Lutte contre les cancers

Menée auprès de 103 patientes atteintes d'un cancer du sein et ayant terminé leur premier traitement, cette étude évalue la fatigue, la dépression et les troubles du sommeil des survivantes en association avec des symptômes inflammatoires causés par la chimiothérapie

• Inflammation and Behavioral Symptoms After Breast Cancer Treatment: Do Fatigue, Depression, and Sleep Disturbance Share a Common Underlying Mechanism?
  • Journal of Clinical Oncology, sous presse, 2011 (résumé)
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  Menée auprès de 103 patientes atteintes d'un cancer du sein et ayant terminé leur premier traitement, cette étude évalue la fatigue, la dépression et les troubles du sommeil des survivantes en association avec des symptômes inflammatoires causés par la chimiothérapie

  “Inflammation and Behavioral Symptoms After Breast Cancer Treatment: Do Fatigue, Depression, and Sleep Disturbance Share a Common Underlying Mechanism?”

  • Bower, Julienne E.;Ganz, Patricia A.;Irwin, Michael R.;Kwan, Lorna;Breen, Elizabeth C.;Cole, Steve W.

  Purpose Fatigue, depression, and sleep disturbance are common adverse effects of cancer treatment and frequently co-occur. However, the possibility that inflammatory processes may underlie this constellation of symptoms has not been examined.Patients and Methods Women (N = 103) who had recently finished primary treatment (ie, surgery, radiation, chemotherapy) for early-stage breast cancer completed self-report scales and provided blood samples for determination of plasma levels of inflammatory markers: soluble tumor necrosis factor (TNF) receptor II (sTNF-RII), interleukin-1 receptor antagonist, and C-reactive protein.Results Symptoms were elevated at the end of treatment; greater than 60% of participants reported clinically significant problems with fatigue and sleep, and 25% reported elevated depressive symptoms. Women treated with chemotherapy endorsed higher levels of all symptoms and also had higher plasma levels of sTNF-RII than women who did not receive chemotherapy (all P < ...

  
  

Mots clés : Sein; Lutte contre les cancers (Qualité de vie, soins de support)

Cette étude en population américaine évalue l'impact de la qualité de vie globale mesurée avant le début des traitements sur la survie de 1 194 patients atteints d'un cancer du poumon non à petites cellules

• Quality of Life Assessment as a Predictor of Survival in Non-Small Cell Lung Cancer
  • BMC Cancer, Vol. 11 (1), pp. 353, 2011 (article en libre accès)
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  Cette étude en population américaine évalue l'impact de la qualité de vie globale mesurée avant le début des traitements sur la survie de 1 194 patients atteints d'un cancer du poumon non à petites cellules

  “Quality of Life Assessment as a Predictor of Survival in Non-Small Cell Lung Cancer”

  • Braun, Donald;Gupta, Digant;Staren, Edgar

  BACKGROUND:There are conflicting and inconsistent results in the literature on the prognostic role of quality of life (QoL) in cancer. We investigated whether QoL at admission could predict survival in lung cancer patients. METHODS:The study population consisted of 1194 non-small cell lung cancer patients treated at our institution between Jan 2001 and Dec 2008. QoL was evaluated using EORTC-QLQ-C30 prior to initiation of treatment. Patient survival was defined as the time interval between the date of first patient visit and the date of death from any cause/date of last contact. Univariate and multivariate Cox regression evaluated the prognostic significance of QoL. RESULTS:Mean age at presentation was 58.3 years. There were 605 newly diagnosed and 589 previously treated patients; 601 males and 593 females. Stage of disease at diagnosis was I, 100; II, 63; III, 348; IV, 656; and 27 indeterminate. Upon multivariate analyses, global QoL as well as physical function predicted patient ...

  
  

Mots clés : Poumon; Lutte contre les cancers (Qualité de vie, soins de support)

Cette étude espagnole évalue, en fonction de caractéristiques sociodémographiques et de composantes psychologiques (estime de soi, perception du métier), la détresse psychologique de 159 soignants de patients atteints d’un cancer avancé ou en phase terminale

• Caregivers’ morbidity in palliative care unit: predicting by gender, age, burden and self-esteem
  • Supportive Care in Cancer, pp. 1-6, 2011 (résumé)
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  Cette étude espagnole évalue, en fonction de caractéristiques sociodémographiques et de composantes psychologiques (estime de soi, perception du métier), la détresse psychologique de 159 soignants de patients atteints d’un cancer avancé ou en phase terminale

  “Caregivers’ morbidity in palliative care unit: predicting by gender, age, burden and self-esteem”

  • Costa-Requena, Gema;Cristófol, Ramon;Cañete, José

  Purpose This study assesses psychological distress suffered by caregivers of patients with a disease at an advanced and terminal state admitted at a palliative care unit. Specifically, these areas were examined in how distress was perceived: the contribution of caregiving burden, caregivers’ self-esteem, caregivers’ age and gender. Methods The sample constituted of 159 caregivers. Measurements included the Hospital Anxiety and Depression Scale (HADS) to assess distress, the shortened version of the Zarit Burden Inventory and Rosenberg self-esteem scale. Results Approximately 77% of the caregivers reported probable significant distress (HADS ≥12), with a similar proportion with anxiety (76.1%) and depression (77.4%) within the caregivers’ symptomatology. Multiple regression analysis revealed that the caregivers’ self-esteem ( p < 0.01) and caregivers’ burden ( p < 0.01) were stronger predictors of caregivers’ distress than the socio-demographic characteristics, age ...

  
  

Mots clés : Lutte contre les cancers (Qualité de vie, soins de support)

Menée sur 83 patients atteints de cancer, cette étude néerlandaise évalue si la réduction de leur fatigue à la suite d’une thérapie comportementale cognitive s'explique par une augmentation de l’activité physique

• Examining the role of physical activity in reducing postcancer fatigue
  • Supportive Care in Cancer, pp. 1-7, 2011 (article en libre accès)
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  Menée sur 83 patients atteints de cancer, cette étude néerlandaise évalue si la réduction de leur fatigue à la suite d’une thérapie comportementale cognitive s'explique par une augmentation de l’activité physique

  “Examining the role of physical activity in reducing postcancer fatigue”

  • Gielissen, Marieke;Wiborg, Jan;Verhagen, Constans;Knoop, Hans;Bleijenberg, Gijs

  Purpose Persistent fatigue is a long-term adverse effect experienced in about a quarter of patients cured of cancer. It was shown that cognitive behavior therapy (CBT) especially designed for postcancer fatigue is highly effective in reducing severe fatigue. However, it is unclear by what mechanism the fatigue reduction is reached. In many fatigue reduction programs, an increase in physical activity is assumed to reduce fatigue. The purpose of the present study is to determine whether the effect of CBT on fatigue is mediated by an increase in physical activity. Methods Data of a previous randomized controlled trial on the efficacy of CBT for postcancer fatigue were reanalyzed (CBT, n = 41; waiting list condition, n = 42). Actigraphy was used to assess the level of objective physical activity. Cancer survivors were assessed prior as well as after the CBT and waiting list period. The mediation hypothesis was tested according to guidelines of Baron and Kenny. A non-parametric bootstrap ...

  
  

Mots clés : Lutte contre les cancers (Qualité de vie, soins de support)

Mené auprès de 400 participants suédois et 695 participants finlandais, cet essai randomisé évalue la qualité de vie à long terme de survivants d'un cancer de la prostate ayant subi une prostatectomie radicale ou bénéficiant d'une surveillance active (durée médiane de suivi : 12 ans)

• Long-term quality of life in prostate cancer
  • The Lancet Oncology, sous presse, 2011 (commentaire)
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  Mené auprès de 400 participants suédois et 695 participants finlandais, cet essai randomisé évalue la qualité de vie à long terme de survivants d'un cancer de la prostate ayant subi une prostatectomie radicale ou bénéficiant d'une surveillance active (durée médiane de suivi : 12 ans)

  “Long-term quality of life in prostate cancer”

  • Hamdy, Freddie C.

  Long-term quality-of-life outcomes after radical prostatectomy or watchful waiting: the Scandinavian Prostate Cancer Group-4 randomised trial

  
  
• Long-term quality-of-life outcomes after radical prostatectomy or watchful waiting: the Scandinavian Prostate Cancer Group-4 randomised trial
  • The Lancet Oncology, sous presse, 2011 (résumé)
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  Mené auprès de 400 participants suédois et 695 participants finlandais, cet essai randomisé évalue la qualité de vie à long terme de survivants d'un cancer de la prostate ayant subi une prostatectomie radicale ou bénéficiant d'une surveillance active (durée médiane de suivi : 12 ans)

  “Long-term quality-of-life outcomes after radical prostatectomy or watchful waiting: the Scandinavian Prostate Cancer Group-4 randomised trial”

  • Johansson, Eva ; Steineck, Gunnar ; Holmberg, Lars ; Johansson, Jan-Erik ; Nyberg, Tommy ; Ruutu, Mirja ; Bill-Axelson, Anna

  For men with localised prostate cancer, surgery provides a survival benefit compared with watchful waiting. Treatments are associated with morbidity. Results for functional outcome and quality of life are rarely reported beyond 10 years and are lacking from randomised settings. We report results for quality of life for men in the Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) after a median follow-up of more than 12 years. All living Swedish and Finnish men (400 of 695) randomly assigned to radical prostatectomy or watchful waiting in SPCG-4 from 1989 to 1999 were included in our analysis. An additional 281 men were included in a population-based control group matched for region and age. Physical symptoms, symptom-induced stress, and self-assessed quality of life were evaluated with a study-specific questionnaire. Longitudinal data were available for 166 Swedish men who had answered quality-of-life questionnaires at an earlier timepoint. 182 (88%) of 208 men in the radical ...

  
  

Mots clés : Prostate; Lutte contre les cancers (Qualité de vie, soins de support)

Menée en population allemande auprès de 234 survivants à 5 ans et de 196 survivants à 10 ans d'un cancer colorectal, cette étude évalue leur qualité de vie

• Health-Related Quality of Life During the 10 Years After Diagnosis of Colorectal Cancer: A Population-Based Study
  • Journal of Clinical Oncology, sous presse, 2011 (résumé)
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  Menée en population allemande auprès de 234 survivants à 5 ans et de 196 survivants à 10 ans d'un cancer colorectal, cette étude évalue leur qualité de vie

  “Health-Related Quality of Life During the 10 Years After Diagnosis of Colorectal Cancer: A Population-Based Study”

  • Jansen, Lina;Herrmann, Antje;Stegmaier, Christa;Singer, Susanne;Brenner, Hermann;Arndt, Volker

  Purpose To compare long-term quality of life (QoL) of colorectal cancer survivors with QoL in the general population and investigate changes in QoL of survivors during the 10 years after diagnosis.Patients and Methods Health-related QoL was assessed 1, 3, 5, and 10 years after diagnosis in a population-based cohort starting with 439 patients with colorectal cancer from Saarland, Germany, using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30. QoL after 5 and 10 years and time course of QoL during the 10 years after diagnosis were compared with controls from the general population of Germany, after controlling for sex and age.Results Overall, 234 and 196 patients were still alive after 5 and 10 years, respectively. Of these survivors, 178 (76%) responded in the 5-year follow-up, 133 (68%) in the 10-year follow-up, and 117 (60%) participated in all follow-ups. Over the entire follow-up, younger survivors (age at diagnosis, < 60 years) ...

  
  

Mots clés : Colon-rectum; Lutte contre les cancers (Qualité de vie, soins de support)

Mené auprès de 744 patients randomisés atteints d’un cancer, cet essai américain multicentrique en double-aveugle montre que le gingembre réduit les nausées liées à une chimiothérapie

• Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients
  • Supportive Care in Cancer, pp. 1-11, 2011 (résumé)
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  Mené auprès de 744 patients randomisés atteints d’un cancer, cet essai américain multicentrique en double-aveugle montre que le gingembre réduit les nausées liées à une chimiothérapie

  “Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients”

  • Ryan, Julie;Heckler, Charles;Roscoe, Joseph;Dakhil, Shaker;Kirshner, Jeffrey;Flynn, Patrick;Hickok, Jane;Morrow, Gary

  Purpose Despite the widespread use of antiemetics, nausea continues to be reported by over 70% of patients receiving chemotherapy. Methods In this double blind, multicenter trial, we randomly assigned 744 cancer patients to four arms: 1) placebo, 2) 0.5 g ginger, 3) 1.0 g ginger, or 4) 1.5 g ginger. Nausea occurrence and severity were assessed at a baseline cycle and the two following cycles during which patients were taking their assigned study medication. All patients received a 5-HT 3 receptor antagonist antiemetic on Day 1 of all cycles. Patients took three capsules of ginger (250 mg) or placebo twice daily for 6 days starting 3 days before the first day of chemotherapy. Patients reported the severity of nausea on a 7-point rating scale (“1” = “Not at all Nauseated” and “7” = “Extremely Nauseated”) for Days 1–4 of each cycle. The primary outcomes were to determine the dose and efficacy of ginger at reducing the severity of chemotherapy-induced nausea on Day 1 of ...

  
  

Mots clés : Lutte contre les cancers (Qualité de vie, soins de support)

Menée auprès de 962 patients atteints de cancer, cette étude américaine évalue l'incidence et la persistence des troubles du sommeil

• Natural Course of Insomnia Comorbid With Cancer: An 18-Month Longitudinal Study
  • Journal of Clinical Oncology, sous presse, 2011 (résumé)
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  Menée auprès de 962 patients atteints de cancer, cette étude américaine évalue l'incidence et la persistence des troubles du sommeil

  “Natural Course of Insomnia Comorbid With Cancer: An 18-Month Longitudinal Study”

  • Savard, Josée;Ivers, Hans;Villa, Julie;Caplette-Gingras, Aude;Morin, Charles M.

  Purpose This study aimed to assess the prevalence and natural course (incidence, persistence, remission, and relapse) of insomnia comorbid with cancer during an 18-month period.Patients and Methods All patients scheduled to receive a curative surgery for a first diagnosis of nonmetastatic cancer were approached on the day of their preoperative visit to participate in the study. A total of 962 patients with cancer (mixed sites) completed an insomnia diagnostic interview at the perioperative phase (T1), as well as at 2 (T2), 6 (T3) 10 (T4), 14 (T5), and 18 (T6) months after surgery.Results Findings revealed high rates of insomnia at baseline (59%), including 28% with an insomnia syndrome. The prevalence of insomnia generally declined over time but remained pervasive even at the end of the 18-month period (36%). Rates were greater in patients with breast (42% to 69%) and gynecologic (33% to 68%) cancer and lower in men with prostate cancer (25% to 39%) throughout the study. Nearly 15% of ...

  
  

Mots clés : Lutte contre les cancers (Qualité de vie, soins de support)

Cette étude transversale coréenne analyse la qualité de vie et la santé mentale de 501 personnes dont un membre de la famille est en phase terminale de cancer

• Quality of life and mental health in the bereaved family members of patients with terminal cancer
  • Psycho-Oncology, sous presse, 2011 (résumé)
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  Cette étude transversale coréenne analyse la qualité de vie et la santé mentale de 501 personnes dont un membre de la famille est en phase terminale de cancer

  “Quality of life and mental health in the bereaved family members of patients with terminal cancer”

  • Song, Jong Im;Shin, Dong Wook;Choi, Jin-Young;Kang, Jina;Baek, Young-Ji;Mo, Ha-Na;Seo, Min-Jeong;Hwang, Yun Hee;Lim, Yeun-Keun;Lee, Ok Kyoung

  Objective : This study specifically aimed to compare quality of life (QOL) and mental health in bereaved family members of patients with cancer with that of the general population and to examine factors associated with QOL and mental health in this population. Design : A nationwide multicenter, cross-sectional survey was administered to the bereaved family members of patients with terminal cancer. Setting : Thirty-three palliative care centers designated by the Ministry of Health and Welfare participated in this study. Participants : The participants in this study were 501 bereaved family members of patients with terminal cancer and matched control individuals from the Korean National Health and Nutrition Examination Survey. Measurement : EQ-5D and several questions used in Korean National Health And Nutrition Examination Survey were used in to measure health-related QOL and mental health. Results : Health-related QOL, as determined by EQ-5D, was significantly lower in bereaved family ...

  
  

Mots clés : Lutte contre les cancers (Qualité de vie, soins de support)

Menée sur 39 patients atteints d’un cancer colorectal de stade III/IV et d’une neuropathie chronique induite par l’oxaliplatine, cette étude taïwanaise évalue l’efficacité et la tolérabilité de la duloxétine, un antidépresseur, dans le traitement de la douleur liée à la neuropathie

• Duloxetine improves oxaliplatin-induced neuropathy in patients with colorectal cancer: an open-label pilot study
  • Supportive Care in Cancer, pp. 1-7, 2011 (résumé)
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  Menée sur 39 patients atteints d’un cancer colorectal de stade III/IV et d’une neuropathie chronique induite par l’oxaliplatine, cette étude taïwanaise évalue l’efficacité et la tolérabilité de la duloxétine, un antidépresseur, dans le traitement de la douleur liée à la neuropathie

  “Duloxetine improves oxaliplatin-induced neuropathy in patients with colorectal cancer: an open-label pilot study”

  • Yang, Ya-Hsu;Lin, Jen-Kou;Chen, Wei-Shone;Lin, Tzu-Chen;Yang, Shung-Haur;Jiang, Jeng-Kai;Chang, Shih-Ching;Lan, Yuan-Tzu;Lin, Chun-Chi;Yen, Chueh-Chuan;Tzeng, Cheng-Hwai;Wang, Wei-Shu;Chiang, Huey-Ling;Teng, Chung-Jen;Teng, Hao-Wei

  Background This open-label pilot study is aimed to evaluate the efficacy and tolerability of the antidepressant duloxetine, which is effective for diabetic neuropathic pain, in the treatment of chronic oxaliplatin-induced peripheral neuropathy (OIPN). Methods We enrolled a total of 39 patients with stage III or IV colorectal cancer with chronic OIPN. They were treated with duloxetine by increasing the dose from 30 mg/day to 60 mg/day. Patients’ pain intensity was rated at baseline and 12 weeks after duloxetine administration. The severity of neuropathic pain was evaluated using the visual analog scale (VAS) score and the National Cancer Institute Common Toxicity Criteria for Adverse Events, version 3 (NCI-CTCAE v3.0). Results Nine patients (23.1%) discontinued duloxetine before the end of treatment because of adverse events. Of the remaining 30 patients, 19 patients (63.3%) had a VAS score improvement. Among them, nine (47.4%) showed a simultaneous grade improvement, and the other ...

  
  

Mots clés : Colon-rectum; Lutte contre les cancers (Qualité de vie, soins de support)

A partir des données du registre des cancers, cette étude espagnole (698 cas) analyse l'incidence des tumeurs neuroendocriniennes et le taux de survie dans la province de Girone entre 1994 et 2004

• Neuroendocrine tumors: A population-based study of incidence and survival in Girona province, 1994-2004
  • Cancer Epidemiology, sous presse, 2011 (résumé)
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  A partir des données du registre des cancers, cette étude espagnole (698 cas) analyse l'incidence des tumeurs neuroendocriniennes et le taux de survie dans la province de Girone entre 1994 et 2004

  “Neuroendocrine tumors: A population-based study of incidence and survival in Girona province, 1994-2004”

  • Alsina, Maria;Marcos-Gragera, Rafael;Capdevila, Jaume;Buxó, Maria;Ortiz, Rosa Maria;Barretina, Pilar;Vilardell, Loreto;Brunet, Joan;Beltran, Miquel;Izquierdo, Àngel

  Background: Neuroendocrine tumors (NETs) belong to a rare and heterogeneous group of neoplasms with a wide range of aggressiveness. Little information is available about incidence and mortality of NETs in the World population. The objective of this study was to report the incidence and survival of these tumors in Girona Province. Methods: We include all ICD-O3 codes that codified a NET, period 1994-2004. Data from malignant NETs came directly from the Girona Cancer Registry, and data from benign or with uncertain behavior NETs directly from the Anatomic-Pathological Laboratories. Results: We identified 698 NETs, the most frequent were those aroused in the bronco-pulmonary system (65.75%), followed by the gastro-entero-pancreatics (GEP) (12.75%). Small cell lung carcinomas were the most frequent NETs of the bronco-pulmonary system (92.59%), with an age-standardized incidence rate (ASRw, world population standard) of 4.29/100,000 person-years. Carcinoid lung tumors had an ASRw of ...

  
  

Mots clés : Glande endocrine (autre); Lutte contre les cancers (Observation)

Menée au Royaume-Uni, cette étude de cohorte, incluant 3 866 patients atteints d'un cancer de l'oesophage ou de l'estomac, évalue l'association entre le volume d'opérations chirurgicales effectuées en hôpital et la survie des patients traités

• Hospital volume and survival in oesophagectomy and gastrectomy for cancer
  • European journal of cancer (Oxford, England : 1990), sous presse, 2011 (résumé)
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  Menée au Royaume-Uni, cette étude de cohorte, incluant 3 866 patients atteints d'un cancer de l'oesophage ou de l'estomac, évalue l'association entre le volume d'opérations chirurgicales effectuées en hôpital et la survie des patients traités

  “Hospital volume and survival in oesophagectomy and gastrectomy for cancer”

  • Anderson, Oliver;Ni, Zhifang;Møller, Henrik;Coupland, Victoria H.;Davies, Elizabeth A.;Allum, William H.;Hanna, George B.

  High volume upper gastrointestinal cancer hospitals demonstrate improved postoperative mortality rates, but the impact on survival is unclear. This population-based cohort study explores the effect of hospital volume on survival following upper gastrointestinal cancer surgery. This study used a population-based cohort of 3866 patients who underwent surgery for oesophageal or gastric cancer between 1998 and 2008 with follow-up until December 2008. Hospital volume ranged from 1 to 68 cases/year. Overall, 5-year survival was 27%. Increasing age and advanced stage of disease were independently correlated with shorter survival. High hospital volume was significantly and independently correlated with improved 30-day mortality postoperatively (P<0.001), but not with survival beyond 30days. The correlation between hospital volume and improved 30-day mortality following oesophageal and gastric cancer surgery supports the centralisation of upper gastrointestinal cancer surgery services. The low ...

  
  

Mots clés : Lutte contre les cancers (Observation)

A partir des données du registre des cancers suédois, cette étude évalue l'augmentation de l'incidence de carcinome épidermoïde de la peau entre 1970 et 2007 dans la partie ouest de la Suède

• Incidence of cutaneous squamous cell carcinoma in coastal and inland areas of Western Sweden
  • Cancer Epidemiology, sous presse, 2011 (résumé)
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  A partir des données du registre des cancers suédois, cette étude évalue l'augmentation de l'incidence de carcinome épidermoïde de la peau entre 1970 et 2007 dans la partie ouest de la Suède

  “Incidence of cutaneous squamous cell carcinoma in coastal and inland areas of Western Sweden”

  • Andersson, E. M.;Paoli, J.;Wastensson, G.

  Background The incidence of squamous cell carcinoma (SCC) has increased in recent decades, both in Sweden and worldwide. The aim of this study was to investigate the development of SCC over time (1970-2007) in the western part of Sweden (WS), with emphasis on the incidence trends on the coast and in the inland areas.Methods Cancer data on SCC for different subareas in WS were obtained from the Swedish Cancer Registry. The incidence standardized for the Swedish population in 2000 was analyzed. The incidence trends were estimated and compared using regression analysis.Results The incidence was significantly higher in the coastal areas. The incidence rate in 2007 was higher for men than for women, whereas the average growth of the incidence was higher among women.Conclusion This study shows that another important aspect regarding sun exposure, apart from latitude, is whether an area lies in the inland or on the coast. The higher sun exposure on the coast is associated with higher ...

  
  

Mots clés : Peau (hors mélanome); Lutte contre les cancers (Observation)

Menée en Italie, cette étude en population analyse l'évolution de la mortalité des patients atteints de carcinome à cellules de Merkel sur la période 1995-2006 et l'association de cette pathologie avec d'autres cancers

• Merkel cell carcinoma: a population-based study on mortality and the association with other cancers
  • Cancer Causes and Control, pp. 1-7, 0 (article en libre accès)
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  Menée en Italie, cette étude en population analyse l'évolution de la mortalité des patients atteints de carcinome à cellules de Merkel sur la période 1995-2006 et l'association de cette pathologie avec d'autres cancers

  “Merkel cell carcinoma: a population-based study on mortality and the association with other cancers”

  • Ascoli, Valeria;Minelli, Giada;Kanieff, Mark;Frova, Luisa;Conti, Susanna

  Background Few population-based epidemiological data are available on Merkel cell carcinoma (MCC), a rare lethal non-melanoma skin cancer. We analysed multiple-cause-of-death records to describe MCC mortality and trends and the association with other primary cancers. Methods We reviewed all 6,713,059 death certificates in Italy (1995–2006) to identify those mentioning MCC. We evaluated the association with other primary cancers by calculating the ratio of observed to expected deaths, using a standardized mortality ratio (SMR)-like analysis. We also evaluated the geographic distribution of deaths. Results We identified 351 death certificates with the mention of MCC. The age-adjusted mortality was 0.031/100,000, with a significant trend of increase and a slight north–south gradient. There was a significant deficit for solid cancers (SMR = 0.15) and a non-significant excess for lymphohematopoietic malignancies (SMR = 1.62). There were significant excesses for chronic lymphocytic ...

  
  

Mots clés : Peau (hors mélanome); Lutte contre les cancers (Observation)

A partir des données des registres suédois du cancer, cette étude évalue les disparités socioéconomiques dans les traitements et la mortalité des hommes à haut risque de cancer de la prostate

• Differences according to socioeconomic status in the management and mortality in men with high risk prostate cancer
  • European journal of cancer (Oxford, England : 1990), sous presse, 2011 (résumé)
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  A partir des données des registres suédois du cancer, cette étude évalue les disparités socioéconomiques dans les traitements et la mortalité des hommes à haut risque de cancer de la prostate

  “Differences according to socioeconomic status in the management and mortality in men with high risk prostate cancer”

  • Berglund, Anders;Garmo, Hans;Robinson, David;Tishelman, Carol;Holmberg, Lars;Bratt, Ola;Adolfsson, Jan;Stattin, Pär;Lambe, Mats

  Outcomes for many cancer forms are associated with socioeconomic status (SES).We investigated if SES was associated with management and mortality in men with high risk prostate cancer. A nation-wide population-based cohort in Prostate Cancer Data Base Sweden (PCBaSe), a merged database including data on incident prostate cancer identified in the National Prostate Cancer Register (NPCR) between 1997 and 2006. High risk PCa was defined as T3 tumour, and/or Gleason score 8–10 and/or PSA 20–50ng/mL. Use of bone scan, curative treatment, and mortality in relation to SES was assessed by logistic, Cox, and competing risk regression with hazard ratios (HR), sub-distributed HR and 95% confidence intervals (CI) adjusted for co-morbidity, age, calendar period and clinical subgroups. Amongst 17,522 high risk prostate cancer patients, a bone scan was more often performed in higher white-collar than in blue-collar workers (OR 1.30; 95% CI 1.21–1.40). Amongst men without metastases, the ...

  
  

Mots clés : Prostate; Lutte contre les cancers (Observation)

A partir des données des registres néerlandais du cancer, cette étude évalue les disparités géographiques dans l'incidence du cancer colorectal aux Pays-Bas sur la période 2001-2005

• Spatial variation in stage distribution in colorectal cancer in the Netherlands
  • European journal of cancer (Oxford, England : 1990), sous presse, 2011 (résumé)
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  A partir des données des registres néerlandais du cancer, cette étude évalue les disparités géographiques dans l'incidence du cancer colorectal aux Pays-Bas sur la période 2001-2005

  “Spatial variation in stage distribution in colorectal cancer in the Netherlands”

  • Elferink, M. A. G.;Pukkala, E.;Klaase, J. M.;Siesling, S.

  In the Netherlands the incidence of colorectal cancer has increased, mainly in the eastern part of the country. Patient delay due to unawareness or ignorance of symptoms and differences in use of diagnostic tools could have influence on the stage distribution. The aim of this study was to evaluate geographical differences in stage-specific incidence rates of colon and rectal cancer in the Netherlands. Age-adjusted incidence rates for cancers of the colon and rectum diagnosed in 2001–2005 and registered in the Netherlands Cancer Registry were calculated for each municipality and stage. The incidence for each 500m by 500m grid was estimated as a weighted average of the incidence rates of the neighbouring municipalities. The incidence rates and the stage distribution are both presented as maps. Geographic variation in stage-specific incidence was evaluated using spatial scan statistic. In both colon and rectal cancer, significant spatial variation in stage-specific incidences was ...

  
  

Mots clés : Colon-rectum; Lutte contre les cancers (Observation)

A partir des données du registre régional des cancers, cette étude évalue les disparités géographiques et socio-économiques dans le risque de cancers du poumon et du côlon-rectum en Bavière

• Associations between regional socioeconomic deprivation and cancer risk: Analysis of Population-based Cancer Registry data from Bavaria, Germany
  • Preventive Medicine, sous presse, 0 (résumé)
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  A partir des données du registre régional des cancers, cette étude évalue les disparités géographiques et socio-économiques dans le risque de cancers du poumon et du côlon-rectum en Bavière

  “Associations between regional socioeconomic deprivation and cancer risk: Analysis of Population-based Cancer Registry data from Bavaria, Germany”

  • Kuznetsov, Laura;Maier, Werner;Hunger, Matthias;Meyer, Martin;Mielck, Andreas

  Objective Previous research from other countries shows a positive association between cancer risk and regional deprivation. This study explores this association for lung and colorectal cancers in Germany. Method Regional deprivation was assessed by the ‘Bavarian Index of Multiple Deprivation’. Cancer data were provided by the Cancer Registry of Bavaria (2003–2006). The association between cancer risk and regional deprivation was evaluated by multilevel Poisson regression analysis. Results Crude incidence and mortality rates (per 1000 people) in the least deprived areas were 1.46 and 0.92 for lung cancer, 2.82 and 0.69 for colorectal cancer. For lung cancer, the age-adjusted relative risk (RR) for incidence in the most deprived districts (compared with the least deprived) in men was 1.41 (95% CI: 1.28–1.54), for mortality 1.59 (95% CI: 1.40–1.80); in women, an elevated RR was seen for mortality (1.24, 95% CI: 1.06–1.46). For colorectal cancer, the RR for incidence (men: ...

  
  

Mots clés : Lutte contre les cancers (Observation)

Menée à partir des données des registres britanniques du cancer, cette étude évalue l'incidence des seconds cancers associés à la radiothérapie pour l'année 2007 au Royaume-Uni

• The cancer burden in the United Kingdom in 2007 due to radiotherapy
  • International Journal of Cancer, sous presse, 2011 (résumé)
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  Menée à partir des données des registres britanniques du cancer, cette étude évalue l'incidence des seconds cancers associés à la radiothérapie pour l'année 2007 au Royaume-Uni

  “The cancer burden in the United Kingdom in 2007 due to radiotherapy”

  • Maddams, Jacob;Parkin, D. Maxwell;Darby, Sarah C.

  Abstract The number of long-term cancer survivors in the general population of the UK is substantial and increasing rapidly. Many cancer survivors have been treated with radiotherapy but the likely number of radiotherapy-related second cancers has not previously been estimated. We used estimates of the numbers of cancer survivors in the UK at the beginning of 2007, in conjunction with estimates of the relative risk of a second primary cancer associated with previous radiotherapy from the United States Surveillance Epidemiology and End Results (SEER) programme, to estimate the numbers of incident cancers in the UK in 2007 that were associated with radiotherapy for a previous cancer and that may have been caused by it. We estimated that 1,346 cases of cancer, or about 0.45% of the 298,000 new cancers registered in the UK in 2007, were associated with radiotherapy for a previous cancer. The largest numbers of radiotherapy-related second cancers were lung cancer (23.7% of the total), ...

  
  

Mots clés : Lutte contre les cancers (Observation)

A partir des données de l'Organisation Mondiale de la Santé, cette étude anglaise compare les taux de mortalité par cancer chez les personnes âgées en Grande Bretagne, aux Etats-Unis et dans 11 pays européens

• High cancer mortality rates in the elderly in the UK
  • Cancer Epidemiology, sous presse, 2011 (résumé)
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  A partir des données de l'Organisation Mondiale de la Santé, cette étude anglaise compare les taux de mortalité par cancer chez les personnes âgées en Grande Bretagne, aux Etats-Unis et dans 11 pays européens

  “High cancer mortality rates in the elderly in the UK”

  • Moller, Holger;Flatt, Gavin;Moran, Anthony

  Introduction: Cancer is largely a disease of older individuals. We compared UK cancer mortality rates with those for other countries to assess progress. Methods: Death details were obtained from the WHO Mortality Database for the UK, the USA and 11 European countries. Mortality rates were calculated for the age groups 55-64, 65-74, 75-84 and >=85 years. Trends between 1995-97 and 2003-05 were determined. The number of excess cancer deaths in the UK was calculated by applying the age-specific mortality rates observed in other regions to the UK. Results: For all cancers combined, UK rates for 2003-05 in those aged >=75 years were 11-31% higher than in other regions. From 1995-97 to 2003-05, UK rates decreased by 16-17% in those aged <75 years, but increased by 2% in those >=85 years compared with decreases of 4-16% for the other geographic areas. More than 14,000 cancer deaths in the UK in those aged >=75 years would be avoided each year if UK mortality rates were identical to those in ...

  
  

Mots clés : Lutte contre les cancers (Observation)

Menée à Mexico, cette étude évalue l'incidence de la leucémie aiguë des enfants agés de moins de 15 ans, sur la période 2006-2007

• Childhood acute leukemias are frequent in Mexico City: descriptive epidemiology
  • BMC Cancer, Vol. 11 (1), pp. 355, 2011 (article en libre accès)
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  Menée à Mexico, cette étude évalue l'incidence de la leucémie aiguë des enfants agés de moins de 15 ans, sur la période 2006-2007

  “Childhood acute leukemias are frequent in Mexico City: descriptive epidemiology”

  • Perez-Saldivar, Maria Luisa;Fajardo-Gutierrez, Arturo;Bernaldez-Rios, Roberto;Martinez-Avalos, Armando;Medina-Sanson, Aurora;Espinosa-Hernandez, Laura;Flores-Chapa, Jose de Diego;Amador-Sanchez, Raquel;Penaloza-Gonzalez, Jose Gabriel;Alvarez-Rodriguez, Francisco Javier;Bolea-Murga, Victoria;Flores-Lujano, Janet;Rodriguez-Zepeda, Maria del Carmen;Rivera-Luna, Roberto;Dorantes-Acosta, Elisa Maria;Jimenez-Hernandez, Elva;Alvarado-Ibarra, Martha;Velazquez-Avina, Martha Margarita;Torres-Nava, Jose Refugio;Duarte-Rodriguez, David Aldebaran;Paredes-Aguilera, Rogelio;del Campo-Martinez, Maria de los Angeles;Cardenas-Cardos, Rocio;Alamilla-Galicia, Paola Hillary;Bekker-Mendez, Vilma Carolina;Ortega-Alvarez, Manuel Carlos;Mejia-Arangure, Juan Manuel

  BACKGROUND:Worldwide, acute leukemia is the most common type of childhood cancer. It is particularly common in the Hispanic populations residing in the United States, Costa Rica, and Mexico City. The objective of this study was to determine the incidence of acute leukemia in children who were diagnosed and treated in public hospitals in Mexico City.METHODS:Included in this study were those children, under 15 years of age and residents of Mexico City, who were diagnosed in 2006 and 2007 with leukemia, as determined by using the International Classification of Childhood Cancer. The average annual incidence rates (AAIR), and the standardized average annual incidence rates (SAAIR) per million children were calculated. We calculated crude, age- and sex-specific incidence rates and adjusted for age by the direct method with the world population as standard. We determined if there were a correlation between the incidence of acute leukemias in the various boroughs of Mexico City and either ...

  
  

Mots clés : Leucémie; Lutte contre les cancers (Observation)

Menée sur la période 1999-2006, cette étude analyse les raisons de l'observation d'une baisse récente du taux de mortalité par cancers myéloprolifératifs aux Etats-Unis

• Recent decline in the U.S. death rate from myeloproliferative neoplasms, 1999-2006
  • Cancer Epidemiology, sous presse, 2011 (résumé)
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  Menée sur la période 1999-2006, cette étude analyse les raisons de l'observation d'une baisse récente du taux de mortalité par cancers myéloprolifératifs aux Etats-Unis

  “Recent decline in the U.S. death rate from myeloproliferative neoplasms, 1999-2006”

  • Polednak, Anthony P.

  Background: Myeloproliferative neoplasms (MPNs) are classified as neoplasms of uncertain or unknown behavior in the International Classification of Diseases (ICD) Version 10 and can contribute to risk of death from complications (especially thrombosis). Methods: U.S age-standardized death rates using ICD-Version 10 codes relevant to classical MPN (i.e., polycythemia vera, essential thrombocythemia, and "chronic myeloproliferative disease") were examined for 1999-2006. The underlying cause of death and also all causes ("multiple causes" or "mentions") coded on death certificates were considered. Trends were assessed by using percentage change (PC) in rate between 1999 and 2006, and annual percentage change (APC) estimated from linear regression. Results: The decline in death rates was large for MPN, whether based only the underlying cause (PC = -19.7%, APC = -3.4%) or on the substantially higher rates based on any cause (PC = -24.1%, APC = -3.8%), and was consistent by gender ...

  
  

Mots clés : Myélome multiple et maladies immunoprolifératives; Lutte contre les cancers (Observation)

A partir d’une enquête menée auprès de 1 052 femmes atteintes d’un cancer de l’ovaire, de l’endomètre ou du col de l’utérus, cette étude danoise évalue l’association entre les facteurs sociodémographiques, la comorbidité et les délais de diagnostic

• Socio-demographic factors, comorbidity and diagnostic delay among women diagnosed with cervical, endometrial or ovarian cancer
  • European Journal of Cancer Care, Vol. 20 (5), pp. 653-661, 2011 (résumé)
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  A partir d’une enquête menée auprès de 1 052 femmes atteintes d’un cancer de l’ovaire, de l’endomètre ou du col de l’utérus, cette étude danoise évalue l’association entre les facteurs sociodémographiques, la comorbidité et les délais de diagnostic

  “Socio-demographic factors, comorbidity and diagnostic delay among women diagnosed with cervical, endometrial or ovarian cancer”

  • Robinson, K. M.;Christensen, K. B.;Ottesen, B.;Krasnik, A.

  ROBINSON K.M., CHRISTENSEN K.B., OTTESEN B. & KRASNIK A. (2011) European Journal of Cancer Care20, 653–661 Socio-demographic factors, comorbidity and diagnostic delay among women diagnosed with cervical, endometrial or ovarian cancer This study investigates the association between socio-demographic factors, comorbidity and diagnostic delay among gynaecological cancer patients. A questionnaire was sent to 1052 women diagnosed with cervical, endometrial or ovarian cancer between October 2006 and December 2007 in Denmark. Long patient delays were associated with diagnosis with a greater risk of experiencing long delays among women diagnosed with cervical and endometrial cancer as opposed to ovarian cancer. The risk of experiencing long GP referral delays was associated with residential area, with a greater risk of long delays in rural vs. urban areas. Long gynaecologist appointment delays were associated with younger age, while long secondary care delays were associated with living in ...

  
  

Mots clés : Ovaire; Lutte contre les cancers (Observation)

A partir des données des registres américains du cancer (34 568 patients), cette étude analyse les causes de mortalité des patients atteints de cancers de la tête et du cou

• Population-Based Study of Competing Mortality in Head and Neck Cancer
  • Journal of Clinical Oncology, sous presse, 2011 (résumé)
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  A partir des données des registres américains du cancer (34 568 patients), cette étude analyse les causes de mortalité des patients atteints de cancers de la tête et du cou

  “Population-Based Study of Competing Mortality in Head and Neck Cancer”

  • Rose, Brent S.;Jeong, Jong-Hyeon;Nath, Sameer K.;Lu, Sharon M.;Mell, Loren K.

  Purpose Patients with head and neck cancer (HNC) are at high risk of death resulting from noncancer causes and second malignancies (ie, competing mortality). Variation in competing mortality risk complicates individual treatment choices and design and interpretation of clinical studies.Methods Using the Surveillance, Epidemiology, and End Results registry, we identified 34,568 patients with nonmetastatic squamous cell carcinoma of the head and neck diagnosed between 1994 and 2003. We developed a multivariable competing-risk regression model to stratify patients according to competing mortality risk and evaluate the impact of this risk on power loss in clinical studies.Results The 5-year cumulative incidences of all-cause mortality, HNC-specific mortality, and competing mortality were 51.3% (95% CI, 50.8% to 51.9%), 23.8% (95% CI, 23.3% to 24.2%), and 27.6% (95% CI, 26.8% to 28.3%), respectively. Factors associated with increased competing mortality were increasing age, male sex, black ...

  
  

Mots clés : Voies aérodigestives supérieures; Lutte contre les cancers (Observation)

A partir des données de 39 registres européens de cancer, cette étude évalue la survie à 5 ans de patients atteints de tumeurs du système nerveux central

• Survival of european patients with central nervous system tumors
  • International Journal of Cancer, sous presse, 2011 (résumé)
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  A partir des données de 39 registres européens de cancer, cette étude évalue la survie à 5 ans de patients atteints de tumeurs du système nerveux central

  “Survival of european patients with central nervous system tumors”

  • Sant, Milena;Minicozzi, Pamela;Lagorio, Susanna;Johannesen, Tom Børge;Marcos-Gragera, Rafael;Francisci, Silvia;The, Eurocare Working Group

  Abstract We present estimates of population-based five-year relative survival for adult Europeans diagnosed with central nervous system tumors, by morphology (14 categories based on cell lineage and malignancy grade), sex, age at diagnosis, and region (UK and Ireland, Northern, Central, Eastern and Southern Europe) for the most recent period with available data (2000-2002). Sources were 39 EUROCARE cancer registries with continuous data from 1996 to 2002. Survival time trends (1988 to 2002) were estimated from 24 cancer registries with continuous data from 1988. Overall five-year relative survival was 85.0% for benign, 19.9% for malignant tumors. Benign tumor survival ranged from 90.6% (Northern Europe) to 77.4% (UK and Ireland); for malignant tumors the range was 25.1% (Northern Europe) to 15.6% (UK and Ireland). Survival decreased with age at diagnosis and was slightly better for women (malignant tumors only). For glial tumors, survival varied from 83.5% (ependymoma and choroid ...

  
  

Mots clés : Système nerveux central; Lutte contre les cancers (Observation)

Menée en Italie, cette étude observationnelle rétrospective évalue la survie à 10 ans de patients atteints de cancer et infectés par le VIH

• Ten-year survival among HIV-1 infected subjects with AIDS- or non-AIDS-defining malignancies
  • International Journal of Cancer, sous presse, 2011 (résumé)
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  Menée en Italie, cette étude observationnelle rétrospective évalue la survie à 10 ans de patients atteints de cancer et infectés par le VIH

  “Ten-year survival among HIV-1 infected subjects with AIDS- or non-AIDS-defining malignancies”

  • Spagnuolo, Vincenzo;Galli, Laura;Salpietro, Stefania;Gianotti, Nicola;Guffanti, Monica;Cossarini, Francesca;Bigoloni, Alba;Cinque, Paola;Bossolasco, Simona;Travi, Giovanna;Fumagalli, Luca;Lazzarin, Adriano;Castagna, Antonella

  Abstract Few data are available regarding the ten-year survival among subjects with HIV and cancer. The aim of this study was to evaluate the ten-year survival of HIV-infected subjects with AIDS-defining malignancies (ADM) or non-AIDS-defining malignancies (NADM). This was a single centre, retrospective, observational study of subjects with HIV infection and a subsequent cancer diagnosis; the data were collected from January 1991 to April 2010. Malignancies were divided into ADM or NADM on the basis of the CDC-1993 classification. Survival curves were estimated using Kaplan-Meyer method and compared by the log-rank test. Six hundred and fifteen (9.5%) of the 6495 subjects recorded in the San Raffaele Infectious Diseases Database developed a malignancy: 431 (70%) an ADM and 184 (30%) a NADM. In the case of ADM, survival was more favourable when cancer was diagnosed during post-HAART era (10-year survival: 43.2±4.4%) than when diagnosed during the pre-HAART era (10-year survival: ...

  
  

Mots clés : Lutte contre les cancers (Observation)

A partir des données des registres néerlandais du cancer, cette étude analyse l'évolution de l'incidence de la leucémie lymphoïde chronique, ses traitements et la survie des patients sur la période 1989-2008

• Chronic Lymphocytic Leukaemia in the Netherlands: Trends in incidence, treatment and survival, 1989–2008
  • European journal of cancer (Oxford, England : 1990), sous presse, 2011 (résumé)
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  A partir des données des registres néerlandais du cancer, cette étude analyse l'évolution de l'incidence de la leucémie lymphoïde chronique, ses traitements et la survie des patients sur la période 1989-2008

  “Chronic Lymphocytic Leukaemia in the Netherlands: Trends in incidence, treatment and survival, 1989–2008”

  • van den Broek, E. C.;Kater, A. P.;van de Schans, S. A. M.;Karim-Kos, H. E.;Janssen-Heijnen, M. L. G.;Peters, W. G.;Nooijen, P. T. G. A.;Coebergh, J. W. W.;Posthuma, E. F. M.

  We present trends in incidence, early treatment and survival of Chronic Lymphocytic Leukaemia (CLL) between 1989 and 2008, based on population-based data from the Netherlands Cancer Registry. Incidence rates were stable at 5.1 per 100,000 person-years for males, but increased from 2.3 to 2.5 for females, especially for females aged 50–64years (from 3.6 to 4.3). Patients were less likely to receive chemotherapy within six months, i.e. from 29% to 24% among males and from 25% to 21% among females. Five-year relative survival increased from 61% in 1989–1993 to 70% 2004–2008 for males, and from 71% to 76% for females. The relative excess risk of dying decreased in time to 0.7 (males) and 0.9 (females) in 2004–2008, reference 1989–1993, and increased with age to 2.9 (males) and 1.8 (females) in patients aged 75–94years, reference 30–64years. The increasing incidence among females aged 50–64 coincided with the introduction of mass screening for breast cancer, which resulted ...

  
  

Mots clés : Leucémie; Lutte contre les cancers (Observation)

Menée par questionnaire auprès de 1 561 femmes ayant un risque modéré ou élevé de cancer du sein, cette étude française évalue l’anxiété et la détresse des patientes avant et après un dépistage du cancer du sein par IRM ou par mammographie standard

• Anxiety and specific distress in women at intermediate and high risk of breast cancer before and after surveillance by magnetic resonance imaging and mammography versus standard mammography
  • Psycho-Oncology, sous presse, 2011 (résumé)
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  Menée par questionnaire auprès de 1 561 femmes ayant un risque modéré ou élevé de cancer du sein, cette étude française évalue l’anxiété et la détresse des patientes avant et après un dépistage du cancer du sein par IRM ou par mammographie standard

  “Anxiety and specific distress in women at intermediate and high risk of breast cancer before and after surveillance by magnetic resonance imaging and mammography versus standard mammography”

  • Brédart, Anne;Kop, Jean-Luc;Fall, Mouhamadou;Pelissier, Sandra;Simondi, Cécile;Dolbeault, Sylvie;Livartowski, Alain;Tardivon, Anne

  Abstract Background Intensive surveillance in women at intermediate and high breast cancer risk is currently investigated in a French prospective, non-randomized, multicentre study. Two surveillance modalities, standard imaging—mammography ± ultrasound (‘Mx’)—or standard imaging with magnetic resonance imaging (‘MRI’), provided according to the level of breast cancer risk, are compared on psychological distress. Methods A total of 1561 women were invited to complete the State–Trait Anxiety Inventory (STAI), Impact of Event Scale (IES) Intrusion and Avoidance subscales and breast cancer-risk perception items at T0 (before examination) and T2 (1 to 3 months later) and the STAI-State anxiety at T1 (just after examination). Multiple regression analyses were performed. Results Baseline compliance was high (>91%). Between surveillance modalities, women differed significantly for age, education level, breast cancer-risk objective estimates and subjective perception. Mean ...

  
  

Mots clés : Sein; Lutte contre les cancers (Approches psycho-sociales)

Cette étude passe en revue les politiques gouvernementales menées au Canada, au Danemark, en Norvège, en Suède et au Royaume-Uni pour inciter les employeurs à mettre en place des mesures facilitant le retour au travail de personnes atteintes de maladies chroniques

• Effectiveness of return-to-work interventions for disabled people: a systematic review of government initiatives focused on changing the behaviour of employers
  • The European Journal of Public Health, sous presse, 2011 (résumé)
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  Cette étude passe en revue les politiques gouvernementales menées au Canada, au Danemark, en Norvège, en Suède et au Royaume-Uni pour inciter les employeurs à mettre en place des mesures facilitant le retour au travail de personnes atteintes de maladies chroniques

  “Effectiveness of return-to-work interventions for disabled people: a systematic review of government initiatives focused on changing the behaviour of employers”

  • Clayton, Stephen;Barr, Ben;Nylen, Lotta;Burström, Bo;Thielen, Karsten;Diderichsen, Finn;Dahl, Espen;Whitehead, Margaret

  Background: OECD countries over the past two decades have implemented a range of labour market integration initiatives to improve the employment chances of disabled and chronically ill individuals. This article presents a systematic review and evidence synthesis on effectiveness of government interventions to influence employers’ employment practices concerning disabled and chronically ill individuals in five OECD countries. A separate paper reports on interventions to influence the behaviour of employees. Methods: Electronic and grey literature searches to identify all empirical studies reporting employment effects and/or process evaluations of government policies aimed at changing the behaviour of employers conducted between 1990 and 2008 from Canada, Denmark, Norway, Sweden and the UK. Results: Few studies provided robust evaluations of the programmes or their differential effects and selection of participants into programmes may distort the findings of even controlled studies. A ...

  
  

Mots clés : Lutte contre les cancers (Approches psycho-sociales)

A partir de l’analyse de la fréquence des prescriptions de psychotropes, cette étude néerlandaise (2 172 cas et 8 129 témoins) évalue la détresse psychologique, liée à la maladie et/ou au traitement, des patientes atteintes d'un cancer du sein et traitées par hormonothérapie

• Psychotropic medication during endocrine treatment for breast cancer
  • Supportive Care in Cancer, pp. 1-8, 2011 (article en libre accès)
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  A partir de l’analyse de la fréquence des prescriptions de psychotropes, cette étude néerlandaise (2 172 cas et 8 129 témoins) évalue la détresse psychologique, liée à la maladie et/ou au traitement, des patientes atteintes d'un cancer du sein et traitées par hormonothérapie

  “Psychotropic medication during endocrine treatment for breast cancer”

  • de Bock, Geertruida;Musters, Regina;Bos, H.;Schröder, Caroline;Mourits, Marian;de Jong-van den Berg, Lolkje

  Purpose Psychological problems are frequently mentioned in women treated for breast cancer in whom depression is mentioned as the most common disorder. The aim was to study the prescription of psychotropic medication in women with endocrine treatment for breast cancer in women in our prospective and consecutive pharmacy database. Methods Women ( n = 2,172) with at least one prescription of tamoxifen, fulvestrant, anastrazole, letrozole or exemestane were considered as breast cancer patients treated with endocrine therapy. This group was compared with an age- and family physician-matched group of women without cancer ( n = 8,129), and the incidence risk ratio (IRR) and the 95% confidence intervals (95% CI) were calculated. In addition, the prevalence of these psychotropic medication prescriptions and the 95% CI were calculated. Results There was an increased prescription of psychotropic medication in the female breast cancer patients on endocrine therapy: anxiolytics (IRR 2.07, 95% CI ...

  
  

Mots clés : Sein; Lutte contre les cancers (Approches psycho-sociales)

A partir d’une enquête menée auprès de 129 personnes ayant un risque élevé de cancer du pancréas, cette étude canadienne évalue les effets à long terme (3 et 12 mois) d’une séance de dépistage et de conseil génétique sur la détresse et l’inquiétude des patients

• Moderators of cancer-related distress and worry after a pancreatic cancer genetic counseling and screening intervention
  • Psycho-Oncology, sous presse, 2011 (résumé)
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  A partir d’une enquête menée auprès de 129 personnes ayant un risque élevé de cancer du pancréas, cette étude canadienne évalue les effets à long terme (3 et 12 mois) d’une séance de dépistage et de conseil génétique sur la détresse et l’inquiétude des patients

  “Moderators of cancer-related distress and worry after a pancreatic cancer genetic counseling and screening intervention”

  • Hart, Stacey L.;Torbit, Lindsey A.;Crangle, Cassandra J.;Esplen, Mary Jane;Holter, Spring;Semotiuk, Kara;Borgida, Ayelet;Ardiles, Paola;Rothenmund, Heidi;Gallinger, Steve

  Abstract Objectives Although the hereditary breast and ovarian cancer literature has demonstrated short-term gains in psychological adjustment following genetic counseling, there has been limited research examining long-term outcomes and moderators. Moreover, there has been minimal research into the psychological effects of this intervention in populations at high risk for pancreatic cancer. This study examines the long-term effects of pancreatic cancer screening and genetic counseling on cancer-related distress and cancer worry in a high-risk population at 1-year follow-up. Additionally, this study explores potential moderators of the effectiveness of this intervention. Methods One hundred twenty-nine participants with familial pancreatic cancer or with the BRCA2 gene mutation completed a baseline questionnaire prior to their first pancreatic cancer screening and genetic counseling session. Participants also completed questionnaires at 3- and 12-month follow-up. Results ...

  
  

Mots clés : Pancréas; Lutte contre les cancers (Approches psycho-sociales)

Menée à partir des données de registres américains sur la période 1995-1998, cette étude rétrospective de cohorte (50 147 patients) évalue le taux de dépression parmi les personnes âgées atteintes d’un cancer de la prostate, les coûts et la surmortalité associés à la dépression durant le traitement

• The burden of depression in prostate cancer
  • Psycho-Oncology, sous presse, 2011 (résumé)
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  Menée à partir des données de registres américains sur la période 1995-1998, cette étude rétrospective de cohorte (50 147 patients) évalue le taux de dépression parmi les personnes âgées atteintes d’un cancer de la prostate, les coûts et la surmortalité associés à la dépression durant le traitement

  “The burden of depression in prostate cancer”

  • Jayadevappa, Ravishankar;Malkowicz, S. Bruce;Chhatre, Sumedha;Johnson, Jerry C.;Gallo, Joseph J.

  Abstract Objective We sought to analyze the prevalence and incremental burden of depression among elderly with prostate cancer. Methods We adopted a retrospective cohort design using the Surveillance, Epidemiology and End Results-Medicare linked database between 1995 and 2003. Patients with prostate cancer diagnosed between 1995 and 1998 were identified and followed retrospectively for 1 year pre-diagnosis and up to 8 years post diagnosis. In this cohort of patients with prostate cancer, depression during treatment phase (1 year after diagnosis of prostate cancer) or in the follow-up phase was identified using the International Classification of Diseases-Ninth Revision depression-related codes. Poisson, general linear (log-link) and Cox regression models were used to determine the association between depression status during treatment and follow-up phases and outcomes–health resource utilization, cost and mortality. Results Of the 50,147 patients newly diagnosed with prostate ...

  
  

Mots clés : Prostate; Lutte contre les cancers (Approches psycho-sociales)

Menée au Royaume-Uni auprès de 40 survivants d'un cancer du sein, du côlon-rectum et de la prostate, cette étude qualitative analyse leurs sentiments vis-à-vis du concept de survivant

• Interpretation and acceptance of the term ‘cancer survivor’: a United Kingdom-based qualitative study
  • European Journal of Cancer Care, pp. no-no, 2011 (résumé)
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  Menée au Royaume-Uni auprès de 40 survivants d'un cancer du sein, du côlon-rectum et de la prostate, cette étude qualitative analyse leurs sentiments vis-à-vis du concept de survivant

  “Interpretation and acceptance of the term ‘cancer survivor’: a United Kingdom-based qualitative study”

  • Khan, N. F.;Harrison, S.;Rose, P. W.;Ward, A.;Evans, J.

  KHAN N.F., HARRISON S., ROSE P.W., WARD A. & EVANS J. (2011) European Journal of Cancer Care Interpretation and acceptance of the term ‘cancer survivor’: a United Kingdom-based qualitative study The concept of cancer survivorship and the term ‘cancer survivor’ remains widely interpreted. The aim is to explore the interpretations of the term ‘cancer survivor’ amongst British people living past a cancer diagnosis. We conducted an in-depth qualitative study of 40 people at least 5 years post-diagnosis of breast, colorectal or prostate cancer. Each interviewee was asked whether they felt they were a cancer survivor and interpretations of the term were explored. The majority of respondents did not endorse the term ‘cancer survivor’, and there was a wide variation in its interpretation. Those who accepted the term understood survivorship as a factual definition of having had cancer and survived. Most rejected the term because it implied a high risk of death that did not ...

  
  

Mots clés : Lutte contre les cancers (Approches psycho-sociales)

A partir des données de la cohorte "Childhood Cancer Survivor Study", cette étude évalue l'état de santé physique, mental et neurocognitif de survivants d'un cancer de l'enfance, ainsi que leur statut social et professionnel

• Physical, Mental, and Neurocognitive Status and Employment Outcomes in the Childhood Cancer Survivor Study Cohort
  • Cancer Epidemiology Biomarkers & Prevention, sous presse, 2011 (résumé)
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  A partir des données de la cohorte "Childhood Cancer Survivor Study", cette étude évalue l'état de santé physique, mental et neurocognitif de survivants d'un cancer de l'enfance, ainsi que leur statut social et professionnel

  “Physical, Mental, and Neurocognitive Status and Employment Outcomes in the Childhood Cancer Survivor Study Cohort”

  • Kirchhoff, Anne C.;Krull, Kevin R.;Ness, Kirsten K.;Armstrong, Gregory T.;Park, Elyse R.;Stovall, Marilyn;Robison, Leslie L.;Leisenring, Wendy

  Introduction: We examined the relationship of physical, mental, and neurocognitive function with employment and occupational status in the Childhood Cancer Survivor Study.Methods: We included survivors 25 years or older with available short form-36 (physical and mental health component scores), brief symptom inventory (depression, anxiety, and somatization), and neurocognitive questionnaire (task efficiency, emotional regulation, organization, and memory). We generated relative risks (RR) from generalized linear models for these measures on unemployment (n = 5,386) and occupation (n = 3,763) outcomes adjusted for demographic and cancer-related factors and generated sex-stratified models.Results: Poor physical health was associated with an almost eightfold higher risk of health-related unemployment (P < 0.001) compared to survivors with normal physical health. Male survivors with somatization and memory problems were approximately 50% (P < 0.05 for both) more likely to report this ...

  
  

Mots clés : Lutte contre les cancers (Approches psycho-sociales)

Menée auprès de 36 patients atteints de sarcome, cette étude longitudinale évalue les facteurs démographiques, cliniques et psychologiques influant sur l'anxiété et la dépression des patients, de leur diagnostic à leur traitement

• A longitudinal study on emotional adjustment of sarcoma patients: the determinant role of demographic, clinical and coping variables
  • European Journal of Cancer Care, pp. no-no, 2011 (résumé)
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  Menée auprès de 36 patients atteints de sarcome, cette étude longitudinale évalue les facteurs démographiques, cliniques et psychologiques influant sur l'anxiété et la dépression des patients, de leur diagnostic à leur traitement

  “A longitudinal study on emotional adjustment of sarcoma patients: the determinant role of demographic, clinical and coping variables”

  • Paredes, T.;Pereira, M.;SimÕEs, M. R.;Canavarro, M. C.

  PAREDES T., PEREIRA M., SIMÕES M.R. & CANAVARRO M.C. (2011) European Journal of Cancer Care. A longitudinal study on emotional adjustment of sarcoma patients: the determinant role of demographic, clinical and coping variables The present study examined change on emotional distress of sarcoma patients from the diagnostic to treatment phases, the distinct trajectories of adjustment and the influence of demographic, clinical and coping variables on anxiety and depression. Thirty-six sarcoma patients completed questionnaires on emotional distress (Hospital Anxiety and Depression Scale) and coping strategies (Brief Cope) at time of diagnosis, and again during treatment. No significant change in emotional distress levels was found from diagnostic to treatment phase, with mean anxiety and depression scores remaining below the clinical range. Over time, 52.8% and 66.7% of patients maintained non-clinical anxious and depressive symptoms respectively, and 25% and 11.1% remained with clinical ...

  
  

Mots clés : Sarcome; Lutte contre les cancers (Approches psycho-sociales)

A partir d'une enquête menée auprès de 1 490 personnes, cette étude danoise évalue l'association entre des facteurs démographiques et cliniques, et le retour au travail des patients après un diagnostic de cancer

• Factors associated with Danish cancer patients' return to work. A report from the population-based study [`]The Cancer Patient's World'
  • Cancer Epidemiology, sous presse, 2011 (résumé)
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  A partir d'une enquête menée auprès de 1 490 personnes, cette étude danoise évalue l'association entre des facteurs démographiques et cliniques, et le retour au travail des patients après un diagnostic de cancer

  “Factors associated with Danish cancer patients' return to work. A report from the population-based study [`]The Cancer Patient's World'”

  • Ross, Lone;Petersen, Morten Aagaard;Johnsen, Anna Thit;Lundstroem, Louise Hyldborg;Carlsen, Kathrine;Groenvold, Mogens

  Purpose: If patients facing difficulties in the process of returning to work after treatment of cancer could be identified, these patients could be assisted in the transition. This might help some patients to stay in work. We therefore assessed demographic and clinical factors associated with returning to work after a cancer diagnosis. Materials and methods: In this cross-sectional survey, 1490 cancer patients who had been in contact with a hospital department during the past 12 months in three Danish counties responded to a mailed questionnaire. Factors associated with employment and return to work (i.e., working more than 0 h in the past month) respectively, were assessed in multivariate ordinal logistic regression models. Results: Of the 598 patients below age 65 who were employed at the time of diagnosis, 75% were still employed when answering the questionnaire at a median of 2.8 years after diagnosis and 63% were working. In multivariate analyses, younger and more recently ...

  
  

Mots clés : Lutte contre les cancers (Approches psycho-sociales)

A partir d’un entretien mené auprès de 20 femmes atteintes d’une néoplasie vulvaire, cette étude qualitative germano-suisse analyse, six mois après l'intervention, l’expérience des patientes face aux symptômes post-chirurgicaux

• The unspoken disease: symptom experience in women with vulval neoplasia and surgical treatment: a qualitative study
  • European Journal of Cancer Care, pp. no-no, 2011 (résumé)
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  A partir d’un entretien mené auprès de 20 femmes atteintes d’une néoplasie vulvaire, cette étude qualitative germano-suisse analyse, six mois après l'intervention, l’expérience des patientes face aux symptômes post-chirurgicaux

  “The unspoken disease: symptom experience in women with vulval neoplasia and surgical treatment: a qualitative study”

  • Senn, B.;Gafner, D.;Happ, M. B.;Eicher, M.;Mueller, M. D.;Engberg, S.;Spirig, R.

  The unspoken disease: symptom experience in women with vulval neoplasia and surgical treatment: a qualitative study Women with vulval neoplasia often experience severe post-surgical complications. This study focuses on symptom experience of women during the first 6 months following surgical treatment for vulval neoplasia considering their socio-cultural context. In this qualitative study using a critical hermeneutic approach, narrative interviews were conducted. A purposeful sample of 20 patients was recruited from one Swiss and two German university hospitals. Content analysis was employed to analyse the transcribed interviews considering women's experiences and social perceptions. Narratives showed eight interrelated themes: delayed diagnosis, disclosed disease, disturbed self-image, changed vulva care, experienced wound-related symptoms, evoked emotions, affected interpersonal interactions and feared illness progression. The women experienced a general lack of information ...

  
  

Mots clés : Organe génital (autre); Lutte contre les cancers (Approches psycho-sociales)

Menée sur 32 adolescents ayant été traités pour des tumeurs osseuses, cette étude analyse leurs attentes et leurs espoirs 1 mois après un traitement ayant entraîné une rémission complète

• Adolescents' struggle against bone cancer: an explorative study on optimistic expectations of the future, resiliency and coping strategies
  • European Journal of Cancer Care, pp. no-no, 2011 (résumé)
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  Menée sur 32 adolescents ayant été traités pour des tumeurs osseuses, cette étude analyse leurs attentes et leurs espoirs 1 mois après un traitement ayant entraîné une rémission complète

  “Adolescents' struggle against bone cancer: an explorative study on optimistic expectations of the future, resiliency and coping strategies”

  • Smorti, M.

  SMORTI M. (2011) European Journal of Cancer Care. Adolescents' struggle against bone cancer: an explorative study on optimistic expectations of the future, resiliency and coping strategies The present study aims to assess adolescents' expectations of the future after bone cancer treatment and to investigate in greater depth the relationship between expectations of the future, resilience and coping strategies. Thirty-two adolescents with cancer experience (11–20 years old), who had a complete first remission at least 1 month after the end of successful treatment, were requested to respond to the Expectations for Future Scale, the Ego-Resiliency Scale and Coping Strategy Indicators. Forty-eight gender- and age-matched control adolescents were randomly selected from a normative sample (NORMs). Adolescents with cancer experience had more optimistic expectations of the future and were less open to experience compared to NORMs. They had lower global ego-resiliency, higher impulse control ...

  
  

Mots clés : Os; Lutte contre les cancers (Approches psycho-sociales)

Menée en Australie, cette étude analyse les besoins des patients atteints de cancer, en termes de soins médicaux et psychosociaux

• Mapping the psychosocial and practical support needs of cancer patients in Western Australia
  • European Journal of Cancer Care, pp. no-no, 2011 (résumé)
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  Menée en Australie, cette étude analyse les besoins des patients atteints de cancer, en termes de soins médicaux et psychosociaux

  “Mapping the psychosocial and practical support needs of cancer patients in Western Australia”

  • White, K.;D'Abrew, N.;Katris, P.;O'Connor, M.;Emery, L.

  WHITE K., D'ABREW N., KATRIS P., O'CONNOR M. & EMERY L. (2011) European Journal of Cancer Care Mapping the psychosocial and practical support needs of cancer patients in Western Australia Understanding the unmet needs of cancer patients is important for developing and refining services to address the identified gaps in cancer care. In order to describe the psychological and practical support needs of Western Australians with cancer, the Western Australian Cancer Registry was used to identify a sample of individuals with cancer. These individuals were then invited to complete the Supportive Care Needs Survey (SCNS-LF59) and a demographic questionnaire. Data from participants who completed and returned both questionnaires were analysed using descriptive statistics, chi-square tests and one-way anova. Of the 1770 participants identified and contacted, a total of 829 individuals (47% response) completed the SCNS-LF59 alone, and 786 (94.8%) completed both questionnaires. Overall, a ...

  
  

Mots clés : Lutte contre les cancers (Approches psycho-sociales)

Cette étude économique présente un modèle prenant en compte les pertes de productivité pour améliorer l'étude du rapport coût-efficacité des statégies de prévention et de lutte contre le cancer colorectal aux Etats-Unis

• Productivity Savings from Colorectal Cancer Prevention and Control Strategies
  • American journal of preventive medicine, Vol. 41 (2), pp. e5-e14, 2011 (résumé)
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  Cette étude économique présente un modèle prenant en compte les pertes de productivité pour améliorer l'étude du rapport coût-efficacité des statégies de prévention et de lutte contre le cancer colorectal aux Etats-Unis

  “Productivity Savings from Colorectal Cancer Prevention and Control Strategies”

  • Bradley, Cathy J.;Lansdorp-Vogelaar, Iris;Yabroff, K. Robin;Dahman, Bassam;Mariotto, Angela;Feuer, Eric J.;Brown, Martin L.

  Lost productivity represents a considerable portion of the total economic burden of colorectal cancer (CRC), but cost-effectiveness studies of CRC prevention and control have not included these costs and therefore underestimate potential savings from CRC prevention and control. To use microsimulation modeling study to estimate and project productivity costs of CRC and to model the savings from four approaches to reducing CRC incidence and mortality: risk factor reduction, improved screening, improved treatment, and a simultaneous approach where all three strategies are implemented. A model was developed to project productivity losses from CRC using the U.S. population with CRC incidence and mortality projected through the year 2020. Outcome measures were CRC mortality, morbidity, and productivity savings. With 2005 levels in risk factors, screening, and treatment, 48,748 CRC deaths occurred in 2010, amounting to $21 billion of lost productivity. Using prevention and treatment ...

  
  

Mots clés : Colon-rectum; Lutte contre les cancers (Analyses économiques et systèmes de soins)

Menée au Danemark auprès de 10 familles, cette étude qualitative analyse leurs expériences relatives à un programme de soins à domicile pour leur enfant atteint de cancer

• Hospital-based home care for children with cancer: a qualitative exploration of family members' experiences in Denmark
  • European Journal of Cancer Care, pp. no-no, 2011 (résumé)
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  Menée au Danemark auprès de 10 familles, cette étude qualitative analyse leurs expériences relatives à un programme de soins à domicile pour leur enfant atteint de cancer

  “Hospital-based home care for children with cancer: a qualitative exploration of family members' experiences in Denmark”

  • Hansson, H.;KjÆRgaard, H.;Schmiegelow, K.;HallstrÖM, I.

  HANSSON H., KJÆRGAARD H., SCHMIEGELOW K. & HALLSTRÖM I. (2011) European Journal of Cancer Care Hospital-based home care for children with cancer: a qualitative exploration of family members' experiences in Denmark The study aims to describe the experiences of a hospital-based home care programme in the families of children with cancer. Fourteen parents, representing 10 families, were interviewed about their experiences of a hospital-based home care programme during a 4-month period in 2009 at a university hospital in Denmark. Five children participated in all or part of the interview. The interviews were transcribed verbatim and analysed using qualitative content analysis. The findings indicate that hospital-based home care enabled the families to remain intact throughout the course of treatment, as it decreased the strain on the family and the ill child, maintained normality and an ordinary everyday life and fulfilled the need for safety and security. According to family members of ...

  
  

Mots clés : Lutte contre les cancers (Analyses économiques et systèmes de soins)

Menée en Irlande par questionnaire auprès de 979 participants, cette étude analyse leurs connaissances relatives au cancer de la prostate

• Prostate Cancer Knowledge in Irish Men
  • Journal of Cancer Education, pp. 1-12, 2011 (résumé)
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  Menée en Irlande par questionnaire auprès de 979 participants, cette étude analyse leurs connaissances relatives au cancer de la prostate

  “Prostate Cancer Knowledge in Irish Men”

  • Casey, Rowan;Rea, David;McDermott, Ted;Grainger, Ronald;Butler, Michael;Thornhill, J.

  Men require prostate cancer (Pca) knowledge to practice health-seeking behaviours. Nine hundred seventy-nine men participated in a Pca screening programme comprising IPSS, bother score and health belief questionnaire. Men with private insurance had greater knowledge. Forty-nine percent (481) assessed their health status as average. Seventy-five percent (735) visited the GP at least once per year. The majority (576) felt well informed about health matters. Fifty-five percent (542) knew the prostate location but only 319 (33%) could identify it on a diagram. Forty-one percent (401) could not name a symptom. Few knew risk factors but 98% would attend a Pca screening clinic and sought more information. Men lack knowledge to pursue healthier behaviours and should be targeted possibly through a men’s health initiative.

  
  

Mots clés : Prostate; Lutte contre les cancers (Sensibilisation et communication)

A partir d'entretiens téléphoniques menés auprès de 231 femmes atteintes d’un carcinome canalaire in situ et de questionnaires adressés à 63 chirurgiens, cette étude australienne évalue leurs connaissances relatives à la maladie

• Understanding a ductal carcinoma in situ diagnosis: patient views and surgeon descriptions
  • European Journal of Cancer Care, pp. no-no, 2011 (résumé)
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  A partir d'entretiens téléphoniques menés auprès de 231 femmes atteintes d’un carcinome canalaire in situ et de questionnaires adressés à 63 chirurgiens, cette étude australienne évalue leurs connaissances relatives à la maladie

  “Understanding a ductal carcinoma in situ diagnosis: patient views and surgeon descriptions”

  • Davey, C.;White, V.;Warne, C.;Kitchen, P.;Villanueva, E.;Erbas, B.

  DAVEY C., WHITE V., WARNE C., KITCHEN P., VILLANUEVA E. & ERBAS B. (2011) European Journal of Cancer Care. Understanding a ductal carcinoma in situ diagnosis: patient's views and surgeon descriptions Following the release of the national clinical treatment recommendations for ductal carcinoma in situ (DCIS), consumers' and surgeons' characterisation of this disease was assessed. Telephone interviews were conducted with 231 women diagnosed with DCIS, in Victoria, Australia in 2006/2007 and 63 treating surgeons completed a mailed survey. The main outcome measures were: women's diagnostic experience, women's and surgeons' description of DCIS, women's understanding of DCIS, confusion and worry about the disease and risk perceptions. While the majority of women had not heard of DCIS prior to diagnosis, most reported a positive diagnostic experience. Surgeons' and women's description of DCIS were consistent. Women understood that DCIS is a contained disease (86%), can progress (88%) and ...

  
  

Mots clés : Sein; Lutte contre les cancers (Sensibilisation et communication)

Mené auprès de 41 participants, cet essai randomisé contrôlé évalue l'efficacité d'un programme de formation destiné aux oncologues visant à améliorer leurs compétences en termes de communication relative aux soins palliatifs

• Specific Training Program Improves Oncologists' Palliative Care Communication Skills in a Randomized Controlled Trial
  • Journal of Clinical Oncology, sous presse, 2011 (résumé)
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  Mené auprès de 41 participants, cet essai randomisé contrôlé évalue l'efficacité d'un programme de formation destiné aux oncologues visant à améliorer leurs compétences en termes de communication relative aux soins palliatifs

  “Specific Training Program Improves Oncologists' Palliative Care Communication Skills in a Randomized Controlled Trial”

  • Goelz, Tanja;Wuensch, Alexander;Stubenrauch, Sara;Ihorst, Gabriele;de Figueiredo, Marcelo;Bertz, Hartmut;Wirsching, Michael;Fritzsche, Kurt

  Purpose The aim of the study was to demonstrate that COM-ON-p, concise and individualized communication skills training (CST), improves oncologists' communication skills in consultations focusing on the transition to palliative care.Methods Forty-one physicians were randomly assigned to a control (CG) or intervention group (IG). At t0, all physicians held two video-recorded consultations with actor-patient pairs. Afterward, physicians in the IG participated in COM-ON-p. Five weeks after t0, a second assessment took place (t1). COM-ON-p consists of an 11-hour workshop (1.5 days), pre- and postassessment (2 hours), and coaching (0.5 hours). Physicians focused on practicing individual learning goals with actor patients in small groups. To evaluate the training, blinded raters assessed communication behavior of the physicians in video-recorded actor-patient consultations using a specific checklist. Data were analyzed using a mixed model with baseline levels as covariates.Results ...

  
  

Mots clés : Lutte contre les cancers (Sensibilisation et communication)

Menée au Canada auprès de 66 participantes immigrées d'origine chinoise, cette étude évalue leurs connaissances relatives aux causes et facteurs de risque du cancer du côlon

• Beliefs about Causes of Colon Cancer by English-as-a-Second-Language Chinese Immigrant Women to Canada
  • Journal of Cancer Education, pp. 1-6, 2011 (résumé)
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  Menée au Canada auprès de 66 participantes immigrées d'origine chinoise, cette étude évalue leurs connaissances relatives aux causes et facteurs de risque du cancer du côlon

  “Beliefs about Causes of Colon Cancer by English-as-a-Second-Language Chinese Immigrant Women to Canada”

  • McWhirter, Jennifer;Todd, Laura;Hoffman-Goetz, Laurie

  Colon cancer is the second leading cause of cancer death for Canadians. Immigrants underutilize screening and may be at greater risk of late stage diagnosis and death from the disease. This mixed-methods study investigated the self-reported causes of colon cancer by 66 English-as-a-Second-Language Chinese immigrant women to Canada after reading a fact sheet which listed two causes of colon cancer (polyps and cause unknown) and six ways to help prevent colon cancer (lifestyle, diet, weight, smoking, alcohol, and screening). Women correctly named or described both causes (6.1%) or one cause (22.7%), could not name or describe either cause (19.7%), or named or described causes not included on the fact sheet (54.5%). The most common causes reported by participants were risk factors : diet (53.0%), family history (28.8%), and lifestyle (22.7%). Women confused cause with risk factor and infrequently mentioned screening. Possible reasons for their reported beliefs are discussed.

  
  

Mots clés : Colon-rectum; Lutte contre les cancers (Sensibilisation et communication)

Menée aux Etats-Unis auprès de 3 571 participants fumeurs, cette étude évalue l'impact d'une campagne médiatique nationale promouvant l'arrêt du tabac

• The Path to Quit: How Awareness of a Large-Scale Mass-Media Smoking Cessation Campaign Promotes Quit Attempts
  • Nicotine & Tobacco Research, sous presse, 2011 (résumé)
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  Menée aux Etats-Unis auprès de 3 571 participants fumeurs, cette étude évalue l'impact d'une campagne médiatique nationale promouvant l'arrêt du tabac

  “The Path to Quit: How Awareness of a Large-Scale Mass-Media Smoking Cessation Campaign Promotes Quit Attempts”

  • Richardson, Amanda;Cullen, Jennifer;Mowery, Paul;McCausland, Kristen;Vallone, Donna

  Introduction: Although awareness of mass-media smoking cessation campaigns is hypothesized to affect quit behavior through changes in cessation-related attitudes, intentions, and motivation (cognitions), this has yet to be formally tested.Methods: Structural equation modeling was used to examine whether changes in cessation-related cognitions mediate the relationship between awareness of a national mass-media smoking cessation campaign, the EX campaign, and quit attempts in a cohort of 3,571 current smokers drawn from eight U.S. Designated Market Areas and followed over an approximate six-month period. Models were examined in the total sample and within racial/ethnic, gender, age, and educational strata.Results: Data suggest that there are both a direct effect of confirmed awareness of EX on quit attempts as well as an indirect effect mediated by positive changes in cessation-related cognitions. Results are not uniform across subgroups; stratified analyses reveal that awareness of EX ...

  
  

Mots clés : Lutte contre les cancers (Sensibilisation et communication)

Menée en Australie auprès de 2 857 participants, cette étude analyse les connaissances des patients atteints de cancer sur les facteurs de risque et les causes de leur maladie

• What factors do cancer patients believe contribute to the development of their cancer? (New South Wales, Australia)
  • Cancer Causes and Control, pp. 1-9, 2011 (résumé)
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  Menée en Australie auprès de 2 857 participants, cette étude analyse les connaissances des patients atteints de cancer sur les facteurs de risque et les causes de leur maladie

  “What factors do cancer patients believe contribute to the development of their cancer? (New South Wales, Australia)”

  • Willcox, Simon;Stewart, Bernard;Sitas, Freddy

  Objective  To analyze Australian cancer patients’ beliefs about factors contributing to the development of their cancer. Methods  As part of a case–control study (The Cancer Council NSW Cancer, Lifestyle and Evaluation of Risk Study), a total of 2,857 cancer patients (open to all types of cancer) were surveyed and via an open-ended question, were asked to specify factors they think contributed to the development of their cancer. Qualitative analysis and categorical techniques were used to analyze the data. Results  About half, 53%, of patients specified at least one contributing factor. The odds of a person specifying a contributing factor increased with time period since diagnosis (p = 0.0006). Patients most frequently specified, respectively: Stress (15.4%), Genetics/hereditary (10.9%) and Smoking (6.2%). Among factors specified the largest proportion (24.1%) was perceived to be Non-modifiable. Conclusion  Cancer patients specified a broad range of factors and agents ...

  
  

Mots clés : Lutte contre les cancers (Sensibilisation et communication)

Menée auprès de 177 patients atteints de cancer traités en unités de soins palliatifs, cette étude analyse le recours à une sédation palliative

• Higher doses of opioids in patients who need palliative sedation prior to death: Cause or consequence?
  • European journal of cancer, sous presse, 2011 (résumé)
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  Menée auprès de 177 patients atteints de cancer traités en unités de soins palliatifs, cette étude analyse le recours à une sédation palliative

  “Higher doses of opioids in patients who need palliative sedation prior to death: Cause or consequence?”

  • Oosten, A. W.;Oldenmenger, W. H.;van Zuylen, C.;Schmitz, P. I. M.;Bannink, M.;Lieverse, P. J.;Bromberg, J. E. C.;van der Rijt, C. C. D.

  Palliative sedation (PS) is necessary in a significant percentage of patients dying on an acute palliative care unit (PCU). Common indications are terminal restlessness, pain and dyspnoea. On our PCU, terminal restlessness was the main indication for PS but pain was the most prevalent symptom during admission. Because delirium is often drug induced in terminal cancer patients and opioids are amongst the most frequently implicated drugs, we hypothesised that the underlying pain problem and its treatment might have been related to the need for sedation. To test this hypothesis, we did a retrospective analysis on the use of medication with potential cognitive side-effects, focusing on analgesics, in 68 patients who died on the PCU after PS and 89 patients who died without PS. Ultimately sedated patients used opioids in significantly higher doses; they were more often treated with a rotation to another opioid and with amitriptyline. The dose of opioids used at various time points between ...

  
  

Mots clés : Lutte contre les cancers (Soins palliatifs)

Menée en Australié auprès de 36 participants, patients atteints de cancer et professionnels de santé, cette étude analyse les raisons de leur non-recours aux médecines complémentaires pendant le traitement

• Why people choose to not use complementary therapies during cancer treatment: a focus group study
  • European Journal of Cancer Care, pp. no-no, 2011 (résumé)
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  Menée en Australié auprès de 36 participants, patients atteints de cancer et professionnels de santé, cette étude analyse les raisons de leur non-recours aux médecines complémentaires pendant le traitement

  “Why people choose to not use complementary therapies during cancer treatment: a focus group study”

  • Beatty, L.;Koczwara, B.;Knott, V.;Wade, T.

  BEATTY L., KOCZWARA B., KNOTT V. & WADE T. (2011) European Journal of Cancer Care Why people choose to not use complementary therapies during cancer treatment: a focus group study While 50% of cancer patients use complementary therapies (CT) during treatment, few studies have examined why individuals choose not to use CT. This study aimed to address this gap in knowledge using a focus group methodology, where 36 participants took part in one of eight groups; participants were recruited until saturation of themes was achieved. Three categories of participants were investigated: patients/recent survivors (n= 14); volunteers/advocates (n= 16), the majority of whom were also long-term survivors; and health professionals (n= 6). Focus groups were digitally audio-recorded, transcribed, and coded thematically using NVivo software. Reasons for non-use fell into four broad themes: (1) Resource barriers, particularly the cost and lack of time; (2) fear and distrust, including the potential for ...

  
  

Mots clés : Lutte contre les cancers (Médecines parallèles)

A partir d'une simulation utilisant les données d'un registre finlandais du cancer de la thyroïde, cette étude compare des méthodes pour calculer la survie relative dans des études de population

• Comparison of methods for calculating relative survival in population-based studies
  • Cancer Epidemiology, sous presse, 2011 (résumé)
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  A partir d'une simulation utilisant les données d'un registre finlandais du cancer de la thyroïde, cette étude compare des méthodes pour calculer la survie relative dans des études de population

  “Comparison of methods for calculating relative survival in population-based studies ”

  • Rutherford, Mark J.;Dickman, Paul W.;Lambert, Paul C.

  Background: It is vital that unbiased estimates of relative survival are estimated and reported by cancer registries. A single figure of relative survival is often required to make reporting simpler. This can be obtained by pooling all ages or, more commonly, by using age-standardisation. The various methods for providing a single figure estimate of relative survival can give very different estimates. Methods: The problem is illustrated through an example using Finnish thyroid cancer data. The differences are further explored through a simulation study that investigates the effect of age on the estimates of relative survival. Results: The example highlights that in practice the all-age estimates from the various methods can be substantially different (up to 6 percentage units at 15 years of follow-up). The simulation study confirms the finding that differing estimates for the all-age estimates of relative survival are obtained. Performing age-standardisation makes the methods more ...

  
  

Mots clés : Lutte contre les cancers (Ressources et infrastructures (Lutte contre les cancers))

Cette étude canadienne analyse l’expérience d’apprentissage de 6 experts en psycho-oncologie formés durant 6 mois à l'animation de groupes d’entraide en ligne sur Internet

• Facilitating online support groups for cancer patients: the learning experience of psycho-oncology clinicians
  • Psycho-Oncology, Vol. 20 (8), pp. 832-840, 2011 (résumé)
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  Cette étude canadienne analyse l’expérience d’apprentissage de 6 experts en psycho-oncologie formés durant 6 mois à l'animation de groupes d’entraide en ligne sur Internet

  “Facilitating online support groups for cancer patients: the learning experience of psycho-oncology clinicians”

  • Stephen, Joanne E.;Christie, Glenda;Flood, Karen;Golant, Mitch;Rahn, Michelle;Rennie, Heather;Speca, Michael;Taylor-Brown, Jill;Turner, Jill

  Abstract Objective: Counsellor familiarity and engagement with technology-mediated communication represents an important factor in the ability to implement support programs to cancer patients. This study describes the experiences of a cohort of expert psycho-oncology counsellors who learned to facilitate online support groups (OSGs) and identifies the important elements of their learning experience that led to their engagement. Procedure and method: Six psycho-oncology counsellors were trained to facilitate OSGs and later facilitated OSGs in their own practice context. They subsequently reflected on and discussed their experiences with OSGs over time: in a panel discussion within 6 months of training, and in two focus groups. A participatory method was used to describe and interpret key elements of the learning process. Results and discussion: Three themes of the counsellors' learning experience emerged: immersion in experiential learning, perceptions of clinical value and benefit, ...

  
  

Mots clés : Lutte contre les cancers (Ressources et infrastructures (Lutte contre les cancers))