Etiologie

A partir des données de la cohorte "NIH-AARP diet and health study", cette étude évalue l'association entre la consommation de graisses alimentaires et le risque de cancer de l'œsophage et de l'estomac

• Association of dietary fat intakes with risk of esophageal and gastric cancer in the NIH-AARP diet and health study
  • International Journal of Cancer, sous presse, 2012 (résumé)
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  A partir des données de la cohorte "NIH-AARP diet and health study", cette étude évalue l'association entre la consommation de graisses alimentaires et le risque de cancer de l'œsophage et de l'estomac

  “Association of dietary fat intakes with risk of esophageal and gastric cancer in the NIH-AARP diet and health study”

  • O'Doherty, Mark G.;Freedman, Neal D.;Hollenbeck, Albert R.;Schatzkin, Arthur;Murray, Liam J.;Cantwell, Marie M.;Abnet, Christian C.

  The aim of our study was to investigate whether intakes of total fat and fat subtypes were associated with esophageal adenocarcinoma (EAC), esophageal squamous cell carcinoma (ESCC), gastric cardia or gastric noncardia adenocarcinoma. From 1995–1996, dietary intake data was reported by 494,978 participants of the NIH-AARP cohort. The 630 EAC, 215 ESCC, 454 gastric cardia and 501 gastric noncardia adenocarcinomas accrued to the cohort. Cox proportional hazards regression was used to examine the association between the dietary fat intakes, whilst adjusting for potential confounders. Although apparent associations were observed in energy-adjusted models, multivariate adjustment attenuated results to null [e.g., EAC energy adjusted hazard ratio (HR) and 95% confidence interval (95% CI) 1.66 (1.27–2.18) p for trend <0.01; EAC multivariate adjusted HR (95% CI) 1.17 (0.84–1.64) p for trend = 0.58]. Similar patterns were also observed for fat subtypes [e.g., EAC saturated fat, energy ...

  
  

Mots clés : Oesophage; Etiologie (Facteurs exogènes : Nutrition et activité physique)

A partir des données de la cohorte américaine "Cancer Prevention Study-II Nutrition Cohort" incluant 146 850 participants, cette étude évalue l'association entre une activité physique de loisir, le temps passé assis et le risque de lymphome non hodgkinien

• Recreational physical activity, leisure sitting time and risk of non-hodgkin lymphoid neoplasms in the american cancer society cancer prevention Study-II cohort
  • International Journal of Cancer, sous presse, 2012 (résumé)
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  A partir des données de la cohorte américaine "Cancer Prevention Study-II Nutrition Cohort" incluant 146 850 participants, cette étude évalue l'association entre une activité physique de loisir, le temps passé assis et le risque de lymphome non hodgkinien

  “Recreational physical activity, leisure sitting time and risk of non-hodgkin lymphoid neoplasms in the american cancer society cancer prevention Study-II cohort”

  • Teras, Lauren R.;Gapstur, Susan M.;Ryan Diver, W.;Birmann, Brenda M.;Patel, Alpa V.

  Results of studies that examined the relationship between physical activity and non-Hodgkin lymphoid neoplasms (NHL) are inconsistent, and only one study to date examined time spent sitting in relation to NHL. We examined recreational physical activity and leisure-time sitting in relation to risk of NHL in the American Cancer Society Cancer Prevention Study-II Nutrition Cohort. Between 1992 and 2007, 2,002 incident cases were identified among 146,850 participants who were cancer-free at enrollment. Cox proportional hazards regression was used to compute hazard ratios (HR) and 95% confidence intervals (CI) while adjusting for potential confounders. Women who sat for at least six hours/day were at 28% higher risk of NHL compared to women who sat for fewer than three hours/day. In analyses of specific subtypes, sitting time was associated with risk of multiple myeloma only (6+ vs. 3 hours/day sitting: HR=2.40, 95% CI: 1.45-3.97). Women who engaged in any recreational physical activity ...

  
  

Mots clés : Lymphome; Etiologie (Facteurs exogènes : Nutrition et activité physique)

Cette étude rétrospective analyse l'impact d'une exposition professionelle à l'arsenic sur la mortalité par cancer du poumon chez une population déjà identifée comme exposée au cadmium

• Cadmium and lung cancer mortality accounting for simultaneous arsenic exposure
  • Occupational and Environmental Medicine, sous presse, 2012 (résumé)
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  Cette étude rétrospective analyse l'impact d'une exposition professionelle à l'arsenic sur la mortalité par cancer du poumon chez une population déjà identifée comme exposée au cadmium

  “Cadmium and lung cancer mortality accounting for simultaneous arsenic exposure”

  • Park, Robert M;Stayner, Leslie T;Petersen, Martin R;Finley-Couch, Melissa;Hornung, Richard;Rice, Carol

  Objectives Prior investigations identified an association between airborne cadmium and lung cancer but questions remain regarding confounding by arsenic, a well-established lung carcinogen.Methods A cadmium smelter population exhibiting excess lung cancer was re-analysed using a retrospective exposure assessment for arsenic (As), updated mortality (1940–2002), a revised cadmium (Cd) exposure matrix and improved work history information.Results Cumulative exposure metrics for both cadmium and arsenic were strongly associated making estimation of their independent effects difficult. Standardised mortality ratios (SMRs) were modelled with Poisson regression with the contribution of arsenic to lung cancer risk constrained by exposure–response estimates previously reported. The results demonstrate (1) a statistically significant effect of Cd independent of As (SMR=3.2 for 10 mg-year/m3 Cd, p=0.012), (2) a substantial healthy worker effect for lung cancer (for unexposed workers, ...

  
  

Mots clés : Poumon; Etiologie (Facteurs exogènes : Exposition professionnelle)

Menée aux Etats-Unis auprès de 6 136 travailleurs de l'industrie textile, cette étude de cohorte évalue l'association entre une exposition à l'amiante chrysotile et le risque de cancer du poumon ainsi que la mortalité

• Lung cancer mortality in North Carolina and South Carolina chrysotile asbestos textile workers
  • Occupational and Environmental Medicine, sous presse, 2012 (résumé)
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  Menée aux Etats-Unis auprès de 6 136 travailleurs de l'industrie textile, cette étude de cohorte évalue l'association entre une exposition à l'amiante chrysotile et le risque de cancer du poumon ainsi que la mortalité

  “Lung cancer mortality in North Carolina and South Carolina chrysotile asbestos textile workers”

  • Elliott, Leslie;Loomis, Dana;Dement, John;Hein, Misty J;Richardson, David;Stayner, Leslie

  Objectives Studies of workers in two US cohorts of asbestos textile workers exposed to chrysotile (North Carolina (NC) and South Carolina (SC)) found increasing risk of lung cancer mortality with cumulative fibre exposure. However, the risk appeared to increase more steeply in SC, possibly due to differences in study methods. The authors conducted pooled analyses of the cohorts and investigated the exposure-disease relationship using uniform cohort inclusion criteria and statistical methods.Methods Workers were included after 30 days of employment in a production job during qualifying years, and vital status ascertained through 2003 (2001 for SC). Poisson regression was used to estimate the exposure-response relationship between asbestos and lung cancer, using both exponential and linear relative rate models adjusted for age, sex, race, birth cohort and decade of follow-up.Results The cohort included 6136 workers, contributing 218 631 person-years of observation and 3356 deaths. ...

  
  

Mots clés : Poumon; Etiologie (Facteurs exogènes : Exposition professionnelle)

Cette étude de cohorte incluant 4 114 travailleurs masculins évalue l'association entre une exposition professionnelle au plomb, le niveau de plomb contenu dans le sang, et le risque de cancer ainsi que la mortalité

• Cancer Incidence, Mortality, and Blood Lead Levels Among Workers Exposed to Inorganic Lead
  • Annals of epidemiology, sous presse, 2012 (résumé)
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  Cette étude de cohorte incluant 4 114 travailleurs masculins évalue l'association entre une exposition professionnelle au plomb, le niveau de plomb contenu dans le sang, et le risque de cancer ainsi que la mortalité

  “Cancer Incidence, Mortality, and Blood Lead Levels Among Workers Exposed to Inorganic Lead”

  • Gwini, StellaMay;Macfarlane, Ewan;Del Monaco, Anthony;McLean, Dave;Pisaniello, Dino;Benke, Geza Paul;Sim, Malcolm Ross

  We aimed to measure mortality and cancer incidence in a cohort of lead-exposed workers by using blood lead levels to assess exposure. The cohort comprised male lead workers. Subjects were matched to cancer and death registries. Observed death and cancer incidence rates were compared with population rates to obtain standardized mortality ratios (SMR) and standardized incidence ratios (SIR). There were 4114 male subjects with average follow-up time of 16.2 years, and 406 deaths were observed. There were significant results for overall death (SMR, 111; 95% confidence interval [95% CI], 101–123), digestive system deaths (SMR, 167; 95% CI, 110–250), and deaths from external causes (SMR, 135; 95% CI, 105–174). A total of 228 subjects had cancer, with an overall SIR of 83 (95% CI, 73–95); liver cancer SIR of 217 (95% CI, 103–454) and esophageal cancer SIR of 240 (95% CI, 129–447). The latter was seven-fold greater (SIR 755; 95% CI, 314–1813) among those with a blood lead level ...

  
  

Mots clés : Cancer (général); Etiologie (Facteurs exogènes : Exposition professionnelle)

Menée en hôpital, cette étude italienne (43 cas et 87 témoins) évalue l'association entre une exposition, professionnelle ou domestique, à des animaux et le risque de lymphome à cellules B des zones marginales (adnexa oculaire)

• Exposure to animals and increased risk of marginal zone B-cell lymphomas of the ocular adnexae
  • British Journal of Cancer, sous presse, 2012 (résumé)
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  Menée en hôpital, cette étude italienne (43 cas et 87 témoins) évalue l'association entre une exposition, professionnelle ou domestique, à des animaux et le risque de lymphome à cellules B des zones marginales (adnexa oculaire)

  “Exposure to animals and increased risk of marginal zone B-cell lymphomas of the ocular adnexae”

  • Dolcetti, R.;Serraino, D.;Dognini, G.;Govi, S.;Crocchiolo, R.;Ghia, P.;Pasini, E.;Ponzoni, M.;Talamini, R.;De Paoli, P.;Doglioni, C.;Ferreri, A. J. M.

  Background: Ocular adnexal marginal zone B-cell lymphoma (OAMZL) has been associated with Chlamydophila psittaci, an infection that may be transmitted by carrier animals. However, it is still unclear whether exposure to animals affects the risk of OAMZL in comparison with other lymphoma histotypes. We therefore investigated the role of professional and/or domestic exposures to animals in the occurrence of OAMZL, as compared with other types of lymphoma. Methods: A hospital-based case–control study was carried out on 43 consecutive OAMZL patients (cases) and 87 consecutive patients with nodal non-Hodgkin's lymphomas (NHLs; controls). Multiple logistic regression (MLR) odds ratios (ORs), and 95% confidence intervals (CIs) were used to estimate the association between exposures to animals and OAMZL risk. Results: A higher proportion of cases reported a lifetime exposure to household animals (79.1% vs 64.4% among controls), with a non-statistical significant MLR-OR of 2.18 (95% CI: ...

  
  

Mots clés : Lymphome; Etiologie (Facteurs exogènes : Environnement)

Menée en Finlande auprès de 262 728 participantes, cette étude de cohorte évalue l'association entre l'utilisation d'un traitement hormonal substitutif de la ménopause et le risque de méningiome

• A Nationwide Cohort Study on the Incidence of Meningioma in Women Using Postmenopausal Hormone Therapy in Finland
  • American Journal of Epidemiology, sous presse, 2012 (résumé)
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  Menée en Finlande auprès de 262 728 participantes, cette étude de cohorte évalue l'association entre l'utilisation d'un traitement hormonal substitutif de la ménopause et le risque de méningiome

  “A Nationwide Cohort Study on the Incidence of Meningioma in Women Using Postmenopausal Hormone Therapy in Finland”

  • Korhonen, Katariina;Auvinen, Anssi;Lyytinen, Heli;Ylikorkala, Olavi;Pukkala, Eero

  The authors conducted a nationwide cohort study to evaluate the association between postmenopausal hormone therapy and meningioma incidence in Finland. All women who had used hormone therapy at least for 6 months at the age of 50 years or older during 1994–2009 were included. Women who had used postmenopausal hormone therapy were identified from the medical reimbursement register of the Social Insurance Institution (131,480 estradiol users and 131,248 estradiol-progestin users), and meningioma cases were identified from the Finnish Cancer Registry. During the average 9 years of follow-up, 289 estradiol users and 196 estradiol-progestin users were diagnosed with meningioma. Ever use of estradiol-only therapy was associated with an increased risk of meningioma (standardized incidence ratio = 1.29, 95% confidence interval: 1.15, 1.44). Among women who had been using estradiol-only therapy for at least 3 years, the incidence of meningioma was 1.40-fold higher (95% confidence interval: ...

  
  

Mots clés : Système nerveux central; Etiologie (Facteurs exogènes : THS et contraceptifs)

Menée sur 46 échantillons de néoplasies intraépithéliales cervicales de haut grade, cette étude analyse les anomalies chromosomiques en fonction de la présence de différents types de papillomavirus humain à haut risque

• HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia
  • BMC Cancer, Vol. 12 (1), pp. 36, 2012 (article en libre accès)
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  Menée sur 46 échantillons de néoplasies intraépithéliales cervicales de haut grade, cette étude analyse les anomalies chromosomiques en fonction de la présence de différents types de papillomavirus humain à haut risque

  “HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia”

  • Bierkens, Mariska;Wilting, Saskia;van Wieringen, Wessel;van de Wiel, Mark;Ylstra, Bauke;Meijer, Chris;Snijders, Peter;Steenbergen, Renske

  BACKGROUND:The development of cervical cancer and its high-grade precursor lesions (Cervical Intraepithelial Neoplasia grade 2/3 [CIN2/3]) result from a persistent infection with high-risk human papillomavirus (hrHPV) types and the accumulation of (epi)genetic host cell aberrations. Epidemiological studies have demonstrated variable CIN2/3 and cancer risks between different hrHPV types. Recent genomic profiling studies revealed substantial heterogeneity in the chromosomal aberrations detected in morphologically indistinguishable CIN2/3 suggestive of varying cancer risk. The current study aimed to investigate whether CIN2/3 with different hrHPV types vary with respect to their chromosomal profiles, both in terms of the number of aberrations and chromosomal loci affected.METHODS:Chromosomal profiles were determined of 43 p16INK4A-immunopositive CIN2/3 of women with long-term hrHPV infection ([greater than or equal to]5 years). Sixteen lesions harboured HPV16, 3 HPV18, 14 HPV31, 1 HPV33, ...

  
  

Mots clés : Col de l'utérus; Etiologie (Facteurs exogènes : Agents infectieux)

Cette étude passe en revue l'association entre le microbiome de la cavité buccale (plus de 700 espèces de bactéries) et le risque de cancer gastrointestinal ou de la cavité buccale

• Oral microbiome and oral and gastrointestinal cancer risk
  • Cancer Causes and Control, pp. 1-6, 2012 (résumé)
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  Cette étude passe en revue l'association entre le microbiome de la cavité buccale (plus de 700 espèces de bactéries) et le risque de cancer gastrointestinal ou de la cavité buccale

  “Oral microbiome and oral and gastrointestinal cancer risk”

  • Ahn, Jiyoung;Chen, Calvin;Hayes, Richard

  A growing body of evidence implicates human oral bacteria in the etiology of oral and gastrointestinal cancers. Epidemiological studies consistently report increased risks of these cancers in men and women with periodontal disease or tooth loss, conditions caused by oral bacteria. More than 700 bacterial species inhabit the oral cavity, including at least 11 bacterial phyla and 70 genera. Oral bacteria may activate alcohol and smoking-related carcinogens locally or act systemically, through chronic inflammation. High-throughput genetic-based assays now make it possible to comprehensively survey the human oral microbiome, the totality of bacteria in the oral cavity. Establishing the association of the oral microbiome with cancer risk may lead to significant advances in understanding of cancer etiology, potentially opening a new research paradigm for cancer prevention.

  
  

Mots clés : Cancer (général); Etiologie (Facteurs exogènes : Agents infectieux)

A partir d'une revue systématique de la littérature (9 études, 829 cas et 1 387 témoins), cette méta-analyse évalue l'association entre le polymorphisme du gène p53 défini au niveau du codon 72 et le risque de cancer de l'endomètre

• Lack of association between p53 codon 72 polymorphism and endometrial cancer: A meta-analysis
  • Cancer Epidemiology, sous presse, 2012 (résumé)
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  A partir d'une revue systématique de la littérature (9 études, 829 cas et 1 387 témoins), cette méta-analyse évalue l'association entre le polymorphisme du gène p53 défini au niveau du codon 72 et le risque de cancer de l'endomètre

  “Lack of association between p53 codon 72 polymorphism and endometrial cancer: A meta-analysis”

  • Tang, Wenru;He, Xinggang;Chan, Ying;Luo, Ying

  Background: It has been suggested that the p53 tumor suppressor gene Arg72Pro polymorphism is associated with endometrial cancer. However, results have been inconsistent. We performed this meta-analysis to estimate the association between p53 Arg72Pro polymorphism and endometrial cancer. Methods: An electronic search of PubMed was conducted to select studies. Studies containing available genotype frequencies of Arg72Pro were chosen, and the association was assessed by pooled odds ratios (ORs) with 95% confidence intervals (CIs). Results: Nine published studies, including 829 endometrial cancer cases and 1387 controls, were identified. The overall results suggested that the variant genotypes were not associated with the endometrial cancer risk in all genetic models (additive model: OR 1.027, 95% CI 0.893–1.18, P = 0.71; recessive model: OR 1.099, 95% CI 0.802–1.507, P = 0.556; dominant model: OR 1.013, 95% CI 0.842–1.219 P = 0.89). Similarly, the ...

  
  

Mots clés : Utérus (autre); Etiologie (Facteurs endogènes)

Menée sur 781 patients et 6 122 témoins, cette étude évalue l'association entre cinq polymorphismes à simple nucléotide et le risque de cancer de la thyroïde

• Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24
  • Journal of Medical Genetics, sous presse, 2012 (article en libre accès)
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  Menée sur 781 patients et 6 122 témoins, cette étude évalue l'association entre cinq polymorphismes à simple nucléotide et le risque de cancer de la thyroïde

  “Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24”

  • Jones, Angela M;Howarth, Kimberley M;Martin, Lynn;Gorman, Maggie;Mihai, Radu;Moss, Laura;Auton, Adam;Lemon, Catherine;Mehanna, Hisham;Mohan, Hosahalli;Clarke, Susan EM;Wadsley, Jonathan;Macias, Elena;Coatesworth, Andrew;Beasley, Matthew;Roques, Tom;Martin, Craig;Ryan, Paul;Gerrard, Georgina;Power, Danielle;Bremmer, Caroline;The TCUKIN Consortium;Tomlinson, Ian;Carmona, Luis G Carvajal

  Five single nucleotide polymorphisms (SNPs) associated with thyroid cancer (TC) risk have been reported: rs2910164 (5q24); rs6983267 (8q24); rs965513 and rs1867277 (9q22); and rs944289 (14q13). Most of these associations have not been replicated in independent populations and the combined effects of the SNPs on risk have not been examined. This study genotyped the five TC SNPs in 781 patients recruited through the TCUKIN study. Genotype data from 6122 controls were obtained from the CORGI and Wellcome Trust Case-Control Consortium studies. Significant associations were detected between TC and rs965513A (p=6.35×10−34), rs1867277A (p=5.90×10−24), rs944289T (p=6.95×10−7), and rs6983267G (p=0.016). rs6983267 was most strongly associated under a recessive model (PGG vs GT + TT=0.004), in contrast to the association of this SNP with other cancer types. However, no evidence was found of an association between rs2910164 and disease under any risk model (p>0.7). The rs1867277 ...

  
  

Mots clés : Thyroïde; Etiologie (Facteurs endogènes)

A partir d'une revue de la littérature, cette étude analyse les disparités sexuelles dans l'incidence des tumeurs cérébrales et passe en revue les mécanismes impliquant les chromosomes X et Y et des hormones sexuelles dans la tumorigénèse du cerveau

• Why Does Jack and not Jill Break His Crown: Sex Disparity in Brain Tumors
  • Biology of Sex Differences, Vol. 3 (1), pp. 3, 2012 (article en libre accès)
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  A partir d'une revue de la littérature, cette étude analyse les disparités sexuelles dans l'incidence des tumeurs cérébrales et passe en revue les mécanismes impliquant les chromosomes X et Y et des hormones sexuelles dans la tumorigénèse du cerveau

  “Why Does Jack and not Jill Break His Crown: Sex Disparity in Brain Tumors”

  • Sun, Tao;Warrington, Nicole;Rubin, Joshua

  It is often reported that brain tumors occur more frequently in males, and that males suffer a worse outcome from brain tumors than females. If correct, these observations suggest that sex plays a fundamental role in brain tumor biology. The following review of the literature regarding primary and metastatic brain tumors, reveals that brain tumors do occur more frequently in males compared to females regardless of age, tumor histology or region of the world. Sexually dimorphic mechanisms that might control tumor cell biology, as well as immune and brain microenvironmental responses to cancer, are explored as the basis for this sex disparity. Elucidating the mechanisms by which sex chromosomes and sex hormones impact on brain tumorigenesis and progression will advance our understanding of basic cancer biology and is likely to be essential for optimizing the care of brain tumor patients.

  
  

Mots clés : Système nerveux central; Etiologie (Facteurs endogènes)

Couplée à une étude cas-témoins, cette étude de cohorte incluant 1 125 femmes non malades évalue l'association entre la densité mammaire et d'autres facteurs de risque de cancer du sein (consommation d'alcool, parité, utilisation d'un traitement hormonal substitutif de la ménopause, histoire familiale de cancer, etc.)

• Relationship between breast cancer risk factors and mammographic breast density in the Fernald Community Cohort
  • British Journal of Cancer, sous presse, 2012 (résumé)
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  Couplée à une étude cas-témoins, cette étude de cohorte incluant 1 125 femmes non malades évalue l'association entre la densité mammaire et d'autres facteurs de risque de cancer du sein (consommation d'alcool, parité, utilisation d'un traitement hormonal substitutif de la ménopause, histoire familiale de cancer, etc.)

  “Relationship between breast cancer risk factors and mammographic breast density in the Fernald Community Cohort”

  • Yaghjyan, L.;Mahoney, M. C.;Succop, P.;Wones, R.;Buckholz, J.;Pinney, S. M.

  Background: We investigated associations of known breast cancer risk factors with breast density, a well-established and very strong predictor of breast cancer risk. Methods: This nested case–control study included breast cancer-free women, 265 with high and 860 with low breast density. Women were required to be 40–80 years old and should have a body mass index (BMI) <35 at the time of the index mammogram. Information on covariates was obtained from annual questionnaires. Results: In the overall analysis, breast density was inversely associated with BMI at mammogram (P for trend<0.001), and parity (P for trend=0.02) and positively associated with alcohol consumption (ever vs never: odds ratio 2.0, 95% confidence interval 1.4–2.8). Alcohol consumption was positively associated with density, and the association was stronger in women with a family history of breast cancer (P<0.001) and in women with hormone replacement therapy (HRT) history (P<0.001). Parity was inversely ...

  
  

Mots clés : Sein; Etiologie (Facteurs endogènes)

Menée en Chine, cette étude (732 cas et 649 témoins) évalue l'association entre un polymorphisme du gène LAPTM4B et le risque de cancer du sein

• Association of LAPTM4B gene polymorphism with breast cancer susceptibility
  • Cancer Epidemiology, sous presse, 2012 (résumé)
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  Menée en Chine, cette étude (732 cas et 649 témoins) évalue l'association entre un polymorphisme du gène LAPTM4B et le risque de cancer du sein

  “Association of LAPTM4B gene polymorphism with breast cancer susceptibility”

  • Fan, Meirong;Liu, Ye;Zhou, Rouli;Zhang, Qingyun

  Background Lysosome associated protein transmembrane 4 beta (LAPTM4B) was a cancer-associated gene that is mapped to chromosome 8q22 with seven exons and six introns. LAPTM4B gene polymorphism has been reported to be significantly associated with susceptibility of several solid tumors. Methods We performed a case-control study was to investigate the association between LAPTM4B polymorphism and the risk of breast cancer in 732 breast cancer patients and 649 controls. Results A significant difference in the frequency of LAPTM4B*2 was observed between the patients and the controls (P < 0.01). Using the LAPTM4B*1/1 genotype as a reference, we found that LAPTM4B allelic variation was significantly associated with breast cancer occurrence, with adjusted odds ratios of 1.387 (95%CI = 1.111–1.730) for LAPTM4B*1/2 and 1.592 (95% CI = 1.043–2.430) for LAPTM4B*2/2 genotype. Conclusion Our results suggested that LAPTM4B*2 is associated with an increased risk ...

  
  

Mots clés : Sein; Etiologie (Facteurs endogènes)

Cette étude évalue l'association entre 15 polymorphismes à simple nucléotide, déjà identifiés dans des études sur des populations caucasiennes, et le risque de cancer du sein chez des populations chinoises, en prenant en compte les critères d'âge à la ménopause et lors de la première grossesse

• Breast cancer risk assessment with five independent genetic variants and two risk factors in chinese women
  • Breast Cancer Research, Vol. 14 (1), pp. R17, 2012 (résumé)
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  Cette étude évalue l'association entre 15 polymorphismes à simple nucléotide, déjà identifiés dans des études sur des populations caucasiennes, et le risque de cancer du sein chez des populations chinoises, en prenant en compte les critères d'âge à la ménopause et lors de la première grossesse

  “Breast cancer risk assessment with five independent genetic variants and two risk factors in chinese women”

  • Dai, Juncheng;Hu, Zhibin;Jiang, Yue;Shen, Hao;Dong, Jing;Ma, Hongxia;Shen, Hongbing

  INTRODUCTION:Recently, several genome-wide association studies (GWAS) have identified novel single nucleotide polymorphisms (SNPs) associated with breast cancer risk. However, most of the studies were conducted among Caucasians and only one from Chinese.METHODS:In the current study, we first tested whether 15 SNPs identified by previous GWAS were also breast cancer marker SNPs in this Chinese population. Then, we grouped the marker SNPs, and modeled them with clinical risk factors, to see the usage of these factors in breast cancer risk assessment. Two methods (risk factors counting and OR weighted risk scoring) were used to evaluate the cumulative effects of the 5 significant SNPs and two clinical risk factors (age at menarche and age at first live birth).RESULTS:Five SNPs located at 2q35, 3p24, 6q22, 6q25 and 10q26 were consistently associated with breast cancer risk in both testing set (878 cases and 900 controls) and validation set (914 cases and 967 controls) samples. Overall, ...

  
  

Mots clés : Sein; Etiologie (Facteurs endogènes)

Menée sur 266 patients coréens atteints d'un cancer de la prostate et 266 patients présentant une hyperplasie bénigne, cette étude montre une association entre une mutation du gène HOGG1 et le risque d'une forme agressive de cancer de la prostate

• The hOGG1 mutant genotype is associated with prostate cancer susceptibility and aggressive clinicopathological characteristics in the Korean population
  • Annals of Oncology, Vol. 23 (2), pp. 401-405, 2012 (résumé)
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  Menée sur 266 patients coréens atteints d'un cancer de la prostate et 266 patients présentant une hyperplasie bénigne, cette étude montre une association entre une mutation du gène HOGG1 et le risque d'une forme agressive de cancer de la prostate

  “The hOGG1 mutant genotype is associated with prostate cancer susceptibility and aggressive clinicopathological characteristics in the Korean population”

  • Yun, S. J.;Ha, Y. S.;Chae, Y.;Kim, J. S.;Kim, I. Y.;Kim, W. J.

  Background : The gene encoding human 8-oxoguanine glycosylase 1 (hOGG1) is involved in DNA base excision repair from oxidatively damaged DNA. A case–control study was conducted to evaluate the correlation between the susceptibility and clinicopathological outcomes of prostate cancer (CaP) and hOGG1 genotype.Patients and methods: Subjects were recruited from 266 CaP patients and 266 age-matched benign prostatic hyperplasia patients. The hOGG1 codon 326 genotype was determined by peptide nucleic acid-mediated PCR clamping and compared with Gleason score and tumor stage.Results: The Cys allele at codon 326 of hOGG1 was associated with an increased risk of CaP in comparison with the Ser allele (P = 0.005). Gleason scores of 8 or higher were observed more often in patients with the mutant genotypes Ser/Cys and Cys/Cys than in those with a wild-type genotype (P = 0.045), and the Cys/Cys homozygous genotype was associated with a significantly higher risk of metastatic disease in comparison ...

  
  

Mots clés : Prostate; Etiologie (Facteurs endogènes)

Menée sur une cohorte initiale de 930 cas de cancer épithélial ovarien et 1 037 témoins, puis sur une cohorte de 3 143 cas et 2 102 témoins, cette étude identifie des variants de deux gènes associés au processus inflammatoire, IL1A et ALOX5, en association avec le risque de cancer de l'ovaire

• Ovarian Cancer Risk Associated with Inherited Inflammation-Related Variants
  • Cancer Research, sous presse, 2012 (résumé)
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  Menée sur une cohorte initiale de 930 cas de cancer épithélial ovarien et 1 037 témoins, puis sur une cohorte de 3 143 cas et 2 102 témoins, cette étude identifie des variants de deux gènes associés au processus inflammatoire, IL1A et ALOX5, en association avec le risque de cancer de l'ovaire

  “Ovarian Cancer Risk Associated with Inherited Inflammation-Related Variants”

  • White, Kristin L.;Schildkraut, Joellen M.;Palmieri, Rachel T.;Iversen, Edwin S.;Berchuck, Andrew;Vierkant, Robert A.;Rider, David N.;Charbonneau, Bridget;Cicek, Mine S.;Sutphen, Rebecca;Birrer, Michael J.;Pharoah, Paul D. P.;Song, Honglin;Tyrer, Jonathan;Gayther, Simon A.;Ramus, Susan J.;Wentzensen, Nicolas;Yang, Hannah P.;Garcia-Closas, Montserrat;Phelan, Catherine M.;Cunningham, Julie M.;Fridley, Brooke L.;Sellers, Thomas A.;Goode, Ellen L.

  The importance of inflammation pathways to the development of many human cancers prompted us to examine the associations between single-nucleotide polymorphisms (SNPs) in inflammation-related genes and risk of ovarian cancer. In a multi-site case-control study, we genotyped SNPs in a large panel of inflammatory genes in 930 epithelial ovarian cancer cases and 1,037 controls using a custom array and analyzed by logistic regression. SNPs with p<0.10 were evaluated among 3,143 cases and 2,102 controls from the Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI) collaboration. Combined analysis revealed association with SNPs rs17561 and rs4848300 in the interleukin gene IL1A which varied by histologic subtype (heterogeneity p=0.03). For example, IL1A rs17561, which correlates with numerous inflammatory phenotypes, was associated with decreased risk of clear cell, mucinous, and endometrioid subtype, but not with the most common serous subtype. Genotype at ...

  
  

Mots clés : Ovaire; Etiologie (Facteurs endogènes)

A partir des données de 26 études observationnelles (1 213 cas et 2 666 témoins), cette étude évalue l'association entre des mutations des gènes BRCA1 et BRCA2 et la survie des patientes atteintes d'un cancer épithélial invasif de l'ovaire

• Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer
  • JAMA: The Journal of the American Medical Association, Vol. 307 (4), pp. 382-389, 2012 (résumé)
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  A partir des données de 26 études observationnelles (1 213 cas et 2 666 témoins), cette étude évalue l'association entre des mutations des gènes BRCA1 et BRCA2 et la survie des patientes atteintes d'un cancer épithélial invasif de l'ovaire

  “Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer”

  • Bolton, Kelly L.;Chenevix- Trench, Georgia;Goh, Cindy;Sadetzki, Siegal;Ramus, Susan J.;Karlan, Beth Y.;Lambrechts, Diether;Despierre, Evelyn;Barrowdale, Daniel;McGuffog, Lesley;Healey, Sue;Easton, Douglas F.;Sinilnikova, Olga;Benítez, Javier;García, María J.;Neuhausen, Susan;Gail, Mitchell H.;Hartge, Patricia;Peock, Susan;Frost, Debra;Evans, D. Gareth;Eeles, Rosalind;Godwin, Andrew K.;Daly, Mary B.;Kwong, Ava;Ma, Edmond S. K.;Lázaro, Conxi;Blanco, Ignacio;Montagna, Marco;D'Andrea, Emma;Nicoletto, Maria Ornella;Johnatty, Sharon E.;Kjær, Susanne Krüger;Jensen, Allan;Høgdall, Estrid;Goode, Ellen L.;Fridley, Brooke L.;Loud, Jennifer T.;Greene, Mark H.;Mai, Phuong L.;Chetrit, Angela;Lubin, Flora;Hirsh-Yechezkel, Galit;Glendon, Gord;Andrulis, Irene L.;Toland, Amanda E.;Senter, Leigha;Gore, Martin E.;Gourley, Charlie;Michie, Caroline O.;Song, Honglin;Tyrer, Jonathan;Whittemore, Alice S.;McGuire, Valerie;Sieh, Weiva;Kristoffersson, Ulf;Olsson, Håkan;Borg, Åke;Levine, Douglas A.;Steele, Linda;Beattie, Mary S.;Chan, Salina;Nussbaum, Robert L.;Moysich, Kirsten B.;Gross, Jenny;Cass, Ilana;Walsh, Christine;Li, Andrew J.;Leuchter, Ronald;Gordon, Ora;Garcia-Closas, Montserrat;Gayther, Simon A.;Chanock, Stephen J.;Antoniou, Antonis C.;Pharoah, Paul D. P.

  Context Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2 -related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear.Objective To characterize the survival of BRCA carriers with EOC compared with noncarriers and to determine whether BRCA1 and BRCA2 carriers show similar survival patterns.Design, Setting, and Participants A pooled analysis of 26 observational studies on the survival of women with ovarian cancer, which included data from 1213 EOC cases with pathogenic germline mutations in BRCA1 (n = 909) or BRCA2 (n = 304) and from 2666 noncarriers recruited and followed up at variable times between 1987 and 2010 (the median year of diagnosis was 1998).Main Outcome Measure Five-year overall mortality.Results The 5-year overall survival was 36% (95% CI, 34%-38%) for noncarriers, 44% (95% CI, 40%-48%) for BRCA1 carriers, and 52% ...

  
  
• Unwrapping the Implications of BRCA1 and BRCA2 Mutations in Ovarian Cancer
  • JAMA: The Journal of the American Medical Association, Vol. 307 (4), pp. 408-410, 2012 (éditorial)
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  A partir des données de 26 études observationnelles (1 213 cas et 2 666 témoins), cette étude évalue l'association entre des mutations des gènes BRCA1 et BRCA2 et la survie des patientes atteintes d'un cancer épithélial invasif de l'ovaire

  “Unwrapping the Implications of BRCA1 and BRCA2 Mutations in Ovarian Cancer”

  • Hyman, David M. ; Spriggs, David R.

  
  

Mots clés : Ovaire; Etiologie (Facteurs endogènes)

Menée à partir de 1 200 cas et 6 417 témoins, cette étude d'association sur le génome entier analyse les variants génétiques impliqués dans l'étiologie du lymphome hodgkinien en fonction de sous-types définis par le statut du virus d'Epstein-Barr (positif ou négatif)

• Genome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein–Barr Virus Status–Defined Subgroups
  • Journal of the National Cancer Institute, sous presse, 2012 (résumé)
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  Menée à partir de 1 200 cas et 6 417 témoins, cette étude d'association sur le génome entier analyse les variants génétiques impliqués dans l'étiologie du lymphome hodgkinien en fonction de sous-types définis par le statut du virus d'Epstein-Barr (positif ou négatif)

  “Genome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein–Barr Virus Status–Defined Subgroups”

  • Urayama, Kevin Y.;Jarrett, Ruth F.;Hjalgrim, Henrik;Diepstra, Arjan;Kamatani, Yoichiro;Chabrier, Amelie;Gaborieau, Valerie;Boland, Anne;Nieters, Alexandra;Becker, Nikolaus;Foretova, Lenka;Benavente, Yolanda;Maynadié, Marc;Staines, Anthony;Shield, Lesley;Lake, Annette;Montgomery, Dorothy;Taylor, Malcolm;Smedby, Karin Ekström;Amini, Rose-Marie;Adami, Hans-Olov;Glimelius, Bengt;Feenstra, Bjarke;Nolte, Ilja M.;Visser, Lydia;van Imhoff, Gustaaf W.;Lightfoot, Tracy;Cocco, Pierluigi;Kiemeney, Lambertus;Vermeulen, Sita H.;Holcatova, Ivana;Vatten, Lars;Macfarlane, Gary J.;Thomson, Peter;Conway, David I.;Benhamou, Simone;Agudo, Antonio;Healy, Claire M.;Overvad, Kim;Tjønneland, Anne;Melin, Beatrice;Canzian, Federico;Khaw, Kay-Tee;Travis, Ruth C.;Peeters, Petra H. M.;González, Carlos A.;Quirós, José Ramón;Sánchez, María-José;Huerta, José María;Ardanaz, Eva;Dorronsoro, Miren;Clavel-Chapelon, Françoise;Bueno-de-Mesquita, H. Bas;Riboli, Elio;Roman, Eve;Boffetta, Paolo;de Sanjosé, Silvia;Zelenika, Diana;Melbye, Mads;van den Berg, Anke;Lathrop, Mark;Brennan, Paul;McKay, James D.

  Background Accumulating evidence suggests that risk factors for classical Hodgkin lymphoma (cHL) differ by tumor Epstein–Barr virus (EBV) status. This potential etiological heterogeneity is not recognized in current disease classification.Methods We conducted a genome-wide association study of 1200 cHL patients and 6417 control subjects, with validation in an independent replication series, to identify common genetic variants associated with total cHL and subtypes defined by tumor EBV status. Multiple logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) assuming a log-additive genetic model for the variants. All statistical tests were two-sided.Results Two novel loci associated with total cHL irrespective of EBV status were identified in the major histocompatibility complex region; one resides adjacent to MICB (rs2248462: OR = 0.61, 95% CI = 0.53 to 0.69, P = 1.3 × 10−13) and the other at HLA-DRA (rs2395185: OR = 0.56, 95% CI = 0.50 to ...

  
  

Mots clés : Lymphome; Etiologie (Facteurs endogènes)

Menée en Corée du Sud auprès de 1 273 patients, cette étude rétrospective évalue l'association entre une histoire familiale de cancer, le risque de cancer de l'estomac, le risque de récidive de ce cancer et la survie des patients

• Association of Family History With Cancer Recurrence and Survival in Patients With Gastric Cancer
  • Journal of Clinical Oncology, sous presse, 2012 (résumé)
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  Menée en Corée du Sud auprès de 1 273 patients, cette étude rétrospective évalue l'association entre une histoire familiale de cancer, le risque de cancer de l'estomac, le risque de récidive de ce cancer et la survie des patients

  “Association of Family History With Cancer Recurrence and Survival in Patients With Gastric Cancer”

  • Han, Mi Ah;Oh, Myueng Guen;Choi, Il Ju;Park, Sook Ryun;Ryu, Keun Won;Nam, Byung-Ho;Cho, Soo-Jeong;Kim, Chan Gyoo;Lee, Jun Ho;Kim, Young-Woo

  Purpose Family history of gastric cancer is a major risk factor for the disease. In this study, we investigated the prognoses of patients with gastric cancer with a family history.Patients and Methods We retrospectively reviewed data from 1,273 patients with gastric adenocarcinoma who had undergone gastrectomy between 2001 and 2005 at a tertiary cancer center hospital. A positive family history was defined as a self-reported history of cancer in first- or second-degree relatives. Patients were followed up until December 2009 for death or recurrence. Clinicopathologic characteristics were compared by family history. Kaplan-Meier plots and Cox proportional hazards regressions were applied for disease-free survival (DFS), recurrence-free survival (RFS), and overall survival (OS).Results Of 1,273 patients, 263 patients (20.6%) had first-degree relatives with a history of gastric cancer. First-degree family history of gastric cancer was associated with better DFS, RFS, and OS (P = .012, ...

  
  
• Family History As a Positive Prognostic Factor in Gastric Cancer
  • Journal of Clinical Oncology, sous presse, 2012 (éditorial)
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  Menée en Corée du Sud auprès de 1 273 patients, cette étude rétrospective évalue l'association entre une histoire familiale de cancer, le risque de cancer de l'estomac, le risque de récidive de ce cancer et la survie des patients

  “Family History As a Positive Prognostic Factor in Gastric Cancer”

  • Nadauld, Lincoln D. ; Ford, James M.

  
  

Mots clés : Estomac; Etiologie (Facteurs endogènes)

Menée en République tchèque, cette étude (717 cas et 1 171 témoins) évalue l'association entre des polymorphismes à simple nucléotide de 140 gènes déjà identifiés et le risque de cancer colorectal

• Identification of candidate genes carrying polymorphisms associated with the risk of colorectal cancer by analyzing the colorectal mutome and microRNAome
  • Cancer, sous presse, 2012 (résumé)
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  Menée en République tchèque, cette étude (717 cas et 1 171 témoins) évalue l'association entre des polymorphismes à simple nucléotide de 140 gènes déjà identifiés et le risque de cancer colorectal

  “Identification of candidate genes carrying polymorphisms associated with the risk of colorectal cancer by analyzing the colorectal mutome and microRNAome”

  • Landi, Debora;Gemignani, Federica;Pardini, Barbara;Naccarati, Alessio;Garritano, Sonia;Vodicka, Pavel;Vodickova, Ludmila;Canzian, Federico;Novotny, Jan;Barale, Roberto;Landi, Stefano

  BACKGROUND: The presence of single-nucleotide polymorphisms (SNPs) within the 3′-untranslated regions of genes could affect the binding between a microRNA (miRNA) and its target, with consequences on gene expression regulation. Considering the important role of miRNAs in carcinogenesis, it is hypothesized here that these SNPs could also affect the individual risk of colorectal cancer (CRC). METHODS: To test this hypothesis, a list was developed of 140 somatically mutated genes deduced from previous works on the mutome of the CRC. A further selection was conducted of SNPs within target sites for miRNAs that are expressed only in the colorectum (the colorectal microRNAome) and having adequate population frequencies. This yielded 12 SNPs that were genotyped in a case-control association study on 717 colorectal cases and 1171 controls from the Czech Republic. RESULTS: Statistically significant associations were found between the risk of CRC and the variant alleles of KIAA0182 (rs709805) ...

  
  

Mots clés : Colon-rectum; Etiologie (Facteurs endogènes)

A partir des données de la cohorte européenne EPIC incluant 1 202 participants, cette étude prospective évalue l'association entre le niveau sanguin de calcifédiol (vitamine D) mesuré avant le diagnostic d'un cancer colorectal, des polymorphismes des gènes VDR et CASR, et la survie des patients

• Pre-diagnostic 25-Hydroxyvitamin D, VDR and CASR Polymorphisms, and Survival in Patients with Colorectal Cancer in Western European Populations
  • Cancer Epidemiology Biomarkers & Prevention, sous presse, 2012 (résumé)
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  A partir des données de la cohorte européenne EPIC incluant 1 202 participants, cette étude prospective évalue l'association entre le niveau sanguin de calcifédiol (vitamine D) mesuré avant le diagnostic d'un cancer colorectal, des polymorphismes des gènes VDR et CASR, et la survie des patients

  “Pre-diagnostic 25-Hydroxyvitamin D, VDR and CASR Polymorphisms, and Survival in Patients with Colorectal Cancer in Western European Populations”

  • Fedirko, Veronika;Riboli, Elio;Tjonneland, Anne;Ferrari, Pietro;Olsen, Anja;Bueno-de-Mesquita, H. Bas;van Duijnhoven, Franzel;Norat, Teresa;Jansen, Eugene;Dahm, Christina C.;Overvad, Kim;Boutron-Ruault, Marie-Christine;Clavel-Chapelon, Francoise;Racine, Antoine;Lukanova, Annekatrin;Teucher, Birgit;Boeing, Heiner;Aleksandrova, Krasimira;Trichopoulou, Antonia;Benetou, Vassiliki;Trichopoulos, Dimitrios;Grioni, Sara;Vineis, Paolo;Panico, Salvatore;Palli, Domenico;Tumino, Rosario;Siersema, Peter D.;Peeters, Petra H.M.;Skeie, Guri;Brustad, Magritt;Chirlaque, Maria-Dolores;Barricarte Gurrea, Aurelio;Quirós Garcia, Jose Ramón;Sanchez, Maria-Jose;Dorronsoro, Miren;Bonet, Catalina;Palmqvist, Richard;Hallmans, Goran;Key, Timothy J.;Crowe, Francesca L.;Khaw, Kay-Tee;Wareham, Nicholas J.;Romieu, Isabelle I.;McKay, James;Wark, Petra A.;Romaguera, Dora;Jenab, Mazda

  Background: Individuals with higher blood 25-hydroxy-vitamin D [25(OH)D] levels have a lower risk of developing colorectal cancer (CRC), but the influence of 25(OH)D on mortality after CRC diagnosis is unknown. Methods: The association between pre-diagnostic 25(OH)D levels and CRC-specific (N=444) and overall mortality (N=541) was prospectively examined among 1,202 participants diagnosed with CRC between 1992-2003 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) according to 25(OH)D quintiles and genetic variation within the VDR and CASR genes. Potential dietary, lifestyle and metabolic effect modifiers were also investigated. Results: There were 541 deaths, 444 (82%) due to CRC. Mean follow-up was 73 months. In multivariable analysis, higher 25(OH)D levels were associated with a statistically significant reduction ...

  
  

Mots clés : Colon-rectum; Etiologie (Facteurs endogènes)

Cette étude de cohorte en population danoise évalue, chez 20 000 patients atteints de la maladie de Parkinson, le risque de mélanome malin, de cancers de la peau hors mélanome, et de cancer du sein

• Malignant melanoma, breast cancer and other cancers in patients with parkinson disease
  • International Journal of Cancer, sous presse, 2012 (résumé)
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  Cette étude de cohorte en population danoise évalue, chez 20 000 patients atteints de la maladie de Parkinson, le risque de mélanome malin, de cancers de la peau hors mélanome, et de cancer du sein

  “Malignant melanoma, breast cancer and other cancers in patients with parkinson disease”

  • Rugbjerg, Kathrine;Friis, Søren;Lassen, Christina Funch;Ritz, Beate;Olsen, Jørgen H.

  Previous studies report an atypical cancer pattern among patients with Parkinson disease. Here we evaluate the cancer pattern among people diagnosed with Parkinson disease in an extension of our previous cohort study. For this Danish population based cohort study we identified 20,000 people with Parkinson disease diagnosed in 1977–2006, from the National Danish Hospital Register. Cohort members were followed up for cancer in the Danish Cancer Registry until 31 December 2008, and their incidence rates of cancer were compared with age-, sex- and calendar period-specific rates in the general population as standardized incidence rate ratios (SIRs). In sub analyses we estimated the risk for cancer among patients with early-onset Parkinson disease and also, we compared breast tumor characteristics among Parkinson disease women to that of a control group. The overall cancer risk in our cohort was decreased (SIR, 0.86; 95% confidence interval (CI), 0.83–0.90), as were those for ...

  
  

Mots clés : Cancer (général); Etiologie (Facteurs endogènes)