Etiologie

Cette étude américaine (570 cas et 343 témoins) analyse l'association entre la dépendance nicotinique mesurée par le temps passé entre le réveil et la première cigarette, et le risque de cancer du larynx

• The nicotine dependence phenotype, time to first cigarette, and larynx cancer risk
  • Cancer Causes and Control, sous presse, 2012 (résumé)
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  Cette étude américaine (570 cas et 343 témoins) analyse l'association entre la dépendance nicotinique mesurée par le temps passé entre le réveil et la première cigarette, et le risque de cancer du larynx

  “The nicotine dependence phenotype, time to first cigarette, and larynx cancer risk”

  • Muscat, Joshua;Liu, Hsiao-Pin;Livelsberger, Craig;Richie, John;Stellman, Steven

  Purpose Cigarette smoking is the major cause of laryngeal cancer. The time to first cigarette after waking in the morning is a behavior associated with several dimensions of nicotine dependence including the dose of smoke uptake. We hypothesized that a short TTFC increases the risk of laryngeal cancer. Methods The analysis was based on data from a hospital-based case–control study of laryngeal cancer. The current analysis included only subjects who were ever cigarette smokers, including 570 cases and 343 controls (832 whites and 81 blacks). Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression adjusting for smoking history and other potential confounders. Incidence data from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute from 1975 to 2006 were analyzed for trends in laryngeal cancer. Results There was a dose–response relationship between TTFC and supraglottic cancer. Compared to ...

  
  

Mots clés : Voies aérodigestives supérieures; Etiologie (Facteurs exogènes : Tabac)

Menée en Inde, cette étude (2 580 cas et 429 306 témoins) analyse l'association entre la mastication de tabac et la mortalité par cancer, en fonction de disparités socio-économiques

• Social inequalities, tobacco chewing, and cancer mortality in south India: a case-control analysis of 2,580 cancer deaths among non-smoking non-drinkers
  • Cancer Causes and Control, sous presse, 2012 (résumé)
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  Menée en Inde, cette étude (2 580 cas et 429 306 témoins) analyse l'association entre la mastication de tabac et la mortalité par cancer, en fonction de disparités socio-économiques

  “Social inequalities, tobacco chewing, and cancer mortality in south India: a case-control analysis of 2,580 cancer deaths among non-smoking non-drinkers”

  • Gajalakshmi, Vendhan;Whitlock, Gary;Peto, Richard

  Objective The objective of this work was to describe the relationships between educational level, tobacco chewing, and cancer mortality in south India, among middle-aged adults who never smoked tobacco or drank alcohol, to eliminate confounding by those habits. Methods This case-control study was conducted in two areas of Tamil Nadu state. The cases studied were 2,580 lifelong non-smoking non-drinkers who died at age 35–69 years during 1995–1998, with interviews in 1998–2000 of a spouse, neighbour, or close associate, who retrospectively provided information on the education and chewing/other habits of the deceased. Underlying neoplastic cause of death was determined by verbal autopsy. The controls were 429,306 lifelong non-smoking non-drinkers aged 35–69 from these two study areas, interviewed during 1998–2001. Results Among the controls, prevalence of current tobacco chewing was much higher in those with less education, irrespective of sex, urban/rural residence, or birth ...

  
  

Mots clés : Cancer (général); Etiologie (Facteurs exogènes : Tabac)

Menée à Taïwan auprès de 2 273 participants, cette étude prospective de cohorte analyse l'impact du tabagisme et de la consommation d'alcool sur la survie de patients atteints d'un carcinome hépatocellulaire

• Influences of tobacco and alcohol use on hepatocellular carcinoma survival
  • International Journal of Cancer, sous presse, 2012 (résumé)
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  Menée à Taïwan auprès de 2 273 participants, cette étude prospective de cohorte analyse l'impact du tabagisme et de la consommation d'alcool sur la survie de patients atteints d'un carcinome hépatocellulaire

  “Influences of tobacco and alcohol use on hepatocellular carcinoma survival”

  • Shih, Wei-Liang;Chang, Hung-Chuen;Liaw, Yun-Fan;Lin, Shi-Ming;Lee, Shou-Dong;Chen, Pei-Jer;Liu, Chun-Jen;Lin, Chih-Lin;Yu, Ming-Whei

  Prognosis of hepatocellular carcinoma (HCC) is generally poor. The role of modifiable lifestyle factors on HCC survival has been less studied. To examine whether prediagnosis smoking and alcohol affected HCC survival stratified by viral etiology, we conducted a prospective cohort study of 2273 (1990 with viral hepatitis and 283 without) incident HCC cases aged 20-75 years who were enrolled between 1997 and 2004 from a Taiwanese multicenter study, and followed up through 2007. Information on habitual smoking and alcohol consumption was obtained at baseline through personal interview. After follow-up to a maximum of 10 years, 1757 participants died and 1488 (84.7%) were attributed to HCC. Prediagnosis smoking and alcohol worsened prognosis independent of each other and clinical predictors. The effects of both risky behaviors were limited to viral hepatitis-related HCC and more profound among those with early-stage HCC. Risk for HCC-specific mortality increased with increasing pack-years ...

  
  

Mots clés : Foie; Etiologie (Facteurs exogènes : Alcool)

A partir des données de la cohorte "NIH–AARP Diet and Health Study" incluant 118 008 participantes âgées de 50 à 71 ans, cette étude évalue l'association entre l'utilisation d'un traitement hormonal substitutif de la ménopause, qu'il s'agisse d'un THS par œstrogènes seuls ou d'un THS combinant œstrogènes et progestatif, et le risque de cancer du poumon

• Unopposed estrogen and estrogen plus progestin menopausal hormone therapy and lung cancer risk in the NIH–AARP Diet and Health Study Cohort
  • Cancer Causes and Control, sous presse, 2012 (résumé)
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  A partir des données de la cohorte "NIH–AARP Diet and Health Study" incluant 118 008 participantes âgées de 50 à 71 ans, cette étude évalue l'association entre l'utilisation d'un traitement hormonal substitutif de la ménopause, qu'il s'agisse d'un THS par œstrogènes seuls ou d'un THS combinant œstrogènes et progestatif, et le risque de cancer du poumon

  “Unopposed estrogen and estrogen plus progestin menopausal hormone therapy and lung cancer risk in the NIH–AARP Diet and Health Study Cohort”

  • Brinton, Louise;Schwartz, Lauren;Spitz, Margaret;Park, Yikyung;Hollenbeck, Albert;Gierach, Gretchen

  Purpose Previous studies have reported that lung cancer risk may be decreased, increased, or unaffected by prior use of menopausal hormone therapy (MHT). Methods To assess this issue further, we examined relationships among 118,008 women, ages 50–71 years who were recruited during 1995–1996 for the NIH–AARP Diet and Health Study and in whom 2,097 incident lung carcinomas were identified during follow-up through 2006. Multivariable Cox proportional hazards models estimated relative risks (RR) and 95% confidence intervals (CIs) associated with various measures of self-reported MHT use. Results We found no evidence that either estrogen therapy (ET)-only or estrogen plus progestin therapy (EPT) use was substantially related to subsequent lung cancer risk (respective RRs and 95% CIs for ever use = 0.97, 0.86–1.09 and 1.03, 0.90–1.17). There were no significant variations according to currency or duration of use of either formulation, nor was there evidence that risks varied ...

  
  

Mots clés : Poumon; Etiologie (Facteurs exogènes : THS et contraceptifs)

A partir des données de 15 registres américains relatifs au cancer et au VIH, cette étude analyse les risques de divers sous-types de cancer chez les patients atteints de sida

• Increased risk of histologically defined cancer subtypes in human immunodeficiency virus–infected individuals
  • Cancer, sous presse, 2012 (résumé)
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  A partir des données de 15 registres américains relatifs au cancer et au VIH, cette étude analyse les risques de divers sous-types de cancer chez les patients atteints de sida

  “Increased risk of histologically defined cancer subtypes in human immunodeficiency virus–infected individuals”

  • Shiels, Meredith S.;Engels, Eric A.

  BACKGROUND: Malignancies that occur in excess among human immunodeficiency virus (HIV)-infected individuals may be caused by immunosuppression or infections. Because histologically defined cancer subtypes have not been systematically evaluated, their risk was assessed among people with acquired immunodeficiency syndrome (AIDS). METHODS: Analyses included 569,268 people with AIDS from the HIV/AIDS Cancer Match Study, a linkage of 15 US population-based HIV/AIDS and cancer registries during 1980 to 2007. Standardized incidence ratios (SIRs) were estimated to compare cancer risk in people with AIDS to the general population overall, and stratified by age, calendar period (a proxy of changing HIV therapies), and time since onset of AIDS (a proxy of immunosuppression). RESULTS: Sixteen individual cancer histologies or histology groupings manifested significantly elevated SIRs. Risks were most elevated for adult T cell leukemia/lymphoma (SIR = 11.3), neoplasms of histiocytes and accessory ...

  
  

Mots clés : Cancer (général); Etiologie (Facteurs exogènes : Agents infectieux)

A partir des données de 13 études (7 911 cas et 13 226 témoins), cette étude analyse l'association entre une endométriose et le risque de cancer de l'ovaire par sous-type histologique

• Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies
  • The Lancet Oncology, sous presse, 2012 (résumé)
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  A partir des données de 13 études (7 911 cas et 13 226 témoins), cette étude analyse l'association entre une endométriose et le risque de cancer de l'ovaire par sous-type histologique

  “Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies”

  • Pearce, Celeste Leigh;Templeman, Claire;Rossing, Mary Anne;Lee, Alice;Near, Aimee M.;Webb, Penelope M.;Nagle, Christina M.;Doherty, Jennifer A.;Cushing-Haugen, Kara L.;Wicklund, Kristine G.;Chang-Claude, Jenny;Hein, Rebecca;Lurie, Galina;Wilkens, Lynne R.;Carney, Michael E.;Goodman, Marc T.;Moysich, Kirsten;Kjaer, Susanne K.;Hogdall, Estrid;Jensen, Allan;Goode, Ellen L.;Fridley, Brooke L.;Larson, Melissa C.;Schildkraut, Joellen M.;Palmieri, Rachel T.;Cramer, Daniel W.;Terry, Kathryn L.;Vitonis, Allison F.;Titus, Linda J.;Ziogas, Argyrios;Brewster, Wendy;Anton-Culver, Hoda;Gentry-Maharaj, Alexandra;Ramus, Susan J.;Anderson, A. Rebecca;Brueggmann, Doerthe;Fasching, Peter A.;Gayther, Simon A.;Huntsman, David G.;Menon, Usha;Ness, Roberta B.;Pike, Malcolm C.;Risch, Harvey;Wu, Anna H.;Berchuck, Andrew

  Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this risk extends to all invasive histological subtypes or borderline tumours is not clear. We undertook an international collaborative study to assess the association between endometriosis and histological subtypes of ovarian cancer. Data from 13 ovarian cancer case?control studies, which were part of the Ovarian Cancer Association Consortium, were pooled and logistic regression analyses were undertaken to assess the association between self-reported endometriosis and risk of ovarian cancer. Analyses of invasive cases were done with respect to histological subtypes, grade, and stage, and analyses of borderline tumours by histological subtype. Age, ethnic origin, study site, parity, and duration of oral contraceptive use were included in all analytical models. 13?226 controls and 7911 women with invasive ovarian cancer were included in this analysis. 818 and 738, respectively, reported a history of ...

  
  
• Link between endometriosis and ovarian-cancer subtypes
  • The Lancet Oncology, sous presse, 2012 (commentaire)
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  A partir des données de 13 études (7 911 cas et 13 226 témoins), cette étude analyse l'association entre une endométriose et le risque de cancer de l'ovaire par sous-type histologique

  “Link between endometriosis and ovarian-cancer subtypes”

  • Gourley, Charlie

  
  

Mots clés : Ovaire; Etiologie (Facteurs exogènes : Autres)

Cette étude américaine analyse l'épidémiologie, les facteurs de risque et les caractéristiques biologiques d'une gammapathie monoclonale familiale de signification indéterminée, un précurseur du myélome multiple

• Familial monoclonal gammopathy of undetermined significance and multiple myeloma: epidemiology, risk factors, and biological characteristics
  • Blood, sous presse, 2012 (résumé)
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  Cette étude américaine analyse l'épidémiologie, les facteurs de risque et les caractéristiques biologiques d'une gammapathie monoclonale familiale de signification indéterminée, un précurseur du myélome multiple

  “Familial monoclonal gammopathy of undetermined significance and multiple myeloma: epidemiology, risk factors, and biological characteristics”

  • Greenberg, Alexandra J.;Rajkumar, S. Vincent;Vachon, Celine M.

  Monoclonal gammopathy of undetermined significance (MGUS), a precursor to multiple myeloma, is one of the most common premalignant conditions in the general population. The etiology of MGUS is largely unknown. Recent studies show that there is an increased prevalence of MGUS in blood relatives of individuals with lymphoproliferative and plasma cell proliferative disorders, suggesting presence of shared underlying genetic influences. In the past few years, additional studies have examined risk factors and biological characteristics that may contribute to the increased prevalence of MGUS among relatives of probands with MGUS, multiple myeloma (MM), and other blood malignancies. This manuscript reviews the known epidemiology and risk factors of familial MGUS and myeloma, the risk of lymphoproliferative disorders and other malignancies among blood-relatives of patients with MGUS and MM, and discusses future directions for research.

  
  

Mots clés : Myélome multiple et maladies immunoprolifératives; Etiologie (Facteurs exogènes : Autres)

A partir des données de la "Women’s Health Initiative Observational Study" incluant 48 725 participantes, cette étude analyse l'association entre la durée auto-déclarée du sommeil et le risque de cancer de l'endomètre

• Sleep duration and endometrial cancer risk
  • Cancer Causes and Control, sous presse, 2012 (résumé)
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  A partir des données de la "Women’s Health Initiative Observational Study" incluant 48 725 participantes, cette étude analyse l'association entre la durée auto-déclarée du sommeil et le risque de cancer de l'endomètre

  “Sleep duration and endometrial cancer risk”

  • Sturgeon, Susan;Luisi, Nicole;Balasubramanian, Raji;Reeves, Katherine

  Purpose Recent data indicate that night shift work is associated with increased endometrial cancer risk, perhaps through a pathway involving lower melatonin production. Melatonin is an antiestrogenic hormone, with production in a circadian pattern that is dependent on presence of dark at night. Sleep duration is positively associated with melatonin production and may be an indicator of melatonin levels in epidemiologic studies. Methods We evaluated associations between self-reported sleep duration and endometrial cancer risk using publicly available prospective data on 48,725 participants in the Women’s Health Initiative Observational Study, among whom 452 adjudicated incident cases of endometrial cancer were diagnosed over approximately 7.5 years of follow-up. Sleep duration was self-reported at baseline. Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for endometrial cancer risk with adjustment for potential ...

  
  

Mots clés : Corps de l'utérus; Etiologie (Facteurs exogènes : Autres)

Menée en Chine, cette étude (226 cas et 254 témoins) identifie, parmi 43 polymorphismes à simple nucléotide, trois gènes associés au risque de gliome

• Polymorphisms of TREH, IL4R and CCDC26 genes associated with risk of glioma
  • Cancer Epidemiology, sous presse, 2012 (résumé)
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  Menée en Chine, cette étude (226 cas et 254 témoins) identifie, parmi 43 polymorphismes à simple nucléotide, trois gènes associés au risque de gliome

  “Polymorphisms of TREH, IL4R and CCDC26 genes associated with risk of glioma”

  • Li, Shanqu;Jin, Tianbo;Zhang, Jiayi;Lou, Huiling;Yang, Bo;Li, Yang;Chen, Chao;Zhang, Yongsheng

  Introduction: Glioma is one of the most aggressive human tumors; however, little is known about its genetic risk factors. The role of heredity is likely to be explained by combinations of common low-risk variants. Previous studies have indicated that more than 100 single nucleotide polymorphisms (SNPs) are associated with the risk of glioma. Methods: To further investigate how and to what extent these SNPs contribute to glioma susceptibility in a Chinese population, we analyzed 43 SNPs of 226 glioma patients and 254 normal people in order to evaluate the associations between SNPs and the risk of glioma. Results: Overall, we found three protective alleles for glioma in patients: the allele “G” of rs1801275 in the IL4R gene by allele model (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.50–0.99; P = 0.04) and dominant model (OR, 0.67; 95% CI, 0.46–0.99; P = 0.04) analysis respectively, the allele “T” of rs17748 in the TREH gene by recessive model ...

  
  

Mots clés : Système nerveux central; Etiologie (Facteurs endogènes)

Menée au Nigéria entre 1998 et 2009, cette étude (1 233 cas et 1 101 témoins) évalue l'association entre l'indice de masse corporelle, l'adiposité et le risque de cancer du sein

• Body fat distribution and breast cancer risk: findings from the Nigerian breast cancer study
  • Cancer Causes and Control, sous presse, 2012 (résumé)
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  Menée au Nigéria entre 1998 et 2009, cette étude (1 233 cas et 1 101 témoins) évalue l'association entre l'indice de masse corporelle, l'adiposité et le risque de cancer du sein

  “Body fat distribution and breast cancer risk: findings from the Nigerian breast cancer study”

  • Ogundiran, Temidayo;Huo, Dezheng;Adenipekun, Adeniyi;Campbell, Oladapo;Oyesegun, Rasaaq;Akang, Effiong;Adebamowo, Clement;Olopade, Olufunmilayo

  Purpose The relationship between overall obesity and breast cancer risk has been well recognized, but the role of central obesity in breast cancer development is uncertain. Methods Between 1998 and 2009, 1,233 invasive breast cancer cases and 1,101 community controls were recruited into the Nigerian Breast Cancer Study at Ibadan, Nigeria. Logistic regressions were used to calculate multivariate odds ratio (OR) and 95% confidence intervals (CI), adjusting for age, body mass index (BMI), and other known risk factors for breast cancer. Results The OR for the highest quartile group of waist circumference relative to the lowest was 2.39 (95% CI, 1.59–3.60; P -trend <0.001). Comparing women with waist/hip ratio (WHR) in the lowest quartile group, the OR for women in the highest quartile category was 2.15 (95% CI, 1.61–2.85; P -trend <0.001). An inverse association was observed between hip circumference and breast cancer, with an OR of 0.36 for the highest quartile (95% CI, ...

  
  

Mots clés : Sein; Etiologie (Facteurs endogènes)

Menée sur 1 509 cas et 1 383 témoins en population d'origine africaine, cette étude évalue l'association entre 19 polymorphismes à simple nucléotide, identifiés dans des populations d'origine européenne, et le risque de cancer du sein

• Evaluation of 19 Susceptibility Loci of Breast Cancer in Women of African Ancestry
  • Carcinogenesis, sous presse, 2012 (résumé)
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  Menée sur 1 509 cas et 1 383 témoins en population d'origine africaine, cette étude évalue l'association entre 19 polymorphismes à simple nucléotide, identifiés dans des populations d'origine européenne, et le risque de cancer du sein

  “Evaluation of 19 Susceptibility Loci of Breast Cancer in Women of African Ancestry”

  • Huo, Dezheng;Zheng, Yonglan;Ogundiran, Temidayo O.;Adebamowo, Clement;Nathanson, Katherine L.;Domchek, Susan M.;Rebbeck, Timothy R.;Simon, Michael S.;John, Esther M.;Hennis, Anselm;Nemesure, Barbara;Wu, Suh-Yuh;Leske, M. Cristina;Ambs, Stefan;Niu, Qun;Zhang, Jing;Cox, Nancy J.;Olopade, Olufunmilayo I.

  Multiple breast cancer susceptibility loci have been identified in genome-wide association studies (GWAS) in populations of European and Asian ancestry using array chips optimized for populations of European ancestry. It is important to examine whether these loci are associated with breast cancer risk in women of African ancestry. We evaluated 25 single nucleotide polymorphisms (SNPs) at 19 loci in a pooled case-control study of breast cancer, which included 1,509 cases and 1,383 controls. Cases and controls were enrolled in Nigeria, Barbados, and the United States; all women were of African ancestry. We found significant associations for three SNPs, which were in the same direction and of similar magnitude as those reported in previous fine-mapping studies in women of African ancestry. The allelic odds ratios were 1.24 (95% confidence interval, CI: 1.04-1.47; p=0.018) for the rs2981578-G allele (10q26/FGFR2), 1.34 (95% CI: 1.10-1.63; p=0.0035) for the rs9397435-G allele (6q25), and ...

  
  

Mots clés : Sein; Etiologie (Facteurs endogènes)

Menée sur 7 141 cas et 11 804 témoins en population japonaise, cette méta-analyse identifie trois nouveaux loci de susceptibilité au cancer de la prostate sur les chromosomes 11q12, 10q26 et 3p11.2

• Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese
  • Nature Genetics, sous presse, 2012 (résumé)
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  Menée sur 7 141 cas et 11 804 témoins en population japonaise, cette méta-analyse identifie trois nouveaux loci de susceptibilité au cancer de la prostate sur les chromosomes 11q12, 10q26 et 3p11.2

  “Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese”

  • Akamatsu, Shusuke;Takata, Ryo;Haiman, Christopher A.;Takahashi, Atsushi;Inoue, Takahiro;Kubo, Michiaki;Furihata, Mutsuo;Kamatani, Naoyuki;Inazawa, Johji;Chen, Gary K.;Le Marchand, Loic;Kolonel, Laurence N.;Katoh, Takahiko;Yamano, Yuko;Yamakado, Minoru;Takahashi, Hiroyuki;Yamada, Hiroki;Egawa, Shin;Fujioka, Tomoaki;Henderson, Brian E.;Habuchi, Tomonori;Ogawa, Osamu;Nakamura, Yusuke;Nakagawa, Hidewaki

  We have previously reported multiple loci associated with prostate cancer susceptibility in a Japanese population using a genome-wide association study (GWAS). To identify additional prostate cancer susceptibility loci, we genotyped nine SNPs that were nominally associated with prostate cancer (P < 1 × 10−4) in our previous GWAS in three independent studies of prostate cancer in Japanese men (2,557 individuals with prostate cancer (cases) and 3,003 controls). In a meta-analysis of our previous GWAS and the replication studies, which included a total of 7,141 prostate cancer cases and 11,804 controls from a single ancestry group, three new loci reached genome-wide significance on chromosomes 11q12 (rs1938781; P = 1.10 × 10−10; FAM111A-FAM111B), 10q26 (rs2252004; P = 1.98 × 10−8) and 3p11.2 (rs2055109; P = 3.94 × 10−8). We also found suggestive evidence of association at a previously reported prostate cancer susceptibility locus at 2p11 (rs2028898; P = 1.08 × 10−7). The ...

  
  

Mots clés : Prostate; Etiologie (Facteurs endogènes)

Cette étude américaine (368 cas et 926 témoins) évalue l'association entre un polymorphisme à simple nucléotide du gène CTLA-4 et le risque de cancer du pancréas

• The functional cytotoxic T lymphocyte–associated Protein 4 49G-to-A genetic variant and risk of pancreatic cancer
  • Cancer, sous presse, 2012 (résumé)
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  Cette étude américaine (368 cas et 926 témoins) évalue l'association entre un polymorphisme à simple nucléotide du gène CTLA-4 et le risque de cancer du pancréas

  “The functional cytotoxic T lymphocyte–associated Protein 4 49G-to-A genetic variant and risk of pancreatic cancer”

  • Yang, Ming;Sun, Tong;Zhou, Yifeng;Wang, Li;Liu, Li;Zhang, Xiaojiao;Tang, Xiaohu;Zhou, Mo;Kuang, Pengqun;Tan, Wen;Li, Hui;Yuan, Qipeng;Yu, Dianke

  BACKGROUND: Antitumor T lymphocytes play an essential part in immune surveillance of cancer cells. Cytotoxic T lymphocyte–associated Protein 4 (CTLA-4) is a negative regulator of T cell activation and proliferation and therefore influences immune surveillance of carcinogenesis of pancreas. Thus, this study examined the association between functional CTLA-4 49G-to-A (49G>A) single-nucleotide polymorphism and pancreatic cancer risk. METHODS: Genotypes were determined in 368 patients with pancreatic cancer and 926 controls, and odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression. RESULTS: A significant increased risk of pancreatic cancer was found to be associated with the CTLA-4 49G>A single-nucleotide polymorphism. Compared with noncarriers, the OR of developing pancreatic cancer for CTLA-4 49 GA or AA carriers was 1.75 (95% CI = 1.34-2.30, P = 4.83 × 10−5) or 2.54 (95% CI = 1.67-3.87, P = 1.36 × 10−5), respectively. In stratified ...

  
  

Mots clés : Pancréas; Etiologie (Facteurs endogènes)

Menée en population japonaise sur la période 1988 à 2007, cette étude analyse l'association entre le nombre de globules blancs et le risque de cancer de l'estomac, en fonction de la présence d'une infection par Helicobacter pylori

• White Blood Cell Count and Risk of Gastric Cancer Incidence in a General Japanese Population
  • American Journal of Epidemiology, sous presse, 2012 (résumé)
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  Menée en population japonaise sur la période 1988 à 2007, cette étude analyse l'association entre le nombre de globules blancs et le risque de cancer de l'estomac, en fonction de la présence d'une infection par Helicobacter pylori

  “White Blood Cell Count and Risk of Gastric Cancer Incidence in a General Japanese Population”

  • Iida, Masahiro;Ikeda, Fumie;Ninomiya, Toshiharu;Yonemoto, Koji;Doi, Yasufumi;Hata, Jun;Matsumoto, Takayuki;Iida, Mitsuo;Kiyohara, Yutaka

  The authors examined the association between white blood cell (WBC) count and the development of gastric cancer in a 19-year follow-up study of 2,558 Japanese subjects aged ≥40 years (1988–2007). The subjects were stratified into 4 groups according to baseline WBC quartile (≤4.4, 4.5–5.2, 5.3–6.3, or ≥6.4 × 103 cells/μL). During follow-up, 128 subjects developed gastric cancer. The age- and sex-adjusted incidence of gastric cancer increased linearly with higher WBC level: 1.7, 2.6, 3.9, and 5.4 per 1,000 person-years, respectively, for the 4 quartile groups (P for trend < 0.01). The risk of gastric cancer was 2.22-fold (95% confidence interval: 1.19, 4.14) higher in the highest WBC quartile group than in the lowest group after adjustment for confounding factors. With respect to Helicobacter pylori infection status, H. pylori-seropositive subjects in the highest WBC quartile group showed a significantly greater risk of gastric cancer than those in the lower 3 quartile ...

  
  

Mots clés : Estomac; Etiologie (Facteurs endogènes)

A partir des données de la "Cancer Prevention Study II Nutrition Cohort" incluant 38 148 femmes ménopausées, cette étude analyse l'association entre des variations cycliques de poids corporel et le risque de cancer de l'endomètre

• Weight Cycling and Risk of Endometrial Cancer
  • Cancer Epidemiology Biomarkers & Prevention, sous presse, 2012 (résumé)
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  A partir des données de la "Cancer Prevention Study II Nutrition Cohort" incluant 38 148 femmes ménopausées, cette étude analyse l'association entre des variations cycliques de poids corporel et le risque de cancer de l'endomètre

  “Weight Cycling and Risk of Endometrial Cancer”

  • Stevens, Victoria L.;Jacobs, Eric J.;Sun, Juzhong;McCullough, Marjorie L.;Patel, Alpa V.;Gaudet, Mia M.;Teras, Lauren R.;Gapstur, Susan M.

  Background: Obesity, as measured by body mass index (BMI), is an established risk factor for endometrial cancer in postmenopausal women. Weight cycling, which consists of repeated cycles of weight loss followed by regain, occurs frequently in overweight and obese women. It is unclear whether weight cycling is associated with risk of endometrial cancer independent of BMI. Methods: This analysis included 38,148 postmenopausal women enrolled in the Cancer Prevention Study II Nutrition Cohort, of whom 559 were diagnosed with endometrial cancer between enrollment in 1992 and June 30, 2007. Number of lifetime weight cycles was determined from questions on the baseline questionnaire asking how many times 10 or more pounds were intentionally lost and later regained. Multivariable-adjusted hazard rate ratios (RR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards regression. Results: Weight cycling was positively associated with endometrial cancer incidence ...

  
  

Mots clés : Corps de l'utérus; Etiologie (Facteurs endogènes)

Couplée aux données de la cohorte multiethnique, cette étude américaine (1 954 cas et 2 587 témoins) évalue l'association entre 5 variants génétiques associés aux facteurs de croissance analogues à l'insuline, à l'insuline ou au glucose et le risque de cancer colorectal

• Genetic variants, prediagnostic levels of insulin-like growth factors, insulin and glucose, and the risk of colorectal cancer: The Multiethnic Cohort Study
  • Cancer Epidemiology Biomarkers & Prevention, sous presse, 2012 (résumé)
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  Couplée aux données de la cohorte multiethnique, cette étude américaine (1 954 cas et 2 587 témoins) évalue l'association entre 5 variants génétiques associés aux facteurs de croissance analogues à l'insuline, à l'insuline ou au glucose et le risque de cancer colorectal

  “Genetic variants, prediagnostic levels of insulin-like growth factors, insulin and glucose, and the risk of colorectal cancer: The Multiethnic Cohort Study”

  • Ollberding, Nicholas J.;Cheng, Iona;Wilkens, Lynne R.;Henderson, Brian E.;Pollak, Michael N.;Kolonel, Laurence N.;Le Marchand, Loic

  Background: Increased exposure of colonic and rectal epithelial cells to the pro-mitotic and anti-apoptotic effects of insulin and insulin-like growth factors (IGFs) is hypothesized to increase colorectal cancer risk. Methods: In a case-control study nested within the Multiethnic Cohort, we attempted to replicate associations for five genetic variants associated with IGF-system biomarkers, insulin, or glucose and to examine their association with the risk of colorectal cancer. In a subset of participants, the association between circulating biomarkers and colorectal cancer risk was examined. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for genetic variants (1,954 cases / 2,587 controls) and serum biomarkers (258 cases / 1,701 controls). Results: Associations with circulating biomarkers were replicated in the MEC for IGF1 rs35767 and for IGFBP3 rs2854744, rs2854746, and rs3110697 (p < 0.05). Homozygous carriers of the GCKR ...

  
  

Mots clés : Colon-rectum; Etiologie (Facteurs endogènes)

Menée auprès de 1 852 survivants à un an d'un rétinoblastome, cette étude de cohorte américaine évalue le risque de second cancer en fonction d'une histoire familiale de rétinoblastome et de la latéralité du cancer

• Variation of Second Cancer Risk by Family History of Retinoblastoma Among Long-Term Survivors
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Menée auprès de 1 852 survivants à un an d'un rétinoblastome, cette étude de cohorte américaine évalue le risque de second cancer en fonction d'une histoire familiale de rétinoblastome et de la latéralité du cancer

  “Variation of Second Cancer Risk by Family History of Retinoblastoma Among Long-Term Survivors”

  • Kleinerman, Ruth A.;Yu, Chu-ling;Little, Mark P.;Li, Yi;Abramson, David;Seddon, Johanna;Tucker, Margaret A.

  Purpose To evaluate the risk of second cancer (SC) in long-term survivors of retinoblastoma (Rb) according to classification of germline mutation, based on family history of Rb and laterality.Patients and Methods We assembled a cohort of 1,852 1-year survivors of Rb (bilateral, n = 1,036; unilateral, n = 816). SCs were ascertained by medical records and self-reports and confirmed by pathology reports. Classification of RB1 germline mutation, inherited or de novo, was inferred by laterality of Rb and positive family history of Rb. Standardized incidence ratios and cumulative incidence for all SCs combined and for soft tissue sarcomas, bone cancers, and melanoma were calculated. The influence of host- and therapy-related risk factors for SC was assessed by Poisson regression for bilateral survivors.Results We observed a relative risk (RR) of 1.37 (95% CI, 1.00 to 1.86) for SCs in bilateral survivors associated with a family history of Rb, adjusted for treatment, age, and length of ...

  
  

Mots clés : Autres organes; Etiologie (Facteurs endogènes)

A partir des données de deux études cas-témoins distinctes conduites en Chine, cette étude évalue l'association entre des polymorphismes fonctionnels des gènes c-Jun et c-Fos, le tabagisme, la consommation d'alcool et le risque de cancer du poumon

• Functional genetic variants of c-Jun and their interaction with smoking and drinking increase the susceptibility to lung cancer in southern and eastern Chinese
  • International Journal of Cancer, sous presse, 2012 (résumé)
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  A partir des données de deux études cas-témoins distinctes conduites en Chine, cette étude évalue l'association entre des polymorphismes fonctionnels des gènes c-Jun et c-Fos, le tabagisme, la consommation d'alcool et le risque de cancer du poumon

  “Functional genetic variants of c-Jun and their interaction with smoking and drinking increase the susceptibility to lung cancer in southern and eastern Chinese”

  • Huang, Binfang;Liu, Bin;Yang, Lei;Li, Yinyan;Cheng, Mei;Huang, Dongsheng;Wang, Hui;Zhang, Xin;Zheng, Jian;Li, Qingchu;Ji, Weidong;Zhou, Yifeng;Lu, Jiachun

  Human proto-oncogene c-Jun and c-Fos assemble the activator protein-1 complex which is a crucial transcription factor responding to environmental factors and promotes tumorgenesis. We hypothesized that genetic variants in these two genes may alter the carriers' susceptibility to lung cancer. In two independent case–control studies, we genotyped three putative functional polymorphisms (−1318T>G and −673T>C of c-Jun; −60C>T of c-Fos) in southern Chinese and then validated the association in eastern Chinese. We found that compared to −1318TT genotype, the −1318GT/GG variant genotypes had an increased lung cancer risk (OR = 1.46, 95% CI = 1.26–1.69), and the −673CC genotype had an increased lung cancer risk compared to −673TT/CT genotypes (OR = 1.35, 95% CI = 1.17–1.56) in the total 1,559 cases versus 1,679 controls. After combining these two loci, the number of the risk genotypes was associated with increased cancer risk in a dose-response manner (ptrend = 2.21 × ...

  
  

Mots clés : Poumon; Etiologie (Interactions gènes-environnement)

Menée auprès de 10 372 participants, cette étude prospective évalue l'association entre 5 polymorphismes à simple nucléotide dans la région du chromosome 8q24, une histoire de diabète, le risque de cancers ainsi que la mortalité

• Association Between Total Number of Deaths, Diabetes Mellitus, Incident Cancers, and Haplotypes in Chromosomal Region 8q24 in a Prospective Study
  • American Journal of Epidemiology, sous presse, 2012 ( résumé)
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  Menée auprès de 10 372 participants, cette étude prospective évalue l'association entre 5 polymorphismes à simple nucléotide dans la région du chromosome 8q24, une histoire de diabète, le risque de cancers ainsi que la mortalité

  “Association Between Total Number of Deaths, Diabetes Mellitus, Incident Cancers, and Haplotypes in Chromosomal Region 8q24 in a Prospective Study”

  • Guarrera, Simonetta;Ricceri, Fulvio;Polidoro, Silvia;Sacerdote, Carlotta;Allione, Alessandra;Rosa, Fabio;Voglino, Floriana;Critelli, Rossana;Russo, Alessia;Vineis, Paolo;Matullo, Giuseppe

  The 8q24 region is a gene desert, although chromosomal aberrations and somatic amplification involving this region, including translocations involving the protooncogene c-MYC, have been frequently reported in people with cancer. To investigate the role of variants in 8q24 region, the authors analyzed data from a prospective study (n = 10,372 participants who were followed for 11 years) in which a large number of health events (>1,500) occurred (1993–1998). They genotyped all subjects for 5 candidate single nucleotide polymorphisms (rs672888, rs1447295, rs9642880, rs16901979, and rs6983267) that were identified in previous genome-wide scans. Although significant associations with individual single nucleotide polymorphisms were small in magnitude, the authors observed higher increases in the risks of different types of cancer with specific haplotypes, particularly when subjects were homozygous for the haplotype: for breast cancer and homozygotes for haplotype CAGCT, hazard ratio = ...

  
  

Mots clés : Cancer (général); Etiologie (Interactions gènes-environnement)