx) pour prédire la réponse thérapeutique à une chimiothérapie adjuvante de patientes atteintes d'un cancer du sein de stade précoce

• Cost effectiveness of gene expression profiling for early stage breast cancer
  • Cancer, sous presse, 2012 (résumé)
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  Cette étude analyse le rapport coût-efficacité de deux tests génomiques (MammaPrint et Oncotype Dx) pour prédire la réponse thérapeutique à une chimiothérapie adjuvante de patientes atteintes d'un cancer du sein de stade précoce

  “Cost effectiveness of gene expression profiling for early stage breast cancer”

  • Yang, Mo;Rajan, Suja;Issa, Amalia M.

  BACKGROUND: Gene expression profiling (GEP) is being used increasingly for risk stratification to identify women with lymph node-negative, estrogen receptor-positive, early stage breast cancer who are most likely to benefit from adjuvant chemotherapy. The authors of this report evaluated the cost effectiveness of recurrence score-guided treatment using 2 commercially available GEP tests, Oncotype DX (Genomic Health, Redwood City, Calif) and MammaPrint (Agendia Inc., Irvine, Calif), from a third-party payer's perspective. METHODS: A 10-year Markov model was developed to compare the costs and quality-adjusted life-years (QALYs) of treatment decisions guided by either Oncotype DX or MammaPrint in a hypothetical cohort of women with early stage, lymph node-negative, estrogen receptor-positive breast cancer who may experience recurrence. Outcomes included no recurrence, recurrence, and death. The costs considered included gene test costs, the costs of adjuvant chemotherapy and other ...

  
  

Mots clés : Sein; Lutte contre les cancers (Analyses économiques et systèmes de soins)

A partir d'une analyse rétrospective des données de séjours hospitaliers à l'échelle nationale, cette étude française évalue l'incidence du cancer du sein avec métastases cérébrales sur l'année 2008 et le coût des traitements associés

• Burden of breast cancer with brain metastasis: a French national hospital database analysis
  • Journal of Medical Economics, sous presse, 2012 (résumé)
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  A partir d'une analyse rétrospective des données de séjours hospitaliers à l'échelle nationale, cette étude française évalue l'incidence du cancer du sein avec métastases cérébrales sur l'année 2008 et le coût des traitements associés

  “Burden of breast cancer with brain metastasis: a French national hospital database analysis”

  • Benjamin, L.;Cotté, F.-E.;Mercier, F.;Vainchtock, A.;Vidal-Trécan, G.;Durand-Zaleski, I.

  Objective: Incidence of breast cancer with brain metastases (BCBM) is increasing, especially among patients over-expressing HER2. Epidemiology on this sub-type of cancer is scarce, since cancer registries carry no information on the HER2 status. A retrospective database analysis was conducted to estimate the burden of BCBM, especially among HER2-positive patients in a secondary objective. Methods: Patients with a new diagnosis of BCBM carried out between January and December 2008 were identified from the national hospital database using the International Disease Classification. Patients receiving a targeted anti-HER2 therapy were identified from the national pharmacy database. Hospital and pharmacy claims were linked to estimate the burden of HER2-positive patients. Data on hospitalizations were extracted to describe treatment patterns and healthcare costs during a 1-year follow-up. Predictors of treatment cost were analyzed through multi-linear regression analysis. Results: Two ...

  
  

Mots clés : Sein; Lutte contre les cancers (Analyses économiques et systèmes de soins)

A partir des données de l'étude "National Cancer Patient Experience Survey" menée en 2010 en Angleterre, cette étude analyse les disparités socioéconomiques dans le nombre de consultations d'un médecin généraliste avant un diagnostic de cancer en hôpital

• Variation in number of general practitioner consultations before hospital referral for cancer: findings from the 2010 National Cancer Patient Experience Survey in England
  • The Lancet Oncology, sous presse, 2012 (résumé)
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  A partir des données de l'étude "National Cancer Patient Experience Survey" menée en 2010 en Angleterre, cette étude analyse les disparités socioéconomiques dans le nombre de consultations d'un médecin généraliste avant un diagnostic de cancer en hôpital

  “Variation in number of general practitioner consultations before hospital referral for cancer: findings from the 2010 National Cancer Patient Experience Survey in England”

  • Lyratzopoulos, Georgios;Neal, Richard D.;Barbiere, Josephine M.;Rubin, Gregory P.;Abel, Gary A.

  Information from patient surveys can help to identify patient groups and cancers with the greatest potential for improvement in the experience and timeliness of cancer diagnosis. We aimed to examine variation in the number of pre-referral consultations with a general practitioner between patients with different cancers and sociodemographic characteristics. We analysed data from 41 299 patients with 24 different cancers who took part in the 2010 National Cancer Patient Experience Survey in England. We examined variation in the number of general practitioner consultations with cancer symptoms before hospital referral to diagnose cancer. Logistic regression was used to identify independent predictors of three or more pre-referral consultations, adjusting for cancer type, age, sex, deprivation quintile, and ethnic group. We identified wide variation between cancer types in the proportion of patients who had visited their general practitioner three or more times before hospital referral ...

  
  
• Primary care and diagnosis of cancer
  • The Lancet Oncology, sous presse, 2012 (commentaire)
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  A partir des données de l'étude "National Cancer Patient Experience Survey" menée en 2010 en Angleterre, cette étude analyse les disparités socioéconomiques dans le nombre de consultations d'un médecin généraliste avant un diagnostic de cancer en hôpital

  “Primary care and diagnosis of cancer”

  • Gulliford, Martin

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Analyses économiques et systèmes de soins)

Menée au Mexique par entretiens auprès de 544 fumeurs adultes et 528 jeunes fumeurs, cette étude analyse l'efficacité perçue des messages d'avertissement, textuels et picturaux, apposés sur les paquets de cigarette

• Perceived effectiveness of pictorial health warnings among Mexican youth and adults: a population-level intervention with potential to reduce tobacco-related inequities
  • Cancer Causes and Control, sous presse, 2012 (résumé)
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  Menée au Mexique par entretiens auprès de 544 fumeurs adultes et 528 jeunes fumeurs, cette étude analyse l'efficacité perçue des messages d'avertissement, textuels et picturaux, apposés sur les paquets de cigarette

  “Perceived effectiveness of pictorial health warnings among Mexican youth and adults: a population-level intervention with potential to reduce tobacco-related inequities”

  • Hammond, David;Thrasher, James;Reid, Jessica;Driezen, Pete;Boudreau, Christian;Santillán, Edna

  Purpose Pictorial health warnings on cigarette packages are a prominent and effective means of communicating the risks of smoking; however, there is little research on effective types of message content and socio-demographic effects. This study tested message themes and content of pictorial warnings in Mexico. Methods Face-to-face surveys were conducted with 544 adult smokers and 528 youth in Mexico City. Participants were randomized to view 5–7 warnings for two of 15 different health effects. Warnings for each health effect included a text-only warning and pictorial warnings with various themes: “graphic” health effects, “lived experience”, symbolic images, and testimonials. Results Pictorial health warnings were rated as more effective than text-only warnings. Pictorial warnings featuring “graphic” depictions of disease were significantly more effective than symbolic images or experiences of human suffering. Adding testimonial information to warnings increased ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Sensibilisation et communication)

Menée au Japon par questionnaire auprès de 663 proches et parents de patients atteints de cancer, cette étude analyse leurs préférences relatives au lieu de fin de vie du malade

• Family member perspectives of deceased relatives’ end-of-life options on admission to a palliative care unit in Japan
  • Supportive Care in Cancer, sous presse, 2012 (résumé)
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  Menée au Japon par questionnaire auprès de 663 proches et parents de patients atteints de cancer, cette étude analyse leurs préférences relatives au lieu de fin de vie du malade

  “Family member perspectives of deceased relatives’ end-of-life options on admission to a palliative care unit in Japan”

  • Sato, Kazuki;Miyashita, Mitsunori;Morita, Tatsuya;Tsuneto, Satoru;Shima, Yasuo

  Purpose Our goal was to better facilitate the desire of terminally ill patients to die in a favorite place, which may not always be the case for patients admitted to palliative care units. Our aims were to assess the perspectives of bereaved family members about (1) available and preferred places of care when their ill loved one was admitted to a palliative care unit and (2) why patients preferred to live at home but could not. Methods A questionnaire was answered by 407 of 663 bereaved family members of cancer patients who were admitted to 95 inpatient palliative care units in Japan. Results Seventy-three percent of respondents answered that a palliative care unit was the only available option. Patients lacking other places for care preferred their home (49%), a hospital (26%), or a long-term care facility (28%). Only 9% retrospectively considered that living at home was feasible for the following reasons: anxiety about the patient’s deteriorating physical condition (85%), ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Soins palliatifs)

Menée en Italie pendant une période de 9 mois dans deux structures hospitalières, cette étude de cohorte longitudinale incluant 327 patients analyse le recours à la sédation palliative et son impact sur la survie des patients

• Prospective observational Italian study on palliative sedation in two hospice settings: differences in casemixes and clinical care
  • Supportive Care in Cancer, sous presse, 2012 (résumé)
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  Menée en Italie pendant une période de 9 mois dans deux structures hospitalières, cette étude de cohorte longitudinale incluant 327 patients analyse le recours à la sédation palliative et son impact sur la survie des patients

  “Prospective observational Italian study on palliative sedation in two hospice settings: differences in casemixes and clinical care”

  • Maltoni, Marco;Miccinesi, Guido;Morino, Piero;Scarpi, Emanuela;Bulli, Francesco;Martini, Francesca;Canzani, Filippo;Dall’Agata, Monia;Paci, Eugenio;Amadori, Dino

  Purpose Palliative sedation (PS) has been defined as the use of sedative medications to relieve intolerable suffering from refractory symptoms by a reduction in patient consciousness. It is sometimes necessary in end-of-life care when patients present refractory symptoms. We investigated PS for refractory symptoms in different hospice casemixes in order to (1) assess clinical decision-making, (2) monitor the practice of PS, and (3) examine the impact of PS on survival. Methods This observational longitudinal cohort study was conducted over a period of 9 months on 327 patients consecutively admitted to two 11-bed Italian hospices (A and B) with different casemixes in terms of median patient age (hospice A, 66 years vs. hospice B, 73 years; P = 0.005), mean duration of hospice stay (hospice A, 13.5 days vs. hospice B, 18.3 days; P = 0.005), and death rate (hospice A, 57.2% vs. hospice B, 89.9%; P < 0.0001). PS was monitored using the Richmond Agitation–Sedation Scale (RASS). ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Soins palliatifs)

Menée auprès de 545 patients atteints de cancer et âgés de plus de 65 ans, cette étude de cohorte américaine analyse leur recours à des médecines complémentaires

• Use of complementary medications among older adults with cancer
  • Cancer, sous presse, 2012 (résumé)
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  Menée auprès de 545 patients atteints de cancer et âgés de plus de 65 ans, cette étude de cohorte américaine analyse leur recours à des médecines complémentaires

  “Use of complementary medications among older adults with cancer”

  • Maggiore, Ronald J.;Gross, Cary P.;Togawa, Kayo;Tew, William P.;Mohile, Supriya G.;Owusu, Cynthia;Klepin, Heidi D.;Lichtman, Stuart M.;Gajra, Ajeet;Ramani, Rupal;Katheria, Vani;Klapper, Shira M.;Hansen, Kurt;Hurria, Arti;on behalf of the, Cancer;Aging Research, Group

  BACKGROUND: Little is known about complementary medication use among older adults with cancer, particularly those who are receiving chemotherapy. The objective of this study was to evaluate the prevalence of complementary medication use and to identify the factors associated with its use among older adults with cancer. METHODS: The prevalence of complementary medication use (defined as herbal agents, minerals, or other dietary supplements, excluding vitamins) was evaluated in a cohort of adults aged ≥65 years who were about to start chemotherapy for their cancer. The associations between complementary medication use and patient characteristics (sociodemographics; comorbidities; and functional, nutritional, psychological, and cognitive status), medication use (number of medications and concurrent vitamin use), and cancer characteristics (type and stage) were analyzed. RESULTS: The cohort included 545 patients (mean age, 73 years; range, 65-91 years; 52% women) with cancer (61% stage ...

  
  

Mots clés : Cancer (général); Lutte contre les cancers (Médecines parallèles)